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Protein

HLA class I histocompatibility antigen, B-57 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-57 alpha chain
Alternative name(s):
Bw-57
MHC class I antigen B*57
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_P18465

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B

Polymorphism and mutation databases

DMDMi122174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001886025 – 362HLA class I histocompatibility antigen, B-57 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP18465
PeptideAtlasiP18465
PRIDEiP18465

PTM databases

GlyConnecti1345
SwissPalmiP18465

Expressioni

Gene expression databases

CleanExiHS_HLA-B

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

Binary interactionsi

Protein-protein interaction databases

IntActiP18465, 10 interactors

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18465
SMRiP18465
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18465

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show allAlign All

P18465-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE
110 120 130 140 150
NLRIALRYYN QSEAGSHIIQ VMYGCDVGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,224
Last modified:November 1, 1990 - v1
Checksum:iC1EFCF089096AFF9
GO

Computationally mapped potential isoform sequencesi

There are 54 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P018891B07_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P039891B27_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304601B08_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q048261B40_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304751B39_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q953651B38_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304861B48_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q298361B67_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304641B15_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q316101B81_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
There are more potential isoformsShow all

Polymorphismi

The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The sequence shown is that of B*57:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016669121V → R in allele B*57:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016670127V → L in allele B*57:05. 1
Natural variantiVAR_016671137H → Y in allele B*57:05. 1
Natural variantiVAR_016495138D → N in allele B*57:02, allele B*57:03 and allele B*57:05. 1
Natural variantiVAR_016496140S → Y in allele B*57:02, allele B*57:03 and allele B*57:05. Combined sources1
Natural variantiVAR_016497180L → R in allele B*57:02 and allele B*57:05. 1
Natural variantiVAR_056416306V → I. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_056417329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1
Natural variantiVAR_061431349C → S. Corresponds to variant dbSNP:rs2308655Ensembl.1
Natural variantiVAR_061432349C → Y. Corresponds to variant dbSNP:rs2308655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32318 mRNA Translation: AAA36231.1
X55711 Genomic DNA Translation: CAA39244.1
AJ458991 Genomic DNA Translation: CAD30339.1
X61707 mRNA Translation: CAA43876.1
U18790 mRNA Translation: AAB60361.1
Y09157 mRNA Translation: CAA70355.1
AH006370 Genomic DNA Translation: AAC32568.1
PIRiD35997
UniGeneiHs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000435618; ENSP00000405178; ENSG00000224608

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32318 mRNA Translation: AAA36231.1
X55711 Genomic DNA Translation: CAA39244.1
AJ458991 Genomic DNA Translation: CAD30339.1
X61707 mRNA Translation: CAA43876.1
U18790 mRNA Translation: AAB60361.1
Y09157 mRNA Translation: CAA70355.1
AH006370 Genomic DNA Translation: AAC32568.1
PIRiD35997
UniGeneiHs.654404
Hs.726974
Hs.77961

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BVOX-ray1.65A25-300[»]
2BVPX-ray1.35A25-300[»]
2BVQX-ray2.00A25-300[»]
2HJLX-ray1.50A25-298[»]
2RFXX-ray2.50A25-299[»]
2YPKX-ray1.95A25-298[»]
2YPLX-ray2.40A25-298[»]
3UPRX-ray2.00A/C25-300[»]
3VH8X-ray1.80A/D25-299[»]
3VRIX-ray1.60A25-300[»]
3VRJX-ray1.90A25-300[»]
3WUWX-ray2.00A25-299[»]
3X11X-ray2.15A25-300[»]
3X12X-ray1.80A25-300[»]
5B38X-ray2.30A25-300[»]
5B39X-ray2.50A25-300[»]
5T6WX-ray1.90A25-300[»]
5T6XX-ray1.69A25-300[»]
5T6YX-ray1.76A25-300[»]
5T6ZX-ray2.00A25-300[»]
5T70X-ray2.10A25-300[»]
5U98X-ray2.00A/D25-300[»]
5V5MX-ray2.88A/C25-300[»]
6BXPX-ray1.45A25-300[»]
6BXQX-ray1.58B25-300[»]
ProteinModelPortaliP18465
SMRiP18465
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18465, 10 interactors

PTM databases

GlyConnecti1345
SwissPalmiP18465

Polymorphism and mutation databases

DMDMi122174

Proteomic databases

MaxQBiP18465
PeptideAtlasiP18465
PRIDEiP18465

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435618; ENSP00000405178; ENSG00000224608

Organism-specific databases

DisGeNETi3106
GeneCardsiHLA-B
HGNCiHGNC:4932 HLA-B
MalaCardsiHLA-B
MIMi142830 gene
neXtProtiNX_P18465
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiHLA-B human
EvolutionaryTraceiP18465
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-B

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1B57_HUMAN
AccessioniPrimary (citable) accession number: P18465
Secondary accession number(s): O62917
, P30497, P79496, Q29679, Q5QT24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 10, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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