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Entry version 188 (05 Jun 2019)
Sequence version 1 (01 Nov 1990)
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Protein

ATP synthase-coupling factor 6, mitochondrial

Gene

ATP5PF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase-coupling factor 6, mitochondrialCurated
Short name:
ATPase subunit F6
Alternative name(s):
ATP synthase peripheral stalk subunit F6Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP5PFImported
Synonyms:ATP5A, ATP5J, ATPM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:847 ATP5PF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603152 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18859

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
522

Open Targets

More...
OpenTargetsi
ENSG00000154723

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25137

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP5J

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114688

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000252733 – 108ATP synthase-coupling factor 6, mitochondrialAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41N6-acetyllysineCombined sources1
Modified residuei46N6-acetyllysineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei94N6-acetyllysine; alternateBy similarity1
Modified residuei94N6-succinyllysine; alternateBy similarity1
Modified residuei99N6-acetyllysine; alternateCombined sources1
Modified residuei99N6-succinyllysine; alternateBy similarity1
Modified residuei105N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P18859

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18859

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18859

PeptideAtlas

More...
PeptideAtlasi
P18859

PRoteomics IDEntifications database

More...
PRIDEi
P18859

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53618

Consortium for Top Down Proteomics

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TopDownProteomicsi
P18859-1 [P18859-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P18859

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18859

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18859

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154723 Expressed in 238 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18859 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18859 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031069

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and MP68 (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107006, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P18859

Protein interaction database and analysis system

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IntActi
P18859, 67 interactors

Molecular INTeraction database

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MINTi
P18859

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389649

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P18859

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4634 Eukaryota
ENOG41122G1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008902

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261672

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18859

KEGG Orthology (KO)

More...
KOi
K02131

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKQKSSG

Database of Orthologous Groups

More...
OrthoDBi
1559269at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P18859

TreeFam database of animal gene trees

More...
TreeFami
TF318998

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008387 ATP_synth_f6_mt
IPR036204 ATP_synth_f6_sf_mt

The PANTHER Classification System

More...
PANTHERi
PTHR12441 PTHR12441, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05511 ATP-synt_F6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002455 ATP_synthase_coupling_factor_6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111357 SSF111357, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P18859-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY
60 70 80 90 100
KSKRQTSGGP VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF

EVIEKPQA
Length:108
Mass (Da):12,588
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDC1A14F01A10F17
GO
Isoform 2 (identifier: P18859-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHCDGGISM

Show »
Length:116
Mass (Da):13,388
Checksum:i2E376C23E0F75171
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUH2A8MUH2_HUMAN
ATP synthase-coupling factor 6, mit...
ATP5PF
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68Q → H in AAA58630 (PubMed:1830479).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0461871M → MHCDGGISM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37104 mRNA Translation: AAA51807.1
M73031 mRNA Translation: AAA58630.1
AL110183 mRNA Translation: CAB53667.1
BT007244 mRNA Translation: AAP35908.1
DT217787 mRNA No translation available.
AP001694 Genomic DNA No translation available.
BC001178 mRNA Translation: AAH01178.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13574.1 [P18859-1]
CCDS46637.1 [P18859-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JT0563

NCBI Reference Sequences

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RefSeqi
NP_001003696.1, NM_001003696.1 [P18859-1]
NP_001003697.1, NM_001003697.1 [P18859-1]
NP_001003701.1, NM_001003701.1 [P18859-2]
NP_001003703.1, NM_001003703.1 [P18859-1]
NP_001307195.1, NM_001320266.1 [P18859-1]
NP_001307196.1, NM_001320267.1 [P18859-1]
NP_001676.2, NM_001685.4 [P18859-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284971; ENSP00000284971; ENSG00000154723 [P18859-1]
ENST00000400087; ENSP00000382959; ENSG00000154723 [P18859-1]
ENST00000400090; ENSP00000382962; ENSG00000154723 [P18859-1]
ENST00000400093; ENSP00000382965; ENSG00000154723 [P18859-1]
ENST00000400094; ENSP00000382966; ENSG00000154723 [P18859-1]
ENST00000457143; ENSP00000389649; ENSG00000154723 [P18859-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:522

UCSC genome browser

More...
UCSCi
uc002ylv.4 human [P18859-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37104 mRNA Translation: AAA51807.1
M73031 mRNA Translation: AAA58630.1
AL110183 mRNA Translation: CAB53667.1
BT007244 mRNA Translation: AAP35908.1
DT217787 mRNA No translation available.
AP001694 Genomic DNA No translation available.
BC001178 mRNA Translation: AAH01178.1
CCDSiCCDS13574.1 [P18859-1]
CCDS46637.1 [P18859-2]
PIRiJT0563
RefSeqiNP_001003696.1, NM_001003696.1 [P18859-1]
NP_001003697.1, NM_001003697.1 [P18859-1]
NP_001003701.1, NM_001003701.1 [P18859-2]
NP_001003703.1, NM_001003703.1 [P18859-1]
NP_001307195.1, NM_001320266.1 [P18859-1]
NP_001307196.1, NM_001320267.1 [P18859-1]
NP_001676.2, NM_001685.4 [P18859-1]

3D structure databases

SMRiP18859
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107006, 51 interactors
CORUMiP18859
IntActiP18859, 67 interactors
MINTiP18859
STRINGi9606.ENSP00000389649

PTM databases

iPTMnetiP18859
PhosphoSitePlusiP18859

Polymorphism and mutation databases

BioMutaiATP5J
DMDMi114688

2D gel databases

SWISS-2DPAGEiP18859

Proteomic databases

EPDiP18859
jPOSTiP18859
PaxDbiP18859
PeptideAtlasiP18859
PRIDEiP18859
ProteomicsDBi53618
TopDownProteomicsiP18859-1 [P18859-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284971; ENSP00000284971; ENSG00000154723 [P18859-1]
ENST00000400087; ENSP00000382959; ENSG00000154723 [P18859-1]
ENST00000400090; ENSP00000382962; ENSG00000154723 [P18859-1]
ENST00000400093; ENSP00000382965; ENSG00000154723 [P18859-1]
ENST00000400094; ENSP00000382966; ENSG00000154723 [P18859-1]
ENST00000457143; ENSP00000389649; ENSG00000154723 [P18859-2]
GeneIDi522
KEGGihsa:522
UCSCiuc002ylv.4 human [P18859-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
522
DisGeNETi522

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP5PF
HGNCiHGNC:847 ATP5PF
HPAiHPA031069
MIMi603152 gene
neXtProtiNX_P18859
OpenTargetsiENSG00000154723
PharmGKBiPA25137

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4634 Eukaryota
ENOG41122G1 LUCA
GeneTreeiENSGT00390000008902
HOGENOMiHOG000261672
InParanoidiP18859
KOiK02131
OMAiYKQKSSG
OrthoDBi1559269at2759
PhylomeDBiP18859
TreeFamiTF318998

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP5J human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATP5J

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
522

Protein Ontology

More...
PROi
PR:P18859

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154723 Expressed in 238 organ(s), highest expression level in heart
ExpressionAtlasiP18859 baseline and differential
GenevisibleiP18859 HS

Family and domain databases

InterProiView protein in InterPro
IPR008387 ATP_synth_f6_mt
IPR036204 ATP_synth_f6_sf_mt
PANTHERiPTHR12441 PTHR12441, 1 hit
PfamiView protein in Pfam
PF05511 ATP-synt_F6, 1 hit
PIRSFiPIRSF002455 ATP_synthase_coupling_factor_6, 1 hit
SUPFAMiSSF111357 SSF111357, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP5J_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18859
Secondary accession number(s): J3KQ83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 5, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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