Beta-2 adrenergic receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• adenylate cyclase binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase."
    Lavine N., Ethier N., Oak J.N., Pei L., Liu F., Trieu P., Rebois R.V., Bouvier M., Hebert T.E., Van Tol H.H.
    J. Biol. Chem. 277:46010-46019(2002) [PubMed] [Europe PMC] [Abstract]
• amyloid-beta binding Source: MGI
• B2 bradykinin receptor binding Source: MGI
• beta2-adrenergic receptor activity Source: MGIInferred from direct assayⁱ
  • "Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance."
    McGraw D.W., Fukuda N., James P.F., Forbes S.L., Woo A.L., Lingrel J.B., Witte D.P., Matthay M.A., Liggett S.B.
    Am. J. Physiol. Lung Cell Mol. Physiol. 281:L895-903(2001) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells."
    Allen J.M., Baetge E.E., Abrass I.B., Palmiter R.D.
    EMBO J. 7:133-138(1988) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  • "Genetic variation in beta-adrenergic receptors in mice: a magnesium effect determined by a single gene."
    Markovac J., Erickson R.P.
    Genet. Res. 42:159-168(1983) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines."
    Rohlfs E.M., Daniel K.W., Premont R.T., Kozak L.P., Collins S.
    J. Biol. Chem. 270:10723-10732(1995) [PubMed] [Europe PMC] [Abstract]
  • "Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects."
    Rohrer D.K., Desai K.H., Jasper J.R., Stevens M.E., Regula D.P. Jr., Barsh G.S., Bernstein D., Kobilka B.K.
    Proc. Natl. Acad. Sci. U.S.A. 93:7375-7380(1996) [PubMed] [Europe PMC] [Abstract]
  • "Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes."
    Hadri K.E., Courtalon A., Gauthereau X., Chambaut-Guerin A.M., Pairault J., Feve B.
    J. Biol. Chem. 272:24514-24521(1997) [PubMed] [Europe PMC] [Abstract]
• dopamine binding Source: MGI
• drug binding Source: MGI
• enzyme binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes."
    De Arcangelis V., Liu R., Soto D., Xiang Y.
    J. Biol. Chem. 284:33824-33832(2009) [PubMed] [Europe PMC] [Abstract]
• epinephrine binding Source: MGI
• G-protein alpha-subunit binding Source: MGI
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: MGI
• ionotropic glutamate receptor binding Source: MGI
• norepinephrine binding Source: HGNC-UCL
• potassium channel regulator activity Source: MGI
• protein-containing complex binding Source: MGI
• protein homodimerization activity Source: HGNC-UCL
• protein phosphatase 2A binding Source: MGI
• receptor-receptor interaction Source: MGI

GO - Biological processⁱ

• activation of adenylate cyclase activity Source: HGNC-UCL
• adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance."
    McGraw D.W., Fukuda N., James P.F., Forbes S.L., Woo A.L., Lingrel J.B., Witte D.P., Matthay M.A., Liggett S.B.
    Am. J. Physiol. Lung Cell Mol. Physiol. 281:L895-903(2001) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells."
    Allen J.M., Baetge E.E., Abrass I.B., Palmiter R.D.
    EMBO J. 7:133-138(1988) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adrenergic receptor signaling pathway Source: MGI
• associative learning Source: MGI
• bone resorption Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Leptin regulation of bone resorption by the sympathetic nervous system and CART."
    Elefteriou F., Ahn J.D., Takeda S., Starbuck M., Yang X., Liu X., Kondo H., Richards W.G., Bannon T.W., Noda M., Clement K., Vaisse C., Karsenty G., Karsenty G.
    Nature 434:514-520(2005) [PubMed] [Europe PMC] [Abstract]
• brown fat cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett. 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to amyloid-beta Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: MGI
• desensitization of G protein-coupled receptor signaling pathway by arrestin Source: HGNC-UCL
• diaphragm contraction Source: MGI
• diet induced thermogenesis Source: MGIInferred from genetic interactionⁱ
  • "betaAR signaling required for diet-induced thermogenesis and obesity resistance."
    Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., Lowell B.B.
    Science 297:843-845(2002) [PubMed] [Europe PMC] [Abstract]
• excitatory postsynaptic potential Source: MGI
• G protein-coupled receptor signaling pathway Source: MGI
• heat generation Source: MGIInferred from genetic interactionⁱ
  • "betaAR signaling required for diet-induced thermogenesis and obesity resistance."
    Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., Lowell B.B.
    Science 297:843-845(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: MGI
• negative regulation of inflammatory response Source: MGI
• negative regulation of multicellular organism growth Source: MGIInferred from genetic interactionⁱ
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett. 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ossification Source: MGI
• negative regulation of platelet aggregation Source: MGI
• negative regulation of smooth muscle contraction Source: MGIInferred from genetic interactionⁱ
  • "Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox."
    McGraw D.W., Almoosa K.F., Paul R.J., Kobilka B.K., Liggett S.B.
    J. Clin. Invest. 112:619-626(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of urine volume Source: MGI
• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • "Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors."
    Rohrer D.K., Chruscinski A., Schauble E.H., Bernstein D., Kobilka B.K.
    J. Biol. Chem. 274:16701-16708(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of AMPA receptor activity Source: MGI
• positive regulation of apoptotic process Source: MGI
• positive regulation of ATPase activity Source: MGI
• positive regulation of autophagosome maturation Source: GO_Central
• positive regulation of blood vessel diameter Source: MGI
• positive regulation of bone mineralization Source: MGIInferred from mutant phenotypeⁱ
  • "Leptin regulation of bone resorption by the sympathetic nervous system and CART."
    Elefteriou F., Ahn J.D., Takeda S., Starbuck M., Yang X., Liu X., Kondo H., Richards W.G., Bannon T.W., Noda M., Clement K., Vaisse C., Karsenty G., Karsenty G.
    Nature 434:514-520(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of calcium ion import across plasma membrane Source: MGI
• positive regulation of cell population proliferation Source: MGI
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from genetic interactionⁱ
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett. 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of heart contraction Source: MGI
• positive regulation of lipophagy Source: GO_Central
• positive regulation of MAPK cascade Source: HGNC-UCL
• positive regulation of mini excitatory postsynaptic potential Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of potassium ion transport Source: MGI
• positive regulation of protein kinase A signaling Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein serine/threonine kinase activity Source: MGI
• positive regulation of protein ubiquitination Source: MGI
• positive regulation of skeletal muscle tissue growth Source: MGI
• positive regulation of sodium ion transport Source: MGI
• positive regulation of the force of heart contraction by epinephrine Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • "Leptin regulation of bone resorption by the sympathetic nervous system and CART."
    Elefteriou F., Ahn J.D., Takeda S., Starbuck M., Yang X., Liu X., Kondo H., Richards W.G., Bannon T.W., Noda M., Clement K., Vaisse C., Karsenty G., Karsenty G.
    Nature 434:514-520(2005) [PubMed] [Europe PMC] [Abstract]
• receptor-mediated endocytosis Source: HGNC-UCL
• regulation of calcium ion transport Source: MGI
• regulation of sensory perception of pain Source: MGI
• regulation of sodium ion transport Source: MGIInferred from mutant phenotypeⁱ
  • "Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling."
    Mutlu G.M., Dumasius V., Burhop J., McShane P.J., Meng F.J., Welch L., Dumasius A., Mohebahmadi N., Thakuria G., Hardiman K., Matalon S., Hollenberg S., Factor P.
    Circ. Res. 94:1091-1100(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic vesicle exocytosis Source: MGI
• regulation of systemic arterial blood pressure by norepinephrine-epinephrine Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted disruption of the beta2 adrenergic receptor gene."
    Chruscinski A.J., Rohrer D.K., Schauble E., Desai K.H., Bernstein D., Kobilka B.K.
    J. Biol. Chem. 274:16694-16700(1999) [PubMed] [Europe PMC] [Abstract]
• response to cold Source: MGIInferred from genetic interactionⁱ
  • "betaAR signaling required for diet-induced thermogenesis and obesity resistance."
    Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., Lowell B.B.
    Science 297:843-845(2002) [PubMed] [Europe PMC] [Abstract]
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett. 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, glutamatergic Source: MGI
• wound healing Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• adenylate cyclase binding Source: BHF-UCLInferred from direct assayⁱ
  • "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase."
    Lavine N., Ethier N., Oak J.N., Pei L., Liu F., Trieu P., Rebois R.V., Bouvier M., Hebert T.E., Van Tol H.H.
    J. Biol. Chem. 277:46010-46019(2002) [PubMed] [Europe PMC] [Abstract]
• B2 bradykinin receptor binding Source: MGI
• enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes."
    De Arcangelis V., Liu R., Soto D., Xiang Y.
    J. Biol. Chem. 284:33824-33832(2009) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: MGI
• identical protein binding Source: MGI
• ionotropic glutamate receptor binding Source: MGI
• protein homodimerization activity Source: HGNC-UCL
• protein phosphatase 2A binding Source: MGI
• receptor-receptor interaction Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGPHGNDSDF LLAPNGSRAP DHDVTQERDE AWVVGMAILM SVIVLAIVFG 
        60         70         80         90        100
NVLVITAIAK FERLQTVTNY FIISLACADL VMGLAVVPFG ASHILMKMWN 
       110        120        130        140        150
FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYVAITSPFK YQSLLTKNKA 
       160        170        180        190        200
RVVILMVWIV SGLTSFLPIQ MHWYRATHKK AIDCYTEETC CDFFTNQAYA 
       210        220        230        240        250
IASSIVSFYV PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HAQNLSQVEQ 
       260        270        280        290        300
DGRSGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIRD 
       310        320        330        340        350
NLIPKEVYIL LNWLGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSSKTY 
       360        370        380        390        400
GNGYSSNSNG RTDYTGEPNT CQLGQEREQE LLCEDPPGME GFVNCQGTVP 
       410 
SLSVDSQGRN CSTNDSPL                                    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families