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Protein

Blood group Rh(CE) polypeptide

Gene

RHCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.11.4.3 the ammonium transporter channel (amt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Blood group Rh(CE) polypeptide
Alternative name(s):
Rh polypeptide 1
Short name:
RhPI
Rh30A
RhIXB
Rhesus C/E antigens
CD_antigen: CD240CE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RHCE
Synonyms:RHC, RHE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188672.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10008 RHCE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
111700 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18577

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Rh-null, amorph type (RHNA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive condition characterized by red blood cells that lack all Rh antigens, have increased osmotic fragility, diminished lifespan, and show changes in morphology resulting in stomatocytosis. Rh-null individuals have mild to moderate hemolytic anemia. They are at risk of having adverse reactions in response to transfusion or pregnancy, because they may produce antibodies against several of the Rh antigens.
See also OMIM:617970

Organism-specific databases

DisGeNET

More...
DisGeNETi
6006

MalaCards human disease database

More...
MalaCardsi
RHCE
MIMi617970 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
71275 Rh deficiency syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34386

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RHCE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
132558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001681892 – 417Blood group Rh(CE) polypeptideAdd BLAST416

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18577

PeptideAtlas

More...
PeptideAtlasi
P18577

PRoteomics IDEntifications database

More...
PRIDEi
P18577

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53578
53579 [P18577-10]
53580 [P18577-11]
53581 [P18577-12]
53582 [P18577-13]
53583 [P18577-14]
53584 [P18577-2]
53585 [P18577-3]
53586 [P18577-4]
53587 [P18577-5]
53588 [P18577-6]
53589 [P18577-7]
53590 [P18577-8]
53591 [P18577-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18577

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18577

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188672 Expressed in 97 organ(s), highest expression level in trabecular bone tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_RHCE

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18577 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18577 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294413

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P18577

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3796 Eukaryota
ENOG410XTF8 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004374

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18577

KEGG Orthology (KO)

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KOi
K06579

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06KX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18577

TreeFam database of animal gene trees

More...
TreeFami
TF314450

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3430.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00909 Ammonium_transp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00342 RHESUSRHD

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (14+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 14 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 14 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform RHI (identifier: P18577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV
60 70 80 90 100
GQDLTVMAAL GLGFLTSNFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ
110 120 130 140 150
FPPGKVVITL FSIRLATMSA MSVLISAGAV LGKVNLAQLV VMVLVEVTAL
160 170 180 190 200
GTLRMVISNI FNTDYHMNLR HFYVFAAYFG LTVAWCLPKP LPKGTEDNDQ
210 220 230 240 250
RATIPSLSAM LGALFLWMFW PSVNSPLLRS PIQRKNAMFN TYYALAVSVV
260 270 280 290 300
TAISGSSLAH PQRKISMTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
310 320 330 340 350
AGLISIGGAK CLPVCCNRVL GIHHISVMHS IFSLLGLLGE ITYIVLLVLH
360 370 380 390 400
TVWNGNGMIG FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHVAK
410
YFDDQVFWKF PHLAVGF
Length:417
Mass (Da):45,560
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29D33E778D9053DF
GO
Isoform RHIV (identifier: P18577-2) [UniParc]FASTAAdd to basket
Also known as: 1e

The sequence of this isoform differs from the canonical sequence as follows:
     314-354: VCCNRVLGIH...VLLVLHTVWN → DWLPGPPQHW...SQNMESTSCG
     355-417: Missing.

Show »
Length:354
Mass (Da):38,698
Checksum:i2ED52E5FF2B9085D
GO
Isoform RHVI (identifier: P18577-3) [UniParc]FASTAAdd to basket
Also known as: 7c

The sequence of this isoform differs from the canonical sequence as follows:
     164-268: Missing.
     359-417: IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVAKYFDDQVFWKFPHLAVGF → FAPKSQNMESTSCG

Show »
Length:267
Mass (Da):28,702
Checksum:iBEF2BF74DCF531E1
GO
Isoform RHVIII (identifier: P18577-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-313: Missing.

Show »
Length:266
Mass (Da):29,256
Checksum:i728E70D6F0CEB46A
GO
Isoform 1c (identifier: P18577-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-417: IGFQVLLSIGELSLAIVIALTSGLLTGLLLNLKIWKAPHVAKYFDDQVFWKFPHLAVGF → FAPKSQNMESTSCG

Show »
Length:372
Mass (Da):40,523
Checksum:iB3B22D8C3FD0E07B
GO
Isoform 1d (identifier: P18577-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-417: MIGFQVLLSI...WKFPHLAVGF → IFLIWLLDFK...LLPAVREKRS

Show »
Length:395
Mass (Da):43,553
Checksum:iEFABE59673D8AD25
GO
Isoform 1h (identifier: P18577-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-409: Missing.

Show »
Length:321
Mass (Da):34,967
Checksum:iE2A4BE357967545A
GO
Isoform 2e (identifier: P18577-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-308: TYVHSAVLAG...LVAGLISIGG → DWLPGPPQHW...SQNMESTSCG
     309-417: Missing.

Show »
Length:308
Mass (Da):34,215
Checksum:i3B4E7B35E439386C
GO
Isoform 4g (identifier: P18577-9) [UniParc]FASTAAdd to basket
Also known as: RhPI-Beta

The sequence of this isoform differs from the canonical sequence as follows:
     212-384: Missing.

Show »
Length:244
Mass (Da):27,259
Checksum:iD33E72E9B94F1D08
GO
Isoform 7a (identifier: P18577-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-268: Missing.

Show »
Length:312
Mass (Da):33,739
Checksum:iC852D699223E9A22
GO
Isoform 8a (identifier: P18577-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-220: Missing.
     301-313: Missing.

Show »
Length:346
Mass (Da):37,643
Checksum:iB72694FC03CA96A1
GO
Isoform 8e (identifier: P18577-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-203: TDYHMNLRHF...GTEDNDQRAT → DWLPGPPQHW...SQNMESTSCG
     204-417: Missing.

Show »
Length:203
Mass (Da):22,394
Checksum:iF219A5EB7706D655
GO
Isoform 8h (identifier: P18577-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-409: Missing.

Show »
Length:170
Mass (Da):18,663
Checksum:i8187115F3B54081F
GO
Isoform RhPI-Alpha (identifier: P18577-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-242: LLRSPIQRKNAMFNTY → DRFAPKSQNMESTSCG
     243-417: Missing.

Show »
Length:242
Mass (Da):26,852
Checksum:iE6EA91C2781C2782
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VSJ8Q5VSJ8_HUMAN
Blood group Rh(CE) polypeptide
RHCE
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VSJ7Q5VSJ7_HUMAN
Blood group Rh(CE) polypeptide
RHCE
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQ47E7EQ47_HUMAN
Blood group Rh(CE) polypeptide
RHCE
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU00E7EU00_HUMAN
Blood group Rh(CE) polypeptide
RHCE
372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XSS0F6XSS0_HUMAN
Blood group Rh(CE) polypeptide
RHCE
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKB3E9PKB3_HUMAN
Blood group Rh(CE) polypeptide
RHCE
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCJ8H0YCJ8_HUMAN
Blood group Rh(CE) polypeptide
RHCE
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10R → W in ACK75562 (Ref. 13) Curated1
Sequence conflicti12C → L AA sequence (PubMed:3135863).Curated1
Sequence conflicti53D → G in CAA44812 (PubMed:1379850).Curated1
Sequence conflicti61G → C in CAA44812 (PubMed:1379850).Curated1
Sequence conflicti114R → W in AAN75123 (PubMed:12393640).Curated1
Sequence conflicti115L → P in ACK75563 (Ref. 13) Curated1
Sequence conflicti115L → P in ACK75565 (Ref. 13) Curated1
Sequence conflicti121M → L in BAB16597 (PubMed:11724987).Curated1
Sequence conflicti121M → L in BAA82627 (PubMed:11724987).Curated1
Sequence conflicti122S → P in ACK75564 (Ref. 13) Curated1
Sequence conflicti125I → N in ACK75565 (Ref. 13) Curated1
Sequence conflicti152T → N in BAB16597 (PubMed:11724987).Curated1
Sequence conflicti152T → N in BAA82627 (PubMed:11724987).Curated1
Sequence conflicti155M → V in AAT35811 (Ref. 8) Curated1
Sequence conflicti166H → L in ACK75566 (Ref. 13) Curated1
Sequence conflicti169L → Q in ACK75567 (Ref. 13) Curated1
Sequence conflicti201R → T in ACK75568 (Ref. 13) Curated1
Sequence conflicti217W → R in ACK75569 (Ref. 13) Curated1
Sequence conflicti241T → I in ACK75570 (Ref. 13) Curated1
Sequence conflicti250V → M in AAN75124 (PubMed:12393640).Curated1
Sequence conflicti273A → V in AAN75122 (PubMed:12393640).Curated1
Sequence conflicti303L → Q in ACK75572 (Ref. 13) Curated1
Sequence conflicti378L → V in AAN75122 (PubMed:12393640).Curated1
Sequence conflicti408 – 409WK → DI AA sequence (PubMed:1898705).Curated2

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00691116W → C Associated with altered expression of E antigen. 10 Publications1
Natural variantiVAR_00691236A → T in C(X)/Rh9 antigen. 1
Natural variantiVAR_00691341Q → R in C(W)/Rh8 antigen. Corresponds to variant dbSNP:rs138268848Ensembl.1
Natural variantiVAR_00691460L → I6 PublicationsCorresponds to variant dbSNP:rs181860403EnsemblClinVar.1
Natural variantiVAR_00691568N → S6 PublicationsCorresponds to variant dbSNP:rs1053344Ensembl.1
Natural variantiVAR_006916103P → S in C/Rh2 antigen. 6 PublicationsCorresponds to variant dbSNP:rs676785EnsemblClinVar.1
Natural variantiVAR_055260127A → V1 PublicationCorresponds to variant dbSNP:rs1053346Ensembl.1
Natural variantiVAR_055261128G → D1 PublicationCorresponds to variant dbSNP:rs1053347Ensembl.1
Natural variantiVAR_013301154R → T Found in antigen RhEKH. 1 Publication1
Natural variantiVAR_055262182T → S. Corresponds to variant dbSNP:rs1053350Ensembl.1
Natural variantiVAR_055263198N → K. Corresponds to variant dbSNP:rs1053354Ensembl.1
Natural variantiVAR_006917226P → A in E/Rh5 antigen. 10 PublicationsCorresponds to variant dbSNP:rs609320Ensembl.1
Natural variantiVAR_013302233Q → E Found in antigen RhEFM. 2 Publications1
Natural variantiVAR_013303238M → V Found in antigen RhEFM. 2 PublicationsCorresponds to variant dbSNP:rs144163296Ensembl.1
Natural variantiVAR_006918245L → V in VS antigen. 2 PublicationsCorresponds to variant dbSNP:rs1053361Ensembl.1
Natural variantiVAR_057987263R → G1 PublicationCorresponds to variant dbSNP:rs1132763Ensembl.1
Natural variantiVAR_057988267M → K2 PublicationsCorresponds to variant dbSNP:rs1132764Ensembl.1
Natural variantiVAR_055264323H → P. Corresponds to variant dbSNP:rs1053366Ensembl.1
Natural variantiVAR_055265325I → S. Corresponds to variant dbSNP:rs1053367Ensembl.1
Natural variantiVAR_055266329H → D. Corresponds to variant dbSNP:rs1053370Ensembl.1
Natural variantiVAR_055267329H → R. Corresponds to variant dbSNP:rs1053371Ensembl.1
Natural variantiVAR_055268330S → Y. Corresponds to variant dbSNP:rs1053372Ensembl.1
Natural variantiVAR_055269331I → N. Corresponds to variant dbSNP:rs1053373Ensembl.1
Natural variantiVAR_057989398V → E1 PublicationCorresponds to variant dbSNP:rs630612Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037505163 – 409Missing in isoform 8h. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_005701163 – 313Missing in isoform RHVIII. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_037506163 – 220Missing in isoform 8a. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_037507163 – 203TDYHM…DQRAT → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform 8e. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_005702164 – 268Missing in isoform RHVI and isoform 7a. 2 PublicationsAdd BLAST105
Alternative sequenceiVSP_037508204 – 417Missing in isoform 8e. 1 PublicationAdd BLAST214
Alternative sequenceiVSP_037509212 – 384Missing in isoform 4g. 2 PublicationsAdd BLAST173
Alternative sequenceiVSP_038405227 – 242LLRSP…MFNTY → DRFAPKSQNMESTSCG in isoform RhPI-Alpha. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038406243 – 417Missing in isoform RhPI-Alpha. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_037510268 – 308TYVHS…ISIGG → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform 2e. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_037511301 – 313Missing in isoform 8a. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_037512309 – 417Missing in isoform 2e. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_037513314 – 409Missing in isoform 1h. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_005703314 – 354VCCNR…HTVWN → DWLPGPPQHWGTQLGHRDSS HVWSPDRFAPKSQNMESTSC G in isoform RHIV. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_005704355 – 417Missing in isoform RHIV. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_037514358 – 417MIGFQ…LAVGF → IFLIWLLDFKQKHPRKTRPV QKQDNFLSLLPAVREKRS in isoform 1d. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_005705359 – 417IGFQV…LAVGF → FAPKSQNMESTSCG in isoform RHVI and isoform 1c. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54534 mRNA Translation: CAA38401.1
M34015 mRNA Translation: AAA36567.1
X63095 mRNA Translation: CAA44809.1
X63096 mRNA Translation: CAA44810.1
X63098 mRNA Translation: CAA44812.1
S57967 mRNA Translation: AAB26080.1
DQ266400 mRNA Translation: ABB69097.1
AB018644 mRNA Translation: BAA33927.1
AB018645 mRNA Translation: BAA33928.1
AB030388 mRNA Translation: BAA82627.1
AB049753 mRNA Translation: BAB16597.1
AF510065 mRNA Translation: AAN75121.1
AF510066 mRNA Translation: AAN75122.1
AF510067 mRNA Translation: AAN75123.1
AF510068 mRNA Translation: AAN75124.1
AY603478 mRNA Translation: AAT35811.1
DQ178642 mRNA Translation: ABA25912.1
DQ266353 mRNA Translation: ABB97471.1
DQ322275 mRNA Translation: ABC55358.1
AM398146 Genomic DNA Translation: CAL44958.1
FJ486155 Genomic DNA Translation: ACK75562.1
FJ486156 Genomic DNA Translation: ACK75563.1
FJ486157 Genomic DNA Translation: ACK75564.1
FJ486158 Genomic DNA Translation: ACK75565.1
FJ486159 Genomic DNA Translation: ACK75566.1
FJ486160 Genomic DNA Translation: ACK75567.1
FJ486161 Genomic DNA Translation: ACK75568.1
FJ486162 Genomic DNA Translation: ACK75569.1
FJ486163 Genomic DNA Translation: ACK75570.1
FJ486164 Genomic DNA Translation: ACK75571.1
FJ486165 Genomic DNA Translation: ACK75572.1
AL031284 Genomic DNA No translation available.
AL928711 Genomic DNA No translation available.
BC075081 mRNA Translation: AAH75081.1
BC139905 mRNA Translation: AAI39906.1
S70456 Genomic DNA Translation: AAD14061.1
BN000065 Genomic DNA Translation: CAD29850.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30634.1 [P18577-4]
CCDS30635.1 [P18577-1]
CCDS30636.1 [P18577-3]
CCDS30637.1 [P18577-2]
CCDS81283.1 [P18577-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A30405
I54193
PC2032
PC2033
S78478
S78479
S78480

NCBI Reference Sequences

More...
RefSeqi
NP_065231.3, NM_020485.4
NP_619522.3, NM_138616.3 [P18577-4]
NP_619523.3, NM_138617.3 [P18577-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.449968
Hs.523054

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294413; ENSP00000294413; ENSG00000188672

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6006

UCSC genome browser

More...
UCSCi
uc001bkf.4 human [P18577-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54534 mRNA Translation: CAA38401.1
M34015 mRNA Translation: AAA36567.1
X63095 mRNA Translation: CAA44809.1
X63096 mRNA Translation: CAA44810.1
X63098 mRNA Translation: CAA44812.1
S57967 mRNA Translation: AAB26080.1
DQ266400 mRNA Translation: ABB69097.1
AB018644 mRNA Translation: BAA33927.1
AB018645 mRNA Translation: BAA33928.1
AB030388 mRNA Translation: BAA82627.1
AB049753 mRNA Translation: BAB16597.1
AF510065 mRNA Translation: AAN75121.1
AF510066 mRNA Translation: AAN75122.1
AF510067 mRNA Translation: AAN75123.1
AF510068 mRNA Translation: AAN75124.1
AY603478 mRNA Translation: AAT35811.1
DQ178642 mRNA Translation: ABA25912.1
DQ266353 mRNA Translation: ABB97471.1
DQ322275 mRNA Translation: ABC55358.1
AM398146 Genomic DNA Translation: CAL44958.1
FJ486155 Genomic DNA Translation: ACK75562.1
FJ486156 Genomic DNA Translation: ACK75563.1
FJ486157 Genomic DNA Translation: ACK75564.1
FJ486158 Genomic DNA Translation: ACK75565.1
FJ486159 Genomic DNA Translation: ACK75566.1
FJ486160 Genomic DNA Translation: ACK75567.1
FJ486161 Genomic DNA Translation: ACK75568.1
FJ486162 Genomic DNA Translation: ACK75569.1
FJ486163 Genomic DNA Translation: ACK75570.1
FJ486164 Genomic DNA Translation: ACK75571.1
FJ486165 Genomic DNA Translation: ACK75572.1
AL031284 Genomic DNA No translation available.
AL928711 Genomic DNA No translation available.
BC075081 mRNA Translation: AAH75081.1
BC139905 mRNA Translation: AAI39906.1
S70456 Genomic DNA Translation: AAD14061.1
BN000065 Genomic DNA Translation: CAD29850.1
CCDSiCCDS30634.1 [P18577-4]
CCDS30635.1 [P18577-1]
CCDS30636.1 [P18577-3]
CCDS30637.1 [P18577-2]
CCDS81283.1 [P18577-5]
PIRiA30405
I54193
PC2032
PC2033
S78478
S78479
S78480
RefSeqiNP_065231.3, NM_020485.4
NP_619522.3, NM_138616.3 [P18577-4]
NP_619523.3, NM_138617.3 [P18577-3]
UniGeneiHs.449968
Hs.523054

3D structure databases

ProteinModelPortaliP18577
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000294413

Protein family/group databases

TCDBi1.A.11.4.3 the ammonium transporter channel (amt) family

PTM databases

iPTMnetiP18577
PhosphoSitePlusiP18577

Polymorphism and mutation databases

BioMutaiRHCE
DMDMi132558

Proteomic databases

PaxDbiP18577
PeptideAtlasiP18577
PRIDEiP18577
ProteomicsDBi53578
53579 [P18577-10]
53580 [P18577-11]
53581 [P18577-12]
53582 [P18577-13]
53583 [P18577-14]
53584 [P18577-2]
53585 [P18577-3]
53586 [P18577-4]
53587 [P18577-5]
53588 [P18577-6]
53589 [P18577-7]
53590 [P18577-8]
53591 [P18577-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294413; ENSP00000294413; ENSG00000188672
GeneIDi6006
KEGGihsa:6006
UCSCiuc001bkf.4 human [P18577-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6006
DisGeNETi6006
EuPathDBiHostDB:ENSG00000188672.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RHCE

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0023511
HGNCiHGNC:10008 RHCE
MalaCardsiRHCE
MIMi111700 gene
617970 phenotype
neXtProtiNX_P18577
Orphaneti71275 Rh deficiency syndrome
PharmGKBiPA34386

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3796 Eukaryota
ENOG410XTF8 LUCA
HOVERGENiHBG004374
InParanoidiP18577
KOiK06579
OrthoDBiEOG091G06KX
PhylomeDBiP18577
TreeFamiTF314450

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RHCE_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6006

Protein Ontology

More...
PROi
PR:P18577

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188672 Expressed in 97 organ(s), highest expression level in trabecular bone tissue
CleanExiHS_RHCE
ExpressionAtlasiP18577 baseline and differential
GenevisibleiP18577 HS

Family and domain databases

Gene3Di1.10.3430.10, 1 hit
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD
PfamiView protein in Pfam
PF00909 Ammonium_transp, 1 hit
PRINTSiPR00342 RHESUSRHD

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHCE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18577
Secondary accession number(s): A7DW68
, B7UDF3, B7UDF4, B7UDF5, B7UDF6, B7UDF7, B7UDF8, B7UDF9, B7UDG0, B7UDG1, B7UDG2, B7UDG3, Q02163, Q02164, Q02165, Q16160, Q2MJW0, Q2VC86, Q3LTM6, Q6AZX5, Q6J2U3, Q7RU06, Q8IZT2, Q8IZT3, Q8IZT4, Q8IZT5, Q9UD13, Q9UD14, Q9UD15, Q9UD16, Q9UD73, Q9UD74, Q9UEC2, Q9UEC3, Q9UPN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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