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Entry version 201 (13 Feb 2019)
Sequence version 1 (01 Nov 1990)
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Protein

DNA ligase 1

Gene

LIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.PROSITE-ProRule annotation EC:6.5.1.1

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei566ATPCombined sources1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei568N6-AMP-lysine intermediatePROSITE-ProRule annotation1
Binding sitei573ATPCombined sources1 Publication1
Binding sitei589ATP1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi621Magnesium 1Curated1
Metal bindingi720Magnesium 2Curated1
Binding sitei725ATPCombined sources1 Publication1
Binding sitei738ATPBy similarity1
Binding sitei744ATPCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: ProtInc
  • DNA ligase (ATP) activity Source: GO_Central
  • DNA ligase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
6.5.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-162594 Early Phase of HIV Life Cycle
R-HSA-174414 Processive synthesis on the C-strand of the telomere
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-69183 Processive synthesis on the lagging strand

SIGNOR Signaling Network Open Resource

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SIGNORi
P18858

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA ligase 1 (EC:6.5.1.1PROSITE-ProRule annotation)
Alternative name(s):
DNA ligase I
Polydeoxyribonucleotide synthase [ATP] 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105486.13

Human Gene Nomenclature Database

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HGNCi
HGNC:6598 LIG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
126391 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18858

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3978

Open Targets

More...
OpenTargetsi
ENSG00000105486

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30372

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5694

Drug and drug target database

More...
DrugBanki
DB00290 Bleomycin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118773

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000595701 – 919DNA ligase 1Add BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei195PhosphothreonineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei207PhosphothreonineCombined sources1
Modified residuei226N6-acetyllysineBy similarity1
Modified residuei229PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei233PhosphothreonineCombined sources1
Modified residuei798PhosphothreonineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei819PhosphoserineCombined sources1
Modified residuei911PhosphoserineCombined sources1
Modified residuei913PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P18858

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P18858

MaxQB - The MaxQuant DataBase

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MaxQBi
P18858

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P18858

PeptideAtlas

More...
PeptideAtlasi
P18858

PRoteomics IDEntifications database

More...
PRIDEi
P18858

ProteomicsDB human proteome resource

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ProteomicsDBi
53617

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P18858

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P18858

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105486 Expressed in 149 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P18858 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P18858 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037015
HPA041431
HPA048071

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCNA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei305Interaction with target DNA1
Sitei590Interaction with target DNA1
Sitei770Interaction with target DNA1
Sitei795Interaction with target DNA1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110166, 22 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P18858

Database of interacting proteins

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DIPi
DIP-24215N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P18858

Protein interaction database and analysis system

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IntActi
P18858, 8 interactors

Molecular INTeraction database

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MINTi
P18858

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263274

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P18858

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1919
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X9NX-ray3.00A233-919[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P18858

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P18858

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18858

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni449 – 458Interaction with target DNA10
Regioni642 – 644Interaction with target DNA3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0967 Eukaryota
COG1793 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000036006

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005514

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P18858

KEGG Orthology (KO)

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KOi
K10747

Identification of Orthologs from Complete Genome Data

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OMAi
WIKYKRD

Database of Orthologous Groups

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OrthoDBi
274264at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P18858

TreeFam database of animal gene trees

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TreeFami
TF300342

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.3260.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00574 dnl1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P18858-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD
60 70 80 90 100
SPVKRPGRKA ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE
110 120 130 140 150
NNASLSDTSP MDSSPSGIPK RRTARKQLPK RTIQEVLEEQ SEDEDREAKR
160 170 180 190 200
KKEEEEEETP KESLTEAEVA TEKEGEDGDQ PTTPPKPLKT SKAETPTESV
210 220 230 240 250
SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK KEVKEEEPGA
260 270 280 290 300
PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE
310 320 330 340 350
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG
360 370 380 390 400
DGVLLKAVAQ ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT
410 420 430 440 450
ASGVFSKFRD IARLTGSAST AKKIDIIKGL FVACRHSEAR FIARSLSGRL
460 470 480 490 500
RLGLAEQSVL AALSQAVSLT PPGQEFPPAM VDAGKGKTAE ARKTWLEEQG
510 520 530 540 550
MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL KPMLAHPTRG
560 570 580 590 600
ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD
610 620 630 640 650
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE
660 670 680 690 700
IQVQVCLYAF DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD
710 720 730 740 750
TKDIEQIAEF LEQSVKDSCE GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL
760 770 780 790 800
DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL ASYDEDSEEL QAICKLGTGF
810 820 830 840 850
SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA VWEVKCADLS
860 870 880 890 900
LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ
910
SQIQNQQGED SGSDPEDTY
Length:919
Mass (Da):101,736
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2854DAE38A8D4AD
GO
Isoform 2 (identifier: P18858-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     796-801: LGTGFS → VLGNWG
     802-919: Missing.

Note: No experimental confirmation available.
Show »
Length:801
Mass (Da):88,516
Checksum:i1AC26C5FB793684F
GO
Isoform 3 (identifier: P18858-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-36: Missing.
     153-153: Missing.

Note: No experimental confirmation available.
Show »
Length:888
Mass (Da):98,228
Checksum:i6A59D9975C259D9F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZ28F5GZ28_HUMAN
DNA ligase
LIG1
851Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0Q7M0R0Q7_HUMAN
DNA ligase
LIG1
800Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E135B4E135_HUMAN
DNA ligase 1
LIG1
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY71M0QY71_HUMAN
DNA ligase 1
LIG1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1G7M0R1G7_HUMAN
DNA ligase 1
LIG1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1S4M0R1S4_HUMAN
DNA ligase 1
LIG1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R254M0R254_HUMAN
DNA ligase 1
LIG1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01880224A → V1 PublicationCorresponds to variant dbSNP:rs3730855Ensembl.1
Natural variantiVAR_02019452P → L. Corresponds to variant dbSNP:rs4987181Ensembl.1
Natural variantiVAR_01880362R → W1 PublicationCorresponds to variant dbSNP:rs3730863Ensembl.1
Natural variantiVAR_02019572D → G. Corresponds to variant dbSNP:rs4987070Ensembl.1
Natural variantiVAR_036511152K → E in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780748107Ensembl.1
Natural variantiVAR_016766249G → E1 PublicationCorresponds to variant dbSNP:rs3730911Ensembl.1
Natural variantiVAR_016767267N → S1 PublicationCorresponds to variant dbSNP:rs3730933Ensembl.1
Natural variantiVAR_018804349V → M1 PublicationCorresponds to variant dbSNP:rs3730947Ensembl.1
Natural variantiVAR_018805369V → I1 PublicationCorresponds to variant dbSNP:rs3730966Ensembl.1
Natural variantiVAR_016768409R → H. Corresponds to variant dbSNP:rs4987068Ensembl.1
Natural variantiVAR_016769480M → V1 PublicationCorresponds to variant dbSNP:rs3730980Ensembl.1
Natural variantiVAR_002262566E → K Found in a patient with a syndrome of immunodeficiency and increased cellular sensitivity to DNA-damaging agents due to LIG1 deficiency; compound heterozygote carrying W-771. 1 PublicationCorresponds to variant dbSNP:rs121434560EnsemblClinVar.1
Natural variantiVAR_036512612S → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780324684Ensembl.1
Natural variantiVAR_016770614T → I1 PublicationCorresponds to variant dbSNP:rs3731003Ensembl.1
Natural variantiVAR_018806677R → L1 PublicationCorresponds to variant dbSNP:rs3731008Ensembl.1
Natural variantiVAR_002263771R → W Found in a patient with a syndrome of immunodeficiency and increased cellular sensitivity to DNA-damaging agents due to LIG1 deficiency; compound heterozygote carrying K-566. 1 PublicationCorresponds to variant dbSNP:rs121434561EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0573207 – 36Missing in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_057321153Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_056139796 – 801LGTGFS → VLGNWG in isoform 2. 1 Publication6
Alternative sequenceiVSP_056140802 – 919Missing in isoform 2. 1 PublicationAdd BLAST118

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M36067 mRNA Translation: AAA59518.1
AF527418 Genomic DNA Translation: AAM77697.1
AK300370 mRNA Translation: BAG62106.1
AK314210 mRNA Translation: BAG36885.1
AC011466 Genomic DNA No translation available.
KC877741 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52316.1
BC108318 mRNA Translation: AAI08319.1
BC110622 mRNA Translation: AAI10623.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12711.1 [P18858-1]
CCDS74409.1 [P18858-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A36048 A41275

NCBI Reference Sequences

More...
RefSeqi
NP_000225.1, NM_000234.2 [P18858-1]
NP_001275992.1, NM_001289063.1 [P18858-3]
NP_001275993.1, NM_001289064.1
NP_001307899.1, NM_001320970.1
NP_001307900.1, NM_001320971.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1770

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263274; ENSP00000263274; ENSG00000105486 [P18858-1]
ENST00000427526; ENSP00000442841; ENSG00000105486 [P18858-3]
ENST00000601091; ENSP00000471836; ENSG00000105486 [P18858-2]
ENST00000613670; ENSP00000483027; ENSG00000105486 [P18858-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3978

UCSC genome browser

More...
UCSCi
uc002pia.2 human [P18858-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

LIG1base

LIG1 mutation db

NIEHS-SNPs
Wikipedia

DNA ligase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36067 mRNA Translation: AAA59518.1
AF527418 Genomic DNA Translation: AAM77697.1
AK300370 mRNA Translation: BAG62106.1
AK314210 mRNA Translation: BAG36885.1
AC011466 Genomic DNA No translation available.
KC877741 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52316.1
BC108318 mRNA Translation: AAI08319.1
BC110622 mRNA Translation: AAI10623.1
CCDSiCCDS12711.1 [P18858-1]
CCDS74409.1 [P18858-3]
PIRiA36048 A41275
RefSeqiNP_000225.1, NM_000234.2 [P18858-1]
NP_001275992.1, NM_001289063.1 [P18858-3]
NP_001275993.1, NM_001289064.1
NP_001307899.1, NM_001320970.1
NP_001307900.1, NM_001320971.1
UniGeneiHs.1770

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X9NX-ray3.00A233-919[»]
ProteinModelPortaliP18858
SMRiP18858
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110166, 22 interactors
CORUMiP18858
DIPiDIP-24215N
ELMiP18858
IntActiP18858, 8 interactors
MINTiP18858
STRINGi9606.ENSP00000263274

Chemistry databases

BindingDBiP18858
ChEMBLiCHEMBL5694
DrugBankiDB00290 Bleomycin

PTM databases

iPTMnetiP18858
PhosphoSitePlusiP18858

Polymorphism and mutation databases

BioMutaiLIG1
DMDMi118773

Proteomic databases

EPDiP18858
jPOSTiP18858
MaxQBiP18858
PaxDbiP18858
PeptideAtlasiP18858
PRIDEiP18858
ProteomicsDBi53617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263274; ENSP00000263274; ENSG00000105486 [P18858-1]
ENST00000427526; ENSP00000442841; ENSG00000105486 [P18858-3]
ENST00000601091; ENSP00000471836; ENSG00000105486 [P18858-2]
ENST00000613670; ENSP00000483027; ENSG00000105486 [P18858-2]
GeneIDi3978
KEGGihsa:3978
UCSCiuc002pia.2 human [P18858-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3978
DisGeNETi3978
EuPathDBiHostDB:ENSG00000105486.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LIG1
HGNCiHGNC:6598 LIG1
HPAiCAB037015
HPA041431
HPA048071
MIMi126391 gene
neXtProtiNX_P18858
OpenTargetsiENSG00000105486
PharmGKBiPA30372

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00940000157783
HOGENOMiHOG000036006
HOVERGENiHBG005514
InParanoidiP18858
KOiK10747
OMAiWIKYKRD
OrthoDBi274264at2759
PhylomeDBiP18858
TreeFamiTF300342

Enzyme and pathway databases

BRENDAi6.5.1.1 2681
ReactomeiR-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-162594 Early Phase of HIV Life Cycle
R-HSA-174414 Processive synthesis on the C-strand of the telomere
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-69183 Processive synthesis on the lagging strand
SIGNORiP18858

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LIG1 human
EvolutionaryTraceiP18858

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LIG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3978

Protein Ontology

More...
PROi
PR:P18858

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105486 Expressed in 149 organ(s), highest expression level in right uterine tube
ExpressionAtlasiP18858 baseline and differential
GenevisibleiP18858 HS

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNLI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18858
Secondary accession number(s): B2RAI8
, B4DTU4, Q2TB12, Q32P23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 13, 2019
This is version 201 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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