UniProtKB - P18847 (ATF3_HUMAN)
Cyclic AMP-dependent transcription factor ATF-3
ATF3
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ParkinsonsUK-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCL
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: ParkinsonsUK-UCL
- protein homodimerization activity Source: ParkinsonsUK-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cellular response to amino acid starvation Source: Ensembl
- gluconeogenesis Source: Ensembl
- negative regulation of ERK1 and ERK2 cascade Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
- PERK-mediated unfolded protein response Source: Reactome
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of TRAIL-activated apoptotic signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: ParkinsonsUK-UCL
- skeletal muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P18847 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency |
SignaLinki | P18847 |
SIGNORi | P18847 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic AMP-dependent transcription factor ATF-3Short name: cAMP-dependent transcription factor ATF-3 Alternative name(s): Activating transcription factor 3 |
Gene namesi | Name:ATF3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:785, ATF3 |
MIMi | 603148, gene |
neXtProti | NX_P18847 |
VEuPathDBi | HostDB:ENSG00000162772.16 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: ParkinsonsUK-UCL
Other locations
- CHOP-ATF3 complex Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 467 |
OpenTargetsi | ENSG00000162772 |
PharmGKBi | PA25085 |
Miscellaneous databases
Pharosi | P18847, Tbio |
Chemistry databases
DrugBanki | DB00852, Pseudoephedrine |
Genetic variation databases
BioMutai | ATF3 |
DMDMi | 1168543 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076581 | 1 – 181 | Cyclic AMP-dependent transcription factor ATF-3Add BLAST | 181 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 162 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 175 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1755 |
EPDi | P18847 |
jPOSTi | P18847 |
MassIVEi | P18847 |
PaxDbi | P18847 |
PeptideAtlasi | P18847 |
PRIDEi | P18847 |
ProteomicsDBi | 53611 [P18847-1] 53612 [P18847-2] 53613 [P18847-3] 53614 [P18847-4] 65367 |
TopDownProteomicsi | P18847-1 [P18847-1] |
PTM databases
iPTMneti | P18847 |
PhosphoSitePlusi | P18847 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162772, Expressed in vena cava and 239 other tissues |
ExpressionAtlasi | P18847, baseline and differential |
Genevisiblei | P18847, HS |
Organism-specific databases
HPAi | ENSG00000162772, Tissue enhanced (seminal) |
Interactioni
Subunit structurei
Binds DNA as a homodimer or a heterodimer.
Binary interactionsi
Hide detailsP18847
Isoform 3 [P18847-3]
With | #Exp. | IntAct |
---|---|---|
RELA [Q04206] | 5 | EBI-9844134,EBI-73886 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: ParkinsonsUK-UCL
- protein homodimerization activity Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 106957, 76 interactors |
CORUMi | P18847 |
DIPi | DIP-344N |
IntActi | P18847, 50 interactors |
MINTi | P18847 |
STRINGi | 9606.ENSP00000344352 |
Miscellaneous databases
RNActi | P18847, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 86 – 149 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 88 – 110 | Basic motifPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 114 – 142 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000156376 |
HOGENOMi | CLU_088612_0_2_1 |
InParanoidi | P18847 |
OMAi | NRPLEMS |
OrthoDBi | 1457971at2759 |
PhylomeDBi | P18847 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR029812, ATF3 IPR004827, bZIP |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF23, PTHR23351:SF23, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
The sequence of this isoform differs from the canonical sequence as follows:
116-181: KESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS → LQY
The sequence of this isoform differs from the canonical sequence as follows:
117-181: ESEKLESVNA...QQIKEGTLQS → LPRPFWVQKTCIWAVDSCK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VTZ4 | Q5VTZ4_HUMAN | Cyclic AMP-dependent transcription ... | ATF3 | 175 | Annotation score: | ||
A0A0A0MRJ2 | A0A0A0MRJ2_HUMAN | Cyclic AMP-dependent transcription ... | ATF3 | 153 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | I → L no nucleotide entry (PubMed:2516827).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048442 | 38 | T → M1 PublicationCorresponds to variant dbSNP:rs11571541Ensembl. | 1 | |
Natural variantiVAR_081532 | 168 | N → T De novo variant found in a patient with childhood apraxia of speech; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046966 | 1 – 57 | Missing in isoform 5. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_043182 | 14 – 42 | Missing in isoform 4. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_000592 | 116 – 181 | KESEK…GTLQS → LQY in isoform 2. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_043150 | 117 – 181 | ESEKL…GTLQS → LPRPFWVQKTCIWAVDSCK in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 65 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000336937; ENSP00000336908; ENSG00000162772 [P18847-4] ENST00000341491; ENSP00000344352; ENSG00000162772 [P18847-1] ENST00000366983; ENSP00000355950; ENSG00000162772 [P18847-3] ENST00000366987; ENSP00000355954; ENSG00000162772 [P18847-1] ENST00000464547; ENSP00000432208; ENSG00000162772 [P18847-3] ENST00000613104; ENSP00000480606; ENSG00000162772 [P18847-5] ENST00000613954; ENSP00000483576; ENSG00000162772 [P18847-5] |
GeneIDi | 467 |
KEGGi | hsa:467 |
UCSCi | uc001hjf.4, human [P18847-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
SMRi | P18847 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106957, 76 interactors |
CORUMi | P18847 |
DIPi | DIP-344N |
IntActi | P18847, 50 interactors |
MINTi | P18847 |
STRINGi | 9606.ENSP00000344352 |
Chemistry databases
DrugBanki | DB00852, Pseudoephedrine |
PTM databases
iPTMneti | P18847 |
PhosphoSitePlusi | P18847 |
Genetic variation databases
BioMutai | ATF3 |
DMDMi | 1168543 |
Proteomic databases
CPTACi | CPTAC-1755 |
EPDi | P18847 |
jPOSTi | P18847 |
MassIVEi | P18847 |
PaxDbi | P18847 |
PeptideAtlasi | P18847 |
PRIDEi | P18847 |
ProteomicsDBi | 53611 [P18847-1] 53612 [P18847-2] 53613 [P18847-3] 53614 [P18847-4] 65367 |
TopDownProteomicsi | P18847-1 [P18847-1] |
Protocols and materials databases
Antibodypediai | 658, 548 antibodies |
DNASUi | 467 |
Genome annotation databases
Organism-specific databases
CTDi | 467 |
DisGeNETi | 467 |
GeneCardsi | ATF3 |
HGNCi | HGNC:785, ATF3 |
HPAi | ENSG00000162772, Tissue enhanced (seminal) |
MIMi | 603148, gene |
neXtProti | NX_P18847 |
OpenTargetsi | ENSG00000162772 |
PharmGKBi | PA25085 |
VEuPathDBi | HostDB:ENSG00000162772.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000156376 |
HOGENOMi | CLU_088612_0_2_1 |
InParanoidi | P18847 |
OMAi | NRPLEMS |
OrthoDBi | 1457971at2759 |
PhylomeDBi | P18847 |
TreeFami | TF326301 |
Enzyme and pathway databases
PathwayCommonsi | P18847 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency |
SignaLinki | P18847 |
SIGNORi | P18847 |
Miscellaneous databases
BioGRID-ORCSi | 467, 8 hits in 904 CRISPR screens |
ChiTaRSi | ATF3, human |
GeneWikii | ATF3 |
GenomeRNAii | 467 |
Pharosi | P18847, Tbio |
PROi | PR:P18847 |
RNActi | P18847, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162772, Expressed in vena cava and 239 other tissues |
ExpressionAtlasi | P18847, baseline and differential |
Genevisiblei | P18847, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR029812, ATF3 IPR004827, bZIP |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF23, PTHR23351:SF23, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATF3_HUMAN | |
Accessioni | P18847Primary (citable) accession number: P18847 Secondary accession number(s): Q5VTZ2 Q8WYM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families