Adrb2

Functionⁱ

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	113	Agonist or antagonistBy similarity		1
Binding siteⁱ	118	Agonist or antagonistBy similarity		1

GO - Molecular functionⁱ

adenylate cyclase binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12297500
adrenergic receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
amyloid-beta binding Source: MGI
B2 bradykinin receptor binding Source: MGI
beta2-adrenergic receptor activity
Source: MGI
Inferred from direct assayⁱ
dopamine binding Source: MGI
drug binding Source: MGI
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19801680
epinephrine binding Source: MGI
G-protein alpha-subunit binding Source: MGI
ionotropic glutamate receptor binding Source: MGI
norepinephrine binding Source: HGNC
potassium channel regulator activity Source: MGI
protein-containing complex binding Source: MGI
protein homodimerization activity Source: HGNC
protein phosphatase 2A binding Source: MGI
receptor-receptor interaction Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of adenylate cyclase activity Source: HGNC
adenylate cyclase-activating adrenergic receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 11557593
- 2834198
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
adrenergic receptor signaling pathway Source: MGI
associative learning Source: MGI
bone resorption
Source: MGI
Inferred from mutant phenotypeⁱ
- 15724149
brown fat cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 12387862
cellular response to amyloid-beta
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 20395454
cellular response to hypoxia Source: MGI
desensitization of G protein-coupled receptor signaling pathway by arrestin Source: HGNC
diaphragm contraction Source: MGI
diet induced thermogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 12161655
excitatory postsynaptic potential Source: MGI
G protein-coupled receptor signaling pathway Source: MGI
heat generation
Source: MGI
Inferred from genetic interactionⁱ
- 12161655
negative regulation of angiogenesis Source: MGI
negative regulation of inflammatory response Source: MGI
negative regulation of multicellular organism growth
Source: MGI
Inferred from genetic interactionⁱ
- 12387862
negative regulation of ossification Source: MGI
negative regulation of platelet aggregation Source: MGI
negative regulation of smooth muscle contraction
Source: MGI
Inferred from genetic interactionⁱ
- 12925702
negative regulation of urine volume Source: MGI
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
Source: MGI
Inferred from mutant phenotypeⁱ
- 10358009
positive regulation of AMPA receptor activity Source: MGI
positive regulation of apoptotic process Source: MGI
positive regulation of ATPase activity Source: MGI
positive regulation of autophagosome maturation Source: GO_Central
positive regulation of blood vessel diameter Source: MGI
positive regulation of bone mineralization
Source: MGI
Inferred from mutant phenotypeⁱ
- 15724149
positive regulation of calcium ion import across plasma membrane Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from genetic interactionⁱ
- 12387862
positive regulation of heart contraction Source: MGI
positive regulation of lipophagy Source: GO_Central
positive regulation of MAPK cascade Source: HGNC
positive regulation of mini excitatory postsynaptic potential
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 20395454
positive regulation of potassium ion transport Source: MGI
positive regulation of protein kinase A signaling
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 20395454
positive regulation of protein serine/threonine kinase activity Source: MGI
positive regulation of protein ubiquitination Source: MGI
positive regulation of skeletal muscle tissue growth Source: MGI
positive regulation of sodium ion transport Source: MGI
positive regulation of the force of heart contraction by epinephrine Source: MGI
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 15724149
receptor-mediated endocytosis Source: HGNC
regulation of calcium ion transport Source: MGI
regulation of sensory perception of pain Source: MGI
regulation of sodium ion transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 15016730
regulation of synaptic vesicle exocytosis Source: MGI
regulation of systemic arterial blood pressure by norepinephrine-epinephrine
Source: MGI
Inferred from mutant phenotypeⁱ
- 10358008
response to cold
Source: MGI
Inferred from genetic interactionⁱ
- 12161655
- 12387862
synaptic transmission, glutamatergic Source: MGI
wound healing Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390696 Adrenoceptors R-MMU-418555 G alpha (s) signalling events R-MMU-5689880 Ub-specific processing proteases R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-390696 Adrenoceptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-2 adrenergic receptor Alternative name(s): Beta-2 adrenoreceptor Short name: Beta-2 adrenoceptor
Gene namesⁱ	Name:Adrb2 Synonyms:Adrb2r
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:87938 Adrb2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 34	ExtracellularBy similarityAdd BLAST	34
Transmembraneⁱ	35 – 58	Helical; Name=1By similarityAdd BLAST	24
Topological domainⁱ	59 – 71	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	72 – 95	Helical; Name=2By similarityAdd BLAST	24
Topological domainⁱ	96 – 106	ExtracellularBy similarityAdd BLAST	11
Transmembraneⁱ	107 – 129	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	130 – 150	CytoplasmicBy similarityAdd BLAST	21
Transmembraneⁱ	151 – 174	Helical; Name=4By similarityAdd BLAST	24
Topological domainⁱ	175 – 196	ExtracellularBy similarityAdd BLAST	22
Transmembraneⁱ	197 – 220	Helical; Name=5By similarityAdd BLAST	24
Topological domainⁱ	221 – 274	CytoplasmicBy similarityAdd BLAST	54
Transmembraneⁱ	275 – 298	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	299 – 305	ExtracellularBy similarity	7
Transmembraneⁱ	306 – 329	Helical; Name=7By similarityAdd BLAST	24
Topological domainⁱ	330 – 418	CytoplasmicBy similarityAdd BLAST	89

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3707

ChEMBLⁱ

CHEMBL3707

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069134	1 – 418	Beta-2 adrenergic receptorAdd BLAST		418

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineCurated	1
Glycosylationⁱ	15	N-linked (GlcNAc...) asparagineCurated	1
Disulfide bondⁱ	106 ↔ 191	PROSITE-ProRule annotation
Modified residueⁱ	141	PhosphotyrosineBy similarity	1
Disulfide bondⁱ	184 ↔ 190	PROSITE-ProRule annotation
Modified residueⁱ	246	PhosphoserineBy similarity	1
Modified residueⁱ	261	Phosphoserine; by PKASequence analysis	1
Modified residueⁱ	262	Phosphoserine; by PKASequence analysis	1
Lipidationⁱ	341	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	345	Phosphoserine; by PKABy similarity	1
Modified residueⁱ	346	Phosphoserine; by PKABy similarity	1
Modified residueⁱ	355	Phosphoserine; by BARKCurated	1
Modified residueⁱ	356	Phosphoserine; by BARKCurated	1
Modified residueⁱ	387	4-hydroxyprolineBy similarity	1
Modified residueⁱ	400	4-hydroxyprolineBy similarity	1

Post-translational modificationⁱ

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).By similarity

Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.

Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.By similarity

Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).By similarity

Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P18762
PRIDEⁱ	P18762

PTM databases

iPTMnetⁱ	P18762
PhosphoSitePlusⁱ	P18762
SwissPalmⁱ	P18762

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000045730 Expressed in 158 organ(s), highest expression level in cornea
CleanExⁱ	MM_ADRB2
Genevisibleⁱ	P18762 MM

Interactionⁱ

Subunit structureⁱ

Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Adrb1	P34971	2	EBI-491143,EBI-7764182
Cav3	P51637	2	EBI-491143,EBI-298576
Erbb2	P70424	3	EBI-491143,EBI-2945468

GO - Molecular functionⁱ

adenylate cyclase binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12297500
B2 bradykinin receptor binding Source: MGI
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19801680
G-protein alpha-subunit binding Source: MGI
ionotropic glutamate receptor binding Source: MGI
protein homodimerization activity Source: HGNC
protein phosphatase 2A binding Source: MGI
receptor-receptor interaction Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	P18762
Database of interacting proteins More...DIPⁱ	DIP-59568N
IntActⁱ	P18762, 9 interactors
Molecular INTeraction database More...MINTⁱ	P18762
STRINGⁱ	10090.ENSMUSP00000062256

Chemistry databases

BindingDBⁱ

P18762

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P18762
SMRⁱ	P18762
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	193 – 207	Agonist and antagonist bindingBy similarityAdd BLAST	15
Regionⁱ	286 – 293	Agonist and antagonist bindingBy similarity	8
Regionⁱ	312 – 316	Agonist and antagonist bindingBy similarity	5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	415 – 418	PDZ-binding		4

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P18762
KEGG Orthology (KO) More...KOⁱ	K04142
OMAⁱ	KETCCDF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
TreeFamⁱ	TF316350

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15957 7tmA_Beta2_AR, 1 hit
InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000332 ADRB2_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF21 PTHR24248:SF21, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00562 ADRENRGCB2AR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P18762-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPHGNDSDF LLAPNGSRAP DHDVTQERDE AWVVGMAILM SVIVLAIVFG 
        60         70         80         90        100
NVLVITAIAK FERLQTVTNY FIISLACADL VMGLAVVPFG ASHILMKMWN 
       110        120        130        140        150
FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYVAITSPFK YQSLLTKNKA 
       160        170        180        190        200
RVVILMVWIV SGLTSFLPIQ MHWYRATHKK AIDCYTEETC CDFFTNQAYA 
       210        220        230        240        250
IASSIVSFYV PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HAQNLSQVEQ 
       260        270        280        290        300
DGRSGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIRD 
       310        320        330        340        350
NLIPKEVYIL LNWLGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSSKTY 
       360        370        380        390        400
GNGYSSNSNG RTDYTGEPNT CQLGQEREQE LLCEDPPGME GFVNCQGTVP 
       410 
SLSVDSQGRN CSTNDSPL

Length:418

Mass (Da):46,998

Last modified:July 27, 2011 - v2

Checksum:ⁱ51D1EC73D7619D58

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	21	D → H in CAA33664 (PubMed:2549959).Curated	1
Sequence conflictⁱ	94 – 95	IL → TS in CAA33664 (PubMed:2549959).Curated	2
Sequence conflictⁱ	254	S → T in CAA33664 (PubMed:2549959).Curated	1
Sequence conflictⁱ	347 – 348	SK → FE in CAA33664 (PubMed:2549959).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15643 Genomic DNA Translation: CAA33664.1 AK080241 mRNA Translation: BAC37856.1 CH466528 Genomic DNA Translation: EDL09746.1 BC032883 mRNA Translation: AAH32883.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29289.1
PIRⁱ	S00260
NCBI Reference Sequences More...RefSeqⁱ	NP_031446.2, NM_007420.3
UniGeneⁱ	Mm.5598

Genome annotation databases

Ensemblⁱ	ENSMUST00000053640; ENSMUSP00000062256; ENSMUSG00000045730
GeneIDⁱ	11555
KEGGⁱ	mmu:11555
UCSC genome browser More...UCSCⁱ	uc008fcy.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18762	Beta-2 adrenergic receptor (Fragment)		MOUSE		275	UniRef100_P18762

Protein	Similar proteins		Species	Score	Length	Source
P18762	Beta-2 adrenergic receptor		RAT		418	UniRef90_P10608
Beta-2 adrenergic receptor		MESAU		418
Beta-2 adrenergic receptor		TSCTR		418
Beta-2 adrenergic receptor (Fragment)		MOUSE		275
Beta-2 adrenergic receptor		CASCN		418
+15

Protein	Similar proteins		Species	Score	Length	Source
P18762	Beta-2 adrenergic receptor	)	HUMAN		413	UniRef50_P07550
Beta-2 adrenergic receptor		MACMU		415
Beta-2 adrenergic receptor		RAT		418
Beta-2 adrenergic receptor		TSCTR		418
Beta-2 adrenergic receptor		MESAU		418
+273

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15643 Genomic DNA Translation: CAA33664.1 AK080241 mRNA Translation: BAC37856.1 CH466528 Genomic DNA Translation: EDL09746.1 BC032883 mRNA Translation: AAH32883.1
CCDSⁱ	CCDS29289.1
PIRⁱ	S00260
RefSeqⁱ	NP_031446.2, NM_007420.3
UniGeneⁱ	Mm.5598

3D structure databases

ProteinModelPortalⁱ	P18762
SMRⁱ	P18762
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P18762
DIPⁱ	DIP-59568N
IntActⁱ	P18762, 9 interactors
MINTⁱ	P18762
STRINGⁱ	10090.ENSMUSP00000062256

Chemistry databases

BindingDBⁱ	P18762
ChEMBLⁱ	CHEMBL3707

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P18762
PhosphoSitePlusⁱ	P18762
SwissPalmⁱ	P18762

Proteomic databases

PaxDbⁱ	P18762
PRIDEⁱ	P18762

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053640; ENSMUSP00000062256; ENSMUSG00000045730
GeneIDⁱ	11555
KEGGⁱ	mmu:11555
UCSCⁱ	uc008fcy.2 mouse

Organism-specific databases

CTDⁱ	154
MGIⁱ	MGI:87938 Adrb2

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P18762
KOⁱ	K04142
OMAⁱ	KETCCDF
OrthoDBⁱ	EOG091G06VI
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390696 Adrenoceptors R-MMU-418555 G alpha (s) signalling events R-MMU-5689880 Ub-specific processing proteases R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-390696 Adrenoceptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P18762
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000045730 Expressed in 158 organ(s), highest expression level in cornea
CleanExⁱ	MM_ADRB2
Genevisibleⁱ	P18762 MM

Family and domain databases

CDDⁱ	cd15957 7tmA_Beta2_AR, 1 hit
InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000332 ADRB2_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF21 PTHR24248:SF21, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00562 ADRENRGCB2AR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADRB2_MOUSE
Accessionⁱ	P18762Primary (citable) accession number: P18762 Secondary accession number(s): Q8BH38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - P18762 (ADRB2_MOUSE)

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Beta-2 adrenergic receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Endosome

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ