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Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

ADCYAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).By similarity2 Publications

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB
  • peptide hormone receptor binding Source: UniProtKB
  • pituitary adenylate cyclase activating polypeptide activity Source: BHF-UCL
  • pituitary adenylate cyclase-activating polypeptide receptor binding Source: GO_Central
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processNeurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SABIO-RKiP18509
SIGNORiP18509

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:ADCYAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141433.12
HGNCiHGNC:241 ADCYAP1
MIMi102980 gene
neXtProtiNX_P18509

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi150V → G: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi151K → E: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi152K → E: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi153Y → A: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi157V → A: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi158L → A: Strongly reduced affinity for ADCYAP1R1. 1 Publication1

Organism-specific databases

DisGeNETi116
OpenTargetsiENSG00000141433
PharmGKBiPA24564

Chemistry databases

ChEMBLiCHEMBL5692

Polymorphism and mutation databases

BioMutaiADCYAP1
DMDMi71159615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000001148625 – 79Add BLAST55
PeptideiPRO_000001148782 – 129PACAP-related peptideAdd BLAST48
PeptideiPRO_0000011488132 – 169Pituitary adenylate cyclase-activating polypeptide 38Add BLAST38
PeptideiPRO_0000011489132 – 158Pituitary adenylate cyclase-activating polypeptide 27Add BLAST27
PropeptideiPRO_0000011490173 – 1764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158Leucine amide1 Publication1
Modified residuei169Lysine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP18509
PeptideAtlasiP18509
PRIDEiP18509
ProteomicsDBi53571

PTM databases

iPTMnetiP18509
PhosphoSitePlusiP18509

Expressioni

Gene expression databases

BgeeiENSG00000141433 Expressed in 124 organ(s), highest expression level in type B pancreatic cell
CleanExiHS_ADCYAP1
GenevisibleiP18509 HS

Organism-specific databases

HPAiHPA065887

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106629, 26 interactors
DIPiDIP-60936N
IntActiP18509, 4 interactors
MINTiP18509
STRINGi9606.ENSP00000411658

Chemistry databases

BindingDBiP18509

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18509
SMRiP18509
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18509

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 158Important for receptor binding9

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWIZ Eukaryota
ENOG4111FZG LUCA
GeneTreeiENSGT00530000063592
HOVERGENiHBG018069
InParanoidiP18509
KOiK05262
OMAiADGIFNK
OrthoDBiEOG091G0J1P
PhylomeDBiP18509
TreeFamiTF332804

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR039080 PACAP
PANTHERiPTHR11213:SF1 PTHR11213:SF1, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 2 hits
PRINTSiPR00275 GLUCAGON
SMARTiView protein in SMART
SM00070 GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL
60 70 80 90 100
PDFDGSEPPG AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS
110 120 130 140 150
AGKHLQSLVA RGVGGSLGGG AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV
160 170
KKYLAAVLGK RYKQRVKNKG RRIAYL
Length:176
Mass (Da):18,835
Last modified:May 10, 2005 - v3
Checksum:i696DD57D2A510E1D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01459754D → G4 PublicationsCorresponds to variant dbSNP:rs2856966Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83513 mRNA Translation: AAB21470.1
X60435 Genomic DNA Translation: CAA42962.1
AK313050 mRNA Translation: BAG35881.1
BC093837 mRNA Translation: AAH93837.1
BC101803 mRNA Translation: AAI01804.1
CCDSiCCDS11825.1
PIRiI84638
RefSeqiNP_001093203.1, NM_001099733.1
NP_001108.2, NM_001117.4
UniGeneiHs.531719
Hs.727476

Genome annotation databases

EnsembliENST00000450565; ENSP00000411658; ENSG00000141433
ENST00000579794; ENSP00000462647; ENSG00000141433
GeneIDi116
KEGGihsa:116
UCSCiuc010dkg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83513 mRNA Translation: AAB21470.1
X60435 Genomic DNA Translation: CAA42962.1
AK313050 mRNA Translation: BAG35881.1
BC093837 mRNA Translation: AAH93837.1
BC101803 mRNA Translation: AAI01804.1
CCDSiCCDS11825.1
PIRiI84638
RefSeqiNP_001093203.1, NM_001099733.1
NP_001108.2, NM_001117.4
UniGeneiHs.531719
Hs.727476

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GEANMR-A132-152[»]
2D2PNMR-A132-169[»]
2JODNMR-B137-169[»]
ProteinModelPortaliP18509
SMRiP18509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106629, 26 interactors
DIPiDIP-60936N
IntActiP18509, 4 interactors
MINTiP18509
STRINGi9606.ENSP00000411658

Chemistry databases

BindingDBiP18509
ChEMBLiCHEMBL5692

PTM databases

iPTMnetiP18509
PhosphoSitePlusiP18509

Polymorphism and mutation databases

BioMutaiADCYAP1
DMDMi71159615

Proteomic databases

PaxDbiP18509
PeptideAtlasiP18509
PRIDEiP18509
ProteomicsDBi53571

Protocols and materials databases

DNASUi116
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450565; ENSP00000411658; ENSG00000141433
ENST00000579794; ENSP00000462647; ENSG00000141433
GeneIDi116
KEGGihsa:116
UCSCiuc010dkg.4 human

Organism-specific databases

CTDi116
DisGeNETi116
EuPathDBiHostDB:ENSG00000141433.12
GeneCardsiADCYAP1
HGNCiHGNC:241 ADCYAP1
HPAiHPA065887
MIMi102980 gene
neXtProtiNX_P18509
OpenTargetsiENSG00000141433
PharmGKBiPA24564
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWIZ Eukaryota
ENOG4111FZG LUCA
GeneTreeiENSGT00530000063592
HOVERGENiHBG018069
InParanoidiP18509
KOiK05262
OMAiADGIFNK
OrthoDBiEOG091G0J1P
PhylomeDBiP18509
TreeFamiTF332804

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SABIO-RKiP18509
SIGNORiP18509

Miscellaneous databases

EvolutionaryTraceiP18509
GeneWikiiPituitary_adenylate_cyclase-activating_peptide
GenomeRNAii116
PROiPR:P18509
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141433 Expressed in 124 organ(s), highest expression level in type B pancreatic cell
CleanExiHS_ADCYAP1
GenevisibleiP18509 HS

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR039080 PACAP
PANTHERiPTHR11213:SF1 PTHR11213:SF1, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 2 hits
PRINTSiPR00275 GLUCAGON
SMARTiView protein in SMART
SM00070 GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPACA_HUMAN
AccessioniPrimary (citable) accession number: P18509
Secondary accession number(s): B2R7N4, Q52LQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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