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Protein

Delta-conotoxin TxVIA

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Binding of this toxin is strongly calcium-dependent but not voltage-dependent. The binding site is most likely on the extracellular side of the sodium channel. Binds receptor sites on both mollusk and rat central nervous system, but despite its high affinity binding to rat sodium channel, it has no functional effect in vivo and in vitro on it. Has also no effect on Gambusia fish. Is important in mollusk for the paralysis of the prey. Upon injection of the peptide, a subordinate lobster assumes an exaggerated dominant posture (of a 'King-Kong' lobster!).4 Publications

Miscellaneous

Veratridine increases the rate of dissociation in a dose-dependent manner.

Caution

Several genes are coding for this toxin, it is therefore also shown in entry AC Q9U655.Curated

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Protein family/group databases

TCDBi8.B.4.1.7 the conotoxin t (conotoxin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-conotoxin TxVIA2 Publications
Alternative name(s):
Conotoxin King-Kong 01 Publication
Short name:
KK-0Imported
TxIA2 Publications
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusCylinder

Organism-specific databases

ConoServeri598 TxVIA precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003490023 – 49CuratedAdd BLAST27
PeptideiPRO_000003490152 – 78Delta-conotoxin TxVIA3 PublicationsAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 681 PublicationImported
Modified residuei59Methionine sulfoxide; partial1 Publication1
Disulfide bondi60 ↔ 721 PublicationImported
Disulfide bondi67 ↔ 771 PublicationImported

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Oxidation

Expressioni

Tissue specificityi

Expressed by the venom duct.3 Publications

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18511
SMRiP18511
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18511

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.2 Publications
The cysteine framework is VI/VII (C-C-CC-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
IPR012322 Conotoxin_d-typ_CS
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
PROSITEiView protein in PROSITE
PS60005 DELTA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18511-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLTCMMIVA VLFLTAWTFA TADDPRNGLG NLFSNAHHEM KNPEASKLNK
60 70
RWCKQSGEMC NLLDQNCCDG YCIVLVCT
Length:78
Mass (Da):8,760
Last modified:November 1, 1990 - v1
Checksum:iC5CBFD462AD40A35
GO

Mass spectrometryi

Molecular mass is 3034.2±0.05 Da from positions 52 - 78. Determined by ESI. Without oxidation at Met-59.1 Publication
Molecular mass is 3050.189±0.05 Da from positions 52 - 78. Determined by ESI. With oxidation at Met-59.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53283 mRNA Translation: CAA37377.1
PIRiS12513

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53283 mRNA Translation: CAA37377.1
PIRiS12513

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FU3NMR-A52-78[»]
ProteinModelPortaliP18511
SMRiP18511
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.4.1.7 the conotoxin t (conotoxin) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri598 TxVIA precursor

Miscellaneous databases

EvolutionaryTraceiP18511

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
IPR012322 Conotoxin_d-typ_CS
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
PROSITEiView protein in PROSITE
PS60005 DELTA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO16A_CONTE
AccessioniPrimary (citable) accession number: P18511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 10, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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