Cyclic AMP-dependent transcription factor ATF-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells."
    Wei Y., Jiang J., Sun M., Chen X., Wang H., Gu J.
    Biochem Biophys Res Commun 339:591-596(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: ParkinsonsUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib."
    Edagawa M., Kawauchi J., Hirata M., Goshima H., Inoue M., Okamoto T., Murakami A., Maehara Y., Kitajima S.
    J Biol Chem 289:21544-21561(2014) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCLInferred from direct assayⁱ
  • "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."
    Chen B.P., Wolfgang C.D., Hai T.
    Mol Cell Biol 16:1157-1168(1996) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A protein-protein interaction network of transcription factors acting during liver cell proliferation."
    Gao J., Li W.X., Feng S.Q., Yuan Y.S., Wan D.F., Han W., Yu Y.
    Genomics 91:347-355(2008) [PubMed] [Europe PMC] [Abstract]
  • "Networks of bZIP protein-protein interactions diversified over a billion years of evolution."
    Reinke A.W., Baek J., Ashenberg O., Keating A.E.
    Science 340:730-734(2013) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."
    Chen B.P., Wolfgang C.D., Hai T.
    Mol Cell Biol 16:1157-1168(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."
    Chen B.P., Wolfgang C.D., Hai T.
    Mol Cell Biol 16:1157-1168(1996) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • Ref.11

    "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
    Hai T., Liu F., Coukos W.J., Green M.R.
    Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-181.
• sequence-specific double-stranded DNA binding Source: ARUK-UCLInferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• transcription cis-regulatory region binding Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib."
    Edagawa M., Kawauchi J., Hirata M., Goshima H., Inoue M., Okamoto T., Murakami A., Maehara Y., Kitajima S.
    J Biol Chem 289:21544-21561(2014) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to amino acid starvation Source: Ensembl
• endoplasmic reticulum unfolded protein response Source: Ensembl
• gluconeogenesis Source: Ensembl
• negative regulation of ERK1 and ERK2 cascade Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."
    Chen B.P., Wolfgang C.D., Hai T.
    Mol Cell Biol 16:1157-1168(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of gene expression Source: Ensembl
• positive regulation of TRAIL-activated apoptotic signaling pathway Source: ParkinsonsUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib."
    Edagawa M., Kawauchi J., Hirata M., Goshima H., Inoue M., Okamoto T., Murakami A., Maehara Y., Kitajima S.
    J Biol Chem 289:21544-21561(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells."
    Wei Y., Jiang J., Sun M., Chen X., Wang H., Gu J.
    Biochem Biophys Res Commun 339:591-596(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib."
    Edagawa M., Kawauchi J., Hirata M., Goshima H., Inoue M., Okamoto T., Murakami A., Maehara Y., Kitajima S.
    J Biol Chem 289:21544-21561(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: ParkinsonsUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Roles of CHOP/GADD153 in endoplasmic reticulum stress."
    Oyadomari S., Mori M.
    Cell Death Differ. 11:381-389(2004) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "A protein-protein interaction network of transcription factors acting during liver cell proliferation."
    Gao J., Li W.X., Feng S.Q., Yuan Y.S., Wan D.F., Han W., Yu Y.
    Genomics 91:347-355(2008) [PubMed] [Europe PMC] [Abstract]
  • "Networks of bZIP protein-protein interactions diversified over a billion years of evolution."
    Reinke A.W., Baek J., Ashenberg O., Keating A.E.
    Science 340:730-734(2013) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."
    Chen B.P., Wolfgang C.D., Hai T.
    Mol Cell Biol 16:1157-1168(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."
    Chen B.P., Wolfgang C.D., Hai T.
    Mol Cell Biol 16:1157-1168(1996) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ 
        60         70         80         90        100
NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA 
       110        120        130        140        150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR 
       160        170        180 
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S                     

        10         20         30         40         50
MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ 
        60         70         80         90        100
NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA 
       110 
AKCRNKKKEK TECLQLQY                                    

        10         20         30         40         50
MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ 
        60         70         80         90        100
NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA 
       110        120        130 
AKCRNKKKEK TECLQKLPRP FWVQKTCIWA VDSCK                 

        10         20         30         40         50
MMLQHPGQVS ASEEELRFAI QNKHLCHRMS SALESVTVSD RPLGVSITKA 
        60         70         80         90        100
EVAPEEDERK KRRRERNKIA AAKCRNKKKE KTECLQKLPR PFWVQKTCIW 

AVDSCK                                                 

        10         20         30         40         50
MSSALESVTV SDRPLGVSIT KAEVAPEEDE RKKRRRERNK IAAAKCRNKK 
        60         70         80         90        100
KEKTECLQKE SEKLESVNAE LKAQIEELKN EKQHLIYMLN LHRPTCIVRA 
       110        120 
QNGRTPEDER NLFIQQIKEG TLQS                             

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families