UniProtKB - P18608 (HMGN1_MOUSE)
Protein
Non-histone chromosomal protein HMG-14
Gene
Hmgn1
Organism
Mus musculus (Mouse)
Status
Functioni
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.1 Publication
GO - Molecular functioni
- chromatin binding Source: MGI
- nucleosomal DNA binding Source: InterPro
GO - Biological processi
- chromatin organization Source: MGI
- positive regulation of NAD+ ADP-ribosyltransferase activity Source: MGI
- post-embryonic camera-type eye morphogenesis Source: MGI
- pyrimidine dimer repair by nucleotide-excision repair Source: MGI
- regulation of development, heterochronic Source: MGI
- regulation of epithelial cell proliferation Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- response to UV-B Source: MGI
- response to UV-C Source: MGI
- transcription-coupled nucleotide-excision repair Source: MGI
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-6782135, Dual incision in TC-NER R-MMU-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER |
Names & Taxonomyi
Protein namesi | Recommended name: Non-histone chromosomal protein HMG-14Alternative name(s): High mobility group nucleosome-binding domain-containing protein 1 |
Gene namesi | Name:Hmgn1 Synonyms:Hmg-14, Hmg14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96120, Hmgn1 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000206692 | 2 – 96 | Non-histone chromosomal protein HMG-14Add BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | Phosphoserine; by RPS6KA52 Publications | 1 | |
Modified residuei | 13 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 20 | Phosphoserine; by RPS6KA51 Publication | 1 | |
Modified residuei | 24 | ADP-ribosylserine; alternateBy similarity | 1 | |
Modified residuei | 24 | Phosphoserine; alternate; by RPS6KA51 Publication | 1 | |
Modified residuei | 26 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 80 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 84 | PhosphoserineCombined sources | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation favors cytoplasmic localization (By similarity). Phosphorylation on Ser-20 and Ser-24 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.By similarity2 Publications
Keywords - PTMi
Acetylation, ADP-ribosylation, PhosphoproteinProteomic databases
EPDi | P18608 |
jPOSTi | P18608 |
MaxQBi | P18608 |
PaxDbi | P18608 |
PeptideAtlasi | P18608 |
PRIDEi | P18608 |
ProteomicsDBi | 273367 |
TopDownProteomicsi | P18608 |
PTM databases
iPTMneti | P18608 |
PhosphoSitePlusi | P18608 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040681, Expressed in retinal neural layer and 154 other tissues |
ExpressionAtlasi | P18608, baseline and differential |
Genevisiblei | P18608, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 200332, 2 interactors |
STRINGi | 10090.ENSMUSP00000061012 |
Miscellaneous databases
RNActi | P18608, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the HMGN family.Curated
Phylogenomic databases
eggNOGi | ENOG502S7UM, Eukaryota |
GeneTreei | ENSGT00950000182802 |
HOGENOMi | CLU_141985_1_0_1 |
InParanoidi | P18608 |
OMAi | XEAPEEP |
OrthoDBi | 1636546at2759 |
PhylomeDBi | P18608 |
Family and domain databases
InterProi | View protein in InterPro IPR000079, HMGN_fam |
Pfami | View protein in Pfam PF01101, HMG14_17, 1 hit |
PRINTSi | PR00925, NONHISHMG17 |
SMARTi | View protein in SMART SM00527, HMG17, 1 hit |
PROSITEi | View protein in PROSITE PS00355, HMG14_17, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P18608-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKRKVSADG AAKAEPKRRS ARLSAKPAPA KVDAKPKKAA GKDKASDKKV
60 70 80 90
QIKGKRGAKG KQADVADQQT TELPAENGET ENQSPASEEE KEAKSD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2W3M7 | A0A3B2W3M7_MOUSE | Non-histone chromosomal protein HMG... | Hmgn1 | 86 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53476 mRNA Translation: CAA37569.1 BC083138 mRNA Translation: AAH83138.1 BC088834 mRNA Translation: AAH88834.1 |
CCDSi | CCDS28353.1 |
PIRi | S11219 |
RefSeqi | NP_032277.3, NM_008251.3 |
Genome annotation databases
Ensembli | ENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681 |
GeneIDi | 15312 |
KEGGi | mmu:15312 |
UCSCi | uc008aco.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53476 mRNA Translation: CAA37569.1 BC083138 mRNA Translation: AAH83138.1 BC088834 mRNA Translation: AAH88834.1 |
CCDSi | CCDS28353.1 |
PIRi | S11219 |
RefSeqi | NP_032277.3, NM_008251.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 200332, 2 interactors |
STRINGi | 10090.ENSMUSP00000061012 |
PTM databases
iPTMneti | P18608 |
PhosphoSitePlusi | P18608 |
Proteomic databases
EPDi | P18608 |
jPOSTi | P18608 |
MaxQBi | P18608 |
PaxDbi | P18608 |
PeptideAtlasi | P18608 |
PRIDEi | P18608 |
ProteomicsDBi | 273367 |
TopDownProteomicsi | P18608 |
Protocols and materials databases
Antibodypediai | 23386, 389 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050884; ENSMUSP00000061012; ENSMUSG00000040681 |
GeneIDi | 15312 |
KEGGi | mmu:15312 |
UCSCi | uc008aco.1, mouse |
Organism-specific databases
CTDi | 3150 |
MGIi | MGI:96120, Hmgn1 |
Phylogenomic databases
eggNOGi | ENOG502S7UM, Eukaryota |
GeneTreei | ENSGT00950000182802 |
HOGENOMi | CLU_141985_1_0_1 |
InParanoidi | P18608 |
OMAi | XEAPEEP |
OrthoDBi | 1636546at2759 |
PhylomeDBi | P18608 |
Enzyme and pathway databases
Reactomei | R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-6782135, Dual incision in TC-NER R-MMU-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER |
Miscellaneous databases
BioGRID-ORCSi | 15312, 3 hits in 53 CRISPR screens |
ChiTaRSi | Hmgn1, mouse |
PROi | PR:P18608 |
RNActi | P18608, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040681, Expressed in retinal neural layer and 154 other tissues |
ExpressionAtlasi | P18608, baseline and differential |
Genevisiblei | P18608, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000079, HMGN_fam |
Pfami | View protein in Pfam PF01101, HMG14_17, 1 hit |
PRINTSi | PR00925, NONHISHMG17 |
SMARTi | View protein in SMART SM00527, HMG17, 1 hit |
PROSITEi | View protein in PROSITE PS00355, HMG14_17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMGN1_MOUSE | |
Accessioni | P18608Primary (citable) accession number: P18608 Secondary accession number(s): Q5HZY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families