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UniProtKB - P18621 (RL17_HUMAN)

Entry version 213 (10 Feb 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

60S ribosomal protein L17

Gene

RPL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18621

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L17
Alternative name(s):
60S ribosomal protein L23
Large ribosomal subunit protein uL221 Publication
PD-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10307, RPL17

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603661, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18621

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000265681.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6139

Open Targets

More...OpenTargetsi		ENSG00000265681

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34676

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18621, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPL17

Domain mapping of disease mutations (DMDM)

More...DMDMi		132799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001253312 – 18460S ribosomal protein L17Add BLAST183

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P18621

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18621

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18621

MaxQB - The MaxQuant DataBase

More...MaxQBi		P18621

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18621

PeptideAtlas

More...PeptideAtlasi		P18621

PRoteomics IDEntifications database

More...PRIDEi		P18621

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53603 [P18621-1]
5890

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P18621-1 [P18621-1]
P18621-2 [P18621-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18621

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P18621

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18621

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P18621

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000265681, Expressed in left ovary and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18621, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18621, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000265681, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112059, 216 interactors
1529331, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5183, 60S cytosolic large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P18621

Protein interaction database and analysis system

More...IntActi		P18621, 61 interactors

Molecular INTeraction database

More...MINTi		P18621

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000397798

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18621, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18621

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uL22 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3353, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183010

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18621

Identification of Orthologs from Complete Genome Data

More...OMAi		ANAEYKG

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18621

TreeFam database of animal gene trees

More...TreeFami		TF300042

Family and domain databases

Conserved Domains Database

More...CDDi		cd00336, Ribosomal_L22, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.470.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01331_A, Ribosomal_L22_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001063, Ribosomal_L22
IPR018260, Ribosomal_L22/L17_CS
IPR005721, Ribosomal_L22/L17_euk/arc
IPR036394, Ribosomal_L22/L17_sf

The PANTHER Classification System

More...PANTHERi		PTHR11593, PTHR11593, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00237, Ribosomal_L22, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54843, SSF54843, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01038, uL22_arch_euk, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00464, RIBOSOMAL_L22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P18621-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD 
        60         70         80         90        100
VTLQKQCVPF RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES 
       110        120        130        140        150
NAELKGLDVD SLVIEHIQVN KAPKMRRRTY RAHGRINPYM SSPCHIEMIL 
       160        170        180 
TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL MARE
Length:184
Mass (Da):21,397
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FC595DD74ED1CA0
GO
Isoform 2 (identifier: P18621-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:146
Mass (Da):17,094
Checksum:iF29AFEFE03D5CA59
GO
Isoform 3 (identifier: P18621-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-184: ISQKKLKKQKLMARE → LRSSSLGKWCAFLVSSFQFCSGSTKNSWSHIYTLWFPPSLVVYGLRKQYKNPMIQTKAK

Show »
Length:228
Mass (Da):26,373
Checksum:iDF45454F21504C77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLC8J3QLC8_HUMAN
60S ribosomal protein L17
RPL17
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRX5J3KRX5_HUMAN
60S ribosomal protein L17
RPL17
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXM6A0A087WXM6_HUMAN
60S ribosomal protein L17
RPL17
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQT2J3QQT2_HUMAN
60S ribosomal protein L17
RPL17
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS96J3QS96_HUMAN
60S ribosomal protein L17
RPL17
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWH0A0A087WWH0_HUMAN
60S ribosomal protein L17
RPL17
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRB3J3KRB3_HUMAN
60S ribosomal protein L17
RPL17
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY81A0A087WY81_HUMAN
60S ribosomal protein L17
RPL17
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSJ0J3KSJ0_HUMAN
60S ribosomal protein L17
RPL17
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133H → R in AAH66324 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454451 – 38Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_046965170 – 184ISQKK…LMARE → LRSSSLGKWCAFLVSSFQFC SGSTKNSWSHIYTLWFPPSL VVYGLRKQYKNPMIQTKAK in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X53777 mRNA Translation: CAA37793.1
AB061824 Genomic DNA Translation: BAB79462.1
AC100778 Genomic DNA No translation available.
AK304659 mRNA Translation: BAG65434.1
AK311828 mRNA Translation: BAG34770.1
BX393840 mRNA No translation available.
CH471096 Genomic DNA Translation: EAW62940.1
BC000502 mRNA Translation: AAH00502.1
BC017831 mRNA Translation: AAH17831.1
BC066323 mRNA Translation: AAH66323.1
BC066324 mRNA Translation: AAH66324.1
BC106031 mRNA Translation: AAI06032.1
AB007174 Genomic DNA Translation: BAA25834.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45865.1 [P18621-1]
CCDS56070.1 [P18621-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A61192
S11218, R5HU22

NCBI Reference Sequences

More...RefSeqi		NP_000976.1, NM_000985.4 [P18621-1]
NP_001030178.1, NM_001035006.2 [P18621-1]
NP_001186269.1, NM_001199340.1 [P18621-1]
NP_001186270.1, NM_001199341.1 [P18621-1]
NP_001186271.1, NM_001199342.1 [P18621-1]
NP_001186272.1, NM_001199343.1 [P18621-1]
NP_001186273.1, NM_001199344.1 [P18621-1]
NP_001186274.1, NM_001199345.1 [P18621-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000579248; ENSP00000462023; ENSG00000265681 [P18621-1]
ENST00000579408; ENSP00000463842; ENSG00000265681 [P18621-1]
ENST00000580261; ENSP00000462385; ENSG00000265681 [P18621-1]
ENST00000581373; ENSP00000462944; ENSG00000265681 [P18621-2]
ENST00000618613; ENSP00000480555; ENSG00000265681 [P18621-1]
ENST00000618619; ENSP00000482577; ENSG00000265681 [P18621-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6139

UCSC genome browser

More...UCSCi		uc002ldp.4, human [P18621-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53777 mRNA Translation: CAA37793.1
AB061824 Genomic DNA Translation: BAB79462.1
AC100778 Genomic DNA No translation available.
AK304659 mRNA Translation: BAG65434.1
AK311828 mRNA Translation: BAG34770.1
BX393840 mRNA No translation available.
CH471096 Genomic DNA Translation: EAW62940.1
BC000502 mRNA Translation: AAH00502.1
BC017831 mRNA Translation: AAH17831.1
BC066323 mRNA Translation: AAH66323.1
BC066324 mRNA Translation: AAH66324.1
BC106031 mRNA Translation: AAI06032.1
AB007174 Genomic DNA Translation: BAA25834.1
CCDSiCCDS45865.1 [P18621-1]
CCDS56070.1 [P18621-2]
PIRiA61192
S11218, R5HU22
RefSeqiNP_000976.1, NM_000985.4 [P18621-1]
NP_001030178.1, NM_001035006.2 [P18621-1]
NP_001186269.1, NM_001199340.1 [P18621-1]
NP_001186270.1, NM_001199341.1 [P18621-1]
NP_001186271.1, NM_001199342.1 [P18621-1]
NP_001186272.1, NM_001199343.1 [P18621-1]
NP_001186273.1, NM_001199344.1 [P18621-1]
NP_001186274.1, NM_001199345.1 [P18621-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LP1-184[»]
4V6Xelectron microscopy5.00CP1-184[»]
5A8Lelectron microscopy3.80D1-184[»]
5AJ0electron microscopy3.50AP1-184[»]
5LKSelectron microscopy3.60LP1-184[»]
5T2Celectron microscopy3.60J1-160[»]
6EK0electron microscopy2.90LP1-184[»]
6IP5electron microscopy3.902J1-184[»]
6IP6electron microscopy4.502J1-184[»]
6IP8electron microscopy3.902J1-184[»]
6LQMelectron microscopy3.09Y1-184[»]
6LSRelectron microscopy3.13Y1-184[»]
6LSSelectron microscopy3.23Y1-184[»]
6LU8electron microscopy3.13Y1-184[»]
6OLEelectron microscopy3.10Q2-154[»]
6OLFelectron microscopy3.90Q2-154[»]
6OLGelectron microscopy3.40AP2-154[»]
6OLIelectron microscopy3.50Q2-154[»]
6OLZelectron microscopy3.90AP2-154[»]
6OM0electron microscopy3.10Q2-154[»]
6OM7electron microscopy3.70Q2-154[»]
6QZPelectron microscopy2.90LP2-154[»]
6W6Lelectron microscopy3.84Q1-184[»]
6XA1electron microscopy2.80LP2-154[»]
6Y0Gelectron microscopy3.20LP1-184[»]
6Y2Lelectron microscopy3.00LP1-184[»]
6Y57electron microscopy3.50LP1-184[»]
6Y6Xelectron microscopy2.80LP2-154[»]
6Z6Lelectron microscopy3.00LP1-184[»]
6Z6Melectron microscopy3.10LP1-184[»]
6Z6Nelectron microscopy2.90LP1-184[»]
6ZM7electron microscopy2.70LP1-184[»]
6ZMEelectron microscopy3.00LP1-184[»]
6ZMIelectron microscopy2.60LP1-184[»]
6ZMOelectron microscopy3.10LP1-184[»]
SMRiP18621
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112059, 216 interactors
1529331, 2 interactors
ComplexPortaliCPX-5183, 60S cytosolic large ribosomal subunit
CORUMiP18621
IntActiP18621, 61 interactors
MINTiP18621
STRINGi9606.ENSP00000397798

PTM databases

iPTMnetiP18621
MetOSiteiP18621
PhosphoSitePlusiP18621
SwissPalmiP18621

Genetic variation databases

BioMutaiRPL17
DMDMi132799

Proteomic databases

EPDiP18621
jPOSTiP18621
MassIVEiP18621
MaxQBiP18621
PaxDbiP18621
PeptideAtlasiP18621
PRIDEiP18621
ProteomicsDBi53603 [P18621-1]
5890
TopDownProteomicsiP18621-1 [P18621-1]
P18621-2 [P18621-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65728, 299 antibodies

The DNASU plasmid repository

More...DNASUi		6139

Genome annotation databases

EnsembliENST00000579248; ENSP00000462023; ENSG00000265681 [P18621-1]
ENST00000579408; ENSP00000463842; ENSG00000265681 [P18621-1]
ENST00000580261; ENSP00000462385; ENSG00000265681 [P18621-1]
ENST00000581373; ENSP00000462944; ENSG00000265681 [P18621-2]
ENST00000618613; ENSP00000480555; ENSG00000265681 [P18621-1]
ENST00000618619; ENSP00000482577; ENSG00000265681 [P18621-1]
GeneIDi6139
KEGGihsa:6139
UCSCiuc002ldp.4, human [P18621-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6139
DisGeNETi6139

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPL17
HGNCiHGNC:10307, RPL17
HPAiENSG00000265681, Low tissue specificity
MIMi603661, gene
neXtProtiNX_P18621
OpenTargetsiENSG00000265681
PharmGKBiPA34676
VEuPathDBiHostDB:ENSG00000265681.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3353, Eukaryota
GeneTreeiENSGT00950000183010
InParanoidiP18621
OMAiANAEYKG
PhylomeDBiP18621
TreeFamiTF300042

Enzyme and pathway databases

PathwayCommonsiP18621
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6139, 738 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPL17, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPL17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6139
PharosiP18621, Tbio

Protein Ontology

More...PROi		PR:P18621
RNActiP18621, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000265681, Expressed in left ovary and 111 other tissues
ExpressionAtlasiP18621, baseline and differential
GenevisibleiP18621, HS

Family and domain databases

CDDicd00336, Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
HAMAPiMF_01331_A, Ribosomal_L22_A, 1 hit
InterProiView protein in InterPro
IPR001063, Ribosomal_L22
IPR018260, Ribosomal_L22/L17_CS
IPR005721, Ribosomal_L22/L17_euk/arc
IPR036394, Ribosomal_L22/L17_sf
PANTHERiPTHR11593, PTHR11593, 1 hit
PfamiView protein in Pfam
PF00237, Ribosomal_L22, 1 hit
SUPFAMiSSF54843, SSF54843, 1 hit
TIGRFAMsiTIGR01038, uL22_arch_euk, 1 hit
PROSITEiView protein in PROSITE
PS00464, RIBOSOMAL_L22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18621
Secondary accession number(s): B2R4H3
, B4E3C2, B5ME31, J3QL51, Q3KQW2, Q6NZ54, Q7M4M5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 213 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
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