Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor antagonist protein

Gene

IL1RN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6783783 Interleukin-10 signaling
R-HSA-9020702 Interleukin-1 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P18510

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor antagonist protein
Short name:
IL-1RN
Short name:
IL-1ra
Short name:
IRAP
Alternative name(s):
ICIL-1RA
IL1 inhibitor
INN: Anakinra
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL1RN
Synonyms:IL1F3, IL1RA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136689.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6000 IL1RN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147679 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18510

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microvascular complications of diabetes 4 (MVCD4)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionPathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
See also OMIM:612628
Interleukin 1 receptor antagonist deficiency (DIRA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.
See also OMIM:612852

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.

Organism-specific databases

DisGeNET

More...
DisGeNETi
3557

MalaCards human disease database

More...
MalaCardsi
IL1RN
MIMi612628 phenotype
612852 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136689

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
210115 Sterile multifocal osteomyelitis with periostitis and pustulosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29816

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
11858 Hom s Anakinra

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB06372 Rilonacept

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL1RN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124312

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 252 PublicationsAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001532826 – 177Interleukin-1 receptor antagonist proteinAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi91 ↔ 141
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P18510

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18510

PeptideAtlas

More...
PeptideAtlasi
P18510

PRoteomics IDEntifications database

More...
PRIDEi
P18510

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53572
53573 [P18510-2]
53574 [P18510-3]
53575 [P18510-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18510

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18510

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136689 Expressed in 163 organ(s), highest expression level in lower esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL1RN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18510 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18510 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009633
HPA001482

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1026330,EBI-750109

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109772, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P18510, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259206

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P18510

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18510

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18510

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZQ4 Eukaryota
ENOG41119SQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231506

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052099

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18510

KEGG Orthology (KO)

More...
KOi
K05481

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLCLACV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PWA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18510

TreeFam database of animal gene trees

More...
TreeFami
TF300203

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR008996 IL1/FGF
IPR039348 IL1RA

The PANTHER Classification System

More...
PANTHERi
PTHR45042 PTHR45042, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00340 IL1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50353 SSF50353, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P18510-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEICRGLRSH LITLLLFLFH SETICRPSGR KSSKMQAFRI WDVNQKTFYL
60 70 80 90 100
RNNQLVAGYL QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE
110 120 130 140 150
TRLQLEAVNI TDLSENRKQD KRFAFIRSDS GPTTSFESAA CPGWFLCTAM
160 170
EADQPVSLTN MPDEGVMVTK FYFQEDE
Length:177
Mass (Da):20,055
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1690776A7394057
GO
Isoform 2 (identifier: P18510-2) [UniParc]FASTAAdd to basket
Also known as: icIL-1ra

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEICRGLRSHLITLLLFLFHS → MAL

Show »
Length:159
Mass (Da):17,888
Checksum:iC1D66CDF0D2F7B44
GO
Isoform 3 (identifier: P18510-3) [UniParc]FASTAAdd to basket
Also known as: icIL-1ra type II

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEICRGLRSHLITLLLFLFHS → MALADLYEEGGGGGGEGEDNADSK

Show »
Length:180
Mass (Da):19,897
Checksum:i624A1574C2334229
GO
Isoform 4 (identifier: P18510-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:143
Mass (Da):16,142
Checksum:i4CAD6784B890906B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049573124A → T1 PublicationCorresponds to variant dbSNP:rs45507693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0026511 – 34Missing in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0026491 – 21MEICR…FLFHS → MAL in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0026501 – 21MEICR…FLFHS → MALADLYEEGGGGGGEGEDN ADSK in isoform 3. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53296 mRNA Translation: CAA37386.1
X52015 mRNA Translation: CAA36262.1
M63099 Genomic DNA Translation: AAB41943.1
X64532 Genomic DNA Translation: CAA45832.1
U65590 Genomic DNA Translation: AAB92270.1
U65590 Genomic DNA Translation: AAB92268.1
U65590 Genomic DNA Translation: AAB92269.1
M55646 mRNA Translation: AAA59138.1
X84348 mRNA Translation: CAA59087.1
AY196903 Genomic DNA Translation: AAN87150.1
AK290898 mRNA Translation: BAF83587.1
AK290926 mRNA Translation: BAF83615.1
AC024704 Genomic DNA Translation: AAX93278.1
CH471217 Genomic DNA Translation: EAW73625.1
BC009745 mRNA Translation: AAH09745.1
AF043143 mRNA Translation: AAC39672.1
BN000002 Genomic DNA Translation: CAD29879.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2113.1 [P18510-2]
CCDS2114.1 [P18510-3]
CCDS2115.1 [P18510-4]
CCDS46396.1 [P18510-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A40956 A30368
I37893 A39386

NCBI Reference Sequences

More...
RefSeqi
NP_000568.1, NM_000577.4 [P18510-2]
NP_001305843.1, NM_001318914.1 [P18510-4]
NP_776213.1, NM_173841.2 [P18510-3]
NP_776214.1, NM_173842.2 [P18510-1]
NP_776215.1, NM_173843.2 [P18510-4]
XP_005263718.1, XM_005263661.4 [P18510-4]
XP_011509423.1, XM_011511121.1 [P18510-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.81134

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259206; ENSP00000259206; ENSG00000136689 [P18510-3]
ENST00000354115; ENSP00000329072; ENSG00000136689 [P18510-2]
ENST00000361779; ENSP00000354816; ENSG00000136689 [P18510-4]
ENST00000409052; ENSP00000387210; ENSG00000136689 [P18510-4]
ENST00000409930; ENSP00000387173; ENSG00000136689 [P18510-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3557

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3557

UCSC genome browser

More...
UCSCi
uc002tiy.3 human [P18510-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Kineret professional medical information"

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53296 mRNA Translation: CAA37386.1
X52015 mRNA Translation: CAA36262.1
M63099 Genomic DNA Translation: AAB41943.1
X64532 Genomic DNA Translation: CAA45832.1
U65590 Genomic DNA Translation: AAB92270.1
U65590 Genomic DNA Translation: AAB92268.1
U65590 Genomic DNA Translation: AAB92269.1
M55646 mRNA Translation: AAA59138.1
X84348 mRNA Translation: CAA59087.1
AY196903 Genomic DNA Translation: AAN87150.1
AK290898 mRNA Translation: BAF83587.1
AK290926 mRNA Translation: BAF83615.1
AC024704 Genomic DNA Translation: AAX93278.1
CH471217 Genomic DNA Translation: EAW73625.1
BC009745 mRNA Translation: AAH09745.1
AF043143 mRNA Translation: AAC39672.1
BN000002 Genomic DNA Translation: CAD29879.1
CCDSiCCDS2113.1 [P18510-2]
CCDS2114.1 [P18510-3]
CCDS2115.1 [P18510-4]
CCDS46396.1 [P18510-1]
PIRiA40956 A30368
I37893 A39386
RefSeqiNP_000568.1, NM_000577.4 [P18510-2]
NP_001305843.1, NM_001318914.1 [P18510-4]
NP_776213.1, NM_173841.2 [P18510-3]
NP_776214.1, NM_173842.2 [P18510-1]
NP_776215.1, NM_173843.2 [P18510-4]
XP_005263718.1, XM_005263661.4 [P18510-4]
XP_011509423.1, XM_011511121.1 [P18510-4]
UniGeneiHs.81134

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILRX-ray2.101/226-177[»]
1ILTX-ray2.00A/B26-177[»]
1IRAX-ray2.70X26-177[»]
1IRPNMR-A26-177[»]
1ITNmodel-A31-177[»]
2IRTX-ray3.20A/B26-177[»]
ProteinModelPortaliP18510
SMRiP18510
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109772, 12 interactors
IntActiP18510, 3 interactors
STRINGi9606.ENSP00000259206

Chemistry databases

DrugBankiDB06372 Rilonacept

Protein family/group databases

Allergomei11858 Hom s Anakinra

PTM databases

iPTMnetiP18510
PhosphoSitePlusiP18510

Polymorphism and mutation databases

BioMutaiIL1RN
DMDMi124312

Proteomic databases

MaxQBiP18510
PaxDbiP18510
PeptideAtlasiP18510
PRIDEiP18510
ProteomicsDBi53572
53573 [P18510-2]
53574 [P18510-3]
53575 [P18510-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3557
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259206; ENSP00000259206; ENSG00000136689 [P18510-3]
ENST00000354115; ENSP00000329072; ENSG00000136689 [P18510-2]
ENST00000361779; ENSP00000354816; ENSG00000136689 [P18510-4]
ENST00000409052; ENSP00000387210; ENSG00000136689 [P18510-4]
ENST00000409930; ENSP00000387173; ENSG00000136689 [P18510-1]
GeneIDi3557
KEGGihsa:3557
UCSCiuc002tiy.3 human [P18510-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3557
DisGeNETi3557
EuPathDBiHostDB:ENSG00000136689.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL1RN
HGNCiHGNC:6000 IL1RN
HPAiCAB009633
HPA001482
MalaCardsiIL1RN
MIMi147679 gene
612628 phenotype
612852 phenotype
neXtProtiNX_P18510
OpenTargetsiENSG00000136689
Orphaneti210115 Sterile multifocal osteomyelitis with periostitis and pustulosis
PharmGKBiPA29816

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZQ4 Eukaryota
ENOG41119SQ LUCA
GeneTreeiENSGT00900000141028
HOGENOMiHOG000231506
HOVERGENiHBG052099
InParanoidiP18510
KOiK05481
OMAiKLCLACV
OrthoDBiEOG091G0PWA
PhylomeDBiP18510
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-9020702 Interleukin-1 signaling
SIGNORiP18510

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL1RN human
EvolutionaryTraceiP18510

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Interleukin_1_receptor_antagonist

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3557

Protein Ontology

More...
PROi
PR:P18510

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136689 Expressed in 163 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_IL1RN
ExpressionAtlasiP18510 baseline and differential
GenevisibleiP18510 HS

Family and domain databases

InterProiView protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR008996 IL1/FGF
IPR039348 IL1RA
PANTHERiPTHR45042 PTHR45042, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL1RA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18510
Secondary accession number(s): A8K4G1
, Q14628, Q53SC2, Q7RTZ4, Q96GD6, Q9UPC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 5, 2018
This is version 206 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again