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Entry version 142 (08 May 2019)
Sequence version 4 (16 Mar 2016)
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Protein

Protein pecanex

Gene

pcx

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neurogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein pecanex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pcx
ORF Names:CG3443
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003048 pcx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei1315 – 1335HelicalSequence analysisAdd BLAST21
Transmembranei1343 – 1363HelicalSequence analysisAdd BLAST21
Transmembranei1376 – 1396HelicalSequence analysisAdd BLAST21
Transmembranei1423 – 1443HelicalSequence analysisAdd BLAST21
Transmembranei1474 – 1494HelicalSequence analysisAdd BLAST21
Transmembranei1504 – 1524HelicalSequence analysisAdd BLAST21
Transmembranei1830 – 1850HelicalSequence analysisAdd BLAST21
Transmembranei1856 – 1876HelicalSequence analysisAdd BLAST21
Transmembranei1914 – 1934HelicalSequence analysisAdd BLAST21
Transmembranei1940 – 1960HelicalSequence analysisAdd BLAST21
Transmembranei1976 – 1996HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002157921 – 3413Protein pecanexAdd BLAST3413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1015N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1069N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1791N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2717N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3246N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18490

PRoteomics IDEntifications database

More...
PRIDEi
P18490

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003048 Expressed in 32 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18490 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18490 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
57742, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P18490, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304656

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18490

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1776 – 177712
Repeati1778 – 177922
Repeati1780 – 178132
Repeati1782 – 178342
Repeati1784 – 178552

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1776 – 17855 X 2 AA tandem repeats of G-T10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi541 – 609Gly-richAdd BLAST69
Compositional biasi1178 – 1215Ala-richAdd BLAST38
Compositional biasi1636 – 1669Ser-richAdd BLAST34
Compositional biasi1773 – 1807Gly-richAdd BLAST35
Compositional biasi2348 – 2373Ala-richAdd BLAST26
Compositional biasi2424 – 2446Gly-richAdd BLAST23
Compositional biasi2787 – 3055Gly-richAdd BLAST269
Compositional biasi3291 – 3413Glu-richAdd BLAST123

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3604 Eukaryota
ENOG410XPRI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168683

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18490

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCFARPL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039797 Pecanex
IPR007735 Pecanex_C

The PANTHER Classification System

More...
PANTHERi
PTHR12372 PTHR12372, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05041 Pecanex_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P18490-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSQTLEILR QGVWASLTGG YFYDPHQGVF CNVVHLYLWL YLLCSPFVAY
60 70 80 90 100
LYFPSTWLTW CLYCVITSLT ILMVKLANLA LHRLYDRAQT MSEGNLKGQF
110 120 130 140 150
VKVTKETEPR HDDEGGIEMK VIRPGGSRIS GEQAINEASE ENSIMSIDNV
160 170 180 190 200
NSIIDLKVDV HRKNSSESIE LMFYAPSMLS GGSQQDQQSL AGSASVSKSI
210 220 230 240 250
RSTGPGGNSS TSAAAQADMF NKYLTVYPEV VEAAGSSAGS ADGGSSGGDS
260 270 280 290 300
RSGAAVSTLG HTGAGTAPAQ HVRTGHLSRK CSEVFSRRHR RRLERQSSLD
310 320 330 340 350
TAAAAANSNA ENKLMRNQSD TIATAAPSFL HSQPTNKARG QTNPRQHFIT
360 370 380 390 400
SAPSTGIGGG DAPTSSTAVV VIAPASNSLV NPGRSSRLQR HRSSETHDER
410 420 430 440 450
LKHQSRGGLF QPILQLPHHS AASSIGALAV LGGGGNVAAN DVEDMELGLV
460 470 480 490 500
RNAGSGGVAD ACSRALQSWI LDPFPDGYLE DDSYTKSDLG IEQPHQPTFR
510 520 530 540 550
TQHRHHHHHH HLHHHLGGAI IRKDPTSTMS ALQLAAVTQP GTGGSVTGGG
560 570 580 590 600
GAAGGGGSAA GMKRRRHSNA TSYKHGSSQS NKSSLVGGGG SRGPSGEAGT
610 620 630 640 650
SGGAGGTGGV RRIKSAALEV LCPQPSVSNL SPHPNSVEAI SGQQQMRNPL
660 670 680 690 700
PPPSKSLVRN QHLNLYPTQG YGDGTPSAGG GGPGNSSTCS SLFFGSSSAC
710 720 730 740 750
GSTTALIEPP VYPIVEHSDE KTAHEEHGDD CLGIGQGNAD DDDEVDDVPI
760 770 780 790 800
RRRTRALGCS QTHYSVESDV GGFLADEVGA DEDVFKDFDD NLEHILSELQ
810 820 830 840 850
QTHNQLDDVL KTHDLHHHSH LHHHKAASVE GAGPSGGSVA VGVSAGNDDE
860 870 880 890 900
DEETEDNNTG SRSPLLNDRN RQPATLREIQ ADKQLRQELS HQSGAVIPAP
910 920 930 940 950
NPPVPIRSEA DSGCPSSDCE QVSASSKDQL LSGIELELQQ YQILQRCQLD
960 970 980 990 1000
EEQPCTSKMA AKSLGAIPKV VKYREVDELR RRRRGGSPAD AAEAGNEFAL
1010 1020 1030 1040 1050
VKQTKQASRN SSSSNSTHSI SLTDSLTADI HKMLWLMHGG AVDDRGRPIT
1060 1070 1080 1090 1100
GTSADGTPIP ASSSLVPPNM SNAHFQFYQD AIQALQGTHP TSGSSVEHMT
1110 1120 1130 1140 1150
NIELARDKLR LDAKLMCEQL VAAAEANSGV RGNTLATQQM TQQQVGMLMR
1160 1170 1180 1190 1200
GGSSSRHPSS APFSVQGLIN VIRSERPAAR SQLDALQQLS DAAAALAANA
1210 1220 1230 1240 1250
SEAASVSASG AGGGASSGGG GVLSALGLAN HPSNQISQIS QLSQMSQPML
1260 1270 1280 1290 1300
NVDGHFAPYC DYWRPACLLS ATEKPAAPKS FYKYRFKWCG QEHEFKIAMD
1310 1320 1330 1340 1350
RLELLALFDR DLHWMHVLLA SLLCTLVACL GAAILQHDHY KDLCALLFCA
1360 1370 1380 1390 1400
VIAGAQYSLV KSVQPDAASP VHGFNKTVAY SRAIYFCLAG GMLLLLKRLD
1410 1420 1430 1440 1450
TDYGERTPDP VVFFGMRYSP ADVVALLLQA LYILLLCFPI IFSVGLCPQI
1460 1470 1480 1490 1500
NTFLMYLLEQ IDMHVFGGNA ASSLLGSFLC VVRSVLAVML LYGPLYGALD
1510 1520 1530 1540 1550
EQRGTQYILF SIFCAMLVPL GYHLSRCASD FSHLWRLIKT CIVSTYRDDE
1560 1570 1580 1590 1600
DEDLSQMQHI ATGTVTGSGT ANSTALQLTT STPKQHRQTD VKTEHEQIEL
1610 1620 1630 1640 1650
SSLEKLTVNE EHHEKDHGAD DQLETDQDLP LQQKHSKSKT SSLGSSQQTL
1660 1670 1680 1690 1700
GKTISSSKRA ITASSSCTSI GTGEPAVEAG ALTEEAVEGE EQRRNTLAGE
1710 1720 1730 1740 1750
VGSKHELAEN YDQAAKIDEC EDKISSSSAT NPGDMSTLTA GAGTATTDAT
1760 1770 1780 1790 1800
PACLEADPDA EAEAPADEKQ HQGILGTGTG TGTGTTEASE NGSGGGANGN
1810 1820 1830 1840 1850
TNSNGTGNDL PDPLPRKLQA TVTTRLKNDL VVMTLLAVSV LGLHCSTVFT
1860 1870 1880 1890 1900
ALQPDLNVVL YSFIGVLGLL LHYIVPQMRK HMPWLCFSRP LLRQREFGQF
1910 1920 1930 1940 1950
EVLNAPKIMW FEKLYIYLSV LERNVLFPLL AISSLTADSQ LIVAKFGLPW
1960 1970 1980 1990 2000
GTLIVAICAL KFVRNAYSDP TNQYLIIIFT VLLFRIDFAM ATETFIIDYF
2010 2020 2030 2040 2050
FVSLAFRKCC DFLLKLQFIV TYIAPWQITW GSAFHAFAQP FSVPHSAMLF
2060 2070 2080 2090 2100
LQAAISAVLS TPLNPFLGSA IFLTSYVRPI KFWERDYNTR RIDHSNTRLS
2110 2120 2130 2140 2150
SQLERDLGAD DNNLNSIFYE HLTRSLQHSL CGDLLMGRWG NVNQGDCFVL
2160 2170 2180 2190 2200
ASDDLNCLVH IIELGNGLCT FQMRGLEFRG TYCQQREVEA ITEDVEDNDG
2210 2220 2230 2240 2250
CCCCDPGHLP QLLSANAMFS TRWLAWQVVA AQYVIEGYSI SDNLASATLQ
2260 2270 2280 2290 2300
VFEYRKVLIT YYIKSIIYYV VKNPKLEQWL ASGPIQDALQ HTLSRQFVDL
2310 2320 2330 2340 2350
DPIFNFNLDE DFDFRAVGIT RSSFCYVYLK WINYCVDMRR DANSMGGAPP
2360 2370 2380 2390 2400
AQAPAAAGGA SSAPATAGVA PPAPVTPAHN DSKSTPNLSA HGGQAGPSSG
2410 2420 2430 2440 2450
QSKSQSQQQL RRPQKSVAQE TSVGGGGVVV GGTTVPGTGG VTGGGGDPQL
2460 2470 2480 2490 2500
SSSHSFANIS RQTSESAPGL GGYVAYMDQN VFVKLAKSST TTGAGAGAPT
2510 2520 2530 2540 2550
SRKESQEKPA LRLKLASVGK DAPLVSLCLA LGLLARRSLA TASHSALTGV
2560 2570 2580 2590 2600
EFFLHGLHAL FKGDFRITSP RDEWVFADME LLHSVVAPAV KMALKLQQDH
2610 2620 2630 2640 2650
ITNPDEFLDP HALYDAIDNC SNELVISHEA DPVWRSAVLR GAPNLLALRH
2660 2670 2680 2690 2700
VMEDGSDEYR IIRLTKRCLS FRVIKLNREC VRGLWAGQQQ ELIYLRNRNP
2710 2720 2730 2740 2750
ERGSIQNAKQ ALRNIINSSC DQPIGYPIYV SPLTTSYADT NAQLCEVIGG
2760 2770 2780 2790 2800
AITLDTIRHT VLGWWHRIRE RCRQGCSSGS ALEPHPGSGP VQLGACNFGS
2810 2820 2830 2840 2850
GGSVVGAAST ATGVGASTGS GLGVAAPGTA GSTGGESGDL APVFISAPLY
2860 2870 2880 2890 2900
NTLTVNSYYS VRPGNVPGGP IPGNLGGNYV SDSLAVVRGG LAVMPVKPTS
2910 2920 2930 2940 2950
TTLIAGLLNR ERDETSGSGI MGAGASGPTR ATSSGGVRSR RPEVGSSRGR
2960 2970 2980 2990 3000
DHERRATLPI ASGGAGGEPG KDLTAPQTQV EHEPSPRSTK LSSSSGSLGL
3010 3020 3030 3040 3050
GMGVGLGNII TTPGDYPRKT KGPICLTAVD TGTSSSAAEG KPAGSGTVAG
3060 3070 3080 3090 3100
TGVGGVIRKP RIEIFKKVII VDDTGIYDCL DIIDAVVWPT ERMRNNGGRL
3110 3120 3130 3140 3150
SWKDWEPSAG MVGHVVHCWT PNHKDIRFRS HVNRYVYLVE IGDHYVPVEE
3160 3170 3180 3190 3200
LGLREYNQIM GSTEEMANSR RSSIQRDFHE YNIQLKLAGL APIIGGGESS
3210 3220 3230 3240 3250
TATTSDASKS HKAKIRAVSS SSSEDEDTSS TRSIPLPQGD DGDLTNFTRL
3260 3270 3280 3290 3300
VSMWKEIILD NNKRRLYDMG ELSPELLQKL DDAVQQQQQL EDALAEESKE
3310 3320 3330 3340 3350
KGTATVTANE GEEGVGEMEI EPEQEQKEVV YLEEQSPLEE VTVSKPDEQP
3360 3370 3380 3390 3400
AQPTIPASPV PAETSSTSSA KSTSSPSLCQ EEEDAVDPEE TPELASEESP
3410
SDENGESEAG TTV
Length:3,413
Mass (Da):365,325
Last modified:March 16, 2016 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2E9C3E19AA7F951
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGB7M9PGB7_DROME
Pecanex, isoform C
pcx Dmel\CG3443, DMPCX, EG:30B8.4, fs(1)12-1012, fs(1)12-1743
3,413Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGU2M9PGU2_DROME
Pecanex, isoform E
pcx Dmel\CG3443, DMPCX, EG:30B8.4, fs(1)12-1012, fs(1)12-1743
3,417Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA28747 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA28749 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL13981 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131G → V (Ref. 1) Curated1
Sequence conflicti131G → V (PubMed:10731137).Curated1
Sequence conflicti211T → I (Ref. 1) Curated1
Sequence conflicti384R → C (Ref. 1) Curated1
Sequence conflicti439A → G (Ref. 1) Curated1
Sequence conflicti449L → Q (Ref. 1) Curated1
Sequence conflicti471L → LL (Ref. 1) Curated1
Sequence conflicti778V → D in AAA28747 (Ref. 1) Curated1
Sequence conflicti1017Missing (PubMed:2478400).Curated1
Sequence conflicti1042Missing in AAA28747 (Ref. 1) Curated1
Sequence conflicti1364Q → L (Ref. 1) Curated1
Sequence conflicti1364Q → L (PubMed:2478400).Curated1
Sequence conflicti1368A → R (Ref. 1) Curated1
Sequence conflicti1368A → R (PubMed:2478400).Curated1
Sequence conflicti1683T → A (Ref. 1) Curated1
Sequence conflicti1683T → A (PubMed:2478400).Curated1
Sequence conflicti1799G → R (Ref. 1) Curated1
Sequence conflicti1799G → R (PubMed:2478400).Curated1
Sequence conflicti2543S → C (Ref. 1) Curated1
Sequence conflicti2543S → C (PubMed:2478400).Curated1
Sequence conflicti3048V → M (PubMed:12537569).Curated1
Sequence conflicti3053V → G (PubMed:12537569).Curated1
Sequence conflicti3111 – 3112MV → NG (Ref. 1) Curated2
Sequence conflicti3111 – 3112MV → NG (PubMed:2478400).Curated2
Sequence conflicti3120T → P (Ref. 1) Curated1
Sequence conflicti3120T → P (PubMed:2478400).Curated1
Sequence conflicti3231T → A (Ref. 1) Curated1
Sequence conflicti3231T → A (PubMed:2478400).Curated1
Sequence conflicti3347D → G (Ref. 1) Curated1
Sequence conflicti3347D → G (PubMed:2478400).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M74329 Genomic DNA Translation: AAA28747.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45756.3
AL009195 Genomic DNA Translation: CAA15708.1
M25662 Genomic DNA Translation: AAA28749.1 Sequence problems.
AY058752 mRNA Translation: AAL13981.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
A37361
T13423

NCBI Reference Sequences

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RefSeqi
NP_001259182.1, NM_001272253.1
NP_525045.3, NM_080306.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0332381; FBpp0304655; FBgn0003048
FBtr0344153; FBpp0310566; FBgn0003048

Database of genes from NCBI RefSeq genomes

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GeneIDi
31204

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3443

UCSC genome browser

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UCSCi
CG3443-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74329 Genomic DNA Translation: AAA28747.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45756.3
AL009195 Genomic DNA Translation: CAA15708.1
M25662 Genomic DNA Translation: AAA28749.1 Sequence problems.
AY058752 mRNA Translation: AAL13981.1 Different initiation.
PIRiA37361
T13423
RefSeqiNP_001259182.1, NM_001272253.1
NP_525045.3, NM_080306.4

3D structure databases

SMRiP18490
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57742, 6 interactors
IntActiP18490, 4 interactors
STRINGi7227.FBpp0304656

Proteomic databases

PaxDbiP18490
PRIDEiP18490

Genome annotation databases

EnsemblMetazoaiFBtr0332381; FBpp0304655; FBgn0003048
FBtr0344153; FBpp0310566; FBgn0003048
GeneIDi31204
KEGGidme:Dmel_CG3443
UCSCiCG3443-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
18563
FlyBaseiFBgn0003048 pcx

Phylogenomic databases

eggNOGiKOG3604 Eukaryota
ENOG410XPRI LUCA
GeneTreeiENSGT00940000168683
InParanoidiP18490
OMAiLCFARPL

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31204

Protein Ontology

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PROi
PR:P18490

Gene expression databases

BgeeiFBgn0003048 Expressed in 32 organ(s), highest expression level in embryo
ExpressionAtlasiP18490 baseline and differential
GenevisibleiP18490 DM

Family and domain databases

InterProiView protein in InterPro
IPR039797 Pecanex
IPR007735 Pecanex_C
PANTHERiPTHR12372 PTHR12372, 1 hit
PfamiView protein in Pfam
PF05041 Pecanex_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCX_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18490
Secondary accession number(s): O46074, Q95TI6, Q9W506
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 16, 2016
Last modified: May 8, 2019
This is version 142 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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