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Protein

Serum amyloid A-1 protein

Gene

SAA1

Organism
Neovison vison (American mink) (Mustela vison)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major acute phase protein.By similarity

Miscellaneous

SAA2 is more amyloidogenic than SAA1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-1 protein
Gene namesi
Name:SAA1
OrganismiNeovison vison (American mink) (Mustela vison)
Taxonomic identifieri452646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeNeovison

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000003159319 – 129Serum amyloid A-1 proteinAdd BLAST111

Expressioni

Tissue specificityi

Detected in liver.1 Publication

Inductioni

By bacterial lipopolysaccharide.1 Publication

Interactioni

Subunit structurei

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin (By similarity).By similarity

Structurei

3D structure databases

SMRiP18575
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 44Important for amyloid formationBy similarityAdd BLAST26

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG016327

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLFTGLIFC SLVLGVSSQW YSFIGEAAQG AWDMYRAYSD MIEAKYKNSD
60 70 80 90 100
KYFHARGNYD AAQRGPGGAW AAKVISDARE RSQRITDLIK YGDSGHGVED
110 120
SKADQAANEW GRSGKDPNHF RPPGLPDKY
Length:129
Mass (Da):14,389
Last modified:November 1, 1990 - v1
Checksum:iD73D3DD95519E068
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34953 mRNA Translation: AAA30968.1
PIRiA36451

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34953 mRNA Translation: AAA30968.1
PIRiA36451

3D structure databases

SMRiP18575
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG016327

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAA1_NEOVI
AccessioniPrimary (citable) accession number: P18575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 15, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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