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Entry version 176 (11 Dec 2019)
Sequence version 3 (10 May 2005)
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Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

ADCYAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone
Biological processNeurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-187024 NGF-independant TRKA activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P18509

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P18509

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADCYAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141433.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:241 ADCYAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
102980 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18509

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150V → G: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi151K → E: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi152K → E: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi153Y → A: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi157V → A: Strongly reduced affinity for ADCYAP1R1. 1 Publication1
Mutagenesisi158L → A: Strongly reduced affinity for ADCYAP1R1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
116

Open Targets

More...
OpenTargetsi
ENSG00000141433

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24564

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P18509 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5692

Drug and drug target database

More...
DrugBanki
DB03988 2,6-Diamino-Hexanoic Acid Amide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADCYAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71159615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001148625 – 79Add BLAST55
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001148782 – 129PACAP-related peptideAdd BLAST48
PeptideiPRO_0000011488132 – 169Pituitary adenylate cyclase-activating polypeptide 38Add BLAST38
PeptideiPRO_0000011489132 – 158Pituitary adenylate cyclase-activating polypeptide 27Add BLAST27
PropeptideiPRO_0000011490173 – 1764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei158Leucine amide1 Publication1
Modified residuei169Lysine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P18509

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18509

PeptideAtlas

More...
PeptideAtlasi
P18509

PRoteomics IDEntifications database

More...
PRIDEi
P18509

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18509

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18509

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141433 Expressed in 124 organ(s), highest expression level in type B pancreatic cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18509 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065887

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106629, 26 interactors

Database of interacting proteins

More...
DIPi
DIP-60936N

Protein interaction database and analysis system

More...
IntActi
P18509, 21 interactors

Molecular INTeraction database

More...
MINTi
P18509

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000462647

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P18509

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P18509 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18509

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18509

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 158Important for receptor binding9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWIZ Eukaryota
ENOG4111FZG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183154

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18509

KEGG Orthology (KO)

More...
KOi
K05262

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRDVAQG

Database of Orthologous Groups

More...
OrthoDBi
1014063at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18509

TreeFam database of animal gene trees

More...
TreeFami
TF332804

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR039080 PACAP

The PANTHER Classification System

More...
PANTHERi
PTHR11213:SF1 PTHR11213:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00123 Hormone_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00275 GLUCAGON

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00070 GLUCA, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00260 GLUCAGON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P18509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL
60 70 80 90 100
PDFDGSEPPG AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS
110 120 130 140 150
AGKHLQSLVA RGVGGSLGGG AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV
160 170
KKYLAAVLGK RYKQRVKNKG RRIAYL
Length:176
Mass (Da):18,835
Last modified:May 10, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i696DD57D2A510E1D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01459754D → G4 PublicationsCorresponds to variant dbSNP:rs2856966Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S83513 mRNA Translation: AAB21470.1
X60435 Genomic DNA Translation: CAA42962.1
AK313050 mRNA Translation: BAG35881.1
BC093837 mRNA Translation: AAH93837.1
BC101803 mRNA Translation: AAI01804.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11825.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I84638

NCBI Reference Sequences

More...
RefSeqi
NP_001093203.1, NM_001099733.1
NP_001108.2, NM_001117.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000450565; ENSP00000411658; ENSG00000141433
ENST00000579794; ENSP00000462647; ENSG00000141433

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116

UCSC genome browser

More...
UCSCi
uc010dkg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83513 mRNA Translation: AAB21470.1
X60435 Genomic DNA Translation: CAA42962.1
AK313050 mRNA Translation: BAG35881.1
BC093837 mRNA Translation: AAH93837.1
BC101803 mRNA Translation: AAI01804.1
CCDSiCCDS11825.1
PIRiI84638
RefSeqiNP_001093203.1, NM_001099733.1
NP_001108.2, NM_001117.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GEANMR-A132-152[»]
2D2PNMR-A132-169[»]
2JODNMR-B137-169[»]
SMRiP18509
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106629, 26 interactors
DIPiDIP-60936N
IntActiP18509, 21 interactors
MINTiP18509
STRINGi9606.ENSP00000462647

Chemistry databases

BindingDBiP18509
ChEMBLiCHEMBL5692
DrugBankiDB03988 2,6-Diamino-Hexanoic Acid Amide

PTM databases

iPTMnetiP18509
PhosphoSitePlusiP18509

Polymorphism and mutation databases

BioMutaiADCYAP1
DMDMi71159615

Proteomic databases

MassIVEiP18509
PaxDbiP18509
PeptideAtlasiP18509
PRIDEiP18509
ProteomicsDBi53571

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
116

Genome annotation databases

EnsembliENST00000450565; ENSP00000411658; ENSG00000141433
ENST00000579794; ENSP00000462647; ENSG00000141433
GeneIDi116
KEGGihsa:116
UCSCiuc010dkg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116
DisGeNETi116
EuPathDBiHostDB:ENSG00000141433.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADCYAP1
HGNCiHGNC:241 ADCYAP1
HPAiHPA065887
MIMi102980 gene
neXtProtiNX_P18509
OpenTargetsiENSG00000141433
PharmGKBiPA24564

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWIZ Eukaryota
ENOG4111FZG LUCA
GeneTreeiENSGT00950000183154
InParanoidiP18509
KOiK05262
OMAiKRDVAQG
OrthoDBi1014063at2759
PhylomeDBiP18509
TreeFamiTF332804

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SABIO-RKiP18509
SIGNORiP18509

Miscellaneous databases

EvolutionaryTraceiP18509

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Pituitary_adenylate_cyclase-activating_peptide

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
116
PharosiP18509 Tbio

Protein Ontology

More...
PROi
PR:P18509
RNActiP18509 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141433 Expressed in 124 organ(s), highest expression level in type B pancreatic cell
GenevisibleiP18509 HS

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR039080 PACAP
PANTHERiPTHR11213:SF1 PTHR11213:SF1, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 2 hits
PRINTSiPR00275 GLUCAGON
SMARTiView protein in SMART
SM00070 GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPACA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18509
Secondary accession number(s): B2R7N4, Q52LQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 10, 2005
Last modified: December 11, 2019
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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