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UniProtKB - P18440 (ARY1_HUMAN)

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Protein

Arylamine N-acetyltransferase 1

Gene

NAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Miscellaneous

NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.

Caution

The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.Curated

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Acyl-thioester intermediate1
Binding sitei103Coenzyme ABy similarity1
Binding sitei104Coenzyme A; via amide nitrogenBy similarity1
Active sitei1071
Active sitei1221
Binding sitei208Coenzyme ABy similarity1
Binding sitei214Coenzyme ABy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.5 2681
2.3.1.88 2681
ReactomeiR-HSA-156582 Acetylation
SIGNORiP18440

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 1
Monomorphic arylamine N-acetyltransferase
Short name:
MNAT
N-acetyltransferase type 1
Short name:
NAT-1
Gene namesi
Name:NAT1
Synonyms:AAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000171428.13
HGNCiHGNC:7645 NAT1
MIMi108345 gene
neXtProtiNX_P18440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64R → A, M, Q or K: Reduced enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNETi9
OpenTargetsiENSG00000171428
PharmGKBiPA17

Chemistry databases

ChEMBLiCHEMBL5101
DrugBankiDB01015 Sulfamethoxazole

Polymorphism and mutation databases

BioMutaiNAT1
DMDMi114234

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079041 – 290Arylamine N-acetyltransferase 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP18440
MaxQBiP18440
PaxDbiP18440
PeptideAtlasiP18440
PRIDEiP18440
ProteomicsDBi53563

PTM databases

iPTMnetiP18440
PhosphoSitePlusiP18440
SwissPalmiP18440

Expressioni

Gene expression databases

BgeeiENSG00000171428
CleanExiHS_NAT1
ExpressionAtlasiP18440 baseline and differential
GenevisibleiP18440 HS

Organism-specific databases

HPAiCAB017782
HPA043704

Interactioni

Protein-protein interaction databases

BioGridi106527, 3 interactors
IntActiP18440, 1 interactor
STRINGi9606.ENSP00000443194

Chemistry databases

BindingDBiP18440

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 9Combined sources8
Helixi21 – 34Combined sources14
Helixi42 – 44Combined sources3
Helixi52 – 60Combined sources9
Helixi68 – 82Combined sources15
Beta strandi85 – 95Combined sources11
Turni96 – 99Combined sources4
Beta strandi107 – 114Combined sources8
Beta strandi117 – 121Combined sources5
Beta strandi123 – 125Combined sources3
Helixi127 – 129Combined sources3
Beta strandi142 – 144Combined sources3
Beta strandi149 – 155Combined sources7
Beta strandi158 – 164Combined sources7
Beta strandi167 – 169Combined sources3
Helixi173 – 175Combined sources3
Beta strandi185 – 192Combined sources8
Helixi199 – 202Combined sources4
Helixi203 – 211Combined sources9
Helixi216 – 219Combined sources4
Beta strandi222 – 226Combined sources5
Beta strandi228 – 235Combined sources8
Beta strandi238 – 243Combined sources6
Beta strandi247 – 257Combined sources11
Helixi260 – 271Combined sources12

3D structure databases

ProteinModelPortaliP18440
SMRiP18440
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18440

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 107Substrate binding2

Sequence similaritiesi

Belongs to the arylamine N-acetyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IFD6 Eukaryota
COG2162 LUCA
GeneTreeiENSGT00390000012054
HOGENOMiHOG000205435
HOVERGENiHBG000165
InParanoidiP18440
KOiK00622
PhylomeDBiP18440

Family and domain databases

InterProiView protein in InterPro
IPR001447 Arylamine_N-AcTrfase
IPR038765 Papain_like_cys_pep_sf
PANTHERiPTHR11786 PTHR11786, 1 hit
PfamiView protein in Pfam
PF00797 Acetyltransf_2, 1 hit
PRINTSiPR01543 ANATRNSFRASE
SUPFAMiSSF54001 SSF54001, 1 hit

Sequencei

Sequence statusi: Complete.

P18440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL 
        60         70         80         90        100
GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK 
       110        120        130        140        150
YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF 
       160        170        180        190        200
RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE 
       210        220        230        240        250
DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT 
       260        270        280        290
DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI
Length:290
Mass (Da):33,899
Last modified:February 1, 1991 - v2
Checksum:iC015F7F3D4830107
GO

Polymorphismi

N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder (PubMed:7585580).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00460664R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs56379106EnsemblClinVar.1
Natural variantiVAR_009510117R → T in allele NAT1*5. 1 PublicationCorresponds to variant dbSNP:rs55641436Ensembl.1
Natural variantiVAR_004607149V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. 5 PublicationsCorresponds to variant dbSNP:rs4987076EnsemblClinVar.1
Natural variantiVAR_009511166 – 167RE → TQ in allele NAT1*5. Corresponds to variant dbSNP:rs72554608Ensembl.2
Natural variantiVAR_009069187R → Q in allele NAT1*14; a slow acetylator. 2 PublicationsCorresponds to variant dbSNP:rs4986782Ensembl.1
Natural variantiVAR_009070205M → V in allele NAT1*21. Corresponds to variant dbSNP:rs72554609Ensembl.1
Natural variantiVAR_020384207T → I. Corresponds to variant dbSNP:rs4987195Ensembl.1
Natural variantiVAR_009071214S → A in allele NAT1*11. 5 PublicationsCorresponds to variant dbSNP:rs4986783Ensembl.1
Natural variantiVAR_009072251D → V in allele NAT1*22. Corresponds to variant dbSNP:rs56172717Ensembl.1
Natural variantiVAR_009073261E → K in allele NAT1*24. Corresponds to variant dbSNP:rs72554610Ensembl.1
Natural variantiVAR_009074263I → V in allele NAT1*25. Corresponds to variant dbSNP:rs72554611Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17059 Genomic DNA Translation: CAA34905.1
D90041 mRNA Translation: BAA14095.1
AF032677 Genomic DNA Translation: AAB86878.1
AF032678 Genomic DNA Translation: AAB86879.1
U80835 Genomic DNA Translation: AAB62398.1
AF008204 Genomic DNA Translation: AAB84384.1
AF071552 Genomic DNA Translation: AAC24712.1
AF067408 Genomic DNA Translation: AAC24707.1
AF082903 Genomic DNA Translation: AAD13343.1
AF082904 Genomic DNA Translation: AAC32388.1
AJ278017 Genomic DNA Translation: CAC01128.1
AJ307007 Genomic DNA Translation: CAC38345.1
DQ305816 Genomic DNA Translation: ABC26192.1
DQ305817 Genomic DNA Translation: ABC26193.1
DQ305818 Genomic DNA Translation: ABC26194.1
DQ305819 Genomic DNA Translation: ABC26195.1
DQ305820 Genomic DNA Translation: ABC26196.1
DQ305821 Genomic DNA Translation: ABC26197.1
DQ305822 Genomic DNA Translation: ABC26198.1
DQ305823 Genomic DNA Translation: ABC26199.1
DQ305824 Genomic DNA Translation: ABC26200.1
DQ305825 Genomic DNA Translation: ABC26201.1
DQ305826 Genomic DNA Translation: ABC26202.1
DQ305827 Genomic DNA Translation: ABC26203.1
DQ305828 Genomic DNA Translation: ABC26204.1
DQ305829 Genomic DNA Translation: ABC26205.1
DQ305830 Genomic DNA Translation: ABC26206.1
DQ305831 Genomic DNA Translation: ABC26207.1
DQ305832 Genomic DNA Translation: ABC26208.1
DQ305833 Genomic DNA Translation: ABC26209.1
DQ305834 Genomic DNA Translation: ABC26210.1
DQ305835 Genomic DNA Translation: ABC26211.1
DQ305836 Genomic DNA Translation: ABC26212.1
DQ305837 Genomic DNA Translation: ABC26213.1
DQ305838 Genomic DNA Translation: ABC26214.1
DQ305839 Genomic DNA Translation: ABC26215.1
DQ305840 Genomic DNA Translation: ABC26216.1
DQ305841 Genomic DNA Translation: ABC26217.1
DQ305842 Genomic DNA Translation: ABC26218.1
DQ305843 Genomic DNA Translation: ABC26219.1
DQ305844 Genomic DNA Translation: ABC26220.1
DQ305845 Genomic DNA Translation: ABC26221.1
DQ305846 Genomic DNA Translation: ABC26222.1
DQ305847 Genomic DNA Translation: ABC26223.1
DQ305848 Genomic DNA Translation: ABC26224.1
DQ305849 Genomic DNA Translation: ABC26225.1
DQ305850 Genomic DNA Translation: ABC26226.1
DQ305851 Genomic DNA Translation: ABC26227.1
DQ305852 Genomic DNA Translation: ABC26228.1
DQ305853 Genomic DNA Translation: ABC26229.1
DQ305854 Genomic DNA Translation: ABC26230.1
DQ305855 Genomic DNA Translation: ABC26231.1
DQ305856 Genomic DNA Translation: ABC26232.1
DQ305857 Genomic DNA Translation: ABC26233.1
DQ305858 Genomic DNA Translation: ABC26234.1
DQ305859 Genomic DNA Translation: ABC26235.1
DQ305860 Genomic DNA Translation: ABC26236.1
DQ305861 Genomic DNA Translation: ABC26237.1
DQ305862 Genomic DNA Translation: ABC26238.1
DQ305863 Genomic DNA Translation: ABC26239.1
DQ305864 Genomic DNA Translation: ABC26240.1
DQ305865 Genomic DNA Translation: ABC26241.1
DQ305866 Genomic DNA Translation: ABC26242.1
DQ305867 Genomic DNA Translation: ABC26243.1
DQ305868 Genomic DNA Translation: ABC26244.1
DQ305869 Genomic DNA Translation: ABC26245.1
DQ305870 Genomic DNA Translation: ABC26246.1
DQ305871 Genomic DNA Translation: ABC26247.1
DQ305872 Genomic DNA Translation: ABC26248.1
DQ305873 Genomic DNA Translation: ABC26249.1
DQ305874 Genomic DNA Translation: ABC26250.1
DQ305875 Genomic DNA Translation: ABC26251.1
DQ305876 Genomic DNA Translation: ABC26252.1
DQ305877 Genomic DNA Translation: ABC26253.1
DQ305878 Genomic DNA Translation: ABC26254.1
DQ305879 Genomic DNA Translation: ABC26255.1
DQ305880 Genomic DNA Translation: ABC26256.1
DQ305881 Genomic DNA Translation: ABC26257.1
DQ305882 Genomic DNA Translation: ABC26258.1
DQ305883 Genomic DNA Translation: ABC26259.1
DQ305884 Genomic DNA Translation: ABC26260.1
DQ305885 Genomic DNA Translation: ABC26261.1
DQ305886 Genomic DNA Translation: ABC26262.1
DQ305887 Genomic DNA Translation: ABC26263.1
DQ305888 Genomic DNA Translation: ABC26264.1
DQ305889 Genomic DNA Translation: ABC26265.1
DQ305890 Genomic DNA Translation: ABC26266.1
DQ305891 Genomic DNA Translation: ABC26267.1
DQ305892 Genomic DNA Translation: ABC26268.1
DQ305893 Genomic DNA Translation: ABC26269.1
DQ305894 Genomic DNA Translation: ABC26270.1
DQ305895 Genomic DNA Translation: ABC26271.1
DQ305896 Genomic DNA Translation: ABC26272.1
DQ305897 Genomic DNA Translation: ABC26273.1
DQ305898 Genomic DNA Translation: ABC26274.1
DQ305899 Genomic DNA Translation: ABC26275.1
DQ305900 Genomic DNA Translation: ABC26276.1
DQ305901 Genomic DNA Translation: ABC26277.1
DQ305902 Genomic DNA Translation: ABC26278.1
DQ305903 Genomic DNA Translation: ABC26279.1
DQ305904 Genomic DNA Translation: ABC26280.1
DQ305905 Genomic DNA Translation: ABC26281.1
DQ305906 Genomic DNA Translation: ABC26282.1
DQ305907 Genomic DNA Translation: ABC26283.1
DQ305908 Genomic DNA Translation: ABC26284.1
DQ305909 Genomic DNA Translation: ABC26285.1
DQ305910 Genomic DNA Translation: ABC26286.1
DQ305911 Genomic DNA Translation: ABC26287.1
DQ305912 Genomic DNA Translation: ABC26288.1
DQ305913 Genomic DNA Translation: ABC26289.1
DQ305914 Genomic DNA Translation: ABC26290.1
DQ305915 Genomic DNA Translation: ABC26291.1
DQ305916 Genomic DNA Translation: ABC26292.1
DQ305917 Genomic DNA Translation: ABC26293.1
DQ305918 Genomic DNA Translation: ABC26294.1
DQ305919 Genomic DNA Translation: ABC26295.1
DQ305920 Genomic DNA Translation: ABC26296.1
DQ305921 Genomic DNA Translation: ABC26297.1
DQ305922 Genomic DNA Translation: ABC26298.1
DQ305923 Genomic DNA Translation: ABC26299.1
DQ305924 Genomic DNA Translation: ABC26300.1
DQ305925 Genomic DNA Translation: ABC26301.1
DQ305926 Genomic DNA Translation: ABC26302.1
DQ305927 Genomic DNA Translation: ABC26303.1
DQ305928 Genomic DNA Translation: ABC26304.1
DQ305929 Genomic DNA Translation: ABC26305.1
DQ305930 Genomic DNA Translation: ABC26306.1
DQ305931 Genomic DNA Translation: ABC26307.1
DQ305932 Genomic DNA Translation: ABC26308.1
DQ305933 Genomic DNA Translation: ABC26309.1
DQ305934 Genomic DNA Translation: ABC26310.1
DQ305935 Genomic DNA Translation: ABC26311.1
DQ305936 Genomic DNA Translation: ABC26312.1
DQ305937 Genomic DNA Translation: ABC26313.1
DQ305938 Genomic DNA Translation: ABC26314.1
DQ305939 Genomic DNA Translation: ABC26315.1
DQ305940 Genomic DNA Translation: ABC26316.1
DQ305941 Genomic DNA Translation: ABC26317.1
DQ305942 Genomic DNA Translation: ABC26318.1
DQ305943 Genomic DNA Translation: ABC26319.1
DQ305944 Genomic DNA Translation: ABC26320.1
DQ305945 Genomic DNA Translation: ABC26321.1
DQ305946 Genomic DNA Translation: ABC26322.1
DQ305947 Genomic DNA Translation: ABC26323.1
DQ305948 Genomic DNA Translation: ABC26324.1
DQ305949 Genomic DNA Translation: ABC26325.1
DQ305950 Genomic DNA Translation: ABC26326.1
DQ305951 Genomic DNA Translation: ABC26327.1
DQ305952 Genomic DNA Translation: ABC26328.1
DQ305953 Genomic DNA Translation: ABC26329.1
DQ305954 Genomic DNA Translation: ABC26330.1
DQ305955 Genomic DNA Translation: ABC26331.1
DQ305956 Genomic DNA Translation: ABC26332.1
DQ305957 Genomic DNA Translation: ABC26333.1
DQ305958 Genomic DNA Translation: ABC26334.1
DQ305959 Genomic DNA Translation: ABC26335.1
DQ305960 Genomic DNA Translation: ABC26336.1
DQ305961 Genomic DNA Translation: ABC26337.1
DQ305962 Genomic DNA Translation: ABC26338.1
DQ305963 Genomic DNA Translation: ABC26339.1
DQ305964 Genomic DNA Translation: ABC26340.1
DQ305965 Genomic DNA Translation: ABC26341.1
DQ305966 Genomic DNA Translation: ABC26342.1
DQ305967 Genomic DNA Translation: ABC26343.1
DQ305968 Genomic DNA Translation: ABC26344.1
DQ305969 Genomic DNA Translation: ABC26345.1
DQ305970 Genomic DNA Translation: ABC26346.1
DQ305971 Genomic DNA Translation: ABC26347.1
DQ305972 Genomic DNA Translation: ABC26348.1
DQ305973 Genomic DNA Translation: ABC26349.1
DQ305974 Genomic DNA Translation: ABC26350.1
DQ305975 Genomic DNA Translation: ABC26351.1
AK290912 mRNA Translation: BAF83601.1
AY338489 Genomic DNA Translation: AAP88036.1
AY800271 Genomic DNA Translation: AAV50002.1
BC047666 mRNA Translation: AAH47666.1
M75164 Genomic DNA Translation: AAA59905.1
CCDSiCCDS6007.1
PIRiA34585
RefSeqiNP_000653.3, NM_000662.7
NP_001153642.1, NM_001160170.3
NP_001153643.1, NM_001160171.3
NP_001153644.1, NM_001160172.3
NP_001153645.1, NM_001160173.3
NP_001153646.1, NM_001160174.2
NP_001153651.1, NM_001160179.2
XP_006716473.1, XM_006716410.3
XP_011542991.1, XM_011544689.2
UniGeneiHs.2
Hs.591847

Genome annotation databases

EnsembliENST00000307719; ENSP00000307218; ENSG00000171428
ENST00000517492; ENSP00000429407; ENSG00000171428
ENST00000518029; ENSP00000428270; ENSG00000171428
ENST00000520546; ENSP00000429341; ENSG00000171428
ENST00000541942; ENSP00000440900; ENSG00000171428
GeneIDi9
KEGGihsa:9
UCSCiuc003wyq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARY1_HUMAN
AccessioniPrimary (citable) accession number: P18440
Secondary accession number(s): A8K4E7
, O15159, O15300, Q546N1, Q96TE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: June 20, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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