PDE6G

Functionⁱ

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityⁱ

Guanosine 3',5'-cyclic phosphate + H₂O = guanosine 5'-phosphate.

GO - Molecular functionⁱ

3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
cGMP binding Source: InterPro
enzyme inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 7828894
spectrin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Ensembl
positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
regulation of rhodopsin mediated signaling pathway Source: Reactome
response to stimulus Source: UniProtKB-KW
visual perception
Source: ProtInc
Traceable author statementⁱ
- 7828894

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Sensory transduction, Vision
Ligand	cGMP

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2485179 Activation of the phototransduction cascade R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-4086398 Ca2+ pathway
SignaLinkⁱ	P18545
SIGNORⁱ	P18545

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35) Short name: GMP-PDE gamma
Gene namesⁱ	Name:PDE6G Synonyms:PDEG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185527.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8789 PDE6G
MIMⁱ	180073 gene
neXtProtⁱ	NX_P18545

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Retinitis pigmentosa 57 (RP57)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Keywords - Diseaseⁱ

Retinitis pigmentosa

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5148
GeneReviewsⁱ	PDE6G
MalaCards human disease database More...MalaCardsⁱ	PDE6G
MIMⁱ	613582 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000185527
Orphanetⁱ	791 Retinitis pigmentosa
PharmGKBⁱ	PA33137

Chemistry databases

ChEMBLⁱ	CHEMBL2363066
Drug and drug target database More...DrugBankⁱ	DB07954 3-isobutyl-1-methyl-7H-xanthine DB00203 Sildenafil DB00862 Vardenafil

Polymorphism and mutation databases

BioMutaⁱ	PDE6G
DMDMⁱ	116583

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000166117	1 – 87	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST		87

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	P18545
PeptideAtlas More...PeptideAtlasⁱ	P18545
PRIDEⁱ	P18545
ProteomicsDBⁱ	53576

PTM databases

iPTMnetⁱ	P18545
PhosphoSitePlusⁱ	P18545

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185527 Expressed in 118 organ(s), highest expression level in retina
CleanExⁱ	HS_PDE6G
ExpressionAtlasⁱ	P18545 baseline and differential
Genevisibleⁱ	P18545 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045118

HPAⁱ

HPA045118

Interactionⁱ

Subunit structureⁱ

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BHLHE40	O14503	3	EBI-2622029,EBI-711810
Fnbp1	Q8R511	2	EBI-2622029,EBI-1111424	From Rattus norvegicus.
Grb2	P62994	2	EBI-2622029,EBI-401775	From Rattus norvegicus.
L3MBTL3	Q96JM7	3	EBI-2622029,EBI-2686809
Pacsin2	Q9QY17	4	EBI-2622029,EBI-491201	From Rattus norvegicus.
Pik3r1	Q63787	2	EBI-2622029,EBI-518443	From Rattus norvegicus.

GO - Molecular functionⁱ

spectrin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111174, 6 interactors
IntActⁱ	P18545, 9 interactors
Molecular INTeraction database More...MINTⁱ	P18545
STRINGⁱ	9606.ENSP00000328412

Chemistry databases

BindingDBⁱ

P18545

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Turnⁱ	75 – 77	Combined sources		3
Helixⁱ	78 – 83	Combined sources		6

Show more details

3D structure databases

ProteinModelPortalⁱ	P18545
SMRⁱ	P18545
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P18545

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	24 – 45	Arg/Lys-rich (basic)Add BLAST		22

Sequence similaritiesⁱ

Belongs to the rod/cone cGMP-PDE gamma subunit family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IZA8 Eukaryota ENOG410YN07 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013260
HOGENOMⁱ	HOG000261673
HOVERGENⁱ	HBG000447
KEGG Orthology (KO) More...KOⁱ	K13759
PhylomeDBⁱ	P18545
TreeFamⁱ	TF333297

Family and domain databases

Gene3Dⁱ	4.10.1120.10, 1 hit
InterProⁱ	View protein in InterPro IPR006952 PDE6_gamma IPR037030 PDE6_gamma_sf
PANTHERⁱ	PTHR12122 PTHR12122, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04868 PDE6_gamma, 1 hit
PIRSFⁱ	PIRSF000969 35-cGMP_Pdiase_g, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P18545-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNLEPPKAEF RSATRVAGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF 
        60         70         80 
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII

Length:87

Mass (Da):9,643

Last modified:November 1, 1990 - v1

Checksum:ⁱ5D7DEE59D7DDB9E0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DGN0	A0A0C4DGN0_HUMAN	Retinal rod rhodopsin-sensitive cGM... Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	137	Annotation score:
I3L446	I3L446_HUMAN	Retinal rod rhodopsin-sensitive cGM... Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	70	Annotation score:

Sequence cautionⁱ

The sequence CAD97656 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence EAW89666 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_009294	27	P → H1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36476 mRNA Translation: AAA60044.1 X62025 Genomic DNA Translation: CAA43975.1 U00482, U00481 Genomic DNA Translation: AAA03653.1 BX537414 mRNA Translation: CAD97656.1 Different initiation. CH471099 Genomic DNA Translation: EAW89666.1 Different initiation. BC106884 mRNA Translation: AAI06885.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11783.1
PIRⁱ	JH0142
NCBI Reference Sequences More...RefSeqⁱ	NP_002593.1, NM_002602.3 XP_006722005.1, XM_006721942.3 XP_016880224.1, XM_017024735.1 XP_016880225.1, XM_017024736.1
UniGeneⁱ	Hs.654482

Genome annotation databases

Ensemblⁱ	ENST00000331056; ENSP00000328412; ENSG00000185527 ENST00000571004; ENSP00000461464; ENSG00000185527 ENST00000571224; ENSP00000458167; ENSG00000185527
GeneIDⁱ	5148
KEGGⁱ	hsa:5148
UCSC genome browser More...UCSCⁱ	uc002kay.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P18545	PDE6G isoform 1		PANTR		87	UniRef100_P18545
PDE6G isoform 2		PONAB		87
UPI0007DC5740		HUMAN		157

Protein	Similar proteins		Species	Score	Length	Source
P18545	PDE6G isoform 1		PANTR		87	UniRef90_P18545
PDE6G isoform 2		PONAB		87
UPI0007DC5740		HUMAN		157

Protein	Similar proteins		Species	Score	Length	Source
P18545	PDE6G isoform 1		PANTR		87	UniRef50_P18545
PDE6G isoform 2		PONAB		87
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		MYODS		87
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		URSMA		87
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		ODORO		87
+61

Cross-referencesⁱ

Web resourcesⁱ

Mutations of the PDE6A/B/G genes

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36476 mRNA Translation: AAA60044.1 X62025 Genomic DNA Translation: CAA43975.1 U00482, U00481 Genomic DNA Translation: AAA03653.1 BX537414 mRNA Translation: CAD97656.1 Different initiation. CH471099 Genomic DNA Translation: EAW89666.1 Different initiation. BC106884 mRNA Translation: AAI06885.1
CCDSⁱ	CCDS11783.1
PIRⁱ	JH0142
RefSeqⁱ	NP_002593.1, NM_002602.3 XP_006722005.1, XM_006721942.3 XP_016880224.1, XM_017024735.1 XP_016880225.1, XM_017024736.1
UniGeneⁱ	Hs.654482

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3JWR	X-ray	2.99	C/D	70-87	[»]
ProteinModelPortalⁱ	P18545
SMRⁱ	P18545
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111174, 6 interactors
IntActⁱ	P18545, 9 interactors
MINTⁱ	P18545
STRINGⁱ	9606.ENSP00000328412

Chemistry databases

BindingDBⁱ	P18545
ChEMBLⁱ	CHEMBL2363066
DrugBankⁱ	DB07954 3-isobutyl-1-methyl-7H-xanthine DB00203 Sildenafil DB00862 Vardenafil

PTM databases

iPTMnetⁱ	P18545
PhosphoSitePlusⁱ	P18545

Polymorphism and mutation databases

BioMutaⁱ	PDE6G
DMDMⁱ	116583

Proteomic databases

PaxDbⁱ	P18545
PeptideAtlasⁱ	P18545
PRIDEⁱ	P18545
ProteomicsDBⁱ	53576

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5148
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000331056; ENSP00000328412; ENSG00000185527 ENST00000571004; ENSP00000461464; ENSG00000185527 ENST00000571224; ENSP00000458167; ENSG00000185527
GeneIDⁱ	5148
KEGGⁱ	hsa:5148
UCSCⁱ	uc002kay.4 human

Organism-specific databases

CTDⁱ	5148
DisGeNETⁱ	5148
EuPathDBⁱ	HostDB:ENSG00000185527.11
GeneCardsⁱ	PDE6G
GeneReviewsⁱ	PDE6G
HGNCⁱ	HGNC:8789 PDE6G
HPAⁱ	HPA045118
MalaCardsⁱ	PDE6G
MIMⁱ	180073 gene 613582 phenotype
neXtProtⁱ	NX_P18545
OpenTargetsⁱ	ENSG00000185527
Orphanetⁱ	791 Retinitis pigmentosa
PharmGKBⁱ	PA33137
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZA8 Eukaryota ENOG410YN07 LUCA
GeneTreeⁱ	ENSGT00390000013260
HOGENOMⁱ	HOG000261673
HOVERGENⁱ	HBG000447
KOⁱ	K13759
PhylomeDBⁱ	P18545
TreeFamⁱ	TF333297

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2485179 Activation of the phototransduction cascade R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-4086398 Ca2+ pathway
SignaLinkⁱ	P18545
SIGNORⁱ	P18545

Miscellaneous databases

EvolutionaryTraceⁱ	P18545
GeneWikiⁱ	PDE6G
GenomeRNAiⁱ	5148
Protein Ontology More...PROⁱ	PR:P18545
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185527 Expressed in 118 organ(s), highest expression level in retina
CleanExⁱ	HS_PDE6G
ExpressionAtlasⁱ	P18545 baseline and differential
Genevisibleⁱ	P18545 HS

Family and domain databases

Gene3Dⁱ	4.10.1120.10, 1 hit
InterProⁱ	View protein in InterPro IPR006952 PDE6_gamma IPR037030 PDE6_gamma_sf
PANTHERⁱ	PTHR12122 PTHR12122, 1 hit
Pfamⁱ	View protein in Pfam PF04868 PDE6_gamma, 1 hit
PIRSFⁱ	PIRSF000969 35-cGMP_Pdiase_g, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CNRG_HUMAN
Accessionⁱ	P18545Primary (citable) accession number: P18545 Secondary accession number(s): Q3KP63, Q7Z3U8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P18545 (CNRG_HUMAN)

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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ