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Protein

Lutropin subunit beta

Gene

LHB

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Lutropin beta chain
Gene namesi
Name:LHB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 17Add BLAST›17
ChainiPRO_000001172018 – 138Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 74By similarity
Glycosylationi30N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi40 ↔ 89By similarity
Disulfide bondi43 ↔ 127By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi55 ↔ 107By similarity
Disulfide bondi110 ↔ 117By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18842

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005719

Structurei

3D structure databases

ProteinModelPortaliP18842
SMRiP18842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP18842
KOiK08521

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LQGLLLWLLL SVGGVWASRG PLRPLCRPIN ATLAAENEAC PVCITFTTTI
60 70 80 90 100
CAGYCPSMVR VLPAALPPVP QPVCTYHELH FASIRLPGCP PGVDPMVSFP
110 120 130
VALSCRCGPC RLSNSDCGGP RAQSLACDRP LLPGLLFL
Length:138
Mass (Da):14,594
Last modified:November 1, 1990 - v1
Checksum:iE3639FE6B03F1948
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00518 mRNA Translation: CAA68572.1
PIRiS00512
RefSeqiNP_001183962.1, NM_001197033.1
UniGeneiCfa.3817

Genome annotation databases

GeneIDi403959
KEGGicfa:403959

Similar proteinsi

Entry informationi

Entry nameiLSHB_CANLF
AccessioniPrimary (citable) accession number: P18842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 10, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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