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Protein

Anaerobic dimethyl sulfoxide reductase chain B

Gene

dmsB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

Cofactori

[4Fe-4S] clusterNote: Binds 4 [4Fe-4S] clusters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi17Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi20Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi24Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi67Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi70Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi75Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi79Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi99Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi102Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi105Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi109Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi126Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi129Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi141Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi145Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: EcoCyc
  • dimethyl sulfoxide reductase activity Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • anaerobic respiration Source: EcoCyc

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:DMSB-MONOMER
MetaCyc:DMSB-MONOMER

Protein family/group databases

TCDBi5.A.3.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic dimethyl sulfoxide reductase chain B
Alternative name(s):
DMSO reductase iron-sulfur subunit
Gene namesi
Name:dmsB
Ordered Locus Names:b0895, JW0878
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10233 dmsB

Subcellular locationi

GO - Cellular componenti

  • dimethyl sulfoxide reductase complex Source: EcoCyc
  • intrinsic component of periplasmic side of plasma membrane Source: EcoCyc

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi102C → F, S, W or Y: Loss of electron transfer from menaquinol to DMSO. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001592422 – 205Anaerobic dimethyl sulfoxide reductase chain BAdd BLAST204

Proteomic databases

PaxDbiP18776
PRIDEiP18776

Interactioni

Subunit structurei

Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).

Binary interactionsi

WithEntry#Exp.IntActNotes
dmsAP187752EBI-1120825,EBI-4411104

Protein-protein interaction databases

BioGridi4260726, 3 interactors
ComplexPortaliCPX-320 DMSO reductase complex
DIPiDIP-9453N
IntActiP18776, 6 interactors
STRINGi316385.ECDH10B_0965

Structurei

3D structure databases

ProteinModelPortaliP18776
SMRiP18776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 334Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST29
Domaini59 – 894Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31
Domaini90 – 1194Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105QAX Bacteria
COG0437 LUCA
HOGENOMiHOG000163387
InParanoidiP18776
KOiK07307
OMAiWDQSRCI
PhylomeDBiP18776

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR014297 DMSO_DmsB
PfamiView protein in Pfam
PF13247 Fer4_11, 1 hit
PF12800 Fer4_4, 1 hit
TIGRFAMsiTIGR02951 DMSO_dmsB, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQYGFFID SSRCTGCKTC ELACKDYKDL TPEVSFRRIY EYAGGDWQED
60 70 80 90 100
NGVWHQNVFA YYLSISCNHC EDPACTKVCP SGAMHKREDG FVVVDEDVCI
110 120 130 140 150
GCRYCHMACP YGAPQYNETK GHMTKCDGCY DRVAEGKKPI CVESCPLRAL
160 170 180 190 200
DFGPIDELRK KHGDLAAVAP LPRAHFTKPN IVIKPNANSR PTGDTTGYLA

NPKEV
Length:205
Mass (Da):22,869
Last modified:January 23, 2007 - v4
Checksum:i7EC4417EED0809C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170P → PRA in AAA83844 (PubMed:3062312).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03412 Genomic DNA Translation: AAA83844.1
U00096 Genomic DNA Translation: AAC73981.1
AP009048 Genomic DNA Translation: BAA35627.1
PIRiF64828
RefSeqiNP_415415.1, NC_000913.3
WP_000213098.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73981; AAC73981; b0895
BAA35627; BAA35627; BAA35627
GeneIDi945507
KEGGiecj:JW0878
eco:b0895
PATRICifig|1411691.4.peg.1382

Similar proteinsi

Entry informationi

Entry nameiDMSB_ECOLI
AccessioniPrimary (citable) accession number: P18776
Secondary accession number(s): P77745
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 149 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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