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UniProtKB - P18696 (PUTX_EMENI)
Protein
Proline-specific permease
Gene
prnB
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Required for high-affinity proline transport.
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-specific permeaseAlternative name(s): Proline transport protein |
Gene namesi | Name:prnB ORF Names:AN1732 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 47 | CytoplasmicSequence analysisAdd BLAST | 47 | |
Transmembranei | 48 – 68 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 69 – 72 | ExtracellularSequence analysis | 4 | |
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 94 – 126 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 152 | ExtracellularSequence analysis | 5 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 174 – 183 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 184 – 204 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 205 – 236 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 277 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 321 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 343 – 378 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 379 – 399 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 400 – 406 | ExtracellularSequence analysis | 7 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 457 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 479 – 484 | ExtracellularSequence analysis | 6 | |
Transmembranei | 485 – 505 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 506 – 550 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054159 | 1 – 550 | Proline-specific permeaseAdd BLAST | 550 |
Expressioni
Inductioni
By L-proline.
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
HOGENOMi | CLU_007946_12_1_1 |
InParanoidi | P18696 |
OrthoDBi | 621852at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P18696-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPPSAKSME EGRTPSVQYG YGDPKTLEGE IEEHTATKRG LSSRQLQLLA
60 70 80 90 100
IGGCIGTGLF VGTSTVLTQT GPAPLLMSYI VMASIVWFVM NVLGEMTTYL
110 120 130 140 150
PIRGVSVPYL IGRFTEPSIG FASGYNYWYS FAMLLASEVT ASGLIIEYWN
160 170 180 190 200
PPVSVGLWIA IVLVVILALN VFAVEWYGES EFWFAGLKIL AIIGLIILGV
210 220 230 240 250
VLFFGGGPNH DRLGFRYWQD PGAFNPYLVP GDTGKFLGFW TALIKSGFSF
260 270 280 290 300
IFSPELITTA AGEVEAPRRN IPKATKRFIY RVFTFYILGS LVIGVTVAYN
310 320 330 340 350
DPTLEAGVES GGSGAGASPF VVAIQNAGIG GLNHVVNAAI LISAWSSGNA
360 370 380 390 400
WCYAGSRTLY SLAGEGQAPK IFTRTNRTGV PYVAVLATWT IGLLSFLNLS
410 420 430 440 450
SSGQTVFYWF TNITTVGGFI NWVLIGIAYL RFRKALQFHG MLDMLPFKTP
460 470 480 490 500
LQPYGTYYVM FIISILTLTN GYAVFFPGRF TASDFLVSYI VFAIFLALYA
510 520 530 540 550
GHKIWYRTPW LTKVSEVDIF TGKDEIDRLC ENDMERQPRN WLERVWWWIF
Sequence cautioni
The sequence CBF85456 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA64018 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79797 Genomic DNA Translation: CAA56191.1 AACD01000027 Genomic DNA Translation: EAA64018.1 Sequence problems. BN001307 Genomic DNA Translation: CBF85456.1 Sequence problems. |
PIRi | S04547 |
RefSeqi | XP_659336.1, XM_654244.1 |
Genome annotation databases
EnsemblFungii | EAA64018; EAA64018; AN1732.2 |
GeneIDi | 2875279 |
KEGGi | ani:AN1732.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79797 Genomic DNA Translation: CAA56191.1 AACD01000027 Genomic DNA Translation: EAA64018.1 Sequence problems. BN001307 Genomic DNA Translation: CBF85456.1 Sequence problems. |
PIRi | S04547 |
RefSeqi | XP_659336.1, XM_654244.1 |
3D structure databases
SMRi | P18696 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 227321.P18696 |
Genome annotation databases
EnsemblFungii | EAA64018; EAA64018; AN1732.2 |
GeneIDi | 2875279 |
KEGGi | ani:AN1732.2 |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
HOGENOMi | CLU_007946_12_1_1 |
InParanoidi | P18696 |
OrthoDBi | 621852at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PUTX_EMENI | |
Accessioni | P18696Primary (citable) accession number: P18696 Secondary accession number(s): C8VP33, Q5BCJ8, Q92202 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families