UniProtKB - P18860 (CXA5_CHICK)
Protein
Gap junction alpha-5 protein
Gene
GJA5
Organism
Gallus gallus (Chicken)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Biological processi
- cell communication Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction alpha-5 proteinAlternative name(s): Connexin-42 Short name: Cx42 |
Gene namesi | Name:GJA5 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 19 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 20 – 40 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 76 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 169 | CytoplasmicSequence analysisAdd BLAST | 72 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 191 – 210 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 369 | CytoplasmicSequence analysisAdd BLAST | 138 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000057822 | 2 – 369 | Gap junction alpha-5 proteinAdd BLAST | 368 |
Proteomic databases
PaxDbi | P18860 |
Expressioni
Tissue specificityi
Mostly in heart, and in the whole embryo, liver, stomach, and pectoral muscle.
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000024929 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW11, Eukaryota |
InParanoidi | P18860 |
PhylomeDBi | P18860 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002264, Connexin40 IPR034634, Connexin_C IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf IPR031862, Cx40_C |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF13, PTHR11984:SF13, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit PF16791, Connexin40_C, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01135, CONNEXINA5 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
SUPFAMi | SSF118220, SSF118220, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P18860-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS
60 70 80 90 100
DFMCDTQQPG CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMEEKRKMKE AEREAQEMKN SGDTYYQQKC PVAEKTELSC WDESGGKIIL
160 170 180 190 200
RGSLLNTYVY SILIRTAMEI AFIVGQYILY GIFLETLYIC QRAPCPHPVN
210 220 230 240 250
CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK ERCSRAYKPS
260 270 280 290 300
PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN
310 320 330 340 350
TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR
360
RFSKASRASS KARSDDLSV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35043 mRNA Translation: AAA48716.1 |
PIRi | B37819 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35043 mRNA Translation: AAA48716.1 |
PIRi | B37819 |
3D structure databases
SMRi | P18860 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000024929 |
Proteomic databases
PaxDbi | P18860 |
Phylogenomic databases
eggNOGi | ENOG502QW11, Eukaryota |
InParanoidi | P18860 |
PhylomeDBi | P18860 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002264, Connexin40 IPR034634, Connexin_C IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf IPR031862, Cx40_C |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF13, PTHR11984:SF13, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit PF16791, Connexin40_C, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01135, CONNEXINA5 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
SUPFAMi | SSF118220, SSF118220, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXA5_CHICK | |
Accessioni | P18860Primary (citable) accession number: P18860 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | October 7, 2020 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families