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Entry version 162 (08 May 2019)
Sequence version 3 (03 Oct 2012)
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Protein

Cationic amino acid transporter 2

Gene

Slc7a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Isoform 2 also functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), but it has much higher affinity for arginine than isoform 1. May play a role in classical or alternative activation of macrophages via its role in arginine transport.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.3.2 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 2
Short name:
CAT-2
Short name:
CAT2
Alternative name(s):
20.5
Low affinity cationic amino acid transporter 21 Publication
Solute carrier family 7 member 2
T-cell early activation protein1 Publication
Short name:
TEA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc7a2
Synonyms:Atrc2, Tea
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99828 Slc7a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 59HelicalSequence analysisAdd BLAST22
Topological domaini60 – 63ExtracellularSequence analysis4
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 104CytoplasmicSequence analysisAdd BLAST20
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 163ExtracellularSequence analysisAdd BLAST38
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 192CytoplasmicSequence analysis8
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 248ExtracellularSequence analysisAdd BLAST35
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 289CytoplasmicSequence analysisAdd BLAST20
Transmembranei290 – 309HelicalSequence analysisAdd BLAST20
Topological domaini310 – 339ExtracellularSequence analysisAdd BLAST30
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 385CytoplasmicSequence analysisAdd BLAST25
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 409ExtracellularSequence analysis3
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 489CytoplasmicSequence analysisAdd BLAST59
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 523ExtracellularSequence analysisAdd BLAST13
Transmembranei524 – 548HelicalSequence analysisAdd BLAST25
Topological domaini549 – 556CytoplasmicSequence analysis8
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Topological domaini578 – 581ExtracellularSequence analysis4
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 657CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542651 – 657Cationic amino acid transporter 2Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei463PhosphoserineBy similarity1
Modified residuei645PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18581

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P18581

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18581

PRoteomics IDEntifications database

More...
PRIDEi
P18581

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18581

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18581

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P18581

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver (at protein level) (PubMed:8385111). Highest expression in liver and T-cells. Also expressed in brain and lung.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By macrophage activation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031596 Expressed in 230 organ(s), highest expression level in epithelium of lens

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P18581 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18581 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000096414

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1286 Eukaryota
COG0531 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160440

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000250623

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18581

KEGG Orthology (KO)

More...
KOi
K13864

Identification of Orthologs from Complete Genome Data

More...
OMAi
DILTWVR

Database of Orthologous Groups

More...
OrthoDBi
439017at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293 AA/rel_permease1
IPR004755 Cat_AA_permease
IPR029485 CAT_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00906 2A0303, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P18581-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTVDLI ALGVGSTLGA
60 70 80 90 100
GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY
110 120 130 140 150
LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF
160 170 180 190 200
KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL
210 220 230 240 250
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM
260 270 280 290 300
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
310 320 330 340 350
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVRWSPAKYV VSAGSLCALS
360 370 380 390 400
TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM
410 420 430 440 450
AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYD QPKYTPEKET
460 470 480 490 500
LESCTNATLK SESQVTMLQG QGFSLRTLFS PSALPTRQSA SLVSFLVGFL
510 520 530 540 550
AFLILGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCVAVI LTIWRQPQNQ
560 570 580 590 600
QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWIRFSIWM ALGFLIYFAY
610 620 630 640 650
GIRHSLEGNP RDEEDDEDAF SDNINAATEE KSAMQANDHH QRNLSLPFIL

HEKTSEC
Length:657
Mass (Da):71,856
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i140CC99D3AB96082
GO
Isoform 2 (identifier: P18581-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

Note: Affinity of isoform 2 for arginine uptake is 70-fold higher than for isoform 1.1 Publication
Show »
Length:658
Mass (Da):71,786
Checksum:i4DF5DF9EE57BB7EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QJY0E9QJY0_MOUSE
Cationic amino acid transporter 2
Slc7a2
674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C7ZMY5A0A1C7ZMY5_MOUSE
Cationic amino acid transporter 2
Slc7a2
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142L → P in BAE32720 (PubMed:16141072).Curated1
Sequence conflicti242S → R in BAE32720 (PubMed:16141072).Curated1
Sequence conflicti280E → K in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti335S → G in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti335S → G in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti335S → G in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti335S → G in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti335S → G in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti335S → G in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti335S → G in AAI27083 (PubMed:15489334).Curated1
Sequence conflicti342S → A in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti342S → A in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti342S → A in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti342S → A in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti342S → A in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti342S → A in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti342S → A in AAI27083 (PubMed:15489334).Curated1
Sequence conflicti357M → I in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti357M → I in BAE32720 (PubMed:16141072).Curated1
Sequence conflicti357M → I in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti369R → E in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti369R → E in BAE32720 (PubMed:16141072).Curated1
Sequence conflicti369R → E in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti430I → M in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti440D → E in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti440D → E in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti440D → E in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti440D → E in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti440D → E in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti440D → E in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti440D → E in AAI27083 (PubMed:15489334).Curated1
Sequence conflicti537V → A in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti537V → A in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti537V → A in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti537V → A in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti537V → A in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti537V → A in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti537V → A in AAI27083 (PubMed:15489334).Curated1
Sequence conflicti622D → E in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti622D → E in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti622D → E in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti622D → E in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti622D → E in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti622D → E in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti622D → E in AAI27083 (PubMed:15489334).Curated1
Sequence conflicti626A → V in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti626A → V in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti626A → V in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti626A → V in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti626A → V in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti626A → V in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti626A → V in AAI27083 (PubMed:15489334).Curated1
Sequence conflicti633A → V in AAA75250 (PubMed:1694015).Curated1
Sequence conflicti633A → V in AAA37372 (PubMed:8385111).Curated1
Sequence conflicti633A → V in AAA37350 (PubMed:8385111).Curated1
Sequence conflicti633A → V in AAA20397 (PubMed:8195186).Curated1
Sequence conflicti633A → V in AAY87029 (PubMed:16239143).Curated1
Sequence conflicti633A → V in BAE42415 (PubMed:16141072).Curated1
Sequence conflicti633A → V in AAI27083 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000025357 – 397MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPVIATLSSGA VA in isoform 2. 4 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62838 mRNA Translation: AAA75250.1
L03290 mRNA Translation: AAA37372.1
L11600 mRNA Translation: AAA37350.1
L29006 mRNA Translation: AAA20397.1
DQ086834 mRNA Translation: AAY87029.1
AK154621 mRNA Translation: BAE32720.1
AK171369 mRNA Translation: BAE42415.1
AC116511 Genomic DNA No translation available.
BC127082 mRNA Translation: AAI27083.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22258.1 [P18581-1]
CCDS40327.1 [P18581-2]

Protein sequence database of the Protein Information Resource

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PIRi
A54011

NCBI Reference Sequences

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RefSeqi
NP_001038205.1, NM_001044740.2 [P18581-2]
NP_031540.2, NM_007514.3 [P18581-1]
XP_006509316.1, XM_006509253.3 [P18581-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000057784; ENSMUSP00000058866; ENSMUSG00000031596 [P18581-1]
ENSMUST00000098816; ENSMUSP00000096414; ENSMUSG00000031596 [P18581-2]
ENSMUST00000117077; ENSMUSP00000113729; ENSMUSG00000031596 [P18581-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11988

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:11988

UCSC genome browser

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UCSCi
uc009lnf.1 mouse [P18581-1]
uc009lng.1 mouse [P18581-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62838 mRNA Translation: AAA75250.1
L03290 mRNA Translation: AAA37372.1
L11600 mRNA Translation: AAA37350.1
L29006 mRNA Translation: AAA20397.1
DQ086834 mRNA Translation: AAY87029.1
AK154621 mRNA Translation: BAE32720.1
AK171369 mRNA Translation: BAE42415.1
AC116511 Genomic DNA No translation available.
BC127082 mRNA Translation: AAI27083.1
CCDSiCCDS22258.1 [P18581-1]
CCDS40327.1 [P18581-2]
PIRiA54011
RefSeqiNP_001038205.1, NM_001044740.2 [P18581-2]
NP_031540.2, NM_007514.3 [P18581-1]
XP_006509316.1, XM_006509253.3 [P18581-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096414

Protein family/group databases

TCDBi2.A.3.3.2 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiP18581
PhosphoSitePlusiP18581
SwissPalmiP18581

Proteomic databases

jPOSTiP18581
MaxQBiP18581
PaxDbiP18581
PRIDEiP18581

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057784; ENSMUSP00000058866; ENSMUSG00000031596 [P18581-1]
ENSMUST00000098816; ENSMUSP00000096414; ENSMUSG00000031596 [P18581-2]
ENSMUST00000117077; ENSMUSP00000113729; ENSMUSG00000031596 [P18581-2]
GeneIDi11988
KEGGimmu:11988
UCSCiuc009lnf.1 mouse [P18581-1]
uc009lng.1 mouse [P18581-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6542
MGIiMGI:99828 Slc7a2

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00940000160440
HOGENOMiHOG000250623
InParanoidiP18581
KOiK13864
OMAiDILTWVR
OrthoDBi439017at2759
TreeFamiTF315212

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slc7a2 mouse

Protein Ontology

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PROi
PR:P18581

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031596 Expressed in 230 organ(s), highest expression level in epithelium of lens
ExpressionAtlasiP18581 baseline and differential
GenevisibleiP18581 MM

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR004755 Cat_AA_permease
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
TIGRFAMsiTIGR00906 2A0303, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTR2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18581
Secondary accession number(s): E9QPL9
, Q38RA6, Q3TB99, Q3U3R5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: May 8, 2019
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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