Sdc1

Functionⁱ

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein C-terminus binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

canonical Wnt signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 14681683
inflammatory response Source: MGI
myoblast development
Source: UniProtKB
Inferred from direct assayⁱ
- 9218485
odontogenesis Source: Ensembl
positive regulation of exosomal secretion Source: MGI
positive regulation of extracellular exosome assembly Source: MGI
response to calcium ion Source: Ensembl
response to cAMP Source: Ensembl
response to glucocorticoid Source: Ensembl
response to hydrogen peroxide Source: Ensembl
Sertoli cell development Source: Ensembl
striated muscle cell development Source: Ensembl
ureteric bud development Source: Ensembl
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928 HS-GAG biosynthesis R-MMU-2024096 HS-GAG degradation R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-3000170 Syndecan interactions R-MMU-449836 Other interleukin signaling R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-449836 Other interleukin signaling
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syndecan-1 Short name: SYND1 Alternative name(s): CD_antigen: CD138
Gene namesⁱ	Name:Sdc1 Synonyms:Synd-1, Synd1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:1349162 Sdc1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 255	ExtracellularSequence analysisAdd BLAST	233
Transmembraneⁱ	256 – 276	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	277 – 311	CytoplasmicSequence analysisAdd BLAST	35

Keywords - Cellular componentⁱ

Membrane, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000033501	23 – 311	Syndecan-1Add BLAST		289

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	37	O-linked (Xyl...) (chondroitin sulfate) serine1 Publication	1
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	45	O-linked (Xyl...) (heparan sulfate) serineCurated	1
Glycosylationⁱ	47	O-linked (Xyl...) (heparan sulfate) serineCurated	1
Glycosylationⁱ	207	O-linked (Xyl...) (chondroitin sulfate) serine1 Publication	1
Glycosylationⁱ	217	O-linked (Xyl...) (chondroitin sulfate) serine1 Publication	1
Modified residueⁱ	286	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	243 – 244	Cleavage1 Publication		2

Keywords - PTMⁱ

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbⁱ	P18828
PeptideAtlas More...PeptideAtlasⁱ	P18828
PRIDEⁱ	P18828

PTM databases

iPTMnetⁱ	P18828
PhosphoSitePlusⁱ	P18828

Miscellaneous databases

PMAP-CutDBⁱ	P18828

PMAP-CutDBⁱ

P18828

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020592 Expressed in 261 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_SDC1
ExpressionAtlasⁱ	P18828 baseline and differential
Genevisibleⁱ	P18828 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CDCP1 (By similarity). Interacts (via C-terminus) with TIAM1 (via PDZ domain) (PubMed:20361982).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PCOLCE	Q15113	4	EBI-9985816,EBI-8869614	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

PCOLCE

Q15113

4

EBI-9985816,EBI-8869614

From Homo sapiens.

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein C-terminus binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203602, 1 interactor
ComplexPortalⁱ	CPX-3283 Syndecan-1-syntenin-1-ALIX complex
IntActⁱ	P18828, 1 interactor
STRINGⁱ	10090.ENSMUSP00000020911

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P18828
SMRⁱ	P18828
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IYWX Eukaryota ENOG410Y2QY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063116
HOGENOMⁱ	HOG000133092
HOVERGENⁱ	HBG017783
InParanoidⁱ	P18828
KEGG Orthology (KO) More...KOⁱ	K06257
OMAⁱ	GEQDFTF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EYV
PhylomeDBⁱ	P18828
TreeFamⁱ	TF320463

Family and domain databases

InterProⁱ	View protein in InterPro IPR003585 Neurexin-like IPR001050 Syndecan IPR031190 Syndecan-1 IPR027789 Syndecan/Neurexin_dom IPR030479 Syndecan_CS
PANTHERⁱ	PTHR10915 PTHR10915, 1 hit PTHR10915:SF5 PTHR10915:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit
PROSITEⁱ	View protein in PROSITE PS00964 SYNDECAN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P18828-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG 
        60         70         80         90        100
ALPDTLSRQT PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE 
       110        120        130        140        150
GEPVLHVEAE PGFTARDKEK EVTTRPRETV QLPITQRAST VRVTTAQAAV 
       160        170        180        190        200
TSHPHGGMQP GLHETSAPTA PGQPDHQPPR VEGGGTSVIK EVVEDGTANQ 
       210        220        230        240        250
LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA TGASQSLLDR 
       260        270        280        290        300
KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 
       310 
QKPTKQEEFY A

Note: Major isoform.

Length:311

Mass (Da):32,905

Last modified:November 1, 1990 - v1

Checksum:ⁱ283FEC396FF40FCE

GO

Isoform 2 (identifier: P18828-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
50-93: Missing.

« Hide

        10         20         30         40         50
MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTA 
        60         70         80         90        100
GEKPEEGEPV LHVEAEPGFT ARDKEKEVTT RPRETVQLPI TQRASTVRVT 
       110        120        130        140        150
TAQAAVTSHP HGGMQPGLHE TSAPTAPGQP DHQPPRVEGG GTSVIKEVVE 
       160        170        180        190        200
DGTANQLPAG EGSGEQDFTF ETSGENTAVA AVEPGLRNQP PVDEGATGAS 
       210        220        230        240        250
QSLLDRKEVL GGVIAGGLVG LIFAVCLVAF MLYRMKKKDE GSYSLEEPKQ 
       260 
ANGGAYQKPT KQEEFYA

Note: Minor isoform.

Show »

Length:267

Mass (Da):28,235

Checksum:ⁱB4481F155D7E5454

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E0CYT6	E0CYT6_MOUSE		Syndecan-1 Syndecan-1	Sdc1	206	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	21	L → V in AAA40159 (PubMed:8496192).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_007542	50 – 93	Missing in isoform 2. 1 PublicationAdd BLAST		44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15487 mRNA Translation: CAA33514.1 Z22532 Genomic DNA Translation: CAA80254.1 AF134897 mRNA Translation: AAD42345.1 BC010560 mRNA Translation: AAH10560.1 L11565 Genomic DNA Translation: AAA40159.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25803.1 [P18828-1]
PIRⁱ	S06619
NCBI Reference Sequences More...RefSeqⁱ	NP_035649.1, NM_011519.2 [P18828-1]
UniGeneⁱ	Mm.2580

Genome annotation databases

Ensemblⁱ	ENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592 [P18828-1] ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592 [P18828-1]
GeneIDⁱ	20969
KEGGⁱ	mmu:20969
UCSC genome browser More...UCSCⁱ	uc007nac.1 mouse [P18828-1] uc007nad.1 mouse [P18828-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18828	Syndecan		MOUSE		311	UniRef100_P18828
Syndecan-1 (Fragment)		MELGA		87

Protein	Similar proteins		Species	Score	Length	Source
P18828	Syndecan-1		RAT		313	UniRef90_P18828
Syndecan		MOUSE		311
Syndecan-1 (Fragment)		MELGA		87
UPI000A319C7B		MUSCR		311
UPI000A311225		MUSPA		310
+2

Protein	Similar proteins		Species	Score	Length	Source
P18828	Syndecan-1	)	HUMAN		310	UniRef50_P18827
Syndecan-1		BOVIN		311
Syndecan-1		MESAU		309
Syndecan-1		RAT		313
Syndecan-1		CRIGR		309
+146

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15487 mRNA Translation: CAA33514.1 Z22532 Genomic DNA Translation: CAA80254.1 AF134897 mRNA Translation: AAD42345.1 BC010560 mRNA Translation: AAH10560.1 L11565 Genomic DNA Translation: AAA40159.1
CCDSⁱ	CCDS25803.1 [P18828-1]
PIRⁱ	S06619
RefSeqⁱ	NP_035649.1, NM_011519.2 [P18828-1]
UniGeneⁱ	Mm.2580

3D structure databases

ProteinModelPortalⁱ	P18828
SMRⁱ	P18828
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203602, 1 interactor
ComplexPortalⁱ	CPX-3283 Syndecan-1-syntenin-1-ALIX complex
IntActⁱ	P18828, 1 interactor
STRINGⁱ	10090.ENSMUSP00000020911

PTM databases

iPTMnetⁱ	P18828
PhosphoSitePlusⁱ	P18828

Proteomic databases

PaxDbⁱ	P18828
PeptideAtlasⁱ	P18828
PRIDEⁱ	P18828

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020911; ENSMUSP00000020911; ENSMUSG00000020592 [P18828-1] ENSMUST00000171158; ENSMUSP00000131491; ENSMUSG00000020592 [P18828-1]
GeneIDⁱ	20969
KEGGⁱ	mmu:20969
UCSCⁱ	uc007nac.1 mouse [P18828-1] uc007nad.1 mouse [P18828-2]

Organism-specific databases

CTDⁱ	6382
MGIⁱ	MGI:1349162 Sdc1

Phylogenomic databases

eggNOGⁱ	ENOG410IYWX Eukaryota ENOG410Y2QY LUCA
GeneTreeⁱ	ENSGT00530000063116
HOGENOMⁱ	HOG000133092
HOVERGENⁱ	HBG017783
InParanoidⁱ	P18828
KOⁱ	K06257
OMAⁱ	GEQDFTF
OrthoDBⁱ	EOG091G0EYV
PhylomeDBⁱ	P18828
TreeFamⁱ	TF320463

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928 HS-GAG biosynthesis R-MMU-2024096 HS-GAG degradation R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-3000170 Syndecan interactions R-MMU-449836 Other interleukin signaling R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-449836 Other interleukin signaling
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	Sdc1 mouse
PMAP-CutDBⁱ	P18828
Protein Ontology More...PROⁱ	PR:P18828
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020592 Expressed in 261 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_SDC1
ExpressionAtlasⁱ	P18828 baseline and differential
Genevisibleⁱ	P18828 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003585 Neurexin-like IPR001050 Syndecan IPR031190 Syndecan-1 IPR027789 Syndecan/Neurexin_dom IPR030479 Syndecan_CS
PANTHERⁱ	PTHR10915 PTHR10915, 1 hit PTHR10915:SF5 PTHR10915:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit
PROSITEⁱ	View protein in PROSITE PS00964 SYNDECAN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SDC1_MOUSE
Accessionⁱ	P18828Primary (citable) accession number: P18828 Secondary accession number(s): Q62278, Q9WVD2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P18828 (SDC1_MOUSE)

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Syndecan-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ