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Protein

ATP synthase-coupling factor 6, mitochondrial

Gene

ATP5J

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

GO - Molecular functioni

  • proton transmembrane transporter activity Source: InterPro
  • transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase-coupling factor 6, mitochondrial
Short name:
ATPase subunit F6
Gene namesi
Name:ATP5J
Synonyms:ATP5A, ATPM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000154723.12
HGNCiHGNC:847 ATP5J
MIMi603152 gene
neXtProtiNX_P18859

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi522
OpenTargetsiENSG00000154723
PharmGKBiPA25137

Polymorphism and mutation databases

BioMutaiATP5J
DMDMi114688

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
ChainiPRO_000000252733 – 108ATP synthase-coupling factor 6, mitochondrialAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-acetyllysineCombined sources1
Modified residuei46N6-acetyllysineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei94N6-acetyllysine; alternateBy similarity1
Modified residuei94N6-succinyllysine; alternateBy similarity1
Modified residuei99N6-acetyllysine; alternateCombined sources1
Modified residuei99N6-succinyllysine; alternateBy similarity1
Modified residuei105N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP18859
PaxDbiP18859
PeptideAtlasiP18859
PRIDEiP18859
ProteomicsDBi53618
TopDownProteomicsiP18859-1 [P18859-1]

2D gel databases

SWISS-2DPAGEiP18859

PTM databases

iPTMnetiP18859
PhosphoSitePlusiP18859

Expressioni

Gene expression databases

BgeeiENSG00000154723
CleanExiHS_ATP5J
ExpressionAtlasiP18859 baseline and differential
GenevisibleiP18859 HS

Organism-specific databases

HPAiHPA031069

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107006, 49 interactors
CORUMiP18859
IntActiP18859, 50 interactors
MINTiP18859
STRINGi9606.ENSP00000389649

Structurei

3D structure databases

ProteinModelPortaliP18859
SMRiP18859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4634 Eukaryota
ENOG41122G1 LUCA
GeneTreeiENSGT00390000008902
HOGENOMiHOG000261672
HOVERGENiHBG062261
InParanoidiP18859
KOiK02131
OMAiYKQKSSG
PhylomeDBiP18859
TreeFamiTF318998

Family and domain databases

InterProiView protein in InterPro
IPR008387 ATP_synth_f6_mt
IPR036204 ATP_synth_f6_sf_mt
PANTHERiPTHR12441 PTHR12441, 1 hit
PfamiView protein in Pfam
PF05511 ATP-synt_F6, 1 hit
PIRSFiPIRSF002455 ATP_synthase_coupling_factor_6, 1 hit
SUPFAMiSSF111357 SSF111357, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18859-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY
60 70 80 90 100
KSKRQTSGGP VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF

EVIEKPQA
Length:108
Mass (Da):12,588
Last modified:November 1, 1990 - v1
Checksum:iEDC1A14F01A10F17
GO
Isoform 2 (identifier: P18859-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHCDGGISM

Show »
Length:116
Mass (Da):13,388
Checksum:i2E376C23E0F75171
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68Q → H in AAA58630 (PubMed:1830479).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0461871M → MHCDGGISM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37104 mRNA Translation: AAA51807.1
M73031 mRNA Translation: AAA58630.1
AL110183 mRNA Translation: CAB53667.1
BT007244 mRNA Translation: AAP35908.1
DT217787 mRNA No translation available.
AP001694 Genomic DNA No translation available.
BC001178 mRNA Translation: AAH01178.1
CCDSiCCDS13574.1 [P18859-1]
CCDS46637.1 [P18859-2]
PIRiJT0563
RefSeqiNP_001003696.1, NM_001003696.1 [P18859-1]
NP_001003697.1, NM_001003697.1 [P18859-1]
NP_001003701.1, NM_001003701.1 [P18859-2]
NP_001003703.1, NM_001003703.1 [P18859-1]
NP_001307195.1, NM_001320266.1 [P18859-1]
NP_001307196.1, NM_001320267.1 [P18859-1]
NP_001676.2, NM_001685.4 [P18859-1]
UniGeneiHs.246310

Genome annotation databases

EnsembliENST00000284971; ENSP00000284971; ENSG00000154723 [P18859-1]
ENST00000400087; ENSP00000382959; ENSG00000154723 [P18859-1]
ENST00000400090; ENSP00000382962; ENSG00000154723 [P18859-1]
ENST00000400093; ENSP00000382965; ENSG00000154723 [P18859-1]
ENST00000400094; ENSP00000382966; ENSG00000154723 [P18859-1]
ENST00000457143; ENSP00000389649; ENSG00000154723 [P18859-2]
GeneIDi522
KEGGihsa:522
UCSCiuc002ylv.4 human [P18859-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATP5J_HUMAN
AccessioniPrimary (citable) accession number: P18859
Secondary accession number(s): J3KQ83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 18, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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