GJC1

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functionⁱ

gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: Ensembl
ion channel activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle tissue development Source: Ensembl
cell development Source: Ensembl
chemical synaptic transmission Source: Ensembl
gap junction assembly Source: Ensembl
vasculogenesis Source: Ensembl
visual perception Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-GGA-112303 Electric Transmission Across Gap Junctions R-GGA-190861 Gap junction assembly

Reactomeⁱ

R-GGA-112303 Electric Transmission Across Gap Junctions
R-GGA-190861 Gap junction assembly

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction gamma-1 protein Alternative name(s): Connexin-45 Short name: Cx45 Gap junction alpha-7 protein
Gene namesⁱ	Name:GJC1 Synonyms:GJA7
Organismⁱ	Gallus gallus (Chicken)
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Chromosome 27

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 22	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	23 – 45	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	46 – 75	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	76 – 95	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	96 – 176	CytoplasmicSequence analysisAdd BLAST	81
Transmembraneⁱ	177 – 199	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	200 – 229	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	230 – 252	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	253 – 394	CytoplasmicSequence analysisAdd BLAST	142

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057828	1 – 394	Gap junction gamma-1 proteinAdd BLAST		394

Proteomic databases

PaxDbⁱ	P18861
PRIDEⁱ	P18861

Expressionⁱ

Tissue specificityⁱ

Mostly in heart and stomach.

Gene expression databases

Bgeeⁱ	ENSGALG00000000997 Expressed in 11 organ(s), highest expression level in heart

Bgeeⁱ

ENSGALG00000000997 Expressed in 11 organ(s), highest expression level in heart

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000001471

STRINGⁱ

9031.ENSGALP00000001471

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFK3 Eukaryota ENOG410Z7PN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143998
HOGENOMⁱ	HOG000231126
HOVERGENⁱ	HBG009576
InParanoidⁱ	P18861
KEGG Orthology (KO) More...KOⁱ	K07616
OMAⁱ	IMYGVSC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08B8
PhylomeDBⁱ	P18861
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002265 Connexin45 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01136 CONNEXINA6
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P18861-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLSVLIV FRIVLTAVGG ESIYYDEQSK 
        60         70         80         90        100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA 
       110        120        130        140        150
RMVEHSDVDR RFRSKSFSTR WKQHRGLEEA EDDHEEDPMM YPEIELESER 
       160        170        180        190        200
ENKEQQPPAK AKHDGRRRIR EDGLMRIYVL QLLVRATFEV GFLIGQYLLY 
       210        220        230        240        250
GFEVSPVFVC SRKPCPHKID CFISRPTEKT IFLLIMYGVS CMCLLLNVWE 
       260        270        280        290        300
MLHLGFGTIR DTLNNKRKEL EDSGTYNYPF TWNTPSAPPG YNIAVKPDQM 
       310        320        330        340        350
QYTELSNAKM AYKQNKANIA QEQQYGSNEE NIPADLENLQ REIKVAQERL 
       360        370        380        390 
DMAIQAYNNQ NNPGSSSREK KSKAGSNKSS ASSKSGDGKN SVWI

Length:394

Mass (Da):45,372

Last modified:November 1, 1990 - v1

Checksum:ⁱA270AEDCD5FFCC93

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M35044 mRNA Translation: AAA48717.1
PIRⁱ	A37819
NCBI Reference Sequences More...RefSeqⁱ	NP_990834.1, NM_205503.1 XP_015154699.1, XM_015299213.1 XP_015154700.1, XM_015299214.1 XP_015154701.1, XM_015299215.1 XP_015154702.1, XM_015299216.1 XP_015154704.1, XM_015299218.1 XP_015154705.1, XM_015299219.1 XP_015154706.1, XM_015299220.1 XP_015154707.1, XM_015299221.1 XP_015154708.1, XM_015299222.1
UniGeneⁱ	Gga.862

Genome annotation databases

Ensemblⁱ	ENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997 ENSGALT00000080009; ENSGALP00000056304; ENSGALG00000000997
GeneIDⁱ	396501
KEGGⁱ	gga:396501

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18861	Gap junction protein		BAMTH		394	UniRef90_P18861
Gap junction protein		COLVI		394
Gap junction protein		CALSU		394
Gap junction protein		MELGA		394
Gap junction protein (Fragment)		ANAPL		393
+75

Protein	Similar proteins		Species	Score	Length	Source
P18861	Gap junction protein		MELGA		394	UniRef50_P18861
Gap junction protein		COLVI		394
Gap junction protein		BAMTH		394
Gap junction protein		CALSU		394
Gap junction protein		PYGAD		393
+237

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M35044 mRNA Translation: AAA48717.1
PIRⁱ	A37819
RefSeqⁱ	NP_990834.1, NM_205503.1 XP_015154699.1, XM_015299213.1 XP_015154700.1, XM_015299214.1 XP_015154701.1, XM_015299215.1 XP_015154702.1, XM_015299216.1 XP_015154704.1, XM_015299218.1 XP_015154705.1, XM_015299219.1 XP_015154706.1, XM_015299220.1 XP_015154707.1, XM_015299221.1 XP_015154708.1, XM_015299222.1
UniGeneⁱ	Gga.862

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000001471

STRINGⁱ

9031.ENSGALP00000001471

Proteomic databases

PaxDbⁱ	P18861
PRIDEⁱ	P18861

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997 ENSGALT00000080009; ENSGALP00000056304; ENSGALG00000000997
GeneIDⁱ	396501
KEGGⁱ	gga:396501

Organism-specific databases

CTDⁱ	10052

CTDⁱ

10052

Phylogenomic databases

eggNOGⁱ	ENOG410IFK3 Eukaryota ENOG410Z7PN LUCA
GeneTreeⁱ	ENSGT00910000143998
HOGENOMⁱ	HOG000231126
HOVERGENⁱ	HBG009576
InParanoidⁱ	P18861
KOⁱ	K07616
OMAⁱ	IMYGVSC
OrthoDBⁱ	EOG091G08B8
PhylomeDBⁱ	P18861
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-GGA-112303 Electric Transmission Across Gap Junctions R-GGA-190861 Gap junction assembly

Reactomeⁱ

R-GGA-112303 Electric Transmission Across Gap Junctions
R-GGA-190861 Gap junction assembly

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P18861

PROⁱ

PR:P18861

Gene expression databases

Bgeeⁱ	ENSGALG00000000997 Expressed in 11 organ(s), highest expression level in heart

Bgeeⁱ

ENSGALG00000000997 Expressed in 11 organ(s), highest expression level in heart

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002265 Connexin45 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01136 CONNEXINA6
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXG1_CHICK
Accessionⁱ	P18861Primary (citable) accession number: P18861
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	September 12, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - P18861 (CXG1_CHICK)

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Gap junction gamma-1 protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ