Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 204 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

60S ribosomal protein L17

Gene

RPL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L17
Alternative name(s):
60S ribosomal protein L23
Large ribosomal subunit protein uL221 Publication
PD-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10307 RPL17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603661 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18621

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6139

Open Targets

More...
OpenTargetsi
ENSG00000265681

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34676

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P18621

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPL17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
132799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001253312 – 18460S ribosomal protein L17Add BLAST183

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P18621

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18621

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P18621

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P18621

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18621

PeptideAtlas

More...
PeptideAtlasi
P18621

PRoteomics IDEntifications database

More...
PRIDEi
P18621

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53603 [P18621-1]
5890

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P18621-1 [P18621-1]
P18621-2 [P18621-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18621

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18621

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P18621

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000265681 Expressed in 86 organ(s), highest expression level in left ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18621 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18621 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043724
HPA046385

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112059, 186 interactors
1529331, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P18621

Protein interaction database and analysis system

More...
IntActi
P18621, 57 interactors

Molecular INTeraction database

More...
MINTi
P18621

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397798

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18621

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3353 Eukaryota
COG0091 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000205045

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18621

KEGG Orthology (KO)

More...
KOi
K02880

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANAEYKG

Database of Orthologous Groups

More...
OrthoDBi
1362349at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18621

TreeFam database of animal gene trees

More...
TreeFami
TF300042

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00336 Ribosomal_L22, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.470.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01331_A Ribosomal_L22_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001063 Ribosomal_L22
IPR018260 Ribosomal_L22/L17_CS
IPR005721 Ribosomal_L22/L17_euk/arc
IPR036394 Ribosomal_L22/L17_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11593 PTHR11593, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00237 Ribosomal_L22, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54843 SSF54843, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01038 uL22_arch_euk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00464 RIBOSOMAL_L22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P18621-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD
60 70 80 90 100
VTLQKQCVPF RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES
110 120 130 140 150
NAELKGLDVD SLVIEHIQVN KAPKMRRRTY RAHGRINPYM SSPCHIEMIL
160 170 180
TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL MARE
Length:184
Mass (Da):21,397
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FC595DD74ED1CA0
GO
Isoform 2 (identifier: P18621-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:146
Mass (Da):17,094
Checksum:iF29AFEFE03D5CA59
GO
Isoform 3 (identifier: P18621-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-184: ISQKKLKKQKLMARE → LRSSSLGKWCAFLVSSFQFCSGSTKNSWSHIYTLWFPPSLVVYGLRKQYKNPMIQTKAK

Show »
Length:228
Mass (Da):26,373
Checksum:iDF45454F21504C77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLC8J3QLC8_HUMAN
60S ribosomal protein L17
RPL17
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRX5J3KRX5_HUMAN
60S ribosomal protein L17
RPL17
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQT2J3QQT2_HUMAN
60S ribosomal protein L17
RPL17
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXM6A0A087WXM6_HUMAN
60S ribosomal protein L17
RPL17
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS96J3QS96_HUMAN
60S ribosomal protein L17
RPL17
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRB3J3KRB3_HUMAN
60S ribosomal protein L17
RPL17
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWH0A0A087WWH0_HUMAN
60S ribosomal protein L17
RPL17
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSJ0J3KSJ0_HUMAN
60S ribosomal protein L17
RPL17
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY81A0A087WY81_HUMAN
60S ribosomal protein L17
RPL17
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133H → R in AAH66324 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454451 – 38Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_046965170 – 184ISQKK…LMARE → LRSSSLGKWCAFLVSSFQFC SGSTKNSWSHIYTLWFPPSL VVYGLRKQYKNPMIQTKAK in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53777 mRNA Translation: CAA37793.1
AB061824 Genomic DNA Translation: BAB79462.1
AC100778 Genomic DNA No translation available.
AK304659 mRNA Translation: BAG65434.1
AK311828 mRNA Translation: BAG34770.1
BX393840 mRNA No translation available.
CH471096 Genomic DNA Translation: EAW62940.1
BC000502 mRNA Translation: AAH00502.1
BC017831 mRNA Translation: AAH17831.1
BC066323 mRNA Translation: AAH66323.1
BC066324 mRNA Translation: AAH66324.1
BC106031 mRNA Translation: AAI06032.1
AB007174 Genomic DNA Translation: BAA25834.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45865.1 [P18621-1]
CCDS56070.1 [P18621-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A61192
S11218 R5HU22

NCBI Reference Sequences

More...
RefSeqi
NP_000976.1, NM_000985.4 [P18621-1]
NP_001030178.1, NM_001035006.2 [P18621-1]
NP_001186269.1, NM_001199340.1 [P18621-1]
NP_001186270.1, NM_001199341.1 [P18621-1]
NP_001186271.1, NM_001199342.1 [P18621-1]
NP_001186272.1, NM_001199343.1 [P18621-1]
NP_001186273.1, NM_001199344.1 [P18621-1]
NP_001186274.1, NM_001199345.1 [P18621-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000579248; ENSP00000462023; ENSG00000265681 [P18621-1]
ENST00000579408; ENSP00000463842; ENSG00000265681 [P18621-1]
ENST00000580261; ENSP00000462385; ENSG00000265681 [P18621-1]
ENST00000581373; ENSP00000462944; ENSG00000265681 [P18621-2]
ENST00000618613; ENSP00000480555; ENSG00000265681 [P18621-1]
ENST00000618619; ENSP00000482577; ENSG00000265681 [P18621-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6139

UCSC genome browser

More...
UCSCi
uc002ldp.4 human [P18621-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53777 mRNA Translation: CAA37793.1
AB061824 Genomic DNA Translation: BAB79462.1
AC100778 Genomic DNA No translation available.
AK304659 mRNA Translation: BAG65434.1
AK311828 mRNA Translation: BAG34770.1
BX393840 mRNA No translation available.
CH471096 Genomic DNA Translation: EAW62940.1
BC000502 mRNA Translation: AAH00502.1
BC017831 mRNA Translation: AAH17831.1
BC066323 mRNA Translation: AAH66323.1
BC066324 mRNA Translation: AAH66324.1
BC106031 mRNA Translation: AAI06032.1
AB007174 Genomic DNA Translation: BAA25834.1
CCDSiCCDS45865.1 [P18621-1]
CCDS56070.1 [P18621-2]
PIRiA61192
S11218 R5HU22
RefSeqiNP_000976.1, NM_000985.4 [P18621-1]
NP_001030178.1, NM_001035006.2 [P18621-1]
NP_001186269.1, NM_001199340.1 [P18621-1]
NP_001186270.1, NM_001199341.1 [P18621-1]
NP_001186271.1, NM_001199342.1 [P18621-1]
NP_001186272.1, NM_001199343.1 [P18621-1]
NP_001186273.1, NM_001199344.1 [P18621-1]
NP_001186274.1, NM_001199345.1 [P18621-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LP1-184[»]
4V6Xelectron microscopy5.00CP1-184[»]
5A8Lelectron microscopy3.80D1-184[»]
5AJ0electron microscopy3.50AP1-184[»]
5LKSelectron microscopy3.60LP1-184[»]
5T2Celectron microscopy3.60J1-160[»]
6EK0electron microscopy2.90LP1-184[»]
6IP5electron microscopy3.902J1-184[»]
6IP6electron microscopy4.502J1-184[»]
6IP8electron microscopy3.902J1-184[»]
6OLEelectron microscopy3.10Q2-154[»]
6OLFelectron microscopy3.90Q2-154[»]
6OLGelectron microscopy3.40AP2-154[»]
6OLIelectron microscopy3.50Q2-154[»]
6OLZelectron microscopy3.90AP2-154[»]
6OM0electron microscopy3.10Q2-154[»]
6OM7electron microscopy3.70Q2-154[»]
6QZPelectron microscopy2.90LP2-154[»]
SMRiP18621
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112059, 186 interactors
1529331, 1 interactor
CORUMiP18621
IntActiP18621, 57 interactors
MINTiP18621
STRINGi9606.ENSP00000397798

PTM databases

iPTMnetiP18621
PhosphoSitePlusiP18621
SwissPalmiP18621

Polymorphism and mutation databases

BioMutaiRPL17
DMDMi132799

Proteomic databases

EPDiP18621
jPOSTiP18621
MassIVEiP18621
MaxQBiP18621
PaxDbiP18621
PeptideAtlasiP18621
PRIDEiP18621
ProteomicsDBi53603 [P18621-1]
5890
TopDownProteomicsiP18621-1 [P18621-1]
P18621-2 [P18621-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6139

Genome annotation databases

EnsembliENST00000579248; ENSP00000462023; ENSG00000265681 [P18621-1]
ENST00000579408; ENSP00000463842; ENSG00000265681 [P18621-1]
ENST00000580261; ENSP00000462385; ENSG00000265681 [P18621-1]
ENST00000581373; ENSP00000462944; ENSG00000265681 [P18621-2]
ENST00000618613; ENSP00000480555; ENSG00000265681 [P18621-1]
ENST00000618619; ENSP00000482577; ENSG00000265681 [P18621-1]
GeneIDi6139
KEGGihsa:6139
UCSCiuc002ldp.4 human [P18621-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6139
DisGeNETi6139

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPL17
HGNCiHGNC:10307 RPL17
HPAiHPA043724
HPA046385
MIMi603661 gene
neXtProtiNX_P18621
OpenTargetsiENSG00000265681
PharmGKBiPA34676

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3353 Eukaryota
COG0091 LUCA
GeneTreeiENSGT00950000183010
HOGENOMiHOG000205045
InParanoidiP18621
KOiK02880
OMAiANAEYKG
OrthoDBi1362349at2759
PhylomeDBiP18621
TreeFamiTF300042

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RPL17 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RPL17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6139
PharosiP18621

Protein Ontology

More...
PROi
PR:P18621

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000265681 Expressed in 86 organ(s), highest expression level in left ovary
ExpressionAtlasiP18621 baseline and differential
GenevisibleiP18621 HS

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
HAMAPiMF_01331_A Ribosomal_L22_A, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR018260 Ribosomal_L22/L17_CS
IPR005721 Ribosomal_L22/L17_euk/arc
IPR036394 Ribosomal_L22/L17_sf
PANTHERiPTHR11593 PTHR11593, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
TIGRFAMsiTIGR01038 uL22_arch_euk, 1 hit
PROSITEiView protein in PROSITE
PS00464 RIBOSOMAL_L22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18621
Secondary accession number(s): B2R4H3
, B4E3C2, B5ME31, J3QL51, Q3KQW2, Q6NZ54, Q7M4M5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again