SON

Functionⁱ

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680).3 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, RNA-binding
Biological process	Cell cycle, mRNA processing, mRNA splicing

Enzyme and pathway databases

SIGNORⁱ	P18583

SIGNORⁱ

P18583

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SON Alternative name(s): Bax antagonist selected in saccharomyces 1 Short name: BASS1 Negative regulatory element-binding protein Short name: NRE-binding protein Protein DBP-5 SON3
Gene namesⁱ	Name:SON Synonyms:C21orf50, DBP5, KIAA1019, NREBP ORF Names:HSPC310, HSPC312
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11183 SON
MIMⁱ	182465 gene
neXtProtⁱ	NX_P18583

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

ZTTK syndrome (ZTTKS)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant syndrome characterized by intellectual disability, developmental delay, malformations of the cerebral cortex, epilepsy, vision problems, musculo-skeletal abnormalities, and congenital malformations.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077864	1637	T → S in ZTTKS; unknown pathological significance; de novo mutation associated in cis with Y-1843. 1 Publication		1
Natural variantⁱVAR_077865	1843	S → Y in ZTTKS; unknown pathological significance; de novo mutation associated in cis with S-1637. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6651
MalaCards human disease database More...MalaCardsⁱ	SON
MIMⁱ	617140 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000159140
Orphanetⁱ	500150 Brain malformations-musculoskeletal abnormalities-facial dysmorphism-intellectual disability syndrome
PharmGKBⁱ	PA36020

Polymorphism and mutation databases

BioMutaⁱ	SON
DMDMⁱ	296453022

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000072037	2 – 2426	Protein SONAdd BLAST		2425

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	16	N6-acetyllysineCombined sources	1
Cross-linkⁱ	64	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	94	PhosphoserineCombined sources	1
Modified residueⁱ	142	PhosphoserineCombined sources	1
Modified residueⁱ	152	PhosphoserineCombined sources	1
Modified residueⁱ	154	PhosphoserineCombined sources	1
Modified residueⁱ	160	PhosphoserineCombined sources	1
Modified residueⁱ	283	PhosphoserineCombined sources	1
Modified residueⁱ	288	N6-acetyllysineCombined sources	1
Modified residueⁱ	400	PhosphothreonineCombined sources	1
Modified residueⁱ	950	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	959	PhosphothreonineCombined sources	1
Modified residueⁱ	998	PhosphoserineCombined sources	1
Modified residueⁱ	1007	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1022	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1035	PhosphoserineCombined sources	1
Modified residueⁱ	1043	PhosphoserineCombined sources	1
Modified residueⁱ	1060	PhosphoserineCombined sources	1
Modified residueⁱ	1068	PhosphoserineCombined sources	1
Modified residueⁱ	1082	PhosphoserineCombined sources	1
Modified residueⁱ	1556	PhosphoserineCombined sources	1
Modified residueⁱ	1651	PhosphoserineCombined sources	1
Modified residueⁱ	1697	PhosphoserineCombined sources	1
Modified residueⁱ	1701	PhosphoserineCombined sources	1
Modified residueⁱ	1747	PhosphoserineCombined sources	1
Modified residueⁱ	1759	PhosphoserineCombined sources	1
Modified residueⁱ	1766	PhosphoserineCombined sources	1
Modified residueⁱ	1769	PhosphoserineCombined sources	1
Modified residueⁱ	1782	PhosphoserineCombined sources	1
Modified residueⁱ	1783	PhosphoserineCombined sources	1
Modified residueⁱ	1948	PhosphoserineCombined sources	1
Modified residueⁱ	1950	PhosphoserineCombined sources	1
Modified residueⁱ	1952	PhosphoserineCombined sources	1
Modified residueⁱ	2009	PhosphoserineCombined sources	1
Modified residueⁱ	2011	PhosphoserineCombined sources	1
Modified residueⁱ	2013	PhosphoserineCombined sources	1
Modified residueⁱ	2029	PhosphoserineCombined sources	1
Modified residueⁱ	2031	PhosphoserineCombined sources	1
Modified residueⁱ	2055	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	2055	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	2092	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	2129	PhosphoserineCombined sources	1
Cross-linkⁱ	2149	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	2163	PhosphothreonineCombined sources	1
Modified residueⁱ	2238	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P18583
jPOSTⁱ	P18583
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P18583
PaxDbⁱ	P18583
PeptideAtlas More...PeptideAtlasⁱ	P18583
PRIDEⁱ	P18583
ProteomicsDBⁱ	53592 [P18583-1] 53593 [P18583-10] 53594 [P18583-2] 53595 [P18583-3] 53596 [P18583-4] 53597 [P18583-5] 53598 [P18583-6] 53599 [P18583-7] 53600 [P18583-8] 53601 [P18583-9]

PTM databases

iPTMnetⁱ	P18583
PhosphoSitePlusⁱ	P18583
SwissPalmⁱ	P18583

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with the higher expression seen in leukocyte and heart.

Gene expression databases

Bgeeⁱ	ENSG00000159140 Expressed in 244 organ(s), highest expression level in metanephros
ExpressionAtlasⁱ	P18583 baseline and differential
Genevisibleⁱ	P18583 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023535 HPA031755 HPA031756

HPAⁱ

HPA023535
HPA031755
HPA031756

Interactionⁱ

Subunit structureⁱ

Interacts with SRSF2. Associates with the spliceosome.

Interacts with the AML1-MTG8 (AML1-ETO) fusion protein, possibly leading to trigger signals inhibiting leukemogenesis.

3 Publications

GO - Molecular functionⁱ

RS domain binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112534, 85 interactors
Database of interacting proteins More...DIPⁱ	DIP-42289N
IntActⁱ	P18583, 38 interactors
Molecular INTeraction database More...MINTⁱ	P18583
STRINGⁱ	9606.ENSP00000348984

Structureⁱ

3D structure databases

SMRⁱ	P18583
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	1006 – 1011	1-1	6
Repeatⁱ	1014 – 1019	1-2	6
Repeatⁱ	1021 – 1026	1-3	6
Repeatⁱ	1030 – 1035	1-4	6
Repeatⁱ	1038 – 1043	1-5	6
Repeatⁱ	1046 – 1051	1-6	6
Repeatⁱ	1055 – 1060	1-7	6
Repeatⁱ	1063 – 1068	1-8	6
Repeatⁱ	1071 – 1076	1-9	6
Repeatⁱ	1080 – 1085	1-10	6
Repeatⁱ	1089 – 1094	1-11	6
Repeatⁱ	1100 – 1105	1-12	6
Repeatⁱ	1111 – 1116	1-13	6
Repeatⁱ	1121 – 1126	1-14	6
Repeatⁱ	1925 – 1931	2-1	7
Repeatⁱ	1934 – 1952	3-1Add BLAST	19
Repeatⁱ	1953 – 1959	2-2	7
Repeatⁱ	1960 – 1966	2-3	7
Repeatⁱ	1967 – 1973	2-4	7
Repeatⁱ	1974 – 1980	2-5	7
Repeatⁱ	1981 – 1987	2-6	7
Repeatⁱ	1988 – 1994	2-7	7
Repeatⁱ	1995 – 2013	3-2Add BLAST	19
Domainⁱ	2305 – 2351	G-patchPROSITE-ProRule annotationAdd BLAST	47
Domainⁱ	2371 – 2426	DRBMPROSITE-ProRule annotationAdd BLAST	56

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	726 – 895	17 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQMAdd BLAST	170
Regionⁱ	912 – 988	11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]Add BLAST	77
Regionⁱ	1006 – 1126	14 X 6 AA repeats of [ED]-R-S-M-M-SAdd BLAST	121
Regionⁱ	1147 – 1179	3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]Add BLAST	33
Regionⁱ	1359 – 1390	4 X 8 AA tandem repeats of V-L-E-SS-[AVT]-VTAdd BLAST	32
Regionⁱ	1925 – 1994	7 X 7 AA repeats of P-S-R-R-S-R-[TS]Add BLAST	70
Regionⁱ	1934 – 2013	2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-SAdd BLAST	80
Regionⁱ	2013 – 2039	3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-RAdd BLAST	27

Domainⁱ

Contains 8 types of repeats which are distributed in 3 regions.

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IEDZ Eukaryota ENOG410ZUK5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111141
InParanoidⁱ	P18583
OMAⁱ	LTPNCMF
Database of Orthologous Groups More...OrthoDBⁱ	30934at2759
PhylomeDBⁱ	P18583
TreeFamⁱ	TF330344

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00048 DSRM, 1 hit
InterProⁱ	View protein in InterPro IPR014720 dsRBD_dom IPR000467 G_patch_dom IPR032922 SON IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR46528 PTHR46528, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01585 G-patch, 1 hit
SMARTⁱ	View protein in SMART SM00443 G_patch, 1 hit
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50137 DS_RBD, 1 hit PS50174 G_PATCH, 1 hit

Sequences (10+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 10 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform F (identifier: P18583-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST 
       860        870        880        890        900
MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
       910        920        930        940        950
QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR 
       960        970        980        990       1000
LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 
      1010       1020       1030       1040       1050
MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM 
      1060       1070       1080       1090       1100
SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 
      1110       1120       1130       1140       1150
RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP 
      1160       1170       1180       1190       1200
PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
      1210       1220       1230       1240       1250
SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE 
      1260       1270       1280       1290       1300
PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 
      1310       1320       1330       1340       1350
EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA 
      1360       1370       1380       1390       1400
APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 
      1410       1420       1430       1440       1450
DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP 
      1460       1470       1480       1490       1500
AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
      1510       1520       1530       1540       1550
GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV 
      1560       1570       1580       1590       1600
CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 
      1610       1620       1630       1640       1650
LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG 
      1660       1670       1680       1690       1700
SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 
      1710       1720       1730       1740       1750
SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA 
      1760       1770       1780       1790       1800
GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
      1810       1820       1830       1840       1850
EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR 
      1860       1870       1880       1890       1900
SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 
      1910       1920       1930       1940       1950
SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS 
      1960       1970       1980       1990       2000
ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 
      2010       2020       2030       2040       2050
SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL 
      2060       2070       2080       2090       2100
TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 
      2110       2120       2130       2140       2150
TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP 
      2160       2170       2180       2190       2200
IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK 
      2210       2220       2230       2240       2250
NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN AFDLEAMSML 
      2260       2270       2280       2290       2300
NRAQERIDAW AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ AWIKKDQFLR 
      2310       2320       2330       2340       2350
AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK TDRKGLVAVG 
      2360       2370       2380       2390       2400
ERAQKRSGNF SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH 
      2410       2420 
RKHFLFRVLR NGALTRPNCM FFLNRY

Length:2,426

Mass (Da):263,830

Last modified:May 18, 2010 - v4

Checksum:ⁱAE53B1157A37657D

GO

Isoform A (identifier: P18583-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     687-687: V → Q
     688-1006: Missing.
     2410-2426: RNGALTRPNCMFFLNRY → INGSAYQPSFASPNKKHAKATAATVVLQAMGLVPKDLMANATCFRSASRR

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTQRSM MSSYERSMMS 
       710        720        730        740        750
YERSMMSPMA ERSMMSAYER SMMSAYERSM MSPMAERSMM SAYERSMMSA 
       760        770        780        790        800
YERSMMSPMA DRSMMSMGAD RSMMSSYSAA DRSMMSSYSA ADRSMMSSYT 
       810        820        830        840        850
ADRSMMSMAA DSYTDSYTDT YTEAYMVPPL PPEEPPTMPP LPPEEPPMTP 
       860        870        880        890        900
PLPPEEPPEG PALPTEQSAL TAENTWPTEV PSSPSEESVS QPEPPVSQSE 
       910        920        930        940        950
ISEPSAVPTD YSVSASDPSV LVSEAAVTVP EPPPEPESSI TLTPVESAVV 
       960        970        980        990       1000
AEEHEVVPER PVTCMVSETP AMSAEPTVLA SEPPVMSETA ETFDSMRASG 
      1010       1020       1030       1040       1050
HVASEVSTSL LVPAVTTPVL AESILEPPAM AAPESSAMAV LESSAVTVLE 
      1060       1070       1080       1090       1100
SSTVTVLESS TVTVLEPSVV TVPEPPVVAE PDYVTIPVPV VSALEPSVPV 
      1110       1120       1130       1140       1150
LEPAVSVLQP SMIVSEPSVS VQESTVTVSE PAVTVSEQTQ VIPTEVAIES 
      1160       1170       1180       1190       1200
TPMILESSIM SSHVMKGINL SSGDQNLAPE IGMQEIALHS GEEPHAEEHL 
      1210       1220       1230       1240       1250
KGDFYESEHG INIDLNINNH LIAKEMEHNT VCAAGTSPVG EIGEEKILPT 
      1260       1270       1280       1290       1300
SETKQRTVLD TYPGVSEADA GETLSSTGPF ALEPDATGTS KGIEFTTAST 
      1310       1320       1330       1340       1350
LSLVNKYDVD LSLTTQDTEH DMVISTSPSG GSEADIEGPL PAKDIHLDLP 
      1360       1370       1380       1390       1400
SNNNLVSKDT EEPLPVKESD QTLAALLSPK ESSGGEKEVP PPPKETLPDS 
      1410       1420       1430       1440       1450
GFSANIEDIN EADLVRPLLP KDMERLTSLR AGIEGPLLAS DVGRDRSAAS 
      1460       1470       1480       1490       1500
PVVSSMPERA SESSSEEKDD YEIFVKVKDT HEKSKKNKNR DKGEKEKKRD 
      1510       1520       1530       1540       1550
SSLRSRSKRS KSSEHKSRKR TSESRSRARK RSSKSKSHRS QTRSRSRSRR 
      1560       1570       1580       1590       1600
RRRSSRSRSK SRGRRSVSKE KRKRSPKHRS KSRERKRKRS SSRDNRKTVR 
      1610       1620       1630       1640       1650
ARSRTPSRRS RSHTPSRRRR SRSVGRRRSF SISPSRRSRT PSRRSRTPSR 
      1660       1670       1680       1690       1700
RSRTPSRRSR TPSRRSRTPS RRSRTPSRRR RSRSVVRRRS FSISPVRLRR 
      1710       1720       1730       1740       1750
SRTPLRRRFS RSPIRRKRSR SSERGRSPKR LTDLDKAQLL EIAKANAAAM 
      1760       1770       1780       1790       1800
CAKAGVPLPP NLKPAPPPTI EEKVAKKSGG ATIEELTEKC KQIAQSKEDD 
      1810       1820       1830       1840       1850
DVIVNKPHVS DEEEEEPPFY HHPFKLSEPK PIFFNLNIAA AKPTPPKSQV 
      1860       1870       1880       1890       1900
TLTKEFPVSS GSQHRKKEAD SVYGEWVPVE KNGEENKDDD NVFSSNLPSE 
      1910       1920       1930       1940       1950
PVDISTAMSE RALAQKRLSE NAFDLEAMSM LNRAQERIDA WAQLNSIPGQ 
      1960       1970       1980       1990       2000
FTGSTGVQVL TQEQLANTGA QAWIKKDQFL RAAPVTGGMG AVLMRKMGWR 
      2010       2020       2030       2040       2050
EGEGLGKNKE GNKEPILVDF KTDRKGLVAV GERAQKRSGN FSAAMKDLSG 
      2060       2070       2080       2090       2100
KHPVSALMEI CNKRRWQPPE FLLVHDSGPD HRKHFLFRVL INGSAYQPSF 
      2110       2120       2130       2140
ASPNKKHAKA TAATVVLQAM GLVPKDLMAN ATCFRSASRR

Show »

Length:2,140

Mass (Da):232,307

Checksum:ⁱADE72D9D269A914D

GO

Isoform B (identifier: P18583-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2220-2303: PVDISTAMSE...KKDQFLRAAP → GRVKRQGRVR...SRLYSSRFWW
2304-2426: Missing.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST 
       860        870        880        890        900
MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
       910        920        930        940        950
QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR 
       960        970        980        990       1000
LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 
      1010       1020       1030       1040       1050
MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM 
      1060       1070       1080       1090       1100
SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 
      1110       1120       1130       1140       1150
RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP 
      1160       1170       1180       1190       1200
PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
      1210       1220       1230       1240       1250
SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE 
      1260       1270       1280       1290       1300
PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 
      1310       1320       1330       1340       1350
EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA 
      1360       1370       1380       1390       1400
APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 
      1410       1420       1430       1440       1450
DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP 
      1460       1470       1480       1490       1500
AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
      1510       1520       1530       1540       1550
GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV 
      1560       1570       1580       1590       1600
CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 
      1610       1620       1630       1640       1650
LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG 
      1660       1670       1680       1690       1700
SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 
      1710       1720       1730       1740       1750
SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA 
      1760       1770       1780       1790       1800
GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
      1810       1820       1830       1840       1850
EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR 
      1860       1870       1880       1890       1900
SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 
      1910       1920       1930       1940       1950
SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS 
      1960       1970       1980       1990       2000
ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 
      2010       2020       2030       2040       2050
SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL 
      2060       2070       2080       2090       2100
TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 
      2110       2120       2130       2140       2150
TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP 
      2160       2170       2180       2190       2200
IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK 
      2210       2220       2230       2240       2250
NGEENKDDDN VFSSNLPSEG RVKRQGRVRR QMKQPAASHL TVTRCNSLCG 
      2260       2270       2280       2290       2300
TKPQSEKHRI AENSVITSLP NIGPSLHLWE GSPRYNYLAS RFASRLYSSR 

FWW

Show »

Length:2,303

Mass (Da):250,388

Checksum:ⁱC417A8F16219C1E1

GO

Isoform C (identifier: P18583-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2296-2325: DQFLRAAPVTGGMGAVLMRKMGWREGEGLG → GQILVAVFLPRSVPAVLFTTLLLPRPRISS
2326-2426: Missing.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST 
       860        870        880        890        900
MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
       910        920        930        940        950
QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR 
       960        970        980        990       1000
LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 
      1010       1020       1030       1040       1050
MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM 
      1060       1070       1080       1090       1100
SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 
      1110       1120       1130       1140       1150
RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP 
      1160       1170       1180       1190       1200
PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
      1210       1220       1230       1240       1250
SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE 
      1260       1270       1280       1290       1300
PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 
      1310       1320       1330       1340       1350
EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA 
      1360       1370       1380       1390       1400
APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 
      1410       1420       1430       1440       1450
DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP 
      1460       1470       1480       1490       1500
AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
      1510       1520       1530       1540       1550
GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV 
      1560       1570       1580       1590       1600
CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 
      1610       1620       1630       1640       1650
LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG 
      1660       1670       1680       1690       1700
SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 
      1710       1720       1730       1740       1750
SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA 
      1760       1770       1780       1790       1800
GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
      1810       1820       1830       1840       1850
EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR 
      1860       1870       1880       1890       1900
SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 
      1910       1920       1930       1940       1950
SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS 
      1960       1970       1980       1990       2000
ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 
      2010       2020       2030       2040       2050
SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL 
      2060       2070       2080       2090       2100
TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 
      2110       2120       2130       2140       2150
TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP 
      2160       2170       2180       2190       2200
IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK 
      2210       2220       2230       2240       2250
NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN AFDLEAMSML 
      2260       2270       2280       2290       2300
NRAQERIDAW AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ AWIKKGQILV 
      2310       2320 
AVFLPRSVPA VLFTTLLLPR PRISS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:2,325

Mass (Da):252,254

Checksum:ⁱDEB57EC4B540649C

GO

Isoform D (identifier: P18583-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2410-2426: RNGALTRPNCMFFLNRY → INGSAYQPSFASPNKKHAKATAATVVLQAMGLVPKDLMANATCFRSASRR

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST 
       860        870        880        890        900
MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
       910        920        930        940        950
QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR 
       960        970        980        990       1000
LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 
      1010       1020       1030       1040       1050
MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM 
      1060       1070       1080       1090       1100
SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 
      1110       1120       1130       1140       1150
RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP 
      1160       1170       1180       1190       1200
PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
      1210       1220       1230       1240       1250
SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE 
      1260       1270       1280       1290       1300
PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 
      1310       1320       1330       1340       1350
EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA 
      1360       1370       1380       1390       1400
APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 
      1410       1420       1430       1440       1450
DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP 
      1460       1470       1480       1490       1500
AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
      1510       1520       1530       1540       1550
GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV 
      1560       1570       1580       1590       1600
CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 
      1610       1620       1630       1640       1650
LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG 
      1660       1670       1680       1690       1700
SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 
      1710       1720       1730       1740       1750
SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA 
      1760       1770       1780       1790       1800
GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
      1810       1820       1830       1840       1850
EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR 
      1860       1870       1880       1890       1900
SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 
      1910       1920       1930       1940       1950
SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS 
      1960       1970       1980       1990       2000
ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 
      2010       2020       2030       2040       2050
SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL 
      2060       2070       2080       2090       2100
TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 
      2110       2120       2130       2140       2150
TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP 
      2160       2170       2180       2190       2200
IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK 
      2210       2220       2230       2240       2250
NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN AFDLEAMSML 
      2260       2270       2280       2290       2300
NRAQERIDAW AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ AWIKKDQFLR 
      2310       2320       2330       2340       2350
AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK TDRKGLVAVG 
      2360       2370       2380       2390       2400
ERAQKRSGNF SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH 
      2410       2420       2430       2440       2450
RKHFLFRVLI NGSAYQPSFA SPNKKHAKAT AATVVLQAMG LVPKDLMANA 

TCFRSASRR

Show »

Length:2,459

Mass (Da):267,035

Checksum:ⁱ1C16840BD08A27F7

GO

Isoform E (identifier: P18583-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2108-2108: K → F
2109-2426: Missing.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST 
       860        870        880        890        900
MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
       910        920        930        940        950
QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR 
       960        970        980        990       1000
LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 
      1010       1020       1030       1040       1050
MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM 
      1060       1070       1080       1090       1100
SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 
      1110       1120       1130       1140       1150
RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP 
      1160       1170       1180       1190       1200
PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
      1210       1220       1230       1240       1250
SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE 
      1260       1270       1280       1290       1300
PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 
      1310       1320       1330       1340       1350
EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA 
      1360       1370       1380       1390       1400
APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 
      1410       1420       1430       1440       1450
DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP 
      1460       1470       1480       1490       1500
AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
      1510       1520       1530       1540       1550
GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV 
      1560       1570       1580       1590       1600
CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 
      1610       1620       1630       1640       1650
LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG 
      1660       1670       1680       1690       1700
SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 
      1710       1720       1730       1740       1750
SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA 
      1760       1770       1780       1790       1800
GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
      1810       1820       1830       1840       1850
EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR 
      1860       1870       1880       1890       1900
SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 
      1910       1920       1930       1940       1950
SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS 
      1960       1970       1980       1990       2000
ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 
      2010       2020       2030       2040       2050
SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL 
      2060       2070       2080       2090       2100
TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 

TIEELTEF

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:2,108

Mass (Da):228,181

Checksum:ⁱC1546DDB5FFDBB5E

GO

Isoform G (identifier: P18583-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
748-787: Missing.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLATST 
       760        770        780        790        800
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 
       810        820        830        840        850
MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT 
       860        870        880        890        900
MDAQMLASST QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD 
       910        920        930        940        950
AYRLGQDPYR LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP 
       960        970        980        990       1000
LMLASRRSMM MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS 
      1010       1020       1030       1040       1050
MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR 
      1060       1070       1080       1090       1100
SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 
      1110       1120       1130       1140       1150
TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT 
      1160       1170       1180       1190       1200
AENTWPTEVP SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL 
      1210       1220       1230       1240       1250
VSEAAVTVPE PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA 
      1260       1270       1280       1290       1300
MSAEPTVLAS EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA 
      1310       1320       1330       1340       1350
ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT 
      1360       1370       1380       1390       1400
VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 
      1410       1420       1430       1440       1450
QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS 
      1460       1470       1480       1490       1500
SGDQNLAPEI GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL 
      1510       1520       1530       1540       1550
IAKEMEHNTV CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG 
      1560       1570       1580       1590       1600
ETLSSTGPFA LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD 
      1610       1620       1630       1640       1650
MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ 
      1660       1670       1680       1690       1700
TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 
      1710       1720       1730       1740       1750
DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY 
      1760       1770       1780       1790       1800
EIFVKVKDTH EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT 
      1810       1820       1830       1840       1850
SESRSRARKR SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK 
      1860       1870       1880       1890       1900
RKRSPKHRSK SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS 
      1910       1920       1930       1940       1950
RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR 
      1960       1970       1980       1990       2000
RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 
      2010       2020       2030       2040       2050
SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE 
      2060       2070       2080       2090       2100
EKVAKKSGGA TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH 
      2110       2120       2130       2140       2150
HPFKLSEPKP IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS 
      2160       2170       2180       2190       2200
VYGEWVPVEK NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN 
      2210       2220       2230       2240       2250
AFDLEAMSML NRAQERIDAW AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ 
      2260       2270       2280       2290       2300
AWIKKDQFLR AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK 
      2310       2320       2330       2340       2350
TDRKGLVAVG ERAQKRSGNF SAAMKDLSGK HPVSALMEIC NKRRWQPPEF 
      2360       2370       2380 
LLVHDSGPDH RKHFLFRVLR NGALTRPNCM FFLNRY

Show »

Length:2,386

Mass (Da):259,594

Checksum:ⁱD8DD6D8C39863B51

GO

Isoform H (identifier: P18583-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
687-689: VAQ → NVP
690-2416: Missing.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690 
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTNVPP NCMFFLNRY

Show »

Length:699

Mass (Da):73,884

Checksum:ⁱ38D999DC96C00502

GO

Isoform I (identifier: P18583-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
770-770: S → SMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSS

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLASNT MDSQMLASNT MDSQMLASST 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS MDSQMLATSS 
       860        870        880        890        900
MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST MDSQMLATSS 
       910        920        930        940        950
MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST QDSAMLGSKS 
       960        970        980        990       1000
PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 
      1010       1020       1030       1040       1050
DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM 
      1060       1070       1080       1090       1100
SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS 
      1110       1120       1130       1140       1150
AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD RSMMSSYSAA 
      1160       1170       1180       1190       1200
DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP PEEPPTMPPL 
      1210       1220       1230       1240       1250
PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP SSPSEESVSQ 
      1260       1270       1280       1290       1300
PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 
      1310       1320       1330       1340       1350
LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE 
      1360       1370       1380       1390       1400
TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL 
      1410       1420       1430       1440       1450
ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV 
      1460       1470       1480       1490       1500
SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP AVTVSEQTQV 
      1510       1520       1530       1540       1550
IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI GMQEIALHSG 
      1560       1570       1580       1590       1600
EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 
      1610       1620       1630       1640       1650
IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK 
      1660       1670       1680       1690       1700
GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP 
      1710       1720       1730       1740       1750
AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE SSGGEKEVPP 
      1760       1770       1780       1790       1800
PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA GIEGPLLASD 
      1810       1820       1830       1840       1850
VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH EKSKKNKNRD 
      1860       1870       1880       1890       1900
KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 
      1910       1920       1930       1940       1950
TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS 
      1960       1970       1980       1990       2000
SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP 
      2010       2020       2030       2040       2050
SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF 
      2060       2070       2080       2090       2100
SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL TDLDKAQLLE 
      2110       2120       2130       2140       2150
IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA TIEELTEKCK 
      2160       2170       2180       2190       2200
QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 
      2210       2220       2230       2240       2250
KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN 
      2260       2270       2280       2290       2300
VFSSNLPSEP VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERIDAW 
      2310       2320       2330       2340       2350
AQLNSIPGQF TGSTGVQVLT QEQLANTGAQ AWIKKDQFLR AAPVTGGMGA 
      2360       2370       2380       2390       2400
VLMRKMGWRE GEGLGKNKEG NKEPILVDFK TDRKGLVAVG ERAQKRSGNF 
      2410       2420       2430       2440       2450
SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH RKHFLFRVLR 
      2460 
NGALTRPNCM FFLNRY

Show »

Length:2,466

Mass (Da):268,093

Checksum:ⁱ0BCC85FEA1FACFBE

GO

Isoform J (identifier: P18583-10) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2257-2282: IDAWAQLNSIPGQFTGSTGVQVLTQE → VCSSFLKKIIIYHQPTHTNVPVLMSK
2283-2426: Missing.

« Hide

        10         20         30         40         50
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA 
        60         70         80         90        100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT 
       110        120        130        140        150
DEIPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKT KSHDDGNIDL 
       160        170        180        190        200
ESDSFLKFDS EPSAVALELP TRAFGPSETN ESPAVVLEPP VVSMEVSEPH 
       210        220        230        240        250
ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK ILDSFAAAPV 
       260        270        280        290        300
PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
       310        320        330        340        350
EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI 
       360        370        380        390        400
ADSSMTRPQE LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT 
       410        420        430        440        450
PVLELPGPSA TPVPELPGPL STPVPELPGP PATAVPELPG PSVTPVPQLS 
       460        470        480        490        500
QELPGLPAPS MGLEPPQEVP EPPVMAQELP GLPLVTAAVE LPEQPAVTVA 
       510        520        530        540        550
MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP EATMVLELPG 
       560        570        580        590        600
QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
       610        620        630        640        650
MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA 
       660        670        680        690        700
LEISVQSVVT TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS 
       710        720        730        740        750
VTVGVDPLMA PESHILASNT METHILASNT MDSQMLASNT MDSQMLASNT 
       760        770        780        790        800
MDSQMLASST MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATSS 
       810        820        830        840        850
MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST MDSQMLATST 
       860        870        880        890        900
MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
       910        920        930        940        950
QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR 
       960        970        980        990       1000
LGHDPYRLTP DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM 
      1010       1020       1030       1040       1050
MSYAAERSMM SSYERSMMSY ERSMMSPMAE RSMMSAYERS MMSAYERSMM 
      1060       1070       1080       1090       1100
SPMAERSMMS AYERSMMSAY ERSMMSPMAD RSMMSMGADR SMMSSYSAAD 
      1110       1120       1130       1140       1150
RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY TEAYMVPPLP 
      1160       1170       1180       1190       1200
PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
      1210       1220       1230       1240       1250
SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE 
      1260       1270       1280       1290       1300
PPPEPESSIT LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS 
      1310       1320       1330       1340       1350
EPPVMSETAE TFDSMRASGH VASEVSTSLL VPAVTTPVLA ESILEPPAMA 
      1360       1370       1380       1390       1400
APESSAMAVL ESSAVTVLES STVTVLESST VTVLEPSVVT VPEPPVVAEP 
      1410       1420       1430       1440       1450
DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV QESTVTVSEP 
      1460       1470       1480       1490       1500
AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
      1510       1520       1530       1540       1550
GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV 
      1560       1570       1580       1590       1600
CAAGTSPVGE IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA 
      1610       1620       1630       1640       1650
LEPDATGTSK GIEFTTASTL SLVNKYDVDL SLTTQDTEHD MVISTSPSGG 
      1660       1670       1680       1690       1700
SEADIEGPLP AKDIHLDLPS NNNLVSKDTE EPLPVKESDQ TLAALLSPKE 
      1710       1720       1730       1740       1750
SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK DMERLTSLRA 
      1760       1770       1780       1790       1800
GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
      1810       1820       1830       1840       1850
EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR 
      1860       1870       1880       1890       1900
SSKSKSHRSQ TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK 
      1910       1920       1930       1940       1950
SRERKRKRSS SRDNRKTVRA RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS 
      1960       1970       1980       1990       2000
ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT PSRRSRTPSR RSRTPSRRRR 
      2010       2020       2030       2040       2050
SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS SERGRSPKRL 
      2060       2070       2080       2090       2100
TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 
      2110       2120       2130       2140       2150
TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP 
      2160       2170       2180       2190       2200
IFFNLNIAAA KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK 
      2210       2220       2230       2240       2250
NGEENKDDDN VFSSNLPSEP VDISTAMSER ALAQKRLSEN AFDLEAMSML 
      2260       2270       2280 
NRAQERVCSS FLKKIIIYHQ PTHTNVPVLM SK

Show »

Length:2,282

Mass (Da):247,823

Checksum:ⁱE3951A6A0E3C5DED

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C1M2	H7C1M2_HUMAN	Protein SON Protein SON	SON	1,454	Annotation score:
J3QSZ5	J3QSZ5_HUMAN	Protein SON Protein SON	SON	454	Annotation score:
H7C2G8	H7C2G8_HUMAN	Protein SON Protein SON	SON	343	Annotation score:
H7C1S4	H7C1S4_HUMAN	Protein SON Protein SON	SON	92	Annotation score:
H7C257	H7C257_HUMAN	Protein SON Protein SON	SON	97	Annotation score:

Sequence cautionⁱ

The sequence AAH02422 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence BAA82971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA44793 differs from that shown. Reason: Frameshift at positions 2315, 2412 and 2417.Curated

The sequence CAC69885 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	126	E → K in BAB14985 (PubMed:14702039).Curated	1
Sequence conflictⁱ	129	Y → K in BAB14985 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1402	Y → S in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	1495	N → I in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	1538	N → S in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	1643	I → II in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	1692	L → I in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	1693	A → R in AAA36624 (PubMed:3054499).Curated	1
Sequence conflictⁱ	1820 – 1821	SS → PH in CAA45282 (PubMed:1435773).Curated	2
Sequence conflictⁱ	1820 – 1821	SS → PH in AAA36624 (PubMed:3054499).Curated	2
Sequence conflictⁱ	1939	R → S in AAD50078 (PubMed:10509013).Curated	1
Sequence conflictⁱ	2090	E → V in AAK07692 (PubMed:11306577).Curated	1
Sequence conflictⁱ	2090	E → V in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	2148	P → F in AAK07692 (PubMed:11306577).Curated	1
Sequence conflictⁱ	2148	P → F in CAA45282 (PubMed:1435773).Curated	1
Sequence conflictⁱ	2413 – 2416	ALTR → SPYQ in AAK07692 (PubMed:11306577).Curated	4

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_065456	473	P → S6 PublicationsCorresponds to variant dbSNP:rs35622138Ensembl.	1
Natural variantⁱVAR_065457	555	T → M. Corresponds to variant dbSNP:rs13049658Ensembl.	1
Natural variantⁱVAR_056990	870	T → A. Corresponds to variant dbSNP:rs11908823Ensembl.	1
Natural variantⁱVAR_065458	1202	S → L5 PublicationsCorresponds to variant dbSNP:rs13433428Ensembl.	1
Natural variantⁱVAR_056991	1575	R → C3 PublicationsCorresponds to variant dbSNP:rs13047599Ensembl.	1
Natural variantⁱVAR_077864	1637	T → S in ZTTKS; unknown pathological significance; de novo mutation associated in cis with Y-1843. 1 Publication	1
Natural variantⁱVAR_077865	1843	S → Y in ZTTKS; unknown pathological significance; de novo mutation associated in cis with S-1637. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004411	687 – 689	VAQ → NVP in isoform H. 1 Publication	3
Alternative sequenceⁱVSP_004401	687	V → Q in isoform A. 3 Publications	1
Alternative sequenceⁱVSP_004402	688 – 1006	Missing in isoform A. 3 PublicationsAdd BLAST	319
Alternative sequenceⁱVSP_004412	690 – 2416	Missing in isoform H. 1 PublicationAdd BLAST	1727
Alternative sequenceⁱVSP_004410	748 – 787	Missing in isoform G. 1 PublicationAdd BLAST	40
Alternative sequenceⁱVSP_004413	770	S → SMDSQMLASNTMDSQMLASN TMDSQMLASSTMDSQMLATS S in isoform I. 1 Publication	1
Alternative sequenceⁱVSP_004408	2108	K → F in isoform E. 1 Publication	1
Alternative sequenceⁱVSP_004409	2109 – 2426	Missing in isoform E. 1 PublicationAdd BLAST	318
Alternative sequenceⁱVSP_004404	2220 – 2303	PVDIS…LRAAP → GRVKRQGRVRRQMKQPAASH LTVTRCNSLCGTKPQSEKHR IAENSVITSLPNIGPSLHLW EGSPRYNYLASRFASRLYSS RFWW in isoform B. 2 PublicationsAdd BLAST	84
Alternative sequenceⁱVSP_004414	2257 – 2282	IDAWA…VLTQE → VCSSFLKKIIIYHQPTHTNV PVLMSK in isoform J. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_004415	2283 – 2426	Missing in isoform J. 1 PublicationAdd BLAST	144
Alternative sequenceⁱVSP_004406	2296 – 2325	DQFLR…GEGLG → GQILVAVFLPRSVPAVLFTT LLLPRPRISS in isoform C. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_004405	2304 – 2426	Missing in isoform B. 2 PublicationsAdd BLAST	123
Alternative sequenceⁱVSP_004407	2326 – 2426	Missing in isoform C. 1 PublicationAdd BLAST	101
Alternative sequenceⁱVSP_004403	2410 – 2426	RNGAL…FLNRY → INGSAYQPSFASPNKKHAKA TAATVVLQAMGLVPKDLMAN ATCFRSASRR in isoform A and isoform D. 3 PublicationsAdd BLAST	17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF380179 mRNA Translation: AAL34497.1 AF380180 mRNA Translation: AAL34498.1 AF380181 mRNA Translation: AAL34499.1 AF380182 mRNA Translation: AAL34500.1 AF380183 mRNA Translation: AAL34501.1 AF380184 mRNA Translation: AAL34502.1 AY026895 mRNA Translation: AAK07692.1 AB028942 mRNA Translation: BAA82971.2 Different initiation. AP000303 Genomic DNA No translation available. AP000304 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09814.1 CH471079 Genomic DNA Translation: EAX09818.1 CH471079 Genomic DNA Translation: EAX09821.1 CH471079 Genomic DNA Translation: EAX09823.1 AF435977 mRNA Translation: AAL30810.1 AK024752 mRNA Translation: BAB14985.1 AF161428 mRNA Translation: AAF28988.1 AF161430 mRNA Translation: AAF28990.1 BC002422 mRNA Translation: AAH02422.1 Sequence problems. X63751 mRNA Translation: CAC69885.1 Sequence problems. X63753 mRNA Translation: CAA45282.1 X63071 mRNA Translation: CAA44793.1 Frameshift. M36428 Genomic DNA Translation: AAA36624.1 AF139897 mRNA Translation: AAD50078.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13629.1 [P18583-1] CCDS13631.1 [P18583-3] CCDS74784.1 [P18583-6]
PIRⁱ	S26650
NCBI Reference Sequences More...RefSeqⁱ	NP_001278340.1, NM_001291411.1 NP_001278341.1, NM_001291412.1 NP_115571.2, NM_032195.2 NP_620305.2, NM_138927.2

Genome annotation databases

Ensemblⁱ	ENST00000300278; ENSP00000300278; ENSG00000159140 [P18583-3] ENST00000356577; ENSP00000348984; ENSG00000159140 [P18583-1] ENST00000381679; ENSP00000371095; ENSG00000159140 [P18583-6] ENST00000455528; ENSP00000399783; ENSG00000159140 [P18583-4]
GeneIDⁱ	6651
KEGGⁱ	hsa:6651
UCSC genome browser More...UCSCⁱ	uc002ysc.5 human [P18583-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18583-10	Protein SON (Fragment)		HUMAN		343	UniRef100_P18583-10

Protein	Similar proteins		Species	Score	Length	Source
P18583	LOW QUALITY PROTEIN: protein SON		TURTR		2539	UniRef90_P18583
protein SON isoform X1		TARSY		2470
protein SON isoform X1		ODORO		2466
Uncharacterized protein		MUSPF		2465
protein SON isoform X1		Ursus arctos horribilis		2462
+116
P18583-3	SON DNA binding protein		CALJA		2320	UniRef90_P18583-3
SON DNA binding protein		PANTR		2303
Uncharacterized protein		CERAT		2303
Uncharacterized protein		PAPAN		2303
Uncharacterized protein		NOMLE		2303
+10
P18583-4	SON DNA binding protein		HORSE		2456	UniRef90_P18583-4
SON DNA binding protein		CALJA		2454
SON isoform 2		PONAB		2449
Uncharacterized protein		PROCO		2419
Uncharacterized protein		CANLF		2415
+38
P18583-6	SON DNA binding protein		CALJA		2103	UniRef90_P18583-6
SON isoform 7		PONAB		2098
Uncharacterized protein		COLAP		2087
UPI0005333309		RHIRO		2484
UPI00080A7999		Cebus capucinus imitator		2102
+5
P18583-7	LOW QUALITY PROTEIN: protein SON		BALAS		2501	UniRef90_P18583-7
LOW QUALITY PROTEIN: protein SON		NEOSC		2432
LOW QUALITY PROTEIN: protein SON		Enhydra lutris kenyoni		2425
protein SON isoform X1		CALUR		2421
protein SON		LEPWE		2396
+5
P18583-8	Protein SON isoform F (Fragment)		MACMU		748	UniRef90_P18583-8
SON DNA binding protein, isoform CRA_b		HUMAN		689

Protein	Similar proteins		Species	Score	Length	Source
P18583	Protein SON		MOUSE		2444	UniRef50_P18583
LOW QUALITY PROTEIN: protein SON		TURTR		2539
protein SON isoform X1		TARSY		2470
protein SON isoform X1		ODORO		2466
Uncharacterized protein		MUSPF		2465
+539
P18583-2	SON DNA-binding protein		BOVIN		2136	UniRef50_P18583-2
UPI000C87BE54		PTEVA		2137
P18583-8	Protein SON isoform F (Fragment)		MACMU		748	UniRef50_P18583-8
SON DNA binding protein, isoform CRA_b		HUMAN		689
Protein SON isoform E-like		PIG		611
Uncharacterized protein (Fragment)		NEOLE		711

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF380179 mRNA Translation: AAL34497.1 AF380180 mRNA Translation: AAL34498.1 AF380181 mRNA Translation: AAL34499.1 AF380182 mRNA Translation: AAL34500.1 AF380183 mRNA Translation: AAL34501.1 AF380184 mRNA Translation: AAL34502.1 AY026895 mRNA Translation: AAK07692.1 AB028942 mRNA Translation: BAA82971.2 Different initiation. AP000303 Genomic DNA No translation available. AP000304 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09814.1 CH471079 Genomic DNA Translation: EAX09818.1 CH471079 Genomic DNA Translation: EAX09821.1 CH471079 Genomic DNA Translation: EAX09823.1 AF435977 mRNA Translation: AAL30810.1 AK024752 mRNA Translation: BAB14985.1 AF161428 mRNA Translation: AAF28988.1 AF161430 mRNA Translation: AAF28990.1 BC002422 mRNA Translation: AAH02422.1 Sequence problems. X63751 mRNA Translation: CAC69885.1 Sequence problems. X63753 mRNA Translation: CAA45282.1 X63071 mRNA Translation: CAA44793.1 Frameshift. M36428 Genomic DNA Translation: AAA36624.1 AF139897 mRNA Translation: AAD50078.1
CCDSⁱ	CCDS13629.1 [P18583-1] CCDS13631.1 [P18583-3] CCDS74784.1 [P18583-6]
PIRⁱ	S26650
RefSeqⁱ	NP_001278340.1, NM_001291411.1 NP_001278341.1, NM_001291412.1 NP_115571.2, NM_032195.2 NP_620305.2, NM_138927.2

3D structure databases

SMRⁱ	P18583
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112534, 85 interactors
DIPⁱ	DIP-42289N
IntActⁱ	P18583, 38 interactors
MINTⁱ	P18583
STRINGⁱ	9606.ENSP00000348984

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetⁱ	P18583
PhosphoSitePlusⁱ	P18583
SwissPalmⁱ	P18583

Polymorphism and mutation databases

BioMutaⁱ	SON
DMDMⁱ	296453022

Proteomic databases

EPDⁱ	P18583
jPOSTⁱ	P18583
MaxQBⁱ	P18583
PaxDbⁱ	P18583
PeptideAtlasⁱ	P18583
PRIDEⁱ	P18583
ProteomicsDBⁱ	53592 [P18583-1] 53593 [P18583-10] 53594 [P18583-2] 53595 [P18583-3] 53596 [P18583-4] 53597 [P18583-5] 53598 [P18583-6] 53599 [P18583-7] 53600 [P18583-8] 53601 [P18583-9]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000300278; ENSP00000300278; ENSG00000159140 [P18583-3] ENST00000356577; ENSP00000348984; ENSG00000159140 [P18583-1] ENST00000381679; ENSP00000371095; ENSG00000159140 [P18583-6] ENST00000455528; ENSP00000399783; ENSG00000159140 [P18583-4]
GeneIDⁱ	6651
KEGGⁱ	hsa:6651
UCSCⁱ	uc002ysc.5 human [P18583-1]

Organism-specific databases

CTDⁱ	6651
DisGeNETⁱ	6651
GeneCardsⁱ	SON
HGNCⁱ	HGNC:11183 SON
HPAⁱ	HPA023535 HPA031755 HPA031756
MalaCardsⁱ	SON
MIMⁱ	182465 gene 617140 phenotype
neXtProtⁱ	NX_P18583
OpenTargetsⁱ	ENSG00000159140
Orphanetⁱ	500150 Brain malformations-musculoskeletal abnormalities-facial dysmorphism-intellectual disability syndrome
PharmGKBⁱ	PA36020
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEDZ Eukaryota ENOG410ZUK5 LUCA
GeneTreeⁱ	ENSGT00730000111141
InParanoidⁱ	P18583
OMAⁱ	LTPNCMF
OrthoDBⁱ	30934at2759
PhylomeDBⁱ	P18583
TreeFamⁱ	TF330344

Enzyme and pathway databases

SIGNORⁱ	P18583

SIGNORⁱ

P18583

Miscellaneous databases

ChiTaRSⁱ	SON human
GeneWikiⁱ	SON
GenomeRNAiⁱ	6651
Protein Ontology More...PROⁱ	PR:P18583
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159140 Expressed in 244 organ(s), highest expression level in metanephros
ExpressionAtlasⁱ	P18583 baseline and differential
Genevisibleⁱ	P18583 HS

Family and domain databases

CDDⁱ	cd00048 DSRM, 1 hit
InterProⁱ	View protein in InterPro IPR014720 dsRBD_dom IPR000467 G_patch_dom IPR032922 SON IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR46528 PTHR46528, 2 hits
Pfamⁱ	View protein in Pfam PF01585 G-patch, 1 hit
SMARTⁱ	View protein in SMART SM00443 G_patch, 1 hit
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50137 DS_RBD, 1 hit PS50174 G_PATCH, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SON_HUMAN
Accessionⁱ	P18583Primary (citable) accession number: P18583 Secondary accession number(s): D3DSF5 Q9UPY0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	May 18, 2010
	Last modified:	July 31, 2019
	This is version 197 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P18583 (SON_HUMAN)

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Protein SON

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ