We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P18579 (MURB_BACSU)
Protein
UDP-N-acetylenolpyruvoylglucosamine reductase
Gene
murB
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Cell wall formation.
1 PublicationCatalytic activityi
- EC:1.3.1.98
Cofactori
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 174 | By similarity | 1 | |
Active sitei | 225 | Proton donorBy similarity | 1 | |
Active sitei | 295 | By similarity | 1 |
GO - Molecular functioni
- FAD binding Source: InterPro
- flavin adenine dinucleotide binding Source: GO_Central
- UDP-N-acetylmuramate dehydrogenase activity Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell wall organization Source: GO_Central
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BioCyci | BSUB:BSU15230-MONOMER |
UniPathwayi | UPA00219 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)Alternative name(s): UDP-N-acetylmuramate dehydrogenase |
Gene namesi | Name:murB Synonyms:ylxC Ordered Locus Names:BSU15230 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179178 | 1 – 303 | UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST | 303 |
Proteomic databases
jPOSTi | P18579 |
PaxDbi | P18579 |
PRIDEi | P18579 |
Interactioni
Protein-protein interaction databases
IntActi | P18579, 1 interactor |
MINTi | P18579 |
STRINGi | 224308.BSU15230 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 196 | FAD-binding PCMH-typeAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the MurB family.Curated
Phylogenomic databases
eggNOGi | COG0812, Bacteria |
InParanoidi | P18579 |
OMAi | KMNAGMK |
PhylomeDBi | P18579 |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037, MurB, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR003170, MurB IPR011601, MurB_C IPR036635, MurB_C_sf IPR006094, Oxid_FAD_bind_N |
PANTHERi | PTHR21071, PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565, FAD_binding_4, 1 hit PF02873, MurB_C, 1 hit |
SUPFAMi | SSF56176, SSF56176, 1 hit SSF56194, SSF56194, 1 hit |
TIGRFAMsi | TIGR00179, murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
i Sequence
Sequence statusi: Complete.
P18579-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKVIQELKE REVGKVLANE PLANHTTMKI GGPADVLVIP SSVDAVKDIM
60 70 80 90 100
DVIKKYDVKW TVIGRGSNLL VLDEGIRGVV IKLGAGLDHL ELEGEQVTVG
110 120 130 140 150
GGYSVVRLAT SLSKKGLSGL EFAAGIPGSV GGAVYMNAGA HGSDMSEILV
160 170 180 190 200
KAHILFEDGT IEWLTNEQMD FSYRTSVLQK KRPGVCLEAV LQLEQKDKES
210 220 230 240 250
IVQQMQSNKD YRKNTQPYSS PCAGSIFRNP LPNHAGNLVE KAGLKGYQIG
260 270 280 290 300
GAKISEMHGN FIVNAGGASA KDVLDLIDHV KKTIREKYEI DMHTEVEIIG
GNR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31827 Genomic DNA Translation: AAA83969.1 AL009126 Genomic DNA Translation: CAB13396.1 D10602 Genomic DNA Translation: BAA01455.1 M31800 Genomic DNA Translation: AAA22392.1 |
PIRi | S26500, A43727 |
RefSeqi | NP_389406.1, NC_000964.3 WP_003232182.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13396; CAB13396; BSU_15230 |
GeneIDi | 939804 |
KEGGi | bsu:BSU15230 |
PATRICi | fig|224308.179.peg.1661 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31827 Genomic DNA Translation: AAA83969.1 AL009126 Genomic DNA Translation: CAB13396.1 D10602 Genomic DNA Translation: BAA01455.1 M31800 Genomic DNA Translation: AAA22392.1 |
PIRi | S26500, A43727 |
RefSeqi | NP_389406.1, NC_000964.3 WP_003232182.1, NZ_JNCM01000035.1 |
3D structure databases
SMRi | P18579 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P18579, 1 interactor |
MINTi | P18579 |
STRINGi | 224308.BSU15230 |
Proteomic databases
jPOSTi | P18579 |
PaxDbi | P18579 |
PRIDEi | P18579 |
Genome annotation databases
EnsemblBacteriai | CAB13396; CAB13396; BSU_15230 |
GeneIDi | 939804 |
KEGGi | bsu:BSU15230 |
PATRICi | fig|224308.179.peg.1661 |
Phylogenomic databases
eggNOGi | COG0812, Bacteria |
InParanoidi | P18579 |
OMAi | KMNAGMK |
PhylomeDBi | P18579 |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
BioCyci | BSUB:BSU15230-MONOMER |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037, MurB, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR003170, MurB IPR011601, MurB_C IPR036635, MurB_C_sf IPR006094, Oxid_FAD_bind_N |
PANTHERi | PTHR21071, PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565, FAD_binding_4, 1 hit PF02873, MurB_C, 1 hit |
SUPFAMi | SSF56176, SSF56176, 1 hit SSF56194, SSF56194, 1 hit |
TIGRFAMsi | TIGR00179, murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MURB_BACSU | |
Accessioni | P18579Primary (citable) accession number: P18579 Secondary accession number(s): P16669, P37581 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families