dmsC

Functionⁱ

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it.

GO - Molecular functionⁱ

dimethyl sulfoxide reductase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 3280546

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anaerobic electron transport chain Source: InterPro
anaerobic respiration
Source: EcoCyc
Inferred from expression patternⁱ
- 2544558

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase

Molecular function

Oxidoreductase

Enzyme and pathway databases

BioCycⁱ	EcoCyc:DMSC-MONOMER MetaCyc:DMSC-MONOMER

BioCycⁱ

EcoCyc:DMSC-MONOMER
MetaCyc:DMSC-MONOMER

Protein family/group databases

TCDBⁱ	5.A.3.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

TCDBⁱ

5.A.3.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Anaerobic dimethyl sulfoxide reductase chain C Alternative name(s): DMSO reductase anchor subunit
Gene namesⁱ	Name:dmsC Ordered Locus Names:b0896, JW0879
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10234 dmsC

EcoGeneⁱ

EG10234 dmsC

Subcellular locationⁱ

Cell inner membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 9	PeriplasmicCurated	9
Transmembraneⁱ	10 – 32	HelicalCuratedAdd BLAST	23
Topological domainⁱ	33 – 43	CytoplasmicCuratedAdd BLAST	11
Transmembraneⁱ	44 – 66	HelicalCuratedAdd BLAST	23
Topological domainⁱ	67 – 89	PeriplasmicCuratedAdd BLAST	23
Transmembraneⁱ	90 – 107	HelicalCuratedAdd BLAST	18
Topological domainⁱ	108 – 114	CytoplasmicCurated	7
Transmembraneⁱ	115 – 134	HelicalCuratedAdd BLAST	20
Topological domainⁱ	135 – 156	PeriplasmicCuratedAdd BLAST	22
Transmembraneⁱ	157 – 174	HelicalCuratedAdd BLAST	18
Topological domainⁱ	175 – 182	CytoplasmicCurated	8
Transmembraneⁱ	183 – 201	HelicalCuratedAdd BLAST	19
Topological domainⁱ	202 – 224	PeriplasmicCuratedAdd BLAST	23
Transmembraneⁱ	225 – 242	HelicalCuratedAdd BLAST	18
Topological domainⁱ	243 – 254	CytoplasmicCuratedAdd BLAST	12
Transmembraneⁱ	255 – 280	HelicalCuratedAdd BLAST	26
Topological domainⁱ	281 – 287	PeriplasmicCurated	7

GO - Cellular componentⁱ

dimethyl sulfoxide reductase complex
Source: EcoCyc
Inferred from direct assayⁱ
- 3280546
integral component of plasma membrane
Source: EcoCyc
Inferred from sequence modelⁱ
- 8429002
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079947	1 – 287	Anaerobic dimethyl sulfoxide reductase chain CAdd BLAST		287

Proteomic databases

PaxDbⁱ	P18777
PRIDEⁱ	P18777

Interactionⁱ

Subunit structureⁱ

Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).

Protein-protein interaction databases

BioGridⁱ	4260727, 5 interactors
ComplexPortalⁱ	CPX-320 DMSO reductase complex
IntActⁱ	P18777, 1 interactor
STRINGⁱ	316385.ECDH10B_0966

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P18777
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

To E.coli YnfH.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4107KGK Bacteria COG3302 LUCA
HOGENOMⁱ	HOG000118381
KEGG Orthology (KO) More...KOⁱ	K07308

Family and domain databases

InterProⁱ	View protein in InterPro IPR007059 DmsC
PANTHERⁱ	PTHR38095 PTHR38095, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04976 DmsC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P18777-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSGWHEWPL MIFTVFGQCV AGGFIVLALA LLKGDLRAEA QQRVIACMFG 
        60         70         80         90        100
LWVLMGIGFI ASMLHLGSPM RAFNSLNRVG ASALSNEIAS GSIFFAVGGI 
       110        120        130        140        150
GWLLAMLKKL SPALRTLWLI VTMVLGVIFV WMMVRVYNSI DTVPTWYSIW 
       160        170        180        190        200
TPMGFFLTMF MGGPLLGYLL LSLAGVDGWA MRLLPAISVL ALVVSGVVSV 
       210        220        230        240        250
MQGAELATIH SSVQQAAALV PDYGALMSWR IVLLAVALCL WIAPQLKGYQ 
       260        270        280 
PAVPLLSVSF ILLLAGELIG RGVFYGLHMT VGMAVAS

Length:287

Mass (Da):30,826

Last modified:November 1, 1990 - v1

Checksum:ⁱDB6D26ACD2BE0CEB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03412 Genomic DNA Translation: AAA83845.1 U00096 Genomic DNA Translation: AAC73982.1 AP009048 Genomic DNA Translation: BAA35628.1
PIRⁱ	S03787
NCBI Reference Sequences More...RefSeqⁱ	NP_415416.1, NC_000913.3 WP_000534637.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73982; AAC73982; b0896 BAA35628; BAA35628; BAA35628
GeneIDⁱ	945502
KEGGⁱ	ecj:JW0879 eco:b0896
PATRICⁱ	fig\|1411691.4.peg.1381

Protein	Similar proteins		Species	Score	Length	Source
P18777	Anaerobic dimethyl sulfoxide reductase subunit C		ECOLX		135	UniRef100_P18777
DMSO reductase anchor subunit (DmsC)		Escherichia coli H591		308
DMSO reductase anchor subunit (DmsC)		Escherichia coli H386		308
DMSO reductase anchor subunit (DmsC)		Escherichia coli H736		308
DMSO reductase, anchor subunit DmsC		Escherichia coli 909945-2		277
+58

Protein	Similar proteins		Species	Score	Length	Source
P18777	Anaerobic dimethyl sulfoxide reductase subunit C		ECOLX		135	UniRef90_P18777
DMSO reductase anchor subunit (DmsC)		Escherichia coli H591		308
DMSO reductase anchor subunit (DmsC)		Escherichia coli H386		308
DMSO reductase anchor subunit (DmsC)		Escherichia coli H736		308
DMSO reductase, anchor subunit DmsC		Escherichia coli 909945-2		277
+577

Protein	Similar proteins		Species	Score	Length	Source
P18777	Anaerobic dimethyl sulfoxide reductase chain YnfH		ECOLI		284	UniRef50_P18777
Anaerobic dimethyl sulfoxide reductase subunit C		ECOLX		135
DMSO reductase anchor subunit (DmsC)		Escherichia coli H591		308
DMSO reductase anchor subunit (DmsC)		Escherichia coli H386		308
DMSO reductase anchor subunit (DmsC)		Escherichia coli H736		308
+2864

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03412 Genomic DNA Translation: AAA83845.1 U00096 Genomic DNA Translation: AAC73982.1 AP009048 Genomic DNA Translation: BAA35628.1
PIRⁱ	S03787
RefSeqⁱ	NP_415416.1, NC_000913.3 WP_000534637.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P18777
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260727, 5 interactors
ComplexPortalⁱ	CPX-320 DMSO reductase complex
IntActⁱ	P18777, 1 interactor
STRINGⁱ	316385.ECDH10B_0966

Protein family/group databases

TCDBⁱ	5.A.3.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

TCDBⁱ

5.A.3.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Proteomic databases

PaxDbⁱ	P18777
PRIDEⁱ	P18777

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73982; AAC73982; b0896 BAA35628; BAA35628; BAA35628
GeneIDⁱ	945502
KEGGⁱ	ecj:JW0879 eco:b0896
PATRICⁱ	fig\|1411691.4.peg.1381

Organism-specific databases

EchoBASEⁱ	EB0230
EcoGeneⁱ	EG10234 dmsC

Phylogenomic databases

eggNOGⁱ	ENOG4107KGK Bacteria COG3302 LUCA
HOGENOMⁱ	HOG000118381
KOⁱ	K07308

Enzyme and pathway databases

BioCycⁱ	EcoCyc:DMSC-MONOMER MetaCyc:DMSC-MONOMER

BioCycⁱ

EcoCyc:DMSC-MONOMER
MetaCyc:DMSC-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P18777

PROⁱ

PR:P18777

Family and domain databases

InterProⁱ	View protein in InterPro IPR007059 DmsC
PANTHERⁱ	PTHR38095 PTHR38095, 1 hit
Pfamⁱ	View protein in Pfam PF04976 DmsC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DMSC_ECOLI
Accessionⁱ	P18777Primary (citable) accession number: P18777
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P18777 (DMSC_ECOLI)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Anaerobic dimethyl sulfoxide reductase chain C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ