UniProtKB - P18468 (HB2I_MOUSE)
Protein
H-2 class II histocompatibility antigen, I-A beta chain
Gene
H2-Eb1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: BHF-UCL
- response to interferon-gamma Source: BHF-UCL
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: H-2 class II histocompatibility antigen, I-A beta chain |
Gene namesi | Name:H2-Eb1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95901, H2-Eb1 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Endosome
- late endosome membrane Source: BHF-UCL
Lysosome
- lysosomal membrane Source: BHF-UCL
Plasma Membrane
- MHC class II protein complex Source: BHF-UCL
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 225 | ExtracellularSequence analysisAdd BLAST | 194 | |
Transmembranei | 226 – 248 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 249 – 264 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
Membrane, MHC IIPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Add BLAST | 31 | |
ChainiPRO_0000019003 | 32 – 264 | H-2 class II histocompatibility antigen, I-A beta chainAdd BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 106 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 200 | PROSITE-ProRule annotation1 Publication |
Post-translational modificationi
Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
MaxQBi | P18468 |
PRIDEi | P18468 |
ProteomicsDBi | 270945 |
PTM databases
iPTMneti | P18468 |
PhosphoSitePlusi | P18468 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P18468 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P18468 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 214 | Ig-like C1-typeAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 121 | Beta-1Add BLAST | 90 | |
Regioni | 122 – 215 | Beta-2Add BLAST | 94 | |
Regioni | 216 – 225 | Connecting peptide | 10 |
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P18468-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWLPRVPCV AAVILLLTVL SPPVALVRDS RPWFLEYCKS ECHFYNGTQR
60 70 80 90 100
VRFLKRYFYN LEENLRFDSD VGEFRAVTEL GRPDAENWNS QPEILDEKRA
110 120 130 140 150
AVDTYCRHNY EIFDNFLVPR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC
210 220 230 240 250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL RAGLFIYFRN
260
QKGQSGLQPT GLLS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP18469 | HB2J_MOUSE | H-2 class II histocompatibility ant... | H2-Eb1 | 264 | Annotation score: | ||
P04230 | HB21_MOUSE | H-2 class II histocompatibility ant... | H2-Eb1 | 264 | Annotation score: | ||
P04231 | HB23_MOUSE | H-2 class II histocompatibility ant... | H2-Eb1 | 232 | Annotation score: | ||
O78196 | O78196_MOUSE | H-2 class II histocompatibility ant... | H2-Eb1 Btnl2, IEbeta | 264 | Annotation score: | ||
A0A498U6I0 | A0A498U6I0_MOUSE | H-2 class II histocompatibility ant... | H2-Eb1 | 287 | Annotation score: | ||
A0A494B9C8 | A0A494B9C8_MOUSE | H-2 class II histocompatibility ant... | H2-Eb1 | 92 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52641 mRNA Translation: CAA36863.1 |
PIRi | I48224, S11650 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52641 mRNA Translation: CAA36863.1 |
PIRi | I48224, S11650 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1R5V | X-ray | 2.50 | B/D | 32-215 | [»] | |
SMRi | P18468 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
PTM databases
iPTMneti | P18468 |
PhosphoSitePlusi | P18468 |
Proteomic databases
MaxQBi | P18468 |
PRIDEi | P18468 |
ProteomicsDBi | 270945 |
Organism-specific databases
MGIi | MGI:95901, H2-Eb1 |
Miscellaneous databases
ChiTaRSi | H2-Eb1, mouse |
EvolutionaryTracei | P18468 |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HB2I_MOUSE | |
Accessioni | P18468Primary (citable) accession number: P18468 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families