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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularBy similarityAdd BLAST45
Transmembranei46 – 70Helical; Name=1By similarityAdd BLAST25
Topological domaini71 – 83CytoplasmicBy similarityAdd BLAST13
Transmembranei84 – 105Helical; Name=2By similarityAdd BLAST22
Topological domaini106 – 115ExtracellularBy similarity10
Transmembranei116 – 141Helical; Name=3By similarityAdd BLAST26
Topological domaini142 – 161CytoplasmicBy similarityAdd BLAST20
Transmembranei162 – 184Helical; Name=4By similarityAdd BLAST23
Topological domaini185 – 201ExtracellularBy similarityAdd BLAST17
Transmembranei202 – 224Helical; Name=5By similarityAdd BLAST23
Topological domaini225 – 295CytoplasmicBy similarityAdd BLAST71
Transmembranei296 – 319Helical; Name=6By similarityAdd BLAST24
Topological domaini320 – 326ExtracellularBy similarity7
Transmembranei327 – 351Helical; Name=7By similarityAdd BLAST25
Topological domaini352 – 515CytoplasmicBy similarityAdd BLAST164

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi293A → X: Confers constitutive activity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3122

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690701 – 515Alpha-1B adrenergic receptorAdd BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Modified residuei264PhosphothreonineBy similarity1
Lipidationi365S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP18841

PTM databases

iPTMnetiP18841

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C1qbpO357965EBI-6391008,EBI-915544From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP18841, 1 interactor

Chemistry databases

BindingDBiP18841

Structurei

3D structure databases

ProteinModelPortaliP18841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi368 – 378Nuclear localization signalBy similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi371 – 378Poly-Arg8

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962
OrthoDBiEOG091G06VI

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001115 ADRA1B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF17 PTHR24248:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00556 ADRENRGCA1BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPDLDTGHN TSAPAQWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP
110 120 130 140 150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFM RILGCQCRSG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS
410 420 430 440 450
RKDSLDDSGS CMSGSQRTLP SASPSPGYLG RGAQPPLELC AYPEWKSGAL
460 470 480 490 500
LSLPEPPGRR GRLDSGPLFT FKLLGEPESP GTEGDASNGG CDATTDLANG
510
QPGFKSNMPL APGHF
Length:515
Mass (Da):56,493
Last modified:November 1, 1990 - v1
Checksum:i6DAF1576D1C1CE2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04084 mRNA Translation: AAA58964.1
PIRiA40491
RefSeqiNP_001268623.1, NM_001281694.1

Genome annotation databases

GeneIDi101843941

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04084 mRNA Translation: AAA58964.1
PIRiA40491
RefSeqiNP_001268623.1, NM_001281694.1

3D structure databases

ProteinModelPortaliP18841
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18841, 1 interactor

Chemistry databases

BindingDBiP18841
ChEMBLiCHEMBL3122

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP18841

Proteomic databases

PRIDEiP18841

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101843941

Organism-specific databases

CTDi147

Phylogenomic databases

HOVERGENiHBG106962
OrthoDBiEOG091G06VI

Miscellaneous databases

PROiPR:P18841

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001115 ADRA1B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF17 PTHR24248:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00556 ADRENRGCA1BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA1B_MESAU
AccessioniPrimary (citable) accession number: P18841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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