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Entry version 148 (07 Oct 2020)
Sequence version 2 (15 Dec 1998)
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Protein

Genome polyprotein

Gene
N/A
Organism
Zucchini yellow mosaic virus (strain California) (ZYMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.1 Publication
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.1 Publication
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei223For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei232For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei264For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei652For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei725For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2087For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2122For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2192For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1249 – 1256ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.45, 6761

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZucchini yellow mosaic virus (strain California) (ZYMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri117128 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaePotyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCitrullus lanatus (Watermelon) (Citrullus vulgaris) [TaxID: 3654]
Cucumis melo (Muskmelon) [TaxID: 3656]
Cucumis sativus (Cucumber) [TaxID: 3659]
Cucurbita pepo (Vegetable marrow) (Summer squash) [TaxID: 3663]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008610 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi618P → A: Complete loss of aphid transmission and binding to virions. 1 Publication1
Mutagenesisi619T → A: Complete loss of aphid transmission and binding to virions. 1 Publication1
Mutagenesisi619T → S or V: Strongly reduced aphid transmission and binding to virions. 1 Publication1
Mutagenesisi620K → E: Slightly reduced aphid transmission and binding to virions. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200351 – 3080Genome polyproteinAdd BLAST3080
ChainiPRO_00000405001 – 310P1 proteinaseSequence analysisAdd BLAST310
ChainiPRO_0000040501311 – 766Helper component proteinaseSequence analysisAdd BLAST456
ChainiPRO_0000040502767 – 1112Protein P3By similarityAdd BLAST346
ChainiPRO_00000405031113 – 11646 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000405041165 – 1798Cytoplasmic inclusion proteinBy similarityAdd BLAST634
ChainiPRO_00000405051799 – 18516 kDa protein 2By similarityAdd BLAST53
ChainiPRO_00000405061852 – 2041Viral genome-linked proteinBy similarityAdd BLAST190
ChainiPRO_00000405072042 – 2284Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_00000405082285 – 2801Nuclear inclusion protein BBy similarityAdd BLAST517
ChainiPRO_00000405092802 – 3080Capsid proteinBy similarityAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1915O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei310 – 311Cleavage; by P1 proteinaseSequence analysis2
Sitei766 – 767Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1112 – 1113Cleavage; by NIa-proBy similarity2
Sitei1164 – 1165Cleavage; by NIa-proBy similarity2
Sitei1798 – 1799Cleavage; by NIa-proBy similarity2
Sitei2041 – 2042Cleavage; by NIa-proBy similarity2
Sitei2284 – 2285Cleavage; by NIa-proBy similarity2
Sitei2801 – 2802Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P18479

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 310Peptidase S30PROSITE-ProRule annotationAdd BLAST141
Domaini644 – 766Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1236 – 1388Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1407 – 1566Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2042 – 2260Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini2526 – 2650RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi362 – 365Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi618 – 620Involved in virions binding and aphid transmission3
Motifi1338 – 1341DECH box4
Motifi1891 – 1900Nuclear localization signalSequence analysis10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: P18479-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASIMIGSIS VPIAKTEQCA NTQVSNRANI VAPGHMATCP LPLKTHMYYR
60 70 80 90 100
HESKKLMQSN KSIDILNNFF STDEMKFRLT RNEMSKLKKG PSGRIVLRKP
110 120 130 140 150
SKQRVFARIE QDEAARKEEA VFLEGNYDDS ITNLARVLPP AVTHNVDVSL
160 170 180 190 200
RSPFYKRTYK KERKKVAQKQ IVQAPLNSLC TRVLKIARNK NIPVEMIGNK
210 220 230 240 250
KTRHTLTFKR FRGCFVGKVS VAHEEGRMRH TEMSYEQFKW LLKAICQVTH
260 270 280 290 300
TERIREEDIK PGCSGWVLGT NHTLTKRYSR LPHLVIRGRD DDGIVNALEQ
310 320 330 340 350
VLFYSEVDHS SSQPEVQFFQ GWRRIFDKFR PSPDHVCKAD HNNEECGELA
360 370 380 390 400
AIFCQALFPV VKLSCQTCRE SLVEVSFEEF KDSLNANFII HKDEWGSFKE
410 420 430 440 450
GSQYDNIFKL IKVATQATQN LKLSSEVMKL VQNHTSTHMK QIQDINKALM
460 470 480 490 500
KGSLVAQDEL DLALKQLLEM TQWFKNHMHL TGEEALKMFR NKRSSKAMIN
510 520 530 540 550
PSLLCGNQLD KNGNFVWGER GYHSKRLFKN FFEEVIPSEG YTKYVVRNFP
560 570 580 590 600
NGTRKLAIGS LIVPLNLDRA RTALLGESIE KKPLTSACVS QQNGNYIHSC
610 620 630 640 650
CCVTMDDGTP MYSELKSPTK RHLVIGASSD PKYIDLPASE AERMYIAKEG
660 670 680 690 700
YCYLSIFLAM LVNVNENEAK DFTKMIRDVL IPMLGQWPSL MDVATAAYIL
710 720 730 740 750
GVFHPETRCA ELPRILVDHA TQTMHVIDSY GSLTVGYHVL KAGTVNHLIQ
760 770 780 790 800
FASNDLQSEM KHYRVGGTPT QRIKLEEQLI KGIFKPKLMM QLLHDDPYIL
810 820 830 840 850
LLGMISPTIL VHMYRMRHFE RGIEIWIKRD HEIGKIFVIL EQLTRKVALA
860 870 880 890 900
EVLVDQLNLI SEASPHLLEI MKGCQDNQRA YVPALDLLTI QVEREFSNKE
910 920 930 940 950
LKTNGYPDLQ QTLFDMREKM YAKQLHNSWQ ELSLLEKSCV TVRLKQFSIF
960 970 980 990 1000
TERNLIQRAK EGKRASSLQF VHECFITTRV HAKSIRDAGV RKLNEALVGT
1010 1020 1030 1040 1050
CKFFFSCGFK IFARCYSDII YLVNVCLVFS LVLQMSNTVR SMIAATREEK
1060 1070 1080 1090 1100
ERAMANKADE NERTLMHMYH IFSKKQDDAP IYNDFLEHVR NVRPDLEETL
1110 1120 1130 1140 1150
LYMAGVEVVS TQAKSAVQIQ FEKIIAVLAL LTMCFDAERS DAIFKILTKL
1160 1170 1180 1190 1200
KTVFGTVGET VRLQGLEDIE SLEDDKRLTI DFDINTNEAH SSTTFDVHFD
1210 1220 1230 1240 1250
DWWNRQLQQN RTVPHYRTTG KFLEFTRNTA AFVANEIASS SEGEFLVRGR
1260 1270 1280 1290 1300
VGSGKSTSLP AHLAKKGKVL LLEPTRPLAE NVSRQLAGDP FFQNVTLRMR
1310 1320 1330 1340 1350
GLSCFGSSNI TVMTSGFAFH YYVNNPHQLM EFDFVIIDEC HVTDSATIAF
1360 1370 1380 1390 1400
NCALKEYNFA GKLIKVSATP PGRECDFDTQ FAVKVKTEDH LSFHAFVGAQ
1410 1420 1430 1440 1450
KTGSNADMVQ HGNNILVYVA SYNEVDMLSK LLTERQFSVT KVDGRTMQLG
1460 1470 1480 1490 1500
KTTIETHGTS QKPHFIVATN IIENGVTLDV ECVVDFGLKV GRRTGQRNRC
1510 1520 1530 1540 1550
VRYNKKSVSY GERIQRLGRV GRSKPGTALR IGHTEKGIET IPEFIATEAA
1560 1570 1580 1590 1600
ALSFAYGLPV TTHGVSTNIL GKCTVKQMKC ALNFELTPFF TTHLIRHDGS
1610 1620 1630 1640 1650
MHPLIHEELK QFKLRDSEMV LNKVALPHQF VSQWMDQSEY ERIGVHVQCH
1660 1670 1680 1690 1700
ESNSIPFYTN GIPDKVYERI WKCIQENKND AVFGKLSSAC STKVSYTLST
1710 1720 1730 1740 1750
DPAALPRTIA IIDHLLAEEM MKRNHFDTIS SAVTGYSFSL AGIADSFRKR
1760 1770 1780 1790 1800
YMRDYTAHNI AILQQARAQL LEFNSKNVNI NNLSDLEGIG VIKSVVLQSK
1810 1820 1830 1840 1850
QEVSSFLGLR GKWDGKKFAN DVILAIMTLL GGGWFMWEYF TKKINEPVRV
1860 1870 1880 1890 1900
ESKKRRSQKL KFRDAYDRKV GREIFGDDDT IGRTFGEAYT KRGKVKGNNN
1910 1920 1930 1940 1950
TKGMGRKTRN FVHLYGVEPE NYSFIRFVDP LTGHTLDEST HTDISLVQEE
1960 1970 1980 1990 2000
FGSIREKFLE NDLISRQSII NKPGIQAYFM GKGTEEALKV DLTPHVPLLL
2010 2020 2030 2040 2050
CRNTNAIAGY PERENELRQT GTPVKVSFKD VPEKNEHVEL ESKSIYKGVR
2060 2070 2080 2090 2100
DYNGISTIVC QLTNDSDGLK ETMYGIGYGP IIITNGHLFR KNNGTLLVRS
2110 2120 2130 2140 2150
WHGEFIVKNT TTLKVHFIEG KDVVLVRMPK DFPPFKSNAS FRAPKREERR
2160 2170 2180 2190 2200
CLVGTNFQEK SLRSTVSESS MTIPEGTGSY WIHWISTNEG DCGLPMVSTT
2210 2220 2230 2240 2250
DGKIIGVHGL ASTVSSKNYF VPFTDDFIAT HLSKLDDLTW TQHWLWQPSK
2260 2270 2280 2290 2300
IAWGTLNLVD EQPGPEFRIS NLVKDLFTSG VETQSKRERW VYESCEGNLR
2310 2320 2330 2340 2350
AVGTAQSALV TKHVVKGKCP FFEEYLQTHA EASAYFRPLM GEYQPSKLNK
2360 2370 2380 2390 2400
EAFKKDFFKY NKPVTVNQLD HDKFLGAVDG VIRMMCDFEF NECRFITDPE
2410 2420 2430 2440 2450
EIYNSLNMKA AIGAQYRGKK KEYFEGLDDF DRERLLFQSC ERLFNGYKGL
2460 2470 2480 2490 2500
WNGSLKAELR PLEKVRANKT RTFTAAPIDT LLGAKVCVDD FNNEFYRKNL
2510 2520 2530 2540 2550
KCPWTVGMTK FYGGWDKLMR SLPDGWLYCH ADGSQFDSSL TPALLNAVLI
2560 2570 2580 2590 2600
IRSFYMEDWW VGQEMLENLY AEIVYTPILA PDGTIFKKFR GNNSGQPSTV
2610 2620 2630 2640 2650
VDNTLMVVIS IYYACMKFGW NCEEIENKLV FFANGDDLIL AVKDEDSGLL
2660 2670 2680 2690 2700
DNMSSSFCEL GLNYDFSERT HKREDLWFMS HQAMLVDGMY TPKLEKERIV
2710 2720 2730 2740 2750
SILEWDRSKE IMHRTEAICA AMIEAWGHTE LLQEIRKFYL WFVEKEEVRE
2760 2770 2780 2790 2800
LAALGKAPYI AETALRKLYT DKGADTSELA RYLQALHQDI FFEQGDTVML
2810 2820 2830 2840 2850
QSGTQPTVAD AGATKKDKED DKGKNKDVTG SGSGEKTVAA VTKDKDVNAG
2860 2870 2880 2890 2900
SHGKIVPRLS KITKKMSLPR VKGNVILDID HLLEYKPDQI ELYNTRASHQ
2910 2920 2930 2940 2950
QFASWFNQVK TEYDLNEQQM GVVMNGFMVW CIENGTSPDI NGVWVMMDGN
2960 2970 2980 2990 3000
EQVEYPLKPI VENAKPTLRQ IMHHFSDAAE AYIEMRNAEA PYMPRYGLLR
3010 3020 3030 3040 3050
NLRDRSLARY AFDFYEVNSK TPERAREAVA QMKAAALSNV SSRLFGLDGN
3060 3070 3080
VATTSEDTER HTARDVNRNM HTLLGVNTMQ
Note: Produced by conventional translation.
Length:3,080
Mass (Da):350,629
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A1E501DEA6B9F73
GO
Isoform P3N-PIPO polyprotein (identifier: P0CK13-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CK13.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:991
Mass (Da):113,426
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2694 – 2695LE → ST in AAA48511 (PubMed:2185142).Curated2
Sequence conflicti2699 – 2701IVS → LFP in AAA48511 (PubMed:2185142).Curated3
Sequence conflicti2811A → T in AAA48511 (PubMed:2185142).Curated1
Sequence conflicti2834G → S in AAA48511 (PubMed:2185142).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L31350 Genomic RNA Translation: AAA65559.1
M35095 Genomic RNA Translation: AAA48511.1

Protein sequence database of the Protein Information Resource

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PIRi
JH0103

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31350 Genomic RNA Translation: AAA65559.1
M35095 Genomic RNA Translation: AAA48511.1
PIRiJH0103

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP18479

Enzyme and pathway databases

BRENDAi3.4.22.45, 6761

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_ZYMVC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18479
Secondary accession number(s): Q89334
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 15, 1998
Last modified: October 7, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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