UniProtKB - P18846 (ATF1_HUMAN)
Cyclic AMP-dependent transcription factor ATF-1
ATF1
Functioni
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
2 PublicationsGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- protein-containing complex binding Source: Ensembl
- protein heterodimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- cAMP-mediated signaling Source: MGI
- positive regulation of DNA replication Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: ComplexPortal
- response to cobalt ion Source: Ensembl
- response to purine-containing compound Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P18846 |
Reactomei | R-HSA-199920, CREB phosphorylation R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P18846 |
SIGNORi | P18846 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic AMP-dependent transcription factor ATF-1Short name: cAMP-dependent transcription factor ATF-1 Alternative name(s): Activating transcription factor 1 Protein TREB36 |
Gene namesi | Name:ATF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:783, ATF1 |
MIMi | 123803, gene |
neXtProti | NX_P18846 |
VEuPathDBi | HostDB:ENSG00000123268 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- ATF1-ATF4 transcription factor complex Source: ParkinsonsUK-UCL
- ATF4-CREB1 transcription factor complex Source: GO_Central
- nucleoplasm Source: HPA
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Angiomatoid fibrous histiocytoma (AFH)
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 63 | S → A: Impaired CDK3-mediated phosphorylation and altered transactivation and transcriptional activities. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 110 | Breakpoint for translocation to form chimeric EWSR1/ATF1 protein | 1 | |
Sitei | 112 | Breakpoint for translocation to form chimeric FUS/ATF1 protein | 1 |
Organism-specific databases
DisGeNETi | 466 |
MalaCardsi | ATF1 |
MIMi | 612160, phenotype |
OpenTargetsi | ENSG00000123268 |
Orphaneti | 97338, Melanoma of soft tissue |
PharmGKBi | PA25083 |
Miscellaneous databases
Pharosi | P18846, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3255 |
DrugBanki | DB00852, Pseudoephedrine |
Genetic variation databases
BioMutai | ATF1 |
DMDMi | 1168542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076575 | 1 – 271 | Cyclic AMP-dependent transcription factor ATF-1Add BLAST | 271 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA52 Publications | 1 | |
Modified residuei | 198 | Phosphoserine; by HIPK2PROSITE-ProRule annotationCombined sources1 Publication | 1 | |
Cross-linki | 208 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 215 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P18846 |
jPOSTi | P18846 |
MassIVEi | P18846 |
MaxQBi | P18846 |
PaxDbi | P18846 |
PeptideAtlasi | P18846 |
PRIDEi | P18846 |
ProteomicsDBi | 4950 53610 [P18846-1] |
PTM databases
GlyGeni | P18846, 10 sites, 2 O-linked glycans (10 sites) |
iPTMneti | P18846 |
PhosphoSitePlusi | P18846 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123268, Expressed in biceps brachii and 244 other tissues |
ExpressionAtlasi | P18846, baseline and differential |
Genevisiblei | P18846, HS |
Organism-specific databases
HPAi | ENSG00000123268, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
P18846
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 106956, 48 interactors |
ComplexPortali | CPX-6401, bZIP transcription factor complex, ATF1-ATF1 CPX-6402, bZIP transcription factor complex, ATF1-BACH1 CPX-6404, bZIP transcription factor complex, ATF1-NFIL3 CPX-6405, bZIP transcription factor complex, ATF1-CREB1 CPX-9, bZIP transcription factor complex, ATF1-ATF4 |
DIPi | DIP-652N |
IntActi | P18846, 30 interactors |
MINTi | P18846 |
STRINGi | 9606.ENSP00000262053 |
Chemistry databases
BindingDBi | P18846 |
Miscellaneous databases
RNActi | P18846, protein |
Structurei
3D structure databases
AlphaFoldDBi | P18846 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 90 | KIDPROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 213 – 271 | bZIPPROSITE-ProRule annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 61 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 215 – 239 | Basic motifPROSITE-ProRule annotationAdd BLAST | 25 | |
Regioni | 241 – 262 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 52 | Polar residuesSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3584, Eukaryota |
GeneTreei | ENSGT00940000158200 |
HOGENOMi | CLU_042675_1_0_1 |
InParanoidi | P18846 |
OMAi | THISHIA |
OrthoDBi | 957343at2759 |
PhylomeDBi | P18846 |
TreeFami | TF106464 |
Family and domain databases
InterProi | View protein in InterPro IPR029825, ATF1 IPR004827, bZIP IPR046347, bZIP_sf IPR003102, Coactivator_CBP_pKID IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF2, PTHR45879:SF2, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS
60 70 80 90 100
SQKAHGILAR RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP
110 120 130 140 150
IYQTSSGQYI AIAPNGALQL ASPGTDGVQG LQTLTMTNSG STQQGTTILQ
160 170 180 190 200
YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ IRTTPSATSL PQTVVMTSPV
210 220 230 240 250
TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC LENRVAVLEN
260 270
QNKTLIEELK TLKDLYSNKS V
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VS03 | F8VS03_HUMAN | Cyclic AMP-dependent transcription ... | ATF1 | 170 | Annotation score: | ||
F8VYN3 | F8VYN3_HUMAN | Cyclic AMP-dependent transcription ... | ATF1 | 200 | Annotation score: | ||
F8VRN2 | F8VRN2_HUMAN | Cyclic AMP-dependent transcription ... | ATF1 | 77 | Annotation score: | ||
F8VYE5 | F8VYE5_HUMAN | Cyclic AMP-dependent transcription ... | ATF1 | 55 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | H → A no nucleotide entry (PubMed:2516827).Curated | 1 | |
Sequence conflicti | 227 | Missing no nucleotide entry (PubMed:2516827).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024382 | 191 | P → A. Corresponds to variant dbSNP:rs2230674Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055559 | 1 – 135 | Missing in isoform 2. 1 PublicationAdd BLAST | 135 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55544 Genomic DNA Translation: CAA39150.1 AK299240 mRNA Translation: BAG61271.1 AC013244 Genomic DNA No translation available. BC029619 mRNA Translation: AAH29619.1 AJ295163 mRNA Translation: CAC15058.1 Different initiation. |
CCDSi | CCDS8803.1 [P18846-1] |
PIRi | S12560 |
RefSeqi | NP_005162.1, NM_005171.4 [P18846-1] XP_011536688.1, XM_011538386.2 [P18846-1] XP_011536689.1, XM_011538387.2 [P18846-1] XP_016874821.1, XM_017019332.1 [P18846-1] XP_016874822.1, XM_017019333.1 [P18846-1] XP_016874823.1, XM_017019334.1 [P18846-1] |
Genome annotation databases
Ensembli | ENST00000262053.8; ENSP00000262053.3; ENSG00000123268.9 |
GeneIDi | 466 |
KEGGi | hsa:466 |
MANE-Selecti | ENST00000262053.8; ENSP00000262053.3; NM_005171.5; NP_005162.1 |
UCSCi | uc001rww.5, human [P18846-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55544 Genomic DNA Translation: CAA39150.1 AK299240 mRNA Translation: BAG61271.1 AC013244 Genomic DNA No translation available. BC029619 mRNA Translation: AAH29619.1 AJ295163 mRNA Translation: CAC15058.1 Different initiation. |
CCDSi | CCDS8803.1 [P18846-1] |
PIRi | S12560 |
RefSeqi | NP_005162.1, NM_005171.4 [P18846-1] XP_011536688.1, XM_011538386.2 [P18846-1] XP_011536689.1, XM_011538387.2 [P18846-1] XP_016874821.1, XM_017019332.1 [P18846-1] XP_016874822.1, XM_017019333.1 [P18846-1] XP_016874823.1, XM_017019334.1 [P18846-1] |
3D structure databases
AlphaFoldDBi | P18846 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 106956, 48 interactors |
ComplexPortali | CPX-6401, bZIP transcription factor complex, ATF1-ATF1 CPX-6402, bZIP transcription factor complex, ATF1-BACH1 CPX-6404, bZIP transcription factor complex, ATF1-NFIL3 CPX-6405, bZIP transcription factor complex, ATF1-CREB1 CPX-9, bZIP transcription factor complex, ATF1-ATF4 |
DIPi | DIP-652N |
IntActi | P18846, 30 interactors |
MINTi | P18846 |
STRINGi | 9606.ENSP00000262053 |
Chemistry databases
BindingDBi | P18846 |
ChEMBLi | CHEMBL3255 |
DrugBanki | DB00852, Pseudoephedrine |
PTM databases
GlyGeni | P18846, 10 sites, 2 O-linked glycans (10 sites) |
iPTMneti | P18846 |
PhosphoSitePlusi | P18846 |
Genetic variation databases
BioMutai | ATF1 |
DMDMi | 1168542 |
Proteomic databases
EPDi | P18846 |
jPOSTi | P18846 |
MassIVEi | P18846 |
MaxQBi | P18846 |
PaxDbi | P18846 |
PeptideAtlasi | P18846 |
PRIDEi | P18846 |
ProteomicsDBi | 4950 53610 [P18846-1] |
Protocols and materials databases
ABCDi | P18846, 1 sequenced antibody |
Antibodypediai | 4260, 673 antibodies from 43 providers |
DNASUi | 466 |
Genome annotation databases
Ensembli | ENST00000262053.8; ENSP00000262053.3; ENSG00000123268.9 |
GeneIDi | 466 |
KEGGi | hsa:466 |
MANE-Selecti | ENST00000262053.8; ENSP00000262053.3; NM_005171.5; NP_005162.1 |
UCSCi | uc001rww.5, human [P18846-1] |
Organism-specific databases
CTDi | 466 |
DisGeNETi | 466 |
GeneCardsi | ATF1 |
HGNCi | HGNC:783, ATF1 |
HPAi | ENSG00000123268, Low tissue specificity |
MalaCardsi | ATF1 |
MIMi | 123803, gene 612160, phenotype |
neXtProti | NX_P18846 |
OpenTargetsi | ENSG00000123268 |
Orphaneti | 97338, Melanoma of soft tissue |
PharmGKBi | PA25083 |
VEuPathDBi | HostDB:ENSG00000123268 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3584, Eukaryota |
GeneTreei | ENSGT00940000158200 |
HOGENOMi | CLU_042675_1_0_1 |
InParanoidi | P18846 |
OMAi | THISHIA |
OrthoDBi | 957343at2759 |
PhylomeDBi | P18846 |
TreeFami | TF106464 |
Enzyme and pathway databases
PathwayCommonsi | P18846 |
Reactomei | R-HSA-199920, CREB phosphorylation R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P18846 |
SIGNORi | P18846 |
Miscellaneous databases
BioGRID-ORCSi | 466, 26 hits in 1102 CRISPR screens |
ChiTaRSi | ATF1, human |
GeneWikii | ATF1 |
GenomeRNAii | 466 |
Pharosi | P18846, Tchem |
PROi | PR:P18846 |
RNActi | P18846, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123268, Expressed in biceps brachii and 244 other tissues |
ExpressionAtlasi | P18846, baseline and differential |
Genevisiblei | P18846, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029825, ATF1 IPR004827, bZIP IPR046347, bZIP_sf IPR003102, Coactivator_CBP_pKID IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF2, PTHR45879:SF2, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATF1_HUMAN | |
Accessioni | P18846Primary (citable) accession number: P18846 Secondary accession number(s): B4DRF9, P25168, Q9H4A8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families