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UniProtKB - P18754 (RCC1_HUMAN)

Entry version 219 (07 Apr 2021)
Sequence version 1 (01 Nov 1990)
Previous versions | rss
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Protein

Regulator of chromosome condensation

Gene

RCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).8 Publications

Miscellaneous

Patients with Raynaud disease produce antibodies that bind to RCC1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Guanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18754

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-180746, Nuclear import of Rev protein
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18754

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of chromosome condensation
Alternative name(s):
Cell cycle regulatory protein
Chromosome condensation protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCC1
Synonyms:CHC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1913, RCC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		179710, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18754

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000180198.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2S → A: Does not abolish N-terminal methylation. 1 Publication1
Mutagenesisi2S → Q: Does not abolish N-terminal methylation. 1 Publication1
Mutagenesisi3P → Q: Abolishes N-terminal methylation. 1 Publication1
Mutagenesisi4K → Q: Abolishes N-terminal methylation. 2 Publications1
Mutagenesisi4K → R: Strongly impairs N-terminal methylation and subcellular localization. 2 Publications1
Mutagenesisi9R → A: Decreases KPNA4 binding. Strongly decreases KPNA4 binding; when associated with A-21. 1 Publication1
Mutagenesisi11S → E: Phosphomimetic mutant. Decreases KPNA4 binding by about 10%. 1 Publication1
Mutagenesisi21K → A: Decreases KPNA4 binding. Strongly decreases KPNA4 binding; when associated with A-9. 1 Publication1
Mutagenesisi182D → A: Abolishes interaction with Ran and impairs chromosome localization. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		1104

Open Targets

More...OpenTargetsi		ENSG00000180198

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26449

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18754, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RCC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		132170

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066282 – 421Regulator of chromosome condensationAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N,N,N-trimethylserine; alternate3 Publications1
Modified residuei2N,N-dimethylserine; alternate3 Publications1
Modified residuei2N-methylserine; alternate3 Publications1
Modified residuei2Phosphoserine1 Publication1
Modified residuei11PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.3 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P18754

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18754

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18754

PeptideAtlas

More...PeptideAtlasi		P18754

PRoteomics IDEntifications database

More...PRIDEi		P18754

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53606 [P18754-1]
53607 [P18754-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P18754-1 [P18754-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18754

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P18754

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18754

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P18754

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180198, Expressed in testis and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18754, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18754, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000180198, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAN (PubMed:17435751, PubMed:18762580, PubMed:29040603, PubMed:11336674).

Interacts (via N-terminus and RCC1 repeats) with KPNA4 (PubMed:29042532).

Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (PubMed:16820410).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107529, 140 interactors

Database of interacting proteins

More...DIPi		DIP-35416N

Protein interaction database and analysis system

More...IntActi		P18754, 82 interactors

Molecular INTeraction database

More...MINTi		P18754

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362937

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18754, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18754

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P18754

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 84RCC1 1Add BLAST51
Repeati85 – 136RCC1 2Add BLAST52
Repeati138 – 189RCC1 3Add BLAST52
Repeati191 – 257RCC1 4Add BLAST67
Repeati258 – 311RCC1 5Add BLAST54
Repeati312 – 362RCC1 6Add BLAST51
Repeati363 – 416RCC1 7Add BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi4 – 24Bipartite nuclear localization signal1 PublicationAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1426, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155543

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005210_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18754

Identification of Orthologs from Complete Genome Data

More...OMAi		WGNGQQY

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18754

TreeFam database of animal gene trees

More...TreeFami		TF101139

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00415, RCC1, 7 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00633, RCCNDNSATION

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50985, SSF50985, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00625, RCC1_1, 1 hit
PS00626, RCC1_2, 4 hits
PS50012, RCC1_3, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P18754-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL 
        60         70         80         90        100
GENVMERKKP ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG 
       110        120        130        140        150
RDTSVEGSEM VPGKVELQEK VVQVSAGDSH TAALTDDGRV FLWGSFRDNN 
       160        170        180        190        200
GVIGLLEPMK KSMVPVQVQL DVPVVKVASG NDHLVMLTAD GDLYTLGCGE 
       210        220        230        240        250
QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV RFQDAFCGAY 
       260        270        280        290        300
FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS 
       310        320        330        340        350
GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV 
       360        370        380        390        400
ACGASVGYAV TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV 
       410        420 
VLSVSSGGQH TVLLVKDKEQ S
Length:421
Mass (Da):44,969
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6D225AF81928305
GO
Isoform 2 (identifier: P18754-2) [UniParc]FASTAAdd to basket
Also known as: RCC1-I

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: K → KDTRAAASRRVPGARSCQGACGPSPPDQKTRP

Show »
Length:452
Mass (Da):48,146
Checksum:iA31255E99A01A25F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JRH2C9JRH2_HUMAN
Regulator of chromosome condensatio...
RCC1
230Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW69C9JW69_HUMAN
Regulator of chromosome condensatio...
RCC1
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMJ4C9JMJ4_HUMAN
Regulator of chromosome condensatio...
RCC1
272Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQZ4C9JQZ4_HUMAN
Regulator of chromosome condensatio...
RCC1
283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3R0C9J3R0_HUMAN
Regulator of chromosome condensatio...
RCC1
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1Q8M0R1Q8_HUMAN
Regulator of chromosome condensatio...
RCC1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04112224K → KDTRAAASRRVPGARSCQGA CGPSPPDQKTRP in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X12654 mRNA Translation: CAA31182.1
X06130 mRNA Translation: CAA29496.1
D00591 Genomic DNA Translation: BAA00469.1
AF498924 mRNA Translation: AAM21072.1
BC007300 mRNA Translation: AAH07300.1
BC010067 mRNA Translation: AAH10067.1
BC036903 mRNA Translation: AAH36903.1
BC069198 mRNA Translation: AAH69198.1
S75708 mRNA Translation: AAB32653.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS323.1 [P18754-1]
CCDS41295.1 [P18754-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A26691

NCBI Reference Sequences

More...RefSeqi		NP_001041659.1, NM_001048194.2 [P18754-2]
NP_001041660.1, NM_001048195.2
NP_001041664.1, NM_001048199.2 [P18754-1]
NP_001260.1, NM_001269.4 [P18754-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373831; ENSP00000362937; ENSG00000180198 [P18754-2]
ENST00000373832; ENSP00000362938; ENSG00000180198 [P18754-1]
ENST00000373833; ENSP00000362939; ENSG00000180198 [P18754-1]
ENST00000398958; ENSP00000381931; ENSG00000180198 [P18754-1]
ENST00000649185; ENSP00000497402; ENSG00000180198 [P18754-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1104

UCSC genome browser

More...UCSCi		uc001bqf.3, human [P18754-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12654 mRNA Translation: CAA31182.1
X06130 mRNA Translation: CAA29496.1
D00591 Genomic DNA Translation: BAA00469.1
AF498924 mRNA Translation: AAM21072.1
BC007300 mRNA Translation: AAH07300.1
BC010067 mRNA Translation: AAH10067.1
BC036903 mRNA Translation: AAH36903.1
BC069198 mRNA Translation: AAH69198.1
S75708 mRNA Translation: AAB32653.1
CCDSiCCDS323.1 [P18754-1]
CCDS41295.1 [P18754-2]
PIRiA26691
RefSeqiNP_001041659.1, NM_001048194.2 [P18754-2]
NP_001041660.1, NM_001048195.2
NP_001041664.1, NM_001048199.2 [P18754-1]
NP_001260.1, NM_001269.4 [P18754-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A12X-ray1.70A/B/C9-421[»]
1I2MX-ray1.76B/D20-421[»]
5E1BX-ray1.65D/E2-7[»]
5E1DX-ray1.45D/E3-7[»]
5E1MX-ray1.75D/E3-7[»]
5E1OX-ray2.00D/E3-7[»]
5E2AX-ray1.75D/E3-7[»]
5E2BX-ray1.95D/E3-7[»]
5TBKX-ray3.45I/J/K/L/M/N/O/P1-421[»]
6DUBX-ray1.20E/F3-7[»]
SMRiP18754
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107529, 140 interactors
DIPiDIP-35416N
IntActiP18754, 82 interactors
MINTiP18754
STRINGi9606.ENSP00000362937

PTM databases

iPTMnetiP18754
MetOSiteiP18754
PhosphoSitePlusiP18754
SwissPalmiP18754

Genetic variation databases

BioMutaiRCC1
DMDMi132170

Proteomic databases

EPDiP18754
jPOSTiP18754
MassIVEiP18754
PeptideAtlasiP18754
PRIDEiP18754
ProteomicsDBi53606 [P18754-1]
53607 [P18754-2]
TopDownProteomicsiP18754-1 [P18754-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4212, 408 antibodies

The DNASU plasmid repository

More...DNASUi		1104

Genome annotation databases

EnsembliENST00000373831; ENSP00000362937; ENSG00000180198 [P18754-2]
ENST00000373832; ENSP00000362938; ENSG00000180198 [P18754-1]
ENST00000373833; ENSP00000362939; ENSG00000180198 [P18754-1]
ENST00000398958; ENSP00000381931; ENSG00000180198 [P18754-1]
ENST00000649185; ENSP00000497402; ENSG00000180198 [P18754-2]
GeneIDi1104
KEGGihsa:1104
UCSCiuc001bqf.3, human [P18754-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1104
DisGeNETi1104

GeneCards: human genes, protein and diseases

More...GeneCardsi		RCC1
HGNCiHGNC:1913, RCC1
HPAiENSG00000180198, Low tissue specificity
MIMi179710, gene
neXtProtiNX_P18754
OpenTargetsiENSG00000180198
PharmGKBiPA26449
VEuPathDBiHostDB:ENSG00000180198.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1426, Eukaryota
GeneTreeiENSGT00940000155543
HOGENOMiCLU_005210_6_2_1
InParanoidiP18754
OMAiWGNGQQY
PhylomeDBiP18754
TreeFamiTF101139

Enzyme and pathway databases

PathwayCommonsiP18754
ReactomeiR-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-180746, Nuclear import of Rev protein
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation
SIGNORiP18754

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1104, 765 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RCC1, human
EvolutionaryTraceiP18754

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RCC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1104
PharosiP18754, Tbio

Protein Ontology

More...PROi		PR:P18754
RNActiP18754, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180198, Expressed in testis and 217 other tissues
ExpressionAtlasiP18754, baseline and differential
GenevisibleiP18754, HS

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
PfamiView protein in Pfam
PF00415, RCC1, 7 hits
PRINTSiPR00633, RCCNDNSATION
SUPFAMiSSF50985, SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00625, RCC1_1, 1 hit
PS00626, RCC1_2, 4 hits
PS50012, RCC1_3, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18754
Secondary accession number(s): Q16269, Q6NT97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 7, 2021
This is version 219 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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