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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Miscellaneous

Alpha2-adrenergic receptor shows an allosteric modulation by Na+, H+ and amiloride analogs.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei113Implicated in ligand bindingBy similarity1
Sitei200Implicated in catechol agonist bindingBy similarity1
Sitei204Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • alpha2-adrenergic receptor activity Source: BHF-UCL
  • epinephrine binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

SABIO-RKiP18871

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:ADRA2A
Synonyms:A2AR
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 59Helical; Name=1By similarityAdd BLAST26
Topological domaini60 – 70CytoplasmicBy similarityAdd BLAST11
Transmembranei71 – 96Helical; Name=2By similarityAdd BLAST26
Topological domaini97 – 106ExtracellularBy similarity10
Transmembranei107 – 129Helical; Name=3By similarityAdd BLAST23
Topological domaini130 – 149CytoplasmicBy similarityAdd BLAST20
Transmembranei150 – 173Helical; Name=4By similarityAdd BLAST24
Topological domaini174 – 192ExtracellularBy similarityAdd BLAST19
Transmembranei193 – 217Helical; Name=5By similarityAdd BLAST25
Topological domaini218 – 374CytoplasmicBy similarityAdd BLAST157
Transmembranei375 – 399Helical; Name=6By similarityAdd BLAST25
Topological domaini400 – 409ExtracellularBy similarity10
Transmembranei410 – 430Helical; Name=7By similarityAdd BLAST21
Topological domaini431 – 450CytoplasmicBy similarityAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi442C → A or S: Loss of palmitoylation. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2350

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690821 – 450Alpha-2A adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Modified residuei331PhosphoserineBy similarity1
Modified residuei353Omega-N-methylarginineBy similarity1
Lipidationi442S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP18871
PRIDEiP18871

PTM databases

SwissPalmiP18871

Expressioni

Gene expression databases

BgeeiENSSSCG00000010629 Expressed in 4 organ(s), highest expression level in prefrontal cortex
GenevisibleiP18871 SS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011323

Chemistry databases

BindingDBiP18871

Structurei

3D structure databases

ProteinModelPortaliP18871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP18871
KOiK04138
OMAiIIFIVWV
OrthoDBiEOG091G06VI
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLQPEAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SIEKKAGGGG QQPAEPRCEI NDQKWYVISS
210 220 230 240 250
CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAAA ALPGGAERRP
260 270 280 290 300
NGLGPERGVG RVGAEAEPLP VQLNGAPGEP APAGPRDADG LDLEESSSSE
310 320 330 340 350
HAERPPGPRR SERGPRAKSK ARASQVKPGD SLPRRGPGAP GPGAPATGAG
360 370 380 390 400
EERGGVAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG
410 420 430 440 450
CSVPPTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,976
Last modified:November 1, 1990 - v1
Checksum:i79D7D5B47372074E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05652 Genomic DNA Translation: AAA30984.1
PIRiA38316
RefSeqiNP_999565.1, NM_214400.1
UniGeneiSsc.27594

Genome annotation databases

GeneIDi399501
KEGGissc:399501

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05652 Genomic DNA Translation: AAA30984.1
PIRiA38316
RefSeqiNP_999565.1, NM_214400.1
UniGeneiSsc.27594

3D structure databases

ProteinModelPortaliP18871
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011323

Chemistry databases

BindingDBiP18871
ChEMBLiCHEMBL2350

Protein family/group databases

GPCRDBiSearch...

PTM databases

SwissPalmiP18871

Proteomic databases

PaxDbiP18871
PRIDEiP18871

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399501
KEGGissc:399501

Organism-specific databases

CTDi150

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP18871
KOiK04138
OMAiIIFIVWV
OrthoDBiEOG091G06VI
TreeFamiTF316350

Enzyme and pathway databases

SABIO-RKiP18871

Gene expression databases

BgeeiENSSSCG00000010629 Expressed in 4 organ(s), highest expression level in prefrontal cortex
GenevisibleiP18871 SS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_PIG
AccessioniPrimary (citable) accession number: P18871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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