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Entry version 195 (07 Oct 2020)
Sequence version 3 (05 May 2009)
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Protein

Syndecan-1

Gene

SDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P18827

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928, HS-GAG biosynthesis
R-HSA-2024096, HS-GAG degradation
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-3000170, Syndecan interactions
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3656237, Defective EXT2 causes exostoses 2
R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-449836, Other interleukin signaling
R-HSA-975634, Retinoid metabolism and transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.35.1.2, the peptide translocating syndecan (syndecan) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syndecan-1
Short name:
SYND1
Alternative name(s):
CD_antigen: CD138
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDC1
Synonyms:SDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115884.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10658, SDC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
186355, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18827

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 254ExtracellularSequence analysisAdd BLAST232
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 310CytoplasmicSequence analysisAdd BLAST35

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6382

Open Targets

More...
OpenTargetsi
ENSG00000115884

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35588

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P18827, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712898

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229463011

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003349923 – 310Syndecan-1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi47O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi206O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi216O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei285PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei242 – 243CleavageBy similarity2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P18827

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P18827

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P18827

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P18827

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18827

PeptideAtlas

More...
PeptideAtlasi
P18827

PRoteomics IDEntifications database

More...
PRIDEi
P18827

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53609

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P18827, 19 sites, 6 O-linked glycans (14 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18827

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18827

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P18827

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115884, Expressed in placenta and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P18827, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18827, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000115884, Tissue enhanced (liver, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDCP1.

Interacts (via C-terminus) with TIAM1 (via PDZ domain).

Interacts with MDK (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112284, 60 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3282, Syndecan-1-syntenin-1-ALIX complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P18827

Database of interacting proteins

More...
DIPi
DIP-1123N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P18827

Protein interaction database and analysis system

More...
IntActi
P18827, 46 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370542

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P18827, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P18827

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RZWT, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000161171

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_887201_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P18827

KEGG Orthology (KO)

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KOi
K06257

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPAMPQI

Database of Orthologous Groups

More...
OrthoDBi
1340825at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18827

TreeFam database of animal gene trees

More...
TreeFami
TF320463

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003585, Neurexin-like
IPR001050, Syndecan
IPR031190, Syndecan-1
IPR027789, Syndecan/Neurexin_dom
IPR030479, Syndecan_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10915, PTHR10915, 1 hit
PTHR10915:SF5, PTHR10915:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01034, Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294, 4.1m, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00964, SYNDECAN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P18827-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRAALWLWL CALALSLQPA LPQIVATNLP PEDQDGSGDD SDNFSGSGAG
60 70 80 90 100
ALQDITLSQQ TPSTWKDTQL LTAIPTSPEP TGLEATAAST STLPAGEGPK
110 120 130 140 150
EGEAVVLPEV EPGLTAREQE ATPRPRETTQ LPTTHLASTT TATTAQEPAT
160 170 180 190 200
SHPHRDMQPG HHETSTPAGP SQADLHTPHT EDGGPSATER AAEDGASSQL
210 220 230 240 250
PAAEGSGEQD FTFETSGENT AVVAVEPDRR NQSPVDQGAT GASQGLLDRK
260 270 280 290 300
EVLGGVIAGG LVGLIFAVCL VGFMLYRMKK KDEGSYSLEE PKQANGGAYQ
310
KPTKQEEFYA
Length:310
Mass (Da):32,462
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E9EF4A57F5FDBD0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHH3E9PHH3_HUMAN
Syndecan-1
SDC1
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1K4H7C1K4_HUMAN
Syndecan-1
SDC1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCX9F8WCX9_HUMAN
Syndecan-1
SDC1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19P → L in AAA60605 (PubMed:2324102).Curated1
Sequence conflicti259G → V in AAH08765 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05224276T → M. Corresponds to variant dbSNP:rs2230922EnsemblClinVar.1
Natural variantiVAR_052243136L → Q6 PublicationsCorresponds to variant dbSNP:rs10205485Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60306 mRNA Translation: CAA42851.1
J05392 mRNA Translation: AAA60605.1
AJ551176 mRNA Translation: CAD80245.1
AC104792 Genomic DNA Translation: AAX93151.1
CH471053 Genomic DNA Translation: EAX00828.1
CH471053 Genomic DNA Translation: EAX00829.1
CH471053 Genomic DNA Translation: EAX00830.1
CH471053 Genomic DNA Translation: EAX00831.1
BC008765 mRNA Translation: AAH08765.1
Z48199 Genomic DNA Translation: CAA88235.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1697.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41776

NCBI Reference Sequences

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RefSeqi
NP_001006947.1, NM_001006946.1
NP_002988.3, NM_002997.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254351; ENSP00000254351; ENSG00000115884
ENST00000381150; ENSP00000370542; ENSG00000115884

Database of genes from NCBI RefSeq genomes

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GeneIDi
6382

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6382

UCSC genome browser

More...
UCSCi
uc002rdo.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60306 mRNA Translation: CAA42851.1
J05392 mRNA Translation: AAA60605.1
AJ551176 mRNA Translation: CAD80245.1
AC104792 Genomic DNA Translation: AAX93151.1
CH471053 Genomic DNA Translation: EAX00828.1
CH471053 Genomic DNA Translation: EAX00829.1
CH471053 Genomic DNA Translation: EAX00830.1
CH471053 Genomic DNA Translation: EAX00831.1
BC008765 mRNA Translation: AAH08765.1
Z48199 Genomic DNA Translation: CAA88235.1
CCDSiCCDS1697.1
PIRiA41776
RefSeqiNP_001006947.1, NM_001006946.1
NP_002988.3, NM_002997.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GVCX-ray1.54B303-310[»]
4GVDX-ray1.85C/D303-310[»]
6EJEX-ray2.43B201-212[»]
SMRiP18827
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112284, 60 interactors
ComplexPortaliCPX-3282, Syndecan-1-syntenin-1-ALIX complex
CORUMiP18827
DIPiDIP-1123N
ELMiP18827
IntActiP18827, 46 interactors
STRINGi9606.ENSP00000370542

Chemistry databases

ChEMBLiCHEMBL3712898

Protein family/group databases

TCDBi9.A.35.1.2, the peptide translocating syndecan (syndecan) family

PTM databases

GlyGeniP18827, 19 sites, 6 O-linked glycans (14 sites)
iPTMnetiP18827
PhosphoSitePlusiP18827
SwissPalmiP18827

Polymorphism and mutation databases

BioMutaiSDC1
DMDMi229463011

Proteomic databases

EPDiP18827
jPOSTiP18827
MassIVEiP18827
MaxQBiP18827
PaxDbiP18827
PeptideAtlasiP18827
PRIDEiP18827
ProteomicsDBi53609

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P18827, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
1489, 1452 antibodies

The DNASU plasmid repository

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DNASUi
6382

Genome annotation databases

EnsembliENST00000254351; ENSP00000254351; ENSG00000115884
ENST00000381150; ENSP00000370542; ENSG00000115884
GeneIDi6382
KEGGihsa:6382
UCSCiuc002rdo.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6382
DisGeNETi6382
EuPathDBiHostDB:ENSG00000115884.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SDC1
HGNCiHGNC:10658, SDC1
HPAiENSG00000115884, Tissue enhanced (liver, placenta)
MIMi186355, gene
neXtProtiNX_P18827
OpenTargetsiENSG00000115884
PharmGKBiPA35588

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RZWT, Eukaryota
GeneTreeiENSGT00940000161171
HOGENOMiCLU_887201_0_0_1
InParanoidiP18827
KOiK06257
OMAiQPAMPQI
OrthoDBi1340825at2759
PhylomeDBiP18827
TreeFamiTF320463

Enzyme and pathway databases

PathwayCommonsiP18827
ReactomeiR-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928, HS-GAG biosynthesis
R-HSA-2024096, HS-GAG degradation
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-3000170, Syndecan interactions
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3656237, Defective EXT2 causes exostoses 2
R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-449836, Other interleukin signaling
R-HSA-975634, Retinoid metabolism and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6382, 259 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SDC1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Syndecan_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6382
PharosiP18827, Tbio

Protein Ontology

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PROi
PR:P18827
RNActiP18827, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115884, Expressed in placenta and 192 other tissues
ExpressionAtlasiP18827, baseline and differential
GenevisibleiP18827, HS

Family and domain databases

InterProiView protein in InterPro
IPR003585, Neurexin-like
IPR001050, Syndecan
IPR031190, Syndecan-1
IPR027789, Syndecan/Neurexin_dom
IPR030479, Syndecan_CS
PANTHERiPTHR10915, PTHR10915, 1 hit
PTHR10915:SF5, PTHR10915:SF5, 1 hit
PfamiView protein in Pfam
PF01034, Syndecan, 1 hit
SMARTiView protein in SMART
SM00294, 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964, SYNDECAN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18827
Secondary accession number(s): D6W523
, Q53QV0, Q546D3, Q96HB7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 5, 2009
Last modified: October 7, 2020
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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