UniProtKB - P18861 (CXG1_CHICK)
Protein
Gap junction gamma-1 protein
Gene
GJC1
Organism
Gallus gallus (Chicken)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Molecular functioni
- gap junction channel activity Source: GO_Central
- gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: Ensembl
- ion channel activity Source: Ensembl
GO - Biological processi
- cardiac muscle tissue development Source: Ensembl
- cell-cell signaling Source: GO_Central
- cell development Source: Ensembl
- chemical synaptic transmission Source: Ensembl
- gap junction assembly Source: Ensembl
- vasculogenesis Source: Ensembl
- visual perception Source: Ensembl
Enzyme and pathway databases
Reactomei | R-GGA-112303, Electric Transmission Across Gap Junctions R-GGA-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction gamma-1 proteinAlternative name(s): Connexin-45 Short name: Cx45 Gap junction alpha-7 protein |
Gene namesi | Name:GJC1 Synonyms:GJA7 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 45 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 46 – 75 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 76 – 95 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 96 – 176 | CytoplasmicSequence analysisAdd BLAST | 81 | |
Transmembranei | 177 – 199 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 200 – 229 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 230 – 252 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 253 – 394 | CytoplasmicSequence analysisAdd BLAST | 142 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057828 | 1 – 394 | Gap junction gamma-1 proteinAdd BLAST | 394 |
Proteomic databases
PaxDbi | P18861 |
Expressioni
Tissue specificityi
Mostly in heart and stomach.
Gene expression databases
Bgeei | ENSGALG00000000997, Expressed in heart and 13 other tissues |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000001471 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QV2G, Eukaryota |
GeneTreei | ENSGT00970000193389 |
HOGENOMi | CLU_037388_0_0_1 |
InParanoidi | P18861 |
OMAi | IMYGVSC |
OrthoDBi | 692491at2759 |
PhylomeDBi | P18861 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002265, Connexin45 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01136, CONNEXINA6 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P18861-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWSFLTRLL EEIHNHSTFV GKIWLSVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
RMVEHSDVDR RFRSKSFSTR WKQHRGLEEA EDDHEEDPMM YPEIELESER
160 170 180 190 200
ENKEQQPPAK AKHDGRRRIR EDGLMRIYVL QLLVRATFEV GFLIGQYLLY
210 220 230 240 250
GFEVSPVFVC SRKPCPHKID CFISRPTEKT IFLLIMYGVS CMCLLLNVWE
260 270 280 290 300
MLHLGFGTIR DTLNNKRKEL EDSGTYNYPF TWNTPSAPPG YNIAVKPDQM
310 320 330 340 350
QYTELSNAKM AYKQNKANIA QEQQYGSNEE NIPADLENLQ REIKVAQERL
360 370 380 390
DMAIQAYNNQ NNPGSSSREK KSKAGSNKSS ASSKSGDGKN SVWI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35044 mRNA Translation: AAA48717.1 |
PIRi | A37819 |
RefSeqi | NP_990834.1, NM_205503.1 XP_015154699.1, XM_015299213.1 XP_015154700.1, XM_015299214.1 XP_015154701.1, XM_015299215.1 XP_015154702.1, XM_015299216.1 XP_015154704.1, XM_015299218.1 XP_015154705.1, XM_015299219.1 XP_015154706.1, XM_015299220.1 XP_015154707.1, XM_015299221.1 XP_015154708.1, XM_015299222.1 |
Genome annotation databases
Ensembli | ENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997 |
GeneIDi | 396501 |
KEGGi | gga:396501 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35044 mRNA Translation: AAA48717.1 |
PIRi | A37819 |
RefSeqi | NP_990834.1, NM_205503.1 XP_015154699.1, XM_015299213.1 XP_015154700.1, XM_015299214.1 XP_015154701.1, XM_015299215.1 XP_015154702.1, XM_015299216.1 XP_015154704.1, XM_015299218.1 XP_015154705.1, XM_015299219.1 XP_015154706.1, XM_015299220.1 XP_015154707.1, XM_015299221.1 XP_015154708.1, XM_015299222.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000001471 |
Proteomic databases
PaxDbi | P18861 |
Genome annotation databases
Ensembli | ENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997 |
GeneIDi | 396501 |
KEGGi | gga:396501 |
Organism-specific databases
CTDi | 349149 |
Phylogenomic databases
eggNOGi | ENOG502QV2G, Eukaryota |
GeneTreei | ENSGT00970000193389 |
HOGENOMi | CLU_037388_0_0_1 |
InParanoidi | P18861 |
OMAi | IMYGVSC |
OrthoDBi | 692491at2759 |
PhylomeDBi | P18861 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-GGA-112303, Electric Transmission Across Gap Junctions R-GGA-190861, Gap junction assembly |
Miscellaneous databases
PROi | PR:P18861 |
Gene expression databases
Bgeei | ENSGALG00000000997, Expressed in heart and 13 other tissues |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002265, Connexin45 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01136, CONNEXINA6 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXG1_CHICK | |
Accessioni | P18861Primary (citable) accession number: P18861 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families