ATF4

Functionⁱ

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).By similarity4 Publications

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15788408
- 18940792
DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 11478948
- 12871976
leucine zipper domain binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 11478948
protein C-terminus binding Source: Ensembl
protein heterodimerization activity
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 15775988
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20873783
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 11478948
sequence-specific DNA binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 22915762
transcription regulatory region DNA binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 21113145

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular amino acid metabolic process
Source: UniProtKB
Traceable author statementⁱ
- 12689582
cellular calcium ion homeostasis Source: Ensembl
cellular response to amino acid starvation Source: UniProtKB
cellular response to dopamine
Source: CAFA
Inferred from mutant phenotypeⁱ
- 24136195
cellular response to glucose starvation
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 22915762
cellular response to oxygen-glucose deprivation Source: Ensembl
cellular response to UV Source: UniProtKB
circadian regulation of gene expression Source: UniProtKB
gamma-aminobutyric acid signaling pathway Source: Ensembl
gluconeogenesis Source: UniProtKB
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
mRNA transcription by RNA polymerase II Source: UniProtKB
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 22980225
negative regulation of oxidative stress-induced neuron death
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 23392669
negative regulation of potassium ion transport Source: Ensembl
negative regulation of translational initiation in response to stress Source: UniProtKB
neuron differentiation Source: Ensembl
PERK-mediated unfolded protein response
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22013210
- 22934019
positive regulation of apoptotic process
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 23392669
positive regulation of biomineral tissue development Source: Ensembl
positive regulation of gene expression
Source: CAFA
Inferred from mutant phenotypeⁱ
- 24136195
positive regulation of neuron apoptotic process Source: UniProtKB
positive regulation of sodium-dependent phosphate transport Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15775988
- 18940792
positive regulation of transcription by RNA polymerase I
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 22915762
positive regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 14685163
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 12871976
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 21113145
positive regulation of transcription from RNA polymerase II promoter in response to stress
Source: ParkinsonsUK-UCL
Inferred by curatorⁱ
- 25681212
positive regulation of vascular associated smooth muscle cell apoptotic process Source: Ensembl
positive regulation of vascular endothelial growth factor production
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 22915762
regulation of transcription, DNA-templated Source: UniProtKB
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to endoplasmic reticulum stress
Source: BHF-UCL
Inferred from direct assayⁱ
- 19061639
response to manganese-induced endoplasmic reticulum stress Source: Ensembl
response to toxic substance Source: Ensembl
transcription by RNA polymerase II Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380994 ATF4 activates genes R-HSA-381042 PERK regulates gene expression R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
SIGNORⁱ	P18848

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclic AMP-dependent transcription factor ATF-4 Short name: cAMP-dependent transcription factor ATF-4 Alternative name(s): Activating transcription factor 4 Cyclic AMP-responsive element-binding protein 2 Short name: CREB-2 Short name: cAMP-responsive element-binding protein 2 DNA-binding protein TAXREB67 Tax-responsive enhancer element-binding protein 67 Short name: TaxREB67
Gene namesⁱ	Name:ATF4 Synonyms:CREB2, TXREB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128272.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:786 ATF4
MIMⁱ	604064 gene
neXtProtⁱ	NX_P18848

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	468
Open Targets More...OpenTargetsⁱ	ENSG00000128272
PharmGKBⁱ	PA25086

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00852 Pseudoephedrine

DrugBankⁱ

DB00852 Pseudoephedrine

Polymorphism and mutation databases

BioMutaⁱ	ATF4
DMDMⁱ	116241262

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076584	1 – 351	Cyclic AMP-dependent transcription factor ATF-4Add BLAST		351

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	53	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	213	PhosphothreonineBy similarity	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	224	PhosphoserineBy similarity	1
Modified residueⁱ	231	PhosphoserineBy similarity	1
Modified residueⁱ	235	PhosphoserineBy similarity	1
Modified residueⁱ	248	PhosphoserineBy similarity	1
Cross-linkⁱ	259	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	267	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	272	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.By similarity

Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-219, followed by phosphorylation at Thr-213, Ser-224, Ser-231, Ser-235 and Ser-248, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1 (By similarity).By similarity

Phosphorylated by NEK6.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Lipoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P18848
PaxDbⁱ	P18848
PeptideAtlas More...PeptideAtlasⁱ	P18848
PRIDEⁱ	P18848
ProteomicsDBⁱ	53615

PTM databases

iPTMnetⁱ	P18848
PhosphoSitePlusⁱ	P18848

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000128272 Expressed in 103 organ(s), highest expression level in lower esophagus
CleanExⁱ	HS_ATF4
Genevisibleⁱ	P18848 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011596

HPAⁱ

CAB011596

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer and as a heterodimer (PubMed:11018027). Interacts with CEBPB and binds DNA as a heterodimer with CEBPB (PubMed:11018027). Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production. Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with CEP290 (via an N-terminal region) (PubMed:16682973). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3 (PubMed:20873783, PubMed:21408167). Forms a heterodimer with TXLNG in osteoblasts (PubMed:15911876). Interacts with DDIT3/CHOP (PubMed:18940792). Interacts with ABRAXAS2 (PubMed:22974638).By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATF3	P18847	7	EBI-492498,EBI-712767
BFSP2	Q13515	8	EBI-492498,EBI-10229433
BTRC	A0A0S2Z507	6	EBI-492498,EBI-16429247
BTRC	B7Z3H4	3	EBI-492498,EBI-16429269
BTRC	Q9Y297	18	EBI-492498,EBI-307461
BTRC	Q9Y297-2	5	EBI-492498,EBI-8826333
CCDC106	Q9BWC9	9	EBI-492498,EBI-711501
CEBPA	P49715	2	EBI-492498,EBI-1172054
CEBPB	P17676	2	EBI-492498,EBI-969696
CEBPD	P49716	2	EBI-492498,EBI-7962058
CEBPG	P53567	10	EBI-492498,EBI-740209
CREBZF	Q9NS37	6	EBI-492498,EBI-632965
DAPK2	Q9UIK4-2	2	EBI-492498,EBI-9693115
Dapk3	O54784	2	EBI-492498,EBI-77359	From Mus musculus.
DDIT3	P35638	3	EBI-492498,EBI-742651
DISC1	Q9NRI5	3	EBI-492498,EBI-529989
FOS	P01100	3	EBI-492498,EBI-852851
GCC1	Q96CN9	5	EBI-492498,EBI-746252
GOLGA1	Q92805	8	EBI-492498,EBI-6164177
GOLGA8DP	Q0D2H9	5	EBI-492498,EBI-10181276
GOLGA8G	Q08AF8	6	EBI-492498,EBI-10181260
GPS2	Q13227	9	EBI-492498,EBI-713355
HAUS7	Q99871	3	EBI-492498,EBI-395719
JUN	P05412	2	EBI-492498,EBI-852823
LDOC1	O95751	7	EBI-492498,EBI-740738
NDC80	O14777	5	EBI-492498,EBI-715849
NFE2L2	Q16236	4	EBI-492498,EBI-2007911
POLR2C	P19387	6	EBI-492498,EBI-394729
TRIB3	Q96RU7	14	EBI-492498,EBI-492476

GO - Molecular functionⁱ

leucine zipper domain binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 11478948
protein C-terminus binding Source: Ensembl
protein heterodimerization activity
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 15775988
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20873783
RNA polymerase II transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 11478948

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106958, 76 interactors
ComplexPortalⁱ	CPX-8 ATF4-CREB1 transcription factor complex CPX-9 ATF1-ATF4 transcription factor complex
CORUMⁱ	P18848
Database of interacting proteins More...DIPⁱ	DIP-354N
ELMⁱ	P18848
IntActⁱ	P18848, 59 interactors
Molecular INTeraction database More...MINTⁱ	P18848
STRINGⁱ	9606.ENSP00000336790

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	288 – 340	Combined sources		53

Show more details

3D structure databases

ProteinModelPortalⁱ	P18848
SMRⁱ	P18848
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P18848

EvolutionaryTraceⁱ

P18848

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	278 – 341	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	280 – 300	Basic motifPROSITE-ProRule annotationAdd BLAST	21
Regionⁱ	305 – 341	Interaction with GABBR1By similarityAdd BLAST	37
Regionⁱ	306 – 334	Leucine-zipperPROSITE-ProRule annotationAdd BLAST	29

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	280 – 340	Add BLAST		61

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	215 – 224	BetaTrCP degron motif		10

Domainⁱ

The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.By similarity

Sequence similaritiesⁱ

Belongs to the bZIP family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4571 Eukaryota ENOG4111ZXT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063801
HOGENOMⁱ	HOG000004844
HOVERGENⁱ	HBG004301
InParanoidⁱ	P18848
KEGG Orthology (KO) More...KOⁱ	K04374
OMAⁱ	AFSGMDW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FNW
PhylomeDBⁱ	P18848
TreeFamⁱ	TF316136

Family and domain databases

InterProⁱ	View protein in InterPro IPR029811 ATF4 IPR004827 bZIP
PANTHERⁱ	PTHR13044:SF2 PTHR13044:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P18848-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS 
        60         70         80         90        100
SDKAKAGSSE WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL 
       110        120        130        140        150
GIDDLETMPD DLLTTLDDTC DLFAPLVQET NKQPPQTVNP IGHLPESLTK 
       160        170        180        190        200
PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL ELGSEVDITE GDRKPDYTAY 
       210        220        230        240        250
VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG SPNRSLPSPG 
       260        270        280        290        300
VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR 
       310        320        330        340        350
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV 

P

Length:351

Mass (Da):38,590

Last modified:October 17, 2006 - v3

Checksum:ⁱ3BBB7379DC3B0D07

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	284	K → R no nucleotide entry (PubMed:2516827).Curated	1
Sequence conflictⁱ	290	T → R no nucleotide entry (PubMed:2516827).Curated	1
Sequence conflictⁱ	329 – 331	KEI → REK no nucleotide entry (PubMed:2516827).Curated	3
Sequence conflictⁱ	338	I → L no nucleotide entry (PubMed:2516827).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_028253	22	Q → P3 PublicationsCorresponds to variant dbSNP:rs4894Ensembl.	1
Natural variantⁱVAR_029259	258	P → A. Corresponds to variant dbSNP:rs1803323Ensembl.	1
Natural variantⁱVAR_014768	322	E → D. Corresponds to variant dbSNP:rs1803324Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D90209 mRNA Translation: BAA14234.1 M86842 mRNA Translation: AAA52071.1 CR456384 mRNA Translation: CAG30270.1 AL022312 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60341.1 CH471095 Genomic DNA Translation: EAW60342.1 BC008090 mRNA Translation: AAH08090.1 BC011994 mRNA Translation: AAH11994.1 BC016855 mRNA Translation: AAH16855.1 BC022088 mRNA Translation: AAH22088.1 BC024775 mRNA Translation: AAH24775.1 BC044895 mRNA Translation: AAH44895.1 BC073754 mRNA Translation: AAH73754.1 BC073990 mRNA Translation: AAH73990.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13996.1
PIRⁱ	A45377
NCBI Reference Sequences More...RefSeqⁱ	NP_001666.2, NM_001675.4 NP_877962.1, NM_182810.2 XP_016884296.1, XM_017028807.1
UniGeneⁱ	Hs.496487

Genome annotation databases

Ensemblⁱ	ENST00000337304; ENSP00000336790; ENSG00000128272 ENST00000396680; ENSP00000379912; ENSG00000128272 ENST00000404241; ENSP00000384587; ENSG00000128272
GeneIDⁱ	468
KEGGⁱ	hsa:468
UCSC genome browser More...UCSCⁱ	uc003axz.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18848	cDNA FLJ58799, highly similar to Cyclic AMP-dependent transcription factor ATF-4		HUMAN		267	UniRef100_P18848

Protein	Similar proteins		Species	Score	Length	Source
P18848	cDNA FLJ58799, highly similar to Cyclic AMP-dependent transcription factor ATF-4		HUMAN		267	UniRef90_P18848
ATF4 isoform 1		PONAB		352
Uncharacterized protein		OTOGA		352
Activating transcription factor 4 (Tax-responsive enhancer element B67)		PANTR		351
Cyclic AMP-dependent transcription factor ATF-4		MACMU		351
+32

Protein	Similar proteins		Species	Score	Length	Source
P18848	Cyclic AMP-dependent transcription factor ATF-4		BOVIN		348	UniRef50_P18848
Cyclic AMP-dependent transcription factor ATF-4		MOUSE		349
Cyclic AMP-dependent transcription factor ATF-4		RAT		347
cDNA FLJ58799, highly similar to Cyclic AMP-dependent transcription factor ATF-4		HUMAN		267
Uncharacterized protein		OTOGA		352
+264

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D90209 mRNA Translation: BAA14234.1 M86842 mRNA Translation: AAA52071.1 CR456384 mRNA Translation: CAG30270.1 AL022312 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60341.1 CH471095 Genomic DNA Translation: EAW60342.1 BC008090 mRNA Translation: AAH08090.1 BC011994 mRNA Translation: AAH11994.1 BC016855 mRNA Translation: AAH16855.1 BC022088 mRNA Translation: AAH22088.1 BC024775 mRNA Translation: AAH24775.1 BC044895 mRNA Translation: AAH44895.1 BC073754 mRNA Translation: AAH73754.1 BC073990 mRNA Translation: AAH73990.1
CCDSⁱ	CCDS13996.1
PIRⁱ	A45377
RefSeqⁱ	NP_001666.2, NM_001675.4 NP_877962.1, NM_182810.2 XP_016884296.1, XM_017028807.1
UniGeneⁱ	Hs.496487

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CI6	X-ray	2.60	A	280-341	[»]
ProteinModelPortalⁱ	P18848
SMRⁱ	P18848
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106958, 76 interactors
ComplexPortalⁱ	CPX-8 ATF4-CREB1 transcription factor complex CPX-9 ATF1-ATF4 transcription factor complex
CORUMⁱ	P18848
DIPⁱ	DIP-354N
ELMⁱ	P18848
IntActⁱ	P18848, 59 interactors
MINTⁱ	P18848
STRINGⁱ	9606.ENSP00000336790

Chemistry databases

DrugBankⁱ	DB00852 Pseudoephedrine

DrugBankⁱ

DB00852 Pseudoephedrine

PTM databases

iPTMnetⁱ	P18848
PhosphoSitePlusⁱ	P18848

Polymorphism and mutation databases

BioMutaⁱ	ATF4
DMDMⁱ	116241262

Proteomic databases

EPDⁱ	P18848
PaxDbⁱ	P18848
PeptideAtlasⁱ	P18848
PRIDEⁱ	P18848
ProteomicsDBⁱ	53615

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	468
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337304; ENSP00000336790; ENSG00000128272 ENST00000396680; ENSP00000379912; ENSG00000128272 ENST00000404241; ENSP00000384587; ENSG00000128272
GeneIDⁱ	468
KEGGⁱ	hsa:468
UCSCⁱ	uc003axz.4 human

Organism-specific databases

CTDⁱ	468
DisGeNETⁱ	468
EuPathDBⁱ	HostDB:ENSG00000128272.14
GeneCardsⁱ	ATF4
HGNCⁱ	HGNC:786 ATF4
HPAⁱ	CAB011596
MIMⁱ	604064 gene
neXtProtⁱ	NX_P18848
OpenTargetsⁱ	ENSG00000128272
PharmGKBⁱ	PA25086
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4571 Eukaryota ENOG4111ZXT LUCA
GeneTreeⁱ	ENSGT00530000063801
HOGENOMⁱ	HOG000004844
HOVERGENⁱ	HBG004301
InParanoidⁱ	P18848
KOⁱ	K04374
OMAⁱ	AFSGMDW
OrthoDBⁱ	EOG091G0FNW
PhylomeDBⁱ	P18848
TreeFamⁱ	TF316136

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380994 ATF4 activates genes R-HSA-381042 PERK regulates gene expression R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
SIGNORⁱ	P18848

Miscellaneous databases

ChiTaRSⁱ	ATF4 human
EvolutionaryTraceⁱ	P18848
GeneWikiⁱ	ATF4
GenomeRNAiⁱ	468
Protein Ontology More...PROⁱ	PR:P18848
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128272 Expressed in 103 organ(s), highest expression level in lower esophagus
CleanExⁱ	HS_ATF4
Genevisibleⁱ	P18848 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029811 ATF4 IPR004827 bZIP
PANTHERⁱ	PTHR13044:SF2 PTHR13044:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATF4_HUMAN
Accessionⁱ	P18848Primary (citable) accession number: P18848 Secondary accession number(s): Q96AQ3, Q9UH31
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 206 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P18848 (ATF4_HUMAN)

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Cyclic AMP-dependent transcription factor ATF-4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Plasma membrane

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ