UniProtKB - P18777 (DMSC_ECOLI)
Protein
Anaerobic dimethyl sulfoxide reductase chain C
Gene
dmsC
Organism
Escherichia coli (strain K12)
Status
Functioni
Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it.
GO - Molecular functioni
- dimethyl sulfoxide reductase activity Source: EcoCyc
GO - Biological processi
- anaerobic electron transport chain Source: InterPro
- anaerobic respiration Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
BioCyci | EcoCyc:DMSC-MONOMER MetaCyc:DMSC-MONOMER |
Protein family/group databases
TCDBi | 5.A.3.3.2, the prokaryotic molybdopterin-containing oxidoreductase (pmo) family |
Names & Taxonomyi
Protein namesi | Recommended name: Anaerobic dimethyl sulfoxide reductase chain CAlternative name(s): DMSO reductase anchor subunit |
Gene namesi | Name:dmsC Ordered Locus Names:b0896, JW0879 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Other locations
- dimethyl sulfoxide reductase complex Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | PeriplasmicCurated | 9 | |
Transmembranei | 10 – 32 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 33 – 43 | CytoplasmicCuratedAdd BLAST | 11 | |
Transmembranei | 44 – 66 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 67 – 89 | PeriplasmicCuratedAdd BLAST | 23 | |
Transmembranei | 90 – 107 | HelicalCuratedAdd BLAST | 18 | |
Topological domaini | 108 – 114 | CytoplasmicCurated | 7 | |
Transmembranei | 115 – 134 | HelicalCuratedAdd BLAST | 20 | |
Topological domaini | 135 – 156 | PeriplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 157 – 174 | HelicalCuratedAdd BLAST | 18 | |
Topological domaini | 175 – 182 | CytoplasmicCurated | 8 | |
Transmembranei | 183 – 201 | HelicalCuratedAdd BLAST | 19 | |
Topological domaini | 202 – 224 | PeriplasmicCuratedAdd BLAST | 23 | |
Transmembranei | 225 – 242 | HelicalCuratedAdd BLAST | 18 | |
Topological domaini | 243 – 254 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 255 – 280 | HelicalCuratedAdd BLAST | 26 | |
Topological domaini | 281 – 287 | PeriplasmicCurated | 7 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079947 | 1 – 287 | Anaerobic dimethyl sulfoxide reductase chain CAdd BLAST | 287 |
Proteomic databases
jPOSTi | P18777 |
PaxDbi | P18777 |
PRIDEi | P18777 |
Interactioni
Subunit structurei
Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).
Protein-protein interaction databases
BioGRIDi | 4260727, 5 interactors |
ComplexPortali | CPX-320, DmaABC DMSO reductase complex |
IntActi | P18777, 1 interactor |
STRINGi | 511145.b0896 |
Family & Domainsi
Sequence similaritiesi
Belongs to the DmsC family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3302, Bacteria |
HOGENOMi | CLU_064909_2_0_6 |
Family and domain databases
InterProi | View protein in InterPro IPR007059, DmsC |
PANTHERi | PTHR38095, PTHR38095, 1 hit |
Pfami | View protein in Pfam PF04976, DmsC, 1 hit |
i Sequence
Sequence statusi: Complete.
P18777-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSGWHEWPL MIFTVFGQCV AGGFIVLALA LLKGDLRAEA QQRVIACMFG
60 70 80 90 100
LWVLMGIGFI ASMLHLGSPM RAFNSLNRVG ASALSNEIAS GSIFFAVGGI
110 120 130 140 150
GWLLAMLKKL SPALRTLWLI VTMVLGVIFV WMMVRVYNSI DTVPTWYSIW
160 170 180 190 200
TPMGFFLTMF MGGPLLGYLL LSLAGVDGWA MRLLPAISVL ALVVSGVVSV
210 220 230 240 250
MQGAELATIH SSVQQAAALV PDYGALMSWR IVLLAVALCL WIAPQLKGYQ
260 270 280
PAVPLLSVSF ILLLAGELIG RGVFYGLHMT VGMAVAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03412 Genomic DNA Translation: AAA83845.1 U00096 Genomic DNA Translation: AAC73982.1 AP009048 Genomic DNA Translation: BAA35628.1 |
PIRi | S03787 |
RefSeqi | NP_415416.1, NC_000913.3 WP_000534637.1, NZ_STEB01000006.1 |
Genome annotation databases
EnsemblBacteriai | AAC73982; AAC73982; b0896 BAA35628; BAA35628; BAA35628 |
GeneIDi | 945502 |
KEGGi | ecj:JW0879 eco:b0896 |
PATRICi | fig|1411691.4.peg.1381 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03412 Genomic DNA Translation: AAA83845.1 U00096 Genomic DNA Translation: AAC73982.1 AP009048 Genomic DNA Translation: BAA35628.1 |
PIRi | S03787 |
RefSeqi | NP_415416.1, NC_000913.3 WP_000534637.1, NZ_STEB01000006.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260727, 5 interactors |
ComplexPortali | CPX-320, DmaABC DMSO reductase complex |
IntActi | P18777, 1 interactor |
STRINGi | 511145.b0896 |
Protein family/group databases
TCDBi | 5.A.3.3.2, the prokaryotic molybdopterin-containing oxidoreductase (pmo) family |
Proteomic databases
jPOSTi | P18777 |
PaxDbi | P18777 |
PRIDEi | P18777 |
Genome annotation databases
EnsemblBacteriai | AAC73982; AAC73982; b0896 BAA35628; BAA35628; BAA35628 |
GeneIDi | 945502 |
KEGGi | ecj:JW0879 eco:b0896 |
PATRICi | fig|1411691.4.peg.1381 |
Organism-specific databases
EchoBASEi | EB0230 |
Phylogenomic databases
eggNOGi | COG3302, Bacteria |
HOGENOMi | CLU_064909_2_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:DMSC-MONOMER MetaCyc:DMSC-MONOMER |
Miscellaneous databases
PROi | PR:P18777 |
Family and domain databases
InterProi | View protein in InterPro IPR007059, DmsC |
PANTHERi | PTHR38095, PTHR38095, 1 hit |
Pfami | View protein in Pfam PF04976, DmsC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DMSC_ECOLI | |
Accessioni | P18777Primary (citable) accession number: P18777 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families