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UniProtKB - P18466 (HA19_CANLF)
Protein
DLA class I histocompatibility antigen, A9/A9 alpha chain
Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Biological processi
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- immune response Source: InterPro
Keywordsi
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: DLA class I histocompatibility antigen, A9/A9 alpha chain |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- MHC class I protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 306 | ExtracellularSequence analysisAdd BLAST | 282 | |
Transmembranei | 307 – 329 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 330 – 362 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
Membrane, MHC IPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000018945 | 25 – 362 | DLA class I histocompatibility antigen, A9/A9 alpha chainAdd BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 125 ↔ 189 | PROSITE-ProRule annotation | ||
Disulfide bondi | 228 ↔ 284 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | P18466 |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000000716 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 296 | Ig-like C1-typeAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 114 | Alpha-1Add BLAST | 90 | |
Regioni | 115 – 207 | Alpha-2Add BLAST | 93 | |
Regioni | 208 – 299 | Alpha-3Add BLAST | 92 | |
Regioni | 300 – 306 | Connecting peptide | 7 | |
Regioni | 333 – 362 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RQEK, Eukaryota |
OMAi | QPRAPWV |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P18466-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVVMPRALL VLLSAALALT PTRAGSHSLR YFYTSVSRPG AGDPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAATGRME PRAPWVEQEG PEYWDRQTRT IKETARTFRV
110 120 130 140 150
DLDTLRGYYN QSEAGSHTRQ TMYGCDLGPD GRLLRGYSQD AYDGADYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAGVAELQ WRNYLETTCV EWLRRYLEMG
210 220 230 240 250
KETLLRADPP STRVTHHPVS DHEVTLRCWA LGFYPAEITL TWQRDGEDQT
260 270 280 290 300
QDTEVVDTRP AGDGTFQKWA AVVVPSGQEQ RYTCHVQHEG LPEPITRRWE
310 320 330 340 350
PSPLSTIVIV SIAALVLLVV AGVIGAVIWR KQRSGGKGPG YSHAARDDSA
360
QGSDVSLTAP RV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32283 mRNA Translation: AAA30865.1 |
PIRi | A45845 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32283 mRNA Translation: AAA30865.1 |
PIRi | A45845 |
3D structure databases
SMRi | P18466 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000000716 |
Proteomic databases
PRIDEi | P18466 |
Phylogenomic databases
eggNOGi | ENOG502RQEK, Eukaryota |
OMAi | QPRAPWV |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HA19_CANLF | |
Accessioni | P18466Primary (citable) accession number: P18466 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families