UniProtKB - P18828 (SDC1_MOUSE)
Syndecan-1
Sdc1
Functioni
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- protein C-terminus binding Source: MGI
GO - Biological processi
- canonical Wnt signaling pathway Source: MGI
- cell migration Source: GO_Central
- inflammatory response Source: MGI
- myoblast development Source: UniProtKB
- odontogenesis Source: Ensembl
- positive regulation of exosomal secretion Source: MGI
- positive regulation of extracellular exosome assembly Source: MGI
- response to calcium ion Source: Ensembl
- response to cAMP Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to toxic substance Source: Ensembl
- Sertoli cell development Source: Ensembl
- striated muscle cell development Source: Ensembl
- ureteric bud development Source: Ensembl
- wound healing Source: Ensembl
Enzyme and pathway databases
Reactomei | R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928, HS-GAG biosynthesis R-MMU-2024096, HS-GAG degradation R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-3000170, Syndecan interactions R-MMU-449836, Other interleukin signaling R-MMU-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syndecan-1Short name: SYND1 Alternative name(s): CD_antigen: CD138 |
Gene namesi | Name:Sdc1 Synonyms:Synd-1, Synd1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349162, Sdc1 |
VEuPathDBi | HostDB:ENSMUSG00000020592 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
- extracellular exosome By similarity
Other locations
- Membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
Note: Shedding of the ectodomain produces a soluble form.1 Publication
Extracellular region or secreted
- extracellular region Source: Reactome
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- external side of plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 255 | ExtracellularSequence analysisAdd BLAST | 233 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 277 – 311 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000033501 | 23 – 311 | Syndecan-1Add BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | O-linked (Xyl...) (chondroitin sulfate) serine1 Publication | 1 | |
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 45 | O-linked (Xyl...) (heparan sulfate) serineCurated | 1 | |
Glycosylationi | 47 | O-linked (Xyl...) (heparan sulfate) serineCurated | 1 | |
Glycosylationi | 207 | O-linked (Xyl...) (chondroitin sulfate) serine1 Publication | 1 | |
Glycosylationi | 217 | O-linked (Xyl...) (chondroitin sulfate) serine1 Publication | 1 | |
Modified residuei | 286 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 243 – 244 | Cleavage1 Publication | 2 |
Keywords - PTMi
Glycoprotein, Heparan sulfate, Phosphoprotein, ProteoglycanProteomic databases
CPTACi | non-CPTAC-4060 |
MaxQBi | P18828 |
PaxDbi | P18828 |
PeptideAtlasi | P18828 |
PRIDEi | P18828 |
ProteomicsDBi | 256716 [P18828-1] 256717 [P18828-2] |
PTM databases
GlyGeni | P18828, 6 sites |
iPTMneti | P18828 |
PhosphoSitePlusi | P18828 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020592, Expressed in cumulus cell and 285 other tissues |
ExpressionAtlasi | P18828, baseline and differential |
Genevisiblei | P18828, MM |
Interactioni
Subunit structurei
Interacts with CDCP1 (By similarity).
Interacts (via C-terminus) with TIAM1 (via PDZ domain) (PubMed:20361982).
Interacts with MDK (By similarity).
By similarity1 PublicationBinary interactionsi
P18828
With | #Exp. | IntAct |
---|---|---|
PCOLCE [Q15113] from Homo sapiens. | 4 | EBI-9985816,EBI-8869614 |
GO - Molecular functioni
- identical protein binding Source: MGI
- protein C-terminus binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203602, 2 interactors |
ComplexPortali | CPX-3283, Syndecan-1-syntenin-1-ALIX complex |
IntActi | P18828, 1 interactor |
STRINGi | 10090.ENSMUSP00000020911 |
Miscellaneous databases
RNActi | P18828, protein |
Structurei
3D structure databases
AlphaFoldDBi | P18828 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 59 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 152 – 184 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 285 – 311 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 59 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZWT, Eukaryota |
GeneTreei | ENSGT00940000161171 |
HOGENOMi | CLU_887201_0_0_1 |
InParanoidi | P18828 |
OMAi | QPAMPQI |
PhylomeDBi | P18828 |
TreeFami | TF320463 |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031190, Syndecan-1 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF5, PTHR10915:SF5, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG
60 70 80 90 100
ALPDTLSRQT PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE
110 120 130 140 150
GEPVLHVEAE PGFTARDKEK EVTTRPRETV QLPITQRAST VRVTTAQAAV
160 170 180 190 200
TSHPHGGMQP GLHETSAPTA PGQPDHQPPR VEGGGTSVIK EVVEDGTANQ
210 220 230 240 250
LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA TGASQSLLDR
260 270 280 290 300
KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY
310
QKPTKQEEFY A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE0CYT6 | E0CYT6_MOUSE | Syndecan-1 | Sdc1 | 206 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | L → V in AAA40159 (PubMed:8496192).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007542 | 50 – 93 | Missing in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15487 mRNA Translation: CAA33514.1 Z22532 Genomic DNA Translation: CAA80254.1 AF134897 mRNA Translation: AAD42345.1 BC010560 mRNA Translation: AAH10560.1 L11565 Genomic DNA Translation: AAA40159.1 |
CCDSi | CCDS25803.1 [P18828-1] |
PIRi | S06619 |
RefSeqi | NP_035649.1, NM_011519.2 [P18828-1] |
Genome annotation databases
Ensembli | ENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592 [P18828-1] ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592 [P18828-1] |
GeneIDi | 20969 |
KEGGi | mmu:20969 |
UCSCi | uc007nac.1, mouse [P18828-1] uc007nad.1, mouse [P18828-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15487 mRNA Translation: CAA33514.1 Z22532 Genomic DNA Translation: CAA80254.1 AF134897 mRNA Translation: AAD42345.1 BC010560 mRNA Translation: AAH10560.1 L11565 Genomic DNA Translation: AAA40159.1 |
CCDSi | CCDS25803.1 [P18828-1] |
PIRi | S06619 |
RefSeqi | NP_035649.1, NM_011519.2 [P18828-1] |
3D structure databases
AlphaFoldDBi | P18828 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 203602, 2 interactors |
ComplexPortali | CPX-3283, Syndecan-1-syntenin-1-ALIX complex |
IntActi | P18828, 1 interactor |
STRINGi | 10090.ENSMUSP00000020911 |
PTM databases
GlyGeni | P18828, 6 sites |
iPTMneti | P18828 |
PhosphoSitePlusi | P18828 |
Proteomic databases
CPTACi | non-CPTAC-4060 |
MaxQBi | P18828 |
PaxDbi | P18828 |
PeptideAtlasi | P18828 |
PRIDEi | P18828 |
ProteomicsDBi | 256716 [P18828-1] 256717 [P18828-2] |
Protocols and materials databases
Antibodypediai | 1489, 1545 antibodies from 51 providers |
DNASUi | 20969 |
Genome annotation databases
Ensembli | ENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592 [P18828-1] ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592 [P18828-1] |
GeneIDi | 20969 |
KEGGi | mmu:20969 |
UCSCi | uc007nac.1, mouse [P18828-1] uc007nad.1, mouse [P18828-2] |
Organism-specific databases
CTDi | 6382 |
MGIi | MGI:1349162, Sdc1 |
VEuPathDBi | HostDB:ENSMUSG00000020592 |
Phylogenomic databases
eggNOGi | ENOG502RZWT, Eukaryota |
GeneTreei | ENSGT00940000161171 |
HOGENOMi | CLU_887201_0_0_1 |
InParanoidi | P18828 |
OMAi | QPAMPQI |
PhylomeDBi | P18828 |
TreeFami | TF320463 |
Enzyme and pathway databases
Reactomei | R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928, HS-GAG biosynthesis R-MMU-2024096, HS-GAG degradation R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-3000170, Syndecan interactions R-MMU-449836, Other interleukin signaling R-MMU-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 20969, 1 hit in 73 CRISPR screens |
ChiTaRSi | Sdc1, mouse |
PROi | PR:P18828 |
RNActi | P18828, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020592, Expressed in cumulus cell and 285 other tissues |
ExpressionAtlasi | P18828, baseline and differential |
Genevisiblei | P18828, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031190, Syndecan-1 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF5, PTHR10915:SF5, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDC1_MOUSE | |
Accessioni | P18828Primary (citable) accession number: P18828 Secondary accession number(s): Q62278, Q9WVD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families