ATF1

Functionⁱ

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.2 Publications

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 2196176
- 8401579
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20102225
- 21045134
protein-containing complex binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1655749
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1655749
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein-containing complex assembly Source: Ensembl
positive regulation of DNA replication Source: Ensembl
positive regulation of neuron projection development Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 1655749
response to cobalt ion Source: Ensembl
response to organic cyclic compound Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-199920 CREB phosphorylation
SignaLinkⁱ	P18846
SIGNORⁱ	P18846

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclic AMP-dependent transcription factor ATF-1 Short name: cAMP-dependent transcription factor ATF-1 Alternative name(s): Activating transcription factor 1 Protein TREB36
Gene namesⁱ	Name:ATF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123268.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:783 ATF1
MIMⁱ	123803 gene
neXtProtⁱ	NX_P18846

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Angiomatoid fibrous histiocytoma (AFH)

The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.

Disease descriptionA distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	63	S → A: Impaired CDK3-mediated phosphorylation and altered transactivation and transcriptional activities. 1 Publication		1

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	110	Breakpoint for translocation to form chimeric EWSR1/ATF1 protein		1
Siteⁱ	112	Breakpoint for translocation to form chimeric FUS/ATF1 protein		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	466
MalaCards human disease database More...MalaCardsⁱ	ATF1
MIMⁱ	612160 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000123268
Orphanetⁱ	97338 Melanoma of soft parts
PharmGKBⁱ	PA25083

Chemistry databases

ChEMBLⁱ	CHEMBL3255
Drug and drug target database More...DrugBankⁱ	DB00852 Pseudoephedrine

Polymorphism and mutation databases

BioMutaⁱ	ATF1
DMDMⁱ	1168542

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076575	1 – 271	Cyclic AMP-dependent transcription factor ATF-1Add BLAST		271

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	63	Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA52 Publications	1
Modified residueⁱ	198	Phosphoserine; by HIPK2PROSITE-ProRule annotationCombined sources1 Publication	1
Cross-linkⁱ	208	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	215	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.3 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P18846
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P18846
PaxDbⁱ	P18846
PeptideAtlas More...PeptideAtlasⁱ	P18846
PRIDEⁱ	P18846
ProteomicsDBⁱ	53610

PTM databases

iPTMnetⁱ	P18846
PhosphoSitePlusⁱ	P18846

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000123268 Expressed in 230 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_ATF1
ExpressionAtlasⁱ	P18846 baseline and differential
Genevisibleⁱ	P18846 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016222 HPA055069 HPA055406

HPAⁱ

CAB016222
HPA055069
HPA055406

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-852794,EBI-852794
	P03259-2	2	EBI-852794,EBI-7225021	From a different organism.
CREB1	P16220	6	EBI-852794,EBI-711855
HBZ	P0C746	2	EBI-852794,EBI-10890294	From Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A).
JUN	P05412	2	EBI-852794,EBI-852823
MDV005	Q9DGW5	2	EBI-852794,EBI-10889526	From Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987).
NFATC1	O95644	3	EBI-852794,EBI-6907210
NFIL3	Q16649	2	EBI-852794,EBI-3951858

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20102225
- 21045134
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106956, 32 interactors
ComplexPortalⁱ	CPX-9 ATF1-ATF4 transcription factor complex
Database of interacting proteins More...DIPⁱ	DIP-652N
IntActⁱ	P18846, 12 interactors
Molecular INTeraction database More...MINTⁱ	P18846
STRINGⁱ	9606.ENSP00000262053

Chemistry databases

BindingDBⁱ

P18846

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P18846
SMRⁱ	P18846
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 90	KIDPROSITE-ProRule annotationAdd BLAST		60
Domainⁱ	213 – 271	bZIPPROSITE-ProRule annotationAdd BLAST		59

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	215 – 239	Basic motifPROSITE-ProRule annotationAdd BLAST		25
Regionⁱ	241 – 262	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3584 Eukaryota ENOG410ZZJZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008655
HOGENOMⁱ	HOG000007365
HOVERGENⁱ	HBG011077
InParanoidⁱ	P18846
KEGG Orthology (KO) More...KOⁱ	K09053
OMAⁱ	HIAQQMS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FTJ
PhylomeDBⁱ	P18846
TreeFamⁱ	TF106464

Family and domain databases

InterProⁱ	View protein in InterPro IPR029825 ATF1 IPR004827 bZIP IPR003102 Coactivator_CBP_pKID IPR001630 Leuzip_CREB
PANTHERⁱ	PTHR22952:SF258 PTHR22952:SF258, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit PF02173 pKID, 1 hit
PRINTSⁱ	PR00041 LEUZIPPRCREB
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit PS50953 KID, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P18846-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS 
        60         70         80         90        100
SQKAHGILAR RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP 
       110        120        130        140        150
IYQTSSGQYI AIAPNGALQL ASPGTDGVQG LQTLTMTNSG STQQGTTILQ 
       160        170        180        190        200
YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ IRTTPSATSL PQTVVMTSPV 
       210        220        230        240        250
TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC LENRVAVLEN 
       260        270 
QNKTLIEELK TLKDLYSNKS V

Length:271

Mass (Da):29,233

Last modified:November 1, 1995 - v2

Checksum:ⁱBAFECBFFB244FCED

GO

Isoform 2 (identifier: P18846-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-135: Missing.

« Hide

        10         20         30         40         50
MTNSGSTQQG TTILQYAQTS DGQQILVPSN QVVVQTASGD MQTYQIRTTP 
        60         70         80         90        100
SATSLPQTVV MTSPVTLTSQ TTKTDDPQLK REIRLMKNRE AARECRRKKK 
       110        120        130 
EYVKCLENRV AVLENQNKTL IEELKTLKDL YSNKSV

Note: No experimental confirmation available.

Show »

Length:136

Mass (Da):15,295

Checksum:ⁱ86343F1CF592889F

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
F8VYN3	F8VYN3_HUMAN	Cyclic AMP-dependent transcription ... Cyclic AMP-dependent transcription factor ATF-1	ATF1	200	Annotation score:
F8VS03	F8VS03_HUMAN	Cyclic AMP-dependent transcription ... Cyclic AMP-dependent transcription factor ATF-1	ATF1	170	Annotation score:
F8VYE5	F8VYE5_HUMAN	Cyclic AMP-dependent transcription ... Cyclic AMP-dependent transcription factor ATF-1	ATF1	55	Annotation score:
F8VRN2	F8VRN2_HUMAN	Cyclic AMP-dependent transcription ... Cyclic AMP-dependent transcription factor ATF-1	ATF1	77	Annotation score:

Sequence cautionⁱ

The sequence CAC15058 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	55	H → A no nucleotide entry (PubMed:2516827).Curated		1
Sequence conflictⁱ	227	Missing no nucleotide entry (PubMed:2516827).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024382	191	P → A. Corresponds to variant dbSNP:rs2230674Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055559	1 – 135	Missing in isoform 2. 1 PublicationAdd BLAST		135

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55544 Genomic DNA Translation: CAA39150.1 AK299240 mRNA Translation: BAG61271.1 AC013244 Genomic DNA No translation available. BC029619 mRNA Translation: AAH29619.1 AJ295163 mRNA Translation: CAC15058.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8803.1 [P18846-1]
PIRⁱ	S12560
NCBI Reference Sequences More...RefSeqⁱ	NP_005162.1, NM_005171.4 [P18846-1] XP_011536688.1, XM_011538386.2 [P18846-1] XP_011536689.1, XM_011538387.2 [P18846-1] XP_016874821.1, XM_017019332.1 [P18846-1] XP_016874822.1, XM_017019333.1 [P18846-1] XP_016874823.1, XM_017019334.1 [P18846-1]
UniGeneⁱ	Hs.648565

Genome annotation databases

Ensemblⁱ	ENST00000262053; ENSP00000262053; ENSG00000123268 [P18846-1]
GeneIDⁱ	466
KEGGⁱ	hsa:466
UCSC genome browser More...UCSCⁱ	uc001rww.5 human [P18846-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18846	Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		HUMAN		170	UniRef100_P18846
Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		HUMAN		200
UPI0007DC4FA4		HUMAN		279
P18846-2	EWSR1/ATF1 fusion protein type 1		HUMAN		537	UniRef100_F1JVV5
Cyclic AMP-dependent transcription factor ATF-1		CAMFR		136
Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		ESCRO		114
UPI0005CFF0DF		HUMAN		177

Protein	Similar proteins		Species	Score	Length	Source
P18846	Cyclic AMP-dependent transcription factor ATF-1		MOUSE		269	UniRef90_P18846
Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		HUMAN		170
Activating transcription factor 1		OTOGA		303
Activating transcription factor 1		MONDO		271
Activating transcription factor 1		NOMLE		270
+97
P18846-2	EWSR1/ATF1 fusion protein type 1		HUMAN		537	UniRef90_F1JVV5
Cyclic AMP-dependent transcription factor ATF-1		CAMFR		136
Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		ESCRO		114
UPI0005CFF0DF		HUMAN		177

Protein	Similar proteins		Species	Score	Length	Source
P18846	Cyclic AMP-dependent transcription factor ATF-1		MOUSE		269	UniRef50_P18846
Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		HUMAN		170
Activating transcription factor 1		OTOGA		303
Activating transcription factor 1		MONDO		271
Putative cyclic amp-dependent transcription factor atf-1-like protein		DESRO		270
+208
P18846-2	EWSR1/ATF1 fusion protein type 1		HUMAN		537	UniRef50_F1JVV5
Cyclic AMP-dependent transcription factor ATF-1		CAMFR		136
Cyclic AMP-dependent transcription factor ATF-1 (Fragment)		ESCRO		114
RNA-binding protein EWS		CHEMY		517
RNA-binding protein EWS (Fragment)		PYGAD		443
+13

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55544 Genomic DNA Translation: CAA39150.1 AK299240 mRNA Translation: BAG61271.1 AC013244 Genomic DNA No translation available. BC029619 mRNA Translation: AAH29619.1 AJ295163 mRNA Translation: CAC15058.1 Different initiation.
CCDSⁱ	CCDS8803.1 [P18846-1]
PIRⁱ	S12560
RefSeqⁱ	NP_005162.1, NM_005171.4 [P18846-1] XP_011536688.1, XM_011538386.2 [P18846-1] XP_011536689.1, XM_011538387.2 [P18846-1] XP_016874821.1, XM_017019332.1 [P18846-1] XP_016874822.1, XM_017019333.1 [P18846-1] XP_016874823.1, XM_017019334.1 [P18846-1]
UniGeneⁱ	Hs.648565

3D structure databases

ProteinModelPortalⁱ	P18846
SMRⁱ	P18846
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106956, 32 interactors
ComplexPortalⁱ	CPX-9 ATF1-ATF4 transcription factor complex
DIPⁱ	DIP-652N
IntActⁱ	P18846, 12 interactors
MINTⁱ	P18846
STRINGⁱ	9606.ENSP00000262053

Chemistry databases

BindingDBⁱ	P18846
ChEMBLⁱ	CHEMBL3255
DrugBankⁱ	DB00852 Pseudoephedrine

PTM databases

iPTMnetⁱ	P18846
PhosphoSitePlusⁱ	P18846

Polymorphism and mutation databases

BioMutaⁱ	ATF1
DMDMⁱ	1168542

Proteomic databases

EPDⁱ	P18846
MaxQBⁱ	P18846
PaxDbⁱ	P18846
PeptideAtlasⁱ	P18846
PRIDEⁱ	P18846
ProteomicsDBⁱ	53610

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	466
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262053; ENSP00000262053; ENSG00000123268 [P18846-1]
GeneIDⁱ	466
KEGGⁱ	hsa:466
UCSCⁱ	uc001rww.5 human [P18846-1]

Organism-specific databases

CTDⁱ	466
DisGeNETⁱ	466
EuPathDBⁱ	HostDB:ENSG00000123268.8
GeneCardsⁱ	ATF1
HGNCⁱ	HGNC:783 ATF1
HPAⁱ	CAB016222 HPA055069 HPA055406
MalaCardsⁱ	ATF1
MIMⁱ	123803 gene 612160 phenotype
neXtProtⁱ	NX_P18846
OpenTargetsⁱ	ENSG00000123268
Orphanetⁱ	97338 Melanoma of soft parts
PharmGKBⁱ	PA25083
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3584 Eukaryota ENOG410ZZJZ LUCA
GeneTreeⁱ	ENSGT00390000008655
HOGENOMⁱ	HOG000007365
HOVERGENⁱ	HBG011077
InParanoidⁱ	P18846
KOⁱ	K09053
OMAⁱ	HIAQQMS
OrthoDBⁱ	EOG091G0FTJ
PhylomeDBⁱ	P18846
TreeFamⁱ	TF106464

Enzyme and pathway databases

Reactomeⁱ	R-HSA-199920 CREB phosphorylation
SignaLinkⁱ	P18846
SIGNORⁱ	P18846

Miscellaneous databases

ChiTaRSⁱ	ATF1 human
GeneWikiⁱ	ATF1
GenomeRNAiⁱ	466
Protein Ontology More...PROⁱ	PR:P18846
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123268 Expressed in 230 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_ATF1
ExpressionAtlasⁱ	P18846 baseline and differential
Genevisibleⁱ	P18846 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029825 ATF1 IPR004827 bZIP IPR003102 Coactivator_CBP_pKID IPR001630 Leuzip_CREB
PANTHERⁱ	PTHR22952:SF258 PTHR22952:SF258, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit PF02173 pKID, 1 hit
PRINTSⁱ	PR00041 LEUZIPPRCREB
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit PS50953 KID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATF1_HUMAN
Accessionⁱ	P18846Primary (citable) accession number: P18846 Secondary accession number(s): B4DRF9, P25168, Q9H4A8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1995
	Last modified:	September 12, 2018
	This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P18846 (ATF1_HUMAN)

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Cyclic AMP-dependent transcription factor ATF-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Angiomatoid fibrous histiocytoma (AFH)

Mutagenesis

Sites

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ