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Protein

Nuclear transcription factor Y subunit alpha

Gene

Nfya

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi290 – 315NFYA/HAP2-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • core promoter sequence-specific DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: InterPro
  • transcription cofactor binding Source: RGD
  • transcription factor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit alpha
Alternative name(s):
CAAT box DNA-binding protein subunit A
CCAAT-binding transcription factor subunit A
Short name:
CBF-A
Nuclear transcription factor Y subunit A
Short name:
NF-YA
Gene namesi
Name:Nfya
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi70976 Nfya

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987701 – 341Nuclear transcription factor Y subunit alphaAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP18576
PRIDEiP18576

PTM databases

iPTMnetiP18576
PhosphoSitePlusiP18576

Expressioni

Gene expression databases

BgeeiENSRNOG00000012702
ExpressionAtlasiP18576 baseline and differential
GenevisibleiP18576 RN

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity). Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3. Interacts with ZHX1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Sp1Q017142EBI-862695,EBI-862787

GO - Molecular functioni

  • transcription cofactor binding Source: RGD
  • transcription factor binding Source: RGD

Protein-protein interaction databases

BioGridi248146, 1 interactor
IntActiP18576, 2 interactors
MINTiP18576
STRINGi10116.ENSRNOP00000017157

Structurei

3D structure databases

SMRiP18576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi260 – 283Subunit association domain (SAD)Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 161Gln-richAdd BLAST148
Compositional biasi200 – 216Thr-richAdd BLAST17

Sequence similaritiesi

Belongs to the NFYA/HAP2 subunit family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1561 Eukaryota
COG5224 LUCA
GeneTreeiENSGT00390000015714
HOGENOMiHOG000247016
HOVERGENiHBG005253
InParanoidiP18576
KOiK08064
PhylomeDBiP18576

Family and domain databases

InterProiView protein in InterPro
IPR018362 CCAAT-binding_factor_CS
IPR001289 NFYA
PANTHERiPTHR12632 PTHR12632, 1 hit
PfamiView protein in Pfam
PF02045 CBFB_NFYA, 1 hit
PRINTSiPR00616 CCAATSUBUNTB
SMARTiView protein in SMART
SM00521 CBF, 1 hit
PROSITEiView protein in PROSITE
PS00686 NFYA_HAP2_1, 1 hit
PS51152 NFYA_HAP2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ
60 70 80 90 100
TLQVVQGQPL MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG
110 120 130 140 150
LQQIQLVPPG QIQIQGGQAV QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ
160 170 180 190 200
QIAVQGQQVA QTAEGQTIVY QPVNADGTIL QQGMITIPAA SLAGAQIVQT
210 220 230 240 250
GANTNTTSSG QGTVTVTLPV AGNVVNSGGM VMMVPGAGSV PAIQRIPLPG
260 270 280 290 300
AEMLEEEPLY VNAKQYHRIL KRRQARAKLE AEGKIPKERR KYLHESRHRH
310 320 330 340
AMARKRGEGG RFFSPKEKDS PHMQDPNQAD EEAMTQIIRV S
Length:341
Mass (Da):36,294
Last modified:November 1, 1990 - v1
Checksum:i3332DB595D67B3A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34238 mRNA Translation: AAA40889.1
PIRiA35777
RefSeqiNP_036997.1, NM_012865.1
UniGeneiRn.10747

Genome annotation databases

EnsembliENSRNOT00000017157; ENSRNOP00000017157; ENSRNOG00000012702
GeneIDi29508
KEGGirno:29508
UCSCiRGD:70976 rat

Similar proteinsi

Entry informationi

Entry nameiNFYA_RAT
AccessioniPrimary (citable) accession number: P18576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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