UniProtKB - P18817 (LACY_KLEOX)
Protein
Lactose permease
Gene
lacY
Organism
Klebsiella oxytoca
Status
Functioni
Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 131 | Substrate bindingBy similarity | 1 | |
Sitei | 149 | Substrate bindingBy similarity | 1 | |
Sitei | 274 | Substrate binding and proton translocationBy similarity | 1 | |
Sitei | 307 | Proton translocationBy similarity | 1 | |
Sitei | 327 | Proton translocationBy similarity | 1 | |
Sitei | 330 | Proton translocationBy similarity | 1 |
GO - Molecular functioni
- carbohydrate:proton symporter activity Source: InterPro
Keywordsi
Biological process | Sugar transport, Symport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Lactose permeaseAlternative name(s): Lactose-proton symport |
Gene namesi | Name:lacY |
Organismi | Klebsiella oxytoca |
Taxonomic identifieri | 571 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Klebsiella |
Subcellular locationi
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 13 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 35 – 50 | PeriplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 72 – 80 | CytoplasmicCurated | 9 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 102 | PeriplasmicCurated | 1 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 149 | CytoplasmicCuratedAdd BLAST | 26 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 192 – 223 | CytoplasmicCuratedAdd BLAST | 32 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 245 – 267 | PeriplasmicCuratedAdd BLAST | 23 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 295 | CytoplasmicCurated | 7 | |
Transmembranei | 296 – 316 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 353 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 375 – 384 | PeriplasmicCurated | 10 | |
Transmembranei | 385 – 405 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 406 – 416 | CytoplasmicCuratedAdd BLAST | 11 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000196185 | 1 – 416 | Lactose permeaseAdd BLAST | 416 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Oligosaccharide:H(+) symporter (OHS) (TC 2.A.1.5) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105U0F Bacteria ENOG410XQTD LUCA |
Family and domain databases
InterProi | View protein in InterPro IPR000576 LacY/RafB_perm_fam IPR018457 LacY/RafB_perm_fam_CS IPR020846 MFS_dom IPR036259 MFS_trans_sf |
Pfami | View protein in Pfam PF01306 LacY_symp, 1 hit |
PRINTSi | PR00174 LACYSMPORT |
SUPFAMi | SSF103473 SSF103473, 1 hit |
TIGRFAMsi | TIGR00882 2A0105, 1 hit |
PROSITEi | View protein in PROSITE PS00896 LACY_1, 1 hit PS00897 LACY_2, 1 hit PS50850 MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P18817-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLSELAPRE RHNFIYFMLF FFFYYFIMSA YFPFFPVWLA EVNHLTKTET
60 70 80 90 100
GIVFSCISLF AIIFQPVFGL ISDKLGLRKH LLWTITILLI LFAPFFIFVF
110 120 130 140 150
SPLLQMNIMA GALVGGVYLG IVFSSRSGAV EAYIERVSRA NRFEYGKVRV
160 170 180 190 200
SGCVGWALCA SITGILFSID PNITFWIASG FALILGVLLW VSKPESSNSA
210 220 230 240 250
EVIDALGANR QAFSMRTAAE LFRMPRFWGF IIYVVGVASV YDVFDQQFAN
260 270 280 290 300
FFKGFFSSPQ RGTEVFGFVT TGGELLNALI MFCAPAIINR IGAKNALLIA
310 320 330 340 350
GLIMSVRILG SSFATSAVEV IILKMLHMFE IPFLLVGTFK YISSAFKGKL
360 370 380 390 400
SATLFLIGFN LSKQLSSVVL SAWVGRMYDT VGFHQAYLIL GCITLSFTVI
410
SLFTLKGSKT LLPATA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14154 Genomic DNA Translation: CAA32366.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14154 Genomic DNA Translation: CAA32366.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 571.MC52_23405 |
Phylogenomic databases
eggNOGi | ENOG4105U0F Bacteria ENOG410XQTD LUCA |
Family and domain databases
InterProi | View protein in InterPro IPR000576 LacY/RafB_perm_fam IPR018457 LacY/RafB_perm_fam_CS IPR020846 MFS_dom IPR036259 MFS_trans_sf |
Pfami | View protein in Pfam PF01306 LacY_symp, 1 hit |
PRINTSi | PR00174 LACYSMPORT |
SUPFAMi | SSF103473 SSF103473, 1 hit |
TIGRFAMsi | TIGR00882 2A0105, 1 hit |
PROSITEi | View protein in PROSITE PS00896 LACY_1, 1 hit PS00897 LACY_2, 1 hit PS50850 MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LACY_KLEOX | |
Accessioni | P18817Primary (citable) accession number: P18817 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | August 1, 1991 | |
Last modified: | July 31, 2019 | |
This is version 102 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |