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Protein

Gamma-aminobutyric acid receptor subunit delta

Gene

Gabrd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit delta
Alternative name(s):
GABA(A) receptor subunit delta
Gene namesi
Name:Gabrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61901 Gabrd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 248ExtracellularCuratedAdd BLAST232
Transmembranei249 – 271HelicalCuratedAdd BLAST23
Transmembranei275 – 297HelicalCuratedAdd BLAST23
Transmembranei309 – 331HelicalCuratedAdd BLAST23
Topological domaini332 – 426CytoplasmicCuratedAdd BLAST95
Transmembranei427 – 449HelicalCuratedAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000000047017 – 449Gamma-aminobutyric acid receptor subunit deltaAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 178By similarity
Modified residuei390PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18506
PRIDEiP18506

PTM databases

iPTMnetiP18506
PhosphoSitePlusiP18506

Expressioni

Gene expression databases

BgeeiENSRNOG00000016385 Expressed in 4 organ(s), highest expression level in brain
GenevisibleiP18506 RN

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

ComplexPortaliCPX-280 GABA-A receptor, alpha-4/beta-3/delta
CPX-406 GABA-A receptor, alpha-6/beta-3/delta
CPX-407 GABA-A receptor, alpha-6/beta-2/delta
CPX-408 GABA-A receptor, alpha-4/beta-2/delta
IntActiP18506, 1 interactor
STRINGi10116.ENSRNOP00000022246

Chemistry databases

BindingDBiP18506

Structurei

3D structure databases

ProteinModelPortaliP18506
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP18506
KOiK05184
OMAiFLHQSWR
OrthoDBiEOG091G0805
PhylomeDBiP18506
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008098 GABAAd_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF34 PTHR18945:SF34, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01722 GABAARDELTA
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18506-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG
60 70 80 90 100
YARNFRPGIG GPPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL
110 120 130 140 150
SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG
160 170 180 190 200
VILYSIRITS TVACDMDLAK YPMDEQECML DLESYGYSSE DIVYYWSENQ
210 220 230 240 250
EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY
260 270 280 290 300
IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
310 320 330 340 350
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP
360 370 380 390 400
RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK
410 420 430 440
EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM
Length:449
Mass (Da):50,566
Last modified:June 1, 1994 - v2
Checksum:i64BDBCDEEB2C70AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08496 Genomic DNA Translation: AAC42035.1
BC087714 mRNA Translation: AAH87714.1
M35162 mRNA Translation: AAA41182.1
PIRiA34625
RefSeqiNP_058985.1, NM_017289.1
UniGeneiRn.10927

Genome annotation databases

EnsembliENSRNOT00000022246; ENSRNOP00000022246; ENSRNOG00000016385
GeneIDi29689
KEGGirno:29689

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08496 Genomic DNA Translation: AAC42035.1
BC087714 mRNA Translation: AAH87714.1
M35162 mRNA Translation: AAA41182.1
PIRiA34625
RefSeqiNP_058985.1, NM_017289.1
UniGeneiRn.10927

3D structure databases

ProteinModelPortaliP18506
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-280 GABA-A receptor, alpha-4/beta-3/delta
CPX-406 GABA-A receptor, alpha-6/beta-3/delta
CPX-407 GABA-A receptor, alpha-6/beta-2/delta
CPX-408 GABA-A receptor, alpha-4/beta-2/delta
IntActiP18506, 1 interactor
STRINGi10116.ENSRNOP00000022246

Chemistry databases

BindingDBiP18506
ChEMBLiCHEMBL1907607

PTM databases

iPTMnetiP18506
PhosphoSitePlusiP18506

Proteomic databases

PaxDbiP18506
PRIDEiP18506

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022246; ENSRNOP00000022246; ENSRNOG00000016385
GeneIDi29689
KEGGirno:29689

Organism-specific databases

CTDi2563
RGDi61901 Gabrd

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP18506
KOiK05184
OMAiFLHQSWR
OrthoDBiEOG091G0805
PhylomeDBiP18506
TreeFamiTF315453

Miscellaneous databases

PROiPR:P18506

Gene expression databases

BgeeiENSRNOG00000016385 Expressed in 4 organ(s), highest expression level in brain
GenevisibleiP18506 RN

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008098 GABAAd_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF34 PTHR18945:SF34, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01722 GABAARDELTA
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBRD_RAT
AccessioniPrimary (citable) accession number: P18506
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: June 1, 1994
Last modified: October 10, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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