UniProtKB - P18537 (FRIZ_DROME)
Frizzled
fz
Functioni
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- Wnt-activated receptor activity Source: FlyBase
- Wnt-protein binding Source: FlyBase
GO - Biological processi
- asymmetric cell division Source: FlyBase
- axon extension Source: FlyBase
- border follicle cell migration Source: FlyBase
- canonical Wnt signaling pathway Source: FlyBase
- cardioblast cell fate specification Source: FlyBase
- chitin-based larval cuticle pattern formation Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- establishment of cell polarity Source: FlyBase
- establishment of imaginal disc-derived wing hair orientation Source: FlyBase
- establishment of ommatidial planar polarity Source: FlyBase
- establishment of planar polarity Source: FlyBase
- establishment or maintenance of cell polarity Source: UniProtKB
- germ-line stem-cell niche homeostasis Source: FlyBase
- G protein-coupled receptor signaling pathway Source: FlyBase
- homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
- imaginal disc-derived wing hair organization Source: FlyBase
- imaginal disc-derived wing hair site selection Source: FlyBase
- imaginal disc-derived wing margin morphogenesis Source: FlyBase
- midgut development Source: FlyBase
- morphogenesis of a polarized epithelium Source: FlyBase
- neuron fate specification Source: FlyBase
- ommatidial rotation Source: FlyBase
- positive regulation of axon extension Source: FlyBase
- positive regulation of axon guidance Source: FlyBase
- R3/R4 cell differentiation Source: FlyBase
- R3/R4 cell fate commitment Source: FlyBase
- regulation of actin filament bundle assembly Source: FlyBase
- regulation of hemocyte proliferation Source: FlyBase
- regulation of tube length, open tracheal system Source: FlyBase
- salivary gland morphogenesis Source: FlyBase
- segment polarity determination Source: FlyBase
- sensory organ precursor cell fate determination Source: FlyBase
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-DME-209387, Phosphorylation of ARR R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209472, Assembly of receptor complex R-DME-350368, Activation of RHO1 by FZ:DSH complex R-DME-350376, Activation of RAC1:GTP by FZ:DSH complex R-DME-350379, Homo-/heterophilic binding of transmembrane components R-DME-350411, Formation and asymmetric localisation of transmembrane complexes R-DME-350480, Activation of non-muscle Myosin II R-DME-4086398, Ca2+ pathway R-DME-4086400, PCP/CE pathway R-DME-450728, Inhibition of actin polymerisation R-DME-4608870, Asymmetric localization of PCP proteins R-DME-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
SignaLinki | P18537 |
Protein family/group databases
TCDBi | 9.A.14.16.5, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: FrizzledAlternative name(s): Frizzled-1 Short name: dFz1 |
Gene namesi | Name:fz ORF Names:CG17697 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0001085, fz |
VEuPathDBi | VectorBase:FBgn0001085 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: FlyBase
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 247 | Extracellular1 PublicationAdd BLAST | 229 | |
Transmembranei | 248 – 270 | Helical; Name=1CuratedAdd BLAST | 23 | |
Topological domaini | 271 – 280 | Cytoplasmic1 Publication | 10 | |
Transmembranei | 281 – 303 | Helical; Name=2CuratedAdd BLAST | 23 | |
Topological domaini | 304 – 343 | Extracellular1 PublicationAdd BLAST | 40 | |
Transmembranei | 344 – 364 | Helical; Name=3CuratedAdd BLAST | 21 | |
Topological domaini | 365 – 380 | Cytoplasmic1 PublicationAdd BLAST | 16 | |
Transmembranei | 381 – 401 | Helical; Name=4CuratedAdd BLAST | 21 | |
Topological domaini | 402 – 421 | Extracellular1 PublicationAdd BLAST | 20 | |
Transmembranei | 422 – 439 | Helical; Name=5CuratedAdd BLAST | 18 | |
Topological domaini | 440 – 471 | Cytoplasmic1 PublicationAdd BLAST | 32 | |
Transmembranei | 472 – 492 | Helical; Name=6CuratedAdd BLAST | 21 | |
Topological domaini | 493 – 529 | Extracellular1 PublicationAdd BLAST | 37 | |
Transmembranei | 530 – 553 | Helical; Name=7CuratedAdd BLAST | 24 | |
Topological domaini | 554 – 581 | Cytoplasmic1 PublicationAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000013010 | 19 – 581 | FrizzledAdd BLAST | 563 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 114 | PROSITE-ProRule annotation | ||
Disulfide bondi | 61 ↔ 107 | PROSITE-ProRule annotation | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 134 | PROSITE-ProRule annotation | ||
Disulfide bondi | 124 ↔ 163 | PROSITE-ProRule annotation | ||
Disulfide bondi | 128 ↔ 151 | PROSITE-ProRule annotation | ||
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P18537 |
PTM databases
GlyGeni | P18537, 2 sites |
Expressioni
Gene expression databases
Bgeei | FBgn0001085, Expressed in wing disc (Drosophila) and 34 other tissues |
ExpressionAtlasi | P18537, baseline and differential |
Genevisiblei | P18537, DM |
Interactioni
Subunit structurei
Interacts with ATP6AP2.
1 PublicationBinary interactionsi
P18537
With | #Exp. | IntAct |
---|---|---|
stan [Q9V5N8] | 3 | EBI-251576,EBI-119250 |
GO - Molecular functioni
- Wnt-protein binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 69580, 59 interactors |
DIPi | DIP-22727N |
IntActi | P18537, 3 interactors |
STRINGi | 7227.FBpp0075485 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 166 | FZPROSITE-ProRule annotationAdd BLAST | 119 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 556 – 561 | Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity | 6 | |
Motifi | 579 – 581 | PDZ-binding | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000166686 |
HOGENOMi | CLU_007873_2_1_1 |
InParanoidi | P18537 |
OMAi | WELCAGA |
OrthoDBi | 330751at2759 |
PhylomeDBi | P18537 |
Family and domain databases
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR000539, Frizzled/Smoothened_TM IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR026552, FZD7 IPR017981, GPCR_2-like |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF31, PTHR11309:SF31, 1 hit |
Pfami | View protein in Pfam PF01534, Frizzled, 1 hit PF01392, Fz, 1 hit |
PRINTSi | PR00489, FRIZZLED |
SMARTi | View protein in SMART SM00063, FRI, 1 hit SM01330, Frizzled, 1 hit |
SUPFAMi | SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MWRQILFILP TLIQGVQRYD QSPLDASPYY RSGGGLMASS GTELDGLPHH
60 70 80 90 100
NRCEPITISI CKNIPYNMTI MPNLIGHTKQ EEAGLEVHQF APLVKIGCSD
110 120 130 140 150
DLQLFLCSLY VPVCTILERP IPPCRSLCES ARVCEKLMKT YNFNWPENLE
160 170 180 190 200
CSKFPVHGGE DLCVAENTTS SASTAATPTR SVAKVTTRKH QTGVESPHRN
210 220 230 240 250
IGFVCPVQLK TPLGMGYELK VGGKDLHDCG APCHAMFFPE RERTVLRYWV
260 270 280 290 300
GSWAAVCVAS CLFTVLTFLI DSSRFRYPER AIVFLAVCYL VVGCAYVAGL
310 320 330 340 350
GAGDSVSCRE PFPPPVKLGR LQMMSTITQG HRQTTSCTVL FMALYFCCMA
360 370 380 390 400
AFAWWSCLAF AWFLAAGLKW GHEAIENKSH LFHLVAWAVP ALQTISVLAL
410 420 430 440 450
AKVEGDILSG VCFVGQLDTH SLGAFLILPL CIYLSIGALF LLAGFISLFR
460 470 480 490 500
IRTVMKTDGK RTDKLERLML RIGFFSGLFI LPAVGLLGCL FYEYYNFDEW
510 520 530 540 550
MIQWHRDICK PFSIPCPAAR APGSPEARPI FQIFMVKYLC SMLVGVTSSV
560 570 580
WLYSSKTMVS WRNFVERLQG KEPRTRAQAY V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PFL6 | M9PFL6_DROME | Frizzled, isoform C | fz CG3646, DFz, Dfz, dFz, DFZ1 | 612 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54648 , X54649, X54650, X54651 Genomic DNA Translation: CAA38460.1 X54648 , X54649, X54650, X54652 Genomic DNA Translation: CAA38461.1 Sequence problems. X54646 mRNA Translation: CAA38458.1 X54647 mRNA Translation: CAA38459.1 Sequence problems. AE014296 Genomic DNA Translation: AAF49746.3 AY051808 mRNA Translation: AAK93232.1 |
PIRi | S03540 |
RefSeqi | NP_524812.1, NM_080073.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0075743; FBpp0075485; FBgn0001085 |
GeneIDi | 45307 |
KEGGi | dme:Dmel_CG17697 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54648 , X54649, X54650, X54651 Genomic DNA Translation: CAA38460.1 X54648 , X54649, X54650, X54652 Genomic DNA Translation: CAA38461.1 Sequence problems. X54646 mRNA Translation: CAA38458.1 X54647 mRNA Translation: CAA38459.1 Sequence problems. AE014296 Genomic DNA Translation: AAF49746.3 AY051808 mRNA Translation: AAK93232.1 |
PIRi | S03540 |
RefSeqi | NP_524812.1, NM_080073.3 |
3D structure databases
SMRi | P18537 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 69580, 59 interactors |
DIPi | DIP-22727N |
IntActi | P18537, 3 interactors |
STRINGi | 7227.FBpp0075485 |
Protein family/group databases
TCDBi | 9.A.14.16.5, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P18537, 2 sites |
Proteomic databases
PaxDbi | P18537 |
Protocols and materials databases
DNASUi | 45307 |
Genome annotation databases
EnsemblMetazoai | FBtr0075743; FBpp0075485; FBgn0001085 |
GeneIDi | 45307 |
KEGGi | dme:Dmel_CG17697 |
Organism-specific databases
CTDi | 45307 |
FlyBasei | FBgn0001085, fz |
VEuPathDBi | VectorBase:FBgn0001085 |
Phylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000166686 |
HOGENOMi | CLU_007873_2_1_1 |
InParanoidi | P18537 |
OMAi | WELCAGA |
OrthoDBi | 330751at2759 |
PhylomeDBi | P18537 |
Enzyme and pathway databases
Reactomei | R-DME-209387, Phosphorylation of ARR R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209472, Assembly of receptor complex R-DME-350368, Activation of RHO1 by FZ:DSH complex R-DME-350376, Activation of RAC1:GTP by FZ:DSH complex R-DME-350379, Homo-/heterophilic binding of transmembrane components R-DME-350411, Formation and asymmetric localisation of transmembrane complexes R-DME-350480, Activation of non-muscle Myosin II R-DME-4086398, Ca2+ pathway R-DME-4086400, PCP/CE pathway R-DME-450728, Inhibition of actin polymerisation R-DME-4608870, Asymmetric localization of PCP proteins R-DME-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
SignaLinki | P18537 |
Miscellaneous databases
BioGRID-ORCSi | 45307, 0 hits in 3 CRISPR screens |
GenomeRNAii | 45307 |
PROi | PR:P18537 |
Gene expression databases
Bgeei | FBgn0001085, Expressed in wing disc (Drosophila) and 34 other tissues |
ExpressionAtlasi | P18537, baseline and differential |
Genevisiblei | P18537, DM |
Family and domain databases
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR000539, Frizzled/Smoothened_TM IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR026552, FZD7 IPR017981, GPCR_2-like |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF31, PTHR11309:SF31, 1 hit |
Pfami | View protein in Pfam PF01534, Frizzled, 1 hit PF01392, Fz, 1 hit |
PRINTSi | PR00489, FRIZZLED |
SMARTi | View protein in SMART SM00063, FRI, 1 hit SM01330, Frizzled, 1 hit |
SUPFAMi | SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FRIZ_DROME | |
Accessioni | P18537Primary (citable) accession number: P18537 Secondary accession number(s): Q9VUE0, Q9VUE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 225 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families