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Entry version 185 (07 Oct 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Dimethyl sulfoxide reductase DmsA

Gene

dmsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic conditions, with DMSO being the terminal electron acceptor. Terminal reductase during anaerobic growth on various sulfoxides and N-oxide compounds. Allows E.coli to grow anaerobically on DMSO as respiratory oxidant.1 Publication

Miscellaneous

The Tat signal sequence is essential for the expression of dmsA, the stability of the DmsAB dimer and membrane targeting. Despite the presence of a signal sequence, DmsA is not exported to the periplasm.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dithionite, sodium hydrogensulfite and tungstate.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.043 mM for 2-chloropyridine N-oxide (at pH 5 and at 30 degrees Celsius)1 Publication
  2. KM=0.045 mM for 3-amidopyridine N-oxide (at pH 5 and at 30 degrees Celsius)1 Publication
  3. KM=0.06 mM for tertramethylene sulfoxide (at pH 5 and at 30 degrees Celsius)1 Publication
  4. KM=0.09 mM for methionine sulfoxide (at pH 5 and at 30 degrees Celsius)1 Publication
  5. KM=0.246 mM for 4-phenylpyridine N-oxide (at pH 5 and at 30 degrees Celsius)1 Publication
  6. KM=0.830 mM for dimethyldodecylamin N-oxide (at pH 5 and at 30 degrees Celsius)1 Publication
  7. KM=0.18 mM for DMSO (at pH 6.8 and at 23 degrees Celsius)1 Publication
  8. KM=0.47 mM for L-methionine sulfoxide (at pH 6.8 and at 23 degrees Celsius)1 Publication
  9. KM=0.5 mM for nicotinamide N-oxide (at pH 6.8 and at 23 degrees Celsius)1 Publication
  10. KM=0.6 mM for TMAO (at pH 6.8 and at 23 degrees Celsius)1 Publication
  11. KM=1.0 mM for 4-picoline N-oxide (at pH 6.8 and at 23 degrees Celsius)1 Publication
  12. KM=20.2 mM for TMAO (at pH 5 and at 30 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
    Metal bindingi67Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
    Metal bindingi71Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
    Metal bindingi104Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
    Metal bindingi205MolybdenumBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei390Molybdopterin guanine dinucleotide 1By similarity1
    Binding sitei488Molybdopterin guanine dinucleotide 1By similarity1
    Binding sitei788Molybdopterin guanine dinucleotide 1By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • anaerobic respiration Source: EcoCyc

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:DMSA-MONOMER
    MetaCyc:DMSA-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.8.5.3, 2026

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    5.A.3.3.2, the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dimethyl sulfoxide reductase DmsA (EC:1.8.5.3)
    Short name:
    DMSO reductase
    Short name:
    DMSOR
    Short name:
    Me2SO reductase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:dmsA
    Ordered Locus Names:b0894, JW5118
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi17R → S: Not targeted to the membrane, does not support anaerobic growth. 1 Publication1
    Mutagenesisi57K → D: No alteration of the growth, expression, or catalytic activities. 1 Publication1
    Mutagenesisi67C → S: Electron transfer from the 4Fe-4S clusters of DmsB to the Mo-bisMGD of DmsA is blocked. Little effect on the coordination sphere of the molybdenum and only minor effects on its redox chemistry. 2 Publications1
    Mutagenesisi71C → S: Cannot support growth. 1 Publication1
    Mutagenesisi104C → S: No alteration of the growth, expression, or catalytic activities. 1 Publication1
    Mutagenesisi106R → S: Electron transfer from the 4Fe-4S clusters of DmsB to the Mo-bisMGD of DmsA is blocked. Little effect on the coordination sphere of the molybdenum and only minor effects on its redox chemistry. 2 Publications1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 45Tat-type signalPROSITE-ProRule annotation1 PublicationAdd BLAST45
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001914346 – 814Dimethyl sulfoxide reductase DmsAAdd BLAST769

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P18775

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P18775

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P18775

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4261945, 69 interactors
    849882, 3 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-320, DMSO reductase complex

    Database of interacting proteins

    More...
    DIPi
    DIP-9452N

    Protein interaction database and analysis system

    More...
    IntActi
    P18775, 8 interactors

    Molecular INTeraction database

    More...
    MINTi
    P18775

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b0894

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P18775

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 1184Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST63

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni172 – 176MGD 1 bindingBy similarity5
    Regioni244 – 245MGD 2 bindingBy similarity2
    Regioni270 – 271MGD 2 bindingBy similarity2
    Regioni291 – 293MGD 2 bindingBy similarity3
    Regioni386 – 387MGD 2 bindingBy similarity2
    Regioni512 – 513MGD 1 bindingBy similarity2
    Regioni701MGD 1 bindingBy similarity1
    Regioni707 – 709MGD 1 bindingBy similarity3
    Regioni804 – 805MGD 1 bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG0243, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000422_13_3_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P18775

    KEGG Orthology (KO)

    More...
    KOi
    K07306

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P18775

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011888, Anaer_DMSO_reductase
    IPR009010, Asp_de-COase-like_dom_sf
    IPR006657, MoPterin_dinucl-bd_dom
    IPR006656, Mopterin_OxRdtase
    IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
    IPR006655, Mopterin_OxRdtase_prok_CS
    IPR027467, MopterinOxRdtase_cofactor_BS
    IPR006311, TAT_signal
    IPR019546, TAT_signal_bac_arc

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04879, Molybdop_Fe4S4, 1 hit
    PF00384, Molybdopterin, 1 hit
    PF01568, Molydop_binding, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00926, Molybdop_Fe4S4, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50692, SSF50692, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02166, dmsA_ynfE, 1 hit
    TIGR01409, TAT_signal_seq, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
    PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
    PS00490, MOLYBDOPTERIN_PROK_2, 1 hit
    PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
    PS51318, TAT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P18775-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKTKIPDAVL AAEVSRRGLV KTTAIGGLAM ASSALTLPFS RIAHAVDSAI
    60 70 80 90 100
    PTKSDEKVIW SACTVNCGSR CPLRMHVVDG EIKYVETDNT GDDNYDGLHQ
    110 120 130 140 150
    VRACLRGRSM RRRVYNPDRL KYPMKRVGAR GEGKFERISW EEAYDIIATN
    160 170 180 190 200
    MQRLIKEYGN ESIYLNYGTG TLGGTMTRSW PPGNTLVARL MNCCGGYLNH
    210 220 230 240 250
    YGDYSSAQIA EGLNYTYGGW ADGNSPSDIE NSKLVVLFGN NPGETRMSGG
    260 270 280 290 300
    GVTYYLEQAR QKSNARMIII DPRYTDTGAG REDEWIPIRP GTDAALVNGL
    310 320 330 340 350
    AYVMITENLV DQAFLDKYCV GYDEKTLPAS APKNGHYKAY ILGEGPDGVA
    360 370 380 390 400
    KTPEWASQIT GVPADKIIKL AREIGSTKPA FISQGWGPQR HANGEIATRA
    410 420 430 440 450
    ISMLAILTGN VGINGGNSGA REGSYSLPFV RMPTLENPIQ TSISMFMWTD
    460 470 480 490 500
    AIERGPEMTA LRDGVRGKDK LDVPIKMIWN YAGNCLINQH SEINRTHEIL
    510 520 530 540 550
    QDDKKCELIV VIDCHMTSSA KYADILLPDC TASEQMDFAL DASCGNMSYV
    560 570 580 590 600
    IFNDQVIKPR FECKTIYEMT SELAKRLGVE QQFTEGRTQE EWMRHLYAQS
    610 620 630 640 650
    REAIPELPTF EEFRKQGIFK KRDPQGHHVA YKAFREDPQA NPLTTPSGKI
    660 670 680 690 700
    EIYSQALADI AATWELPEGD VIDPLPIYTP GFESYQDPLN KQYPLQLTGF
    710 720 730 740 750
    HYKSRVHSTY GNVDVLKAAC RQEMWINPLD AQKRGIHNGD KVRIFNDRGE
    760 770 780 790 800
    VHIEAKVTPR MMPGVVALGE GAWYDPDAKR VDKGGCINVL TTQRPSPLAK
    810
    GNPSHTNLVQ VEKV
    Length:814
    Mass (Da):90,399
    Last modified:December 1, 2000 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB97C830ABAC7C32C
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA83843 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J03412 Genomic DNA Translation: AAA83843.1 Different initiation.
    U00096 Genomic DNA Translation: AAC73980.2
    AP009048 Genomic DNA Translation: BAA35626.2

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S03785

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_415414.4, NC_000913.3
    WP_000850303.1, NZ_SSZK01000002.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC73980; AAC73980; b0894
    BAA35626; BAA35626; BAA35626

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    945508

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW5118
    eco:b0894

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.1383

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J03412 Genomic DNA Translation: AAA83843.1 Different initiation.
    U00096 Genomic DNA Translation: AAC73980.2
    AP009048 Genomic DNA Translation: BAA35626.2
    PIRiS03785
    RefSeqiNP_415414.4, NC_000913.3
    WP_000850303.1, NZ_SSZK01000002.1

    3D structure databases

    SMRiP18775
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4261945, 69 interactors
    849882, 3 interactors
    ComplexPortaliCPX-320, DMSO reductase complex
    DIPiDIP-9452N
    IntActiP18775, 8 interactors
    MINTiP18775
    STRINGi511145.b0894

    Protein family/group databases

    TCDBi5.A.3.3.2, the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

    Proteomic databases

    jPOSTiP18775
    PaxDbiP18775
    PRIDEiP18775

    Genome annotation databases

    EnsemblBacteriaiAAC73980; AAC73980; b0894
    BAA35626; BAA35626; BAA35626
    GeneIDi945508
    KEGGiecj:JW5118
    eco:b0894
    PATRICifig|1411691.4.peg.1383

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0228

    Phylogenomic databases

    eggNOGiCOG0243, Bacteria
    HOGENOMiCLU_000422_13_3_6
    InParanoidiP18775
    KOiK07306
    PhylomeDBiP18775

    Enzyme and pathway databases

    BioCyciEcoCyc:DMSA-MONOMER
    MetaCyc:DMSA-MONOMER
    BRENDAi1.8.5.3, 2026

    Miscellaneous databases

    Protein Ontology

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    PROi
    PR:P18775

    Family and domain databases

    InterProiView protein in InterPro
    IPR011888, Anaer_DMSO_reductase
    IPR009010, Asp_de-COase-like_dom_sf
    IPR006657, MoPterin_dinucl-bd_dom
    IPR006656, Mopterin_OxRdtase
    IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
    IPR006655, Mopterin_OxRdtase_prok_CS
    IPR027467, MopterinOxRdtase_cofactor_BS
    IPR006311, TAT_signal
    IPR019546, TAT_signal_bac_arc
    PfamiView protein in Pfam
    PF04879, Molybdop_Fe4S4, 1 hit
    PF00384, Molybdopterin, 1 hit
    PF01568, Molydop_binding, 1 hit
    SMARTiView protein in SMART
    SM00926, Molybdop_Fe4S4, 1 hit
    SUPFAMiSSF50692, SSF50692, 1 hit
    TIGRFAMsiTIGR02166, dmsA_ynfE, 1 hit
    TIGR01409, TAT_signal_seq, 1 hit
    PROSITEiView protein in PROSITE
    PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
    PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
    PS00490, MOLYBDOPTERIN_PROK_2, 1 hit
    PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
    PS51318, TAT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMSA_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18775
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: December 1, 2000
    Last modified: October 7, 2020
    This is version 185 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families
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