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Protein

Interferon-induced GTP-binding protein Mx1

Gene

Mx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTPSequence analysis8
Nucleotide bindingi169 – 173GTPSequence analysis5
Nucleotide bindingi238 – 241GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Myxoma resistance protein 1
Myxovirus resistance protein 1
Gene namesi
Name:Mx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3127 Mx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065951 – 652Interferon-induced GTP-binding protein Mx1Add BLAST652

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP18588
PRIDEiP18588

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043001

Structurei

3D structure databases

ProteinModelPortaliP18588
SMRiP18588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 331Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini564 – 652GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 75G1 motifPROSITE-ProRule annotation8
Regioni93 – 95G2 motifPROSITE-ProRule annotation3
Regioni169 – 172G3 motifPROSITE-ProRule annotation4
Regioni238 – 241G4 motifPROSITE-ProRule annotation4
Regioni270 – 273G5 motifPROSITE-ProRule annotation4
Regioni332 – 357Bundle signaling element (BSE)By similarityAdd BLAST26
Regioni357 – 526Middle domainBy similarityAdd BLAST170
Regioni358 – 622StalkBy similarityAdd BLAST265

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiP18588
PhylomeDBiP18588

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P18588-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKERTSACRH GTPQKHPDTS EESQAMESVD NLCSQYEEKV RPCIDLIDSL
60 70 80 90 100
RALGVEQDLA LPAIAVIGDQ SSGKSSVLEA LSGVALPRGS GIVTRCPLVL
110 120 130 140 150
KLKQLKQGEK WSGKVIYKDT EIEISHPSLV EREINKAQNL IAGEGLKISS
160 170 180 190 200
DLISLEVSSP HVPDLTLIDL PGITRVAVGD QPADIEHKIK RLITEYIQKQ
210 220 230 240 250
ETINLVVVPS NVDIATTEAL KMAQEVDPQG DRTIGILTKP DLVDRGTEDK
260 270 280 290 300
VVDVVRNLVC HLKKGYMIVK CRGQQDIQEQ LSLAEALQKE QVFFKEHPQF
310 320 330 340 350
RVLLEDGKAT VPCLAKRLTM ELTSHICKSL PILENQINVN HQIASEELQK
360 370 380 390 400
YGADIPEDDS KRLSFLMNKI NVFNKDILSL VQAQENISWE ESRLFTKLRN
410 420 430 440 450
EFLAWNDYIE EHFKKTLGSS EKHSQMEKFE SHYRGRELPG FVDYKAFENI
460 470 480 490 500
IKKEVKALEE PALNMLHRVT TMVKNAFTKV SSNNFGDFLN LHSTAKSKIE
510 520 530 540 550
DIRFNQEKEA EKLIRLHFQM EHIVYCQDQA YKKALQEIRE KEAEKEKSTF
560 570 580 590 600
GAFQHNSPRK ELTTTEMTQH LNAYYQECGR NIGRQIPLII QYSILQTFGQ
610 620 630 640 650
EMEKAMLQLL QDTSKCNWFL TEQSDSREKK KFLKRRLLRL DEAQRKLAKF

SN
Length:652
Mass (Da):74,469
Last modified:November 1, 1990 - v1
Checksum:i603468914B0C6F6F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q499S4Q499S4_RAT
Interferon-induced GTP-binding prot...
Mx1 rCG_52734
652Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52711 mRNA Translation: CAA36935.1
PIRiS11735
UniGeneiRn.10373

Genome annotation databases

UCSCiRGD:3127 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52711 mRNA Translation: CAA36935.1
PIRiS11735
UniGeneiRn.10373

3D structure databases

ProteinModelPortaliP18588
SMRiP18588
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043001

Proteomic databases

PaxDbiP18588
PRIDEiP18588

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3127 rat

Organism-specific databases

RGDi3127 Mx1

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiP18588
PhylomeDBiP18588

Miscellaneous databases

PROiPR:P18588

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMX1_RAT
AccessioniPrimary (citable) accession number: P18588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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