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Protein

Alpha-2C adrenergic receptor

Gene

ADRA2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei131Implicated in ligand bindingBy similarity1
Sitei214Implicated in catechol agonist binding and receptor activationBy similarity1
Sitei218Implicated in catechol agonist binding and receptor activationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha-2A adrenergic receptor binding Source: BHF-UCL
  • alpha2-adrenergic receptor activity Source: BHF-UCL
  • epinephrine binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5683826 Surfactant metabolism

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P18825

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRA2C
Synonyms:ADRA2L2, ADRA2RL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184160.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:283 ADRA2C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51ExtracellularBy similarityAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 76Helical; Name=1By similarityAdd BLAST25
Topological domaini77 – 88CytoplasmicBy similarityAdd BLAST12
Transmembranei89 – 114Helical; Name=2By similarityAdd BLAST26
Topological domaini115 – 124ExtracellularBy similarity10
Transmembranei125 – 147Helical; Name=3By similarityAdd BLAST23
Topological domaini148 – 168CytoplasmicBy similarityAdd BLAST21
Transmembranei169 – 191Helical; Name=4By similarityAdd BLAST23
Topological domaini192 – 207ExtracellularBy similarityAdd BLAST16
Transmembranei208 – 231Helical; Name=5By similarityAdd BLAST24
Topological domaini232 – 379CytoplasmicBy similarityAdd BLAST148
Transmembranei380 – 407Helical; Name=6By similarityAdd BLAST28
Topological domaini408 – 420ExtracellularBy similarityAdd BLAST13
Transmembranei421 – 441Helical; Name=7By similarityAdd BLAST21
Topological domaini442 – 462CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
152

Open Targets

More...
OpenTargetsi
ENSG00000184160

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1916

Drug and drug target database

More...
DrugBanki
DB08838 Agmatine
DB00543 Amoxapine
DB00182 Amphetamine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB00217 Bethanidine
DB09128 Brexpiprazole
DB00484 Brimonidine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB01151 Desipramine
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra
DB05492 Epicept NP-1
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB06678 Esmirtazapine
DB00800 Fenoldopam
DB04946 Iloperidone
DB06707 Levonordefrin
DB00589 Lisuride
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB01365 Mephentermine
DB01577 Methamphetamine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB05461 OPC-28326
DB00935 Oxymetazoline
DB01267 Paliperidone
DB01186 Pergolide
DB00925 Phenoxybenzamine
DB00413 Pramipexole
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB13025 Tiapride
DB00697 Tizanidine
DB00797 Tolazoline
DB06694 Xylometazoline
DB01392 Yohimbine
DB00246 Ziprasidone

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
27

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADRA2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141211

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691051 – 462Alpha-2C adrenergic receptorAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi124 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18825

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18825

PeptideAtlas

More...
PeptideAtlasi
P18825

PRoteomics IDEntifications database

More...
PRIDEi
P18825

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53608

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18825

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18825

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184160 Expressed in 213 organ(s), highest expression level in decidua

CleanEx database of gene expression profiles

More...
CleanExi
HS_ADRA2C

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18825 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18825 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057688

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106661, 4 interactors

Protein interaction database and analysis system

More...
IntActi
P18825, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386069

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P18825

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P18825

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 308Arg-rich (basic)Add BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161707

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106962

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18825

KEGG Orthology (KO)

More...
KOi
K04140

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELMNYWY

Database of Orthologous Groups

More...
OrthoDBi
182823at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18825

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR24248:SF25 PTHR24248:SF25, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P18825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSL YRQPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRAP
260 270 280 290 300
VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA
310 320 330 340 350
LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASRSPG PGGRLSRASS
360 370 380 390 400
RSVEFFLSRR RRARSSVCRR KVAQAREKRF TFVLAVVMGV FVLCWFPFFF
410 420 430 440 450
SYSLYGICRE ACQVPGPLFK FFFWIGYCNS SLNPVIYTVF NQDFRRSFKH
460
ILFRRRRRGF RQ
Length:462
Mass (Da):49,522
Last modified:February 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1EF9CA21E7F6EDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGL0D6RGL0_HUMAN
Alpha-2C adrenergic receptor
ADRA2C
374Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35513 differs from that shown. Reason: Frameshift at positions 270, 296 and 300.Curated
The sequence AAC78723 differs from that shown. Reason: Frameshift at positions 270, 296 and 300.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239L → R (PubMed:2842764).Curated1
Sequence conflicti239L → R (PubMed:9371698).Curated1
Sequence conflicti329E → Q (PubMed:2842764).Curated1
Sequence conflicti329E → Q (PubMed:9371698).Curated1
Sequence conflicti401S → I (PubMed:2842764).Curated1
Sequence conflicti401S → I (PubMed:9371698).Curated1
Sequence conflicti446R → P (PubMed:2842764).Curated1
Sequence conflicti446R → P (PubMed:9371698).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012747322 – 325Missing 3 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03853 mRNA Translation: AAA35513.1 Frameshift.
U72648 Genomic DNA Translation: AAC78723.1 Frameshift.
D13538 Genomic DNA Translation: BAA02737.1
AF280399 Genomic DNA Translation: AAG28076.1
AF280400 Genomic DNA Translation: AAG28077.1
AY605898 Genomic DNA Translation: AAT02221.1
AY455666 Genomic DNA Translation: AAR18071.1
X59684 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47004.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A31237

NCBI Reference Sequences

More...
RefSeqi
NP_000674.2, NM_000683.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.123022

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330055; ENSP00000386069; ENSG00000184160

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:152

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03853 mRNA Translation: AAA35513.1 Frameshift.
U72648 Genomic DNA Translation: AAC78723.1 Frameshift.
D13538 Genomic DNA Translation: BAA02737.1
AF280399 Genomic DNA Translation: AAG28076.1
AF280400 Genomic DNA Translation: AAG28077.1
AY605898 Genomic DNA Translation: AAT02221.1
AY455666 Genomic DNA Translation: AAR18071.1
X59684 Genomic DNA No translation available.
CCDSiCCDS47004.1
PIRiA31237
RefSeqiNP_000674.2, NM_000683.3
UniGeneiHs.123022

3D structure databases

ProteinModelPortaliP18825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106661, 4 interactors
IntActiP18825, 11 interactors
STRINGi9606.ENSP00000386069

Chemistry databases

BindingDBiP18825
ChEMBLiCHEMBL1916
DrugBankiDB08838 Agmatine
DB00543 Amoxapine
DB00182 Amphetamine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB00217 Bethanidine
DB09128 Brexpiprazole
DB00484 Brimonidine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB01151 Desipramine
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra
DB05492 Epicept NP-1
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB06678 Esmirtazapine
DB00800 Fenoldopam
DB04946 Iloperidone
DB06707 Levonordefrin
DB00589 Lisuride
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB01365 Mephentermine
DB01577 Methamphetamine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB05461 OPC-28326
DB00935 Oxymetazoline
DB01267 Paliperidone
DB01186 Pergolide
DB00925 Phenoxybenzamine
DB00413 Pramipexole
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB13025 Tiapride
DB00697 Tizanidine
DB00797 Tolazoline
DB06694 Xylometazoline
DB01392 Yohimbine
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi27

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP18825
PhosphoSitePlusiP18825

Polymorphism and mutation databases

BioMutaiADRA2C
DMDMi20141211

Proteomic databases

jPOSTiP18825
PaxDbiP18825
PeptideAtlasiP18825
PRIDEiP18825
ProteomicsDBi53608

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330055; ENSP00000386069; ENSG00000184160
GeneIDi152
KEGGihsa:152

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
152
DisGeNETi152
EuPathDBiHostDB:ENSG00000184160.7

GeneCards: human genes, protein and diseases

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GeneCardsi
ADRA2C

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0031484
HGNCiHGNC:283 ADRA2C
HPAiHPA057688
MIMi104250 gene
neXtProtiNX_P18825
OpenTargetsiENSG00000184160
PharmGKBiPA37

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000161707
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP18825
KOiK04140
OMAiELMNYWY
OrthoDBi182823at2759
PhylomeDBiP18825
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5683826 Surfactant metabolism
SignaLinkiP18825

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Alpha-2C_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
152

Protein Ontology

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PROi
PR:P18825

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184160 Expressed in 213 organ(s), highest expression level in decidua
CleanExiHS_ADRA2C
ExpressionAtlasiP18825 baseline and differential
GenevisibleiP18825 HS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF25 PTHR24248:SF25, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA2C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18825
Secondary accession number(s): P35369, Q9HB49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 11, 2002
Last modified: January 16, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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