UniProtKB - P18621 (RL17_HUMAN)
Protein
60S ribosomal protein L17
Gene
RPL17
Organism
Homo sapiens (Human)
Status
Functioni
Component of the large ribosomal subunit.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cytoplasmic translation Source: GO_Central
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P18621 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L17Alternative name(s): 60S ribosomal protein L23 Large ribosomal subunit protein uL221 Publication PD-1 |
Gene namesi | Name:RPL17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10307, RPL17 |
MIMi | 603661, gene |
neXtProti | NX_P18621 |
VEuPathDBi | HostDB:ENSG00000265681.7 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6139 |
OpenTargetsi | ENSG00000265681 |
PharmGKBi | PA34676 |
Miscellaneous databases
Pharosi | P18621, Tbio |
Genetic variation databases
BioMutai | RPL17 |
DMDMi | 132799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000125331 | 2 – 184 | 60S ribosomal protein L17Add BLAST | 183 |
Proteomic databases
EPDi | P18621 |
jPOSTi | P18621 |
MassIVEi | P18621 |
MaxQBi | P18621 |
PaxDbi | P18621 |
PeptideAtlasi | P18621 |
PRIDEi | P18621 |
ProteomicsDBi | 53603 [P18621-1] 5890 |
TopDownProteomicsi | P18621-1 [P18621-1] P18621-2 [P18621-2] |
PTM databases
iPTMneti | P18621 |
MetOSitei | P18621 |
PhosphoSitePlusi | P18621 |
SwissPalmi | P18621 |
Expressioni
Tissue specificityi
Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.1 Publication
Gene expression databases
Bgeei | ENSG00000265681, Expressed in left ovary and 111 other tissues |
ExpressionAtlasi | P18621, baseline and differential |
Genevisiblei | P18621, HS |
Organism-specific databases
HPAi | ENSG00000265681, Low tissue specificity |
Interactioni
Subunit structurei
Component of the large ribosomal subunit.
1 PublicationProtein-protein interaction databases
BioGRIDi | 112059, 216 interactors 1529331, 2 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P18621 |
IntActi | P18621, 61 interactors |
MINTi | P18621 |
STRINGi | 9606.ENSP00000397798 |
Miscellaneous databases
RNActi | P18621, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL22 family.Curated
Phylogenomic databases
eggNOGi | KOG3353, Eukaryota |
GeneTreei | ENSGT00950000183010 |
InParanoidi | P18621 |
OMAi | ANAEYKG |
PhylomeDBi | P18621 |
TreeFami | TF300042 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_A, Ribosomal_L22_A, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR005721, Ribosomal_L22/L17_euk/arc IPR036394, Ribosomal_L22/L17_sf |
PANTHERi | PTHR11593, PTHR11593, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01038, uL22_arch_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P18621-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD
60 70 80 90 100
VTLQKQCVPF RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES
110 120 130 140 150
NAELKGLDVD SLVIEHIQVN KAPKMRRRTY RAHGRINPYM SSPCHIEMIL
160 170 180
TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL MARE
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QLC8 | J3QLC8_HUMAN | 60S ribosomal protein L17 | RPL17 | 174 | Annotation score: | ||
J3KRX5 | J3KRX5_HUMAN | 60S ribosomal protein L17 | RPL17 | 174 | Annotation score: | ||
A0A087WXM6 | A0A087WXM6_HUMAN | 60S ribosomal protein L17 | RPL17 | 169 | Annotation score: | ||
J3QQT2 | J3QQT2_HUMAN | 60S ribosomal protein L17 | RPL17 | 171 | Annotation score: | ||
J3QS96 | J3QS96_HUMAN | 60S ribosomal protein L17 | RPL17 | 138 | Annotation score: | ||
A0A087WWH0 | A0A087WWH0_HUMAN | 60S ribosomal protein L17 | RPL17 | 131 | Annotation score: | ||
J3KRB3 | J3KRB3_HUMAN | 60S ribosomal protein L17 | RPL17 | 129 | Annotation score: | ||
A0A087WY81 | A0A087WY81_HUMAN | 60S ribosomal protein L17 | RPL17 | 97 | Annotation score: | ||
J3KSJ0 | J3KSJ0_HUMAN | 60S ribosomal protein L17 | RPL17 | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | H → R in AAH66324 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045445 | 1 – 38 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_046965 | 170 – 184 | ISQKK…LMARE → LRSSSLGKWCAFLVSSFQFC SGSTKNSWSHIYTLWFPPSL VVYGLRKQYKNPMIQTKAK in isoform 3. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53777 mRNA Translation: CAA37793.1 AB061824 Genomic DNA Translation: BAB79462.1 AC100778 Genomic DNA No translation available. AK304659 mRNA Translation: BAG65434.1 AK311828 mRNA Translation: BAG34770.1 BX393840 mRNA No translation available. CH471096 Genomic DNA Translation: EAW62940.1 BC000502 mRNA Translation: AAH00502.1 BC017831 mRNA Translation: AAH17831.1 BC066323 mRNA Translation: AAH66323.1 BC066324 mRNA Translation: AAH66324.1 BC106031 mRNA Translation: AAI06032.1 AB007174 Genomic DNA Translation: BAA25834.1 |
CCDSi | CCDS45865.1 [P18621-1] CCDS56070.1 [P18621-2] |
PIRi | A61192 S11218, R5HU22 |
RefSeqi | NP_000976.1, NM_000985.4 [P18621-1] NP_001030178.1, NM_001035006.2 [P18621-1] NP_001186269.1, NM_001199340.1 [P18621-1] NP_001186270.1, NM_001199341.1 [P18621-1] NP_001186271.1, NM_001199342.1 [P18621-1] NP_001186272.1, NM_001199343.1 [P18621-1] NP_001186273.1, NM_001199344.1 [P18621-1] NP_001186274.1, NM_001199345.1 [P18621-2] |
Genome annotation databases
Ensembli | ENST00000579248; ENSP00000462023; ENSG00000265681 [P18621-1] ENST00000579408; ENSP00000463842; ENSG00000265681 [P18621-1] ENST00000580261; ENSP00000462385; ENSG00000265681 [P18621-1] ENST00000581373; ENSP00000462944; ENSG00000265681 [P18621-2] ENST00000618613; ENSP00000480555; ENSG00000265681 [P18621-1] ENST00000618619; ENSP00000482577; ENSG00000265681 [P18621-1] |
GeneIDi | 6139 |
KEGGi | hsa:6139 |
UCSCi | uc002ldp.4, human [P18621-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53777 mRNA Translation: CAA37793.1 AB061824 Genomic DNA Translation: BAB79462.1 AC100778 Genomic DNA No translation available. AK304659 mRNA Translation: BAG65434.1 AK311828 mRNA Translation: BAG34770.1 BX393840 mRNA No translation available. CH471096 Genomic DNA Translation: EAW62940.1 BC000502 mRNA Translation: AAH00502.1 BC017831 mRNA Translation: AAH17831.1 BC066323 mRNA Translation: AAH66323.1 BC066324 mRNA Translation: AAH66324.1 BC106031 mRNA Translation: AAI06032.1 AB007174 Genomic DNA Translation: BAA25834.1 |
CCDSi | CCDS45865.1 [P18621-1] CCDS56070.1 [P18621-2] |
PIRi | A61192 S11218, R5HU22 |
RefSeqi | NP_000976.1, NM_000985.4 [P18621-1] NP_001030178.1, NM_001035006.2 [P18621-1] NP_001186269.1, NM_001199340.1 [P18621-1] NP_001186270.1, NM_001199341.1 [P18621-1] NP_001186271.1, NM_001199342.1 [P18621-1] NP_001186272.1, NM_001199343.1 [P18621-1] NP_001186273.1, NM_001199344.1 [P18621-1] NP_001186274.1, NM_001199345.1 [P18621-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | LP | 1-184 | [»] | |
4V6X | electron microscopy | 5.00 | CP | 1-184 | [»] | |
5A8L | electron microscopy | 3.80 | D | 1-184 | [»] | |
5AJ0 | electron microscopy | 3.50 | AP | 1-184 | [»] | |
5LKS | electron microscopy | 3.60 | LP | 1-184 | [»] | |
5T2C | electron microscopy | 3.60 | J | 1-160 | [»] | |
6EK0 | electron microscopy | 2.90 | LP | 1-184 | [»] | |
6IP5 | electron microscopy | 3.90 | 2J | 1-184 | [»] | |
6IP6 | electron microscopy | 4.50 | 2J | 1-184 | [»] | |
6IP8 | electron microscopy | 3.90 | 2J | 1-184 | [»] | |
6LQM | electron microscopy | 3.09 | Y | 1-184 | [»] | |
6LSR | electron microscopy | 3.13 | Y | 1-184 | [»] | |
6LSS | electron microscopy | 3.23 | Y | 1-184 | [»] | |
6LU8 | electron microscopy | 3.13 | Y | 1-184 | [»] | |
6OLE | electron microscopy | 3.10 | Q | 2-154 | [»] | |
6OLF | electron microscopy | 3.90 | Q | 2-154 | [»] | |
6OLG | electron microscopy | 3.40 | AP | 2-154 | [»] | |
6OLI | electron microscopy | 3.50 | Q | 2-154 | [»] | |
6OLZ | electron microscopy | 3.90 | AP | 2-154 | [»] | |
6OM0 | electron microscopy | 3.10 | Q | 2-154 | [»] | |
6OM7 | electron microscopy | 3.70 | Q | 2-154 | [»] | |
6QZP | electron microscopy | 2.90 | LP | 2-154 | [»] | |
6W6L | electron microscopy | 3.84 | Q | 1-184 | [»] | |
6XA1 | electron microscopy | 2.80 | LP | 2-154 | [»] | |
6Y0G | electron microscopy | 3.20 | LP | 1-184 | [»] | |
6Y2L | electron microscopy | 3.00 | LP | 1-184 | [»] | |
6Y57 | electron microscopy | 3.50 | LP | 1-184 | [»] | |
6Y6X | electron microscopy | 2.80 | LP | 2-154 | [»] | |
6Z6L | electron microscopy | 3.00 | LP | 1-184 | [»] | |
6Z6M | electron microscopy | 3.10 | LP | 1-184 | [»] | |
6Z6N | electron microscopy | 2.90 | LP | 1-184 | [»] | |
6ZM7 | electron microscopy | 2.70 | LP | 1-184 | [»] | |
6ZME | electron microscopy | 3.00 | LP | 1-184 | [»] | |
6ZMI | electron microscopy | 2.60 | LP | 1-184 | [»] | |
6ZMO | electron microscopy | 3.10 | LP | 1-184 | [»] | |
SMRi | P18621 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112059, 216 interactors 1529331, 2 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P18621 |
IntActi | P18621, 61 interactors |
MINTi | P18621 |
STRINGi | 9606.ENSP00000397798 |
PTM databases
iPTMneti | P18621 |
MetOSitei | P18621 |
PhosphoSitePlusi | P18621 |
SwissPalmi | P18621 |
Genetic variation databases
BioMutai | RPL17 |
DMDMi | 132799 |
Proteomic databases
EPDi | P18621 |
jPOSTi | P18621 |
MassIVEi | P18621 |
MaxQBi | P18621 |
PaxDbi | P18621 |
PeptideAtlasi | P18621 |
PRIDEi | P18621 |
ProteomicsDBi | 53603 [P18621-1] 5890 |
TopDownProteomicsi | P18621-1 [P18621-1] P18621-2 [P18621-2] |
Protocols and materials databases
Antibodypediai | 65728, 299 antibodies |
DNASUi | 6139 |
Genome annotation databases
Ensembli | ENST00000579248; ENSP00000462023; ENSG00000265681 [P18621-1] ENST00000579408; ENSP00000463842; ENSG00000265681 [P18621-1] ENST00000580261; ENSP00000462385; ENSG00000265681 [P18621-1] ENST00000581373; ENSP00000462944; ENSG00000265681 [P18621-2] ENST00000618613; ENSP00000480555; ENSG00000265681 [P18621-1] ENST00000618619; ENSP00000482577; ENSG00000265681 [P18621-1] |
GeneIDi | 6139 |
KEGGi | hsa:6139 |
UCSCi | uc002ldp.4, human [P18621-1] |
Organism-specific databases
CTDi | 6139 |
DisGeNETi | 6139 |
GeneCardsi | RPL17 |
HGNCi | HGNC:10307, RPL17 |
HPAi | ENSG00000265681, Low tissue specificity |
MIMi | 603661, gene |
neXtProti | NX_P18621 |
OpenTargetsi | ENSG00000265681 |
PharmGKBi | PA34676 |
VEuPathDBi | HostDB:ENSG00000265681.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3353, Eukaryota |
GeneTreei | ENSGT00950000183010 |
InParanoidi | P18621 |
OMAi | ANAEYKG |
PhylomeDBi | P18621 |
TreeFami | TF300042 |
Enzyme and pathway databases
PathwayCommonsi | P18621 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6139, 738 hits in 843 CRISPR screens |
ChiTaRSi | RPL17, human |
GeneWikii | RPL17 |
GenomeRNAii | 6139 |
Pharosi | P18621, Tbio |
PROi | PR:P18621 |
RNActi | P18621, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000265681, Expressed in left ovary and 111 other tissues |
ExpressionAtlasi | P18621, baseline and differential |
Genevisiblei | P18621, HS |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_A, Ribosomal_L22_A, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR005721, Ribosomal_L22/L17_euk/arc IPR036394, Ribosomal_L22/L17_sf |
PANTHERi | PTHR11593, PTHR11593, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01038, uL22_arch_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL17_HUMAN | |
Accessioni | P18621Primary (citable) accession number: P18621 Secondary accession number(s): B2R4H3 Q7M4M5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries