UniProtKB - P18440 (ARY1_HUMAN)
Protein
Arylamine N-acetyltransferase 1
Gene
NAT1
Organism
Homo sapiens (Human)
Status
Functioni
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Miscellaneous
NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.
Caution
The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.Curated
Catalytic activityi
- EC:2.3.1.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 68 | Acyl-thioester intermediate | 1 | |
Binding sitei | 103 | Coenzyme ABy similarity | 1 | |
Binding sitei | 104 | Coenzyme A; via amide nitrogenBy similarity | 1 | |
Active sitei | 107 | 1 | ||
Active sitei | 122 | 1 | ||
Binding sitei | 208 | Coenzyme ABy similarity | 1 | |
Binding sitei | 214 | Coenzyme ABy similarity | 1 |
GO - Molecular functioni
- arylamine N-acetyltransferase activity Source: GO_Central
GO - Biological processi
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.3.1.5, 2681 2.3.1.88, 2681 |
PathwayCommonsi | P18440 |
Reactomei | R-HSA-156582, Acetylation |
SIGNORi | P18440 |
Names & Taxonomyi
Protein namesi | Recommended name: Arylamine N-acetyltransferase 1 (EC:2.3.1.5)Alternative name(s): Arylamide acetylase 1 Monomorphic arylamine N-acetyltransferase Short name: MNAT N-acetyltransferase type 1 Short name: NAT-1 |
Gene namesi | Name:NAT1 Synonyms:AAC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7645, NAT1 |
MIMi | 108345, gene |
neXtProti | NX_P18440 |
VEuPathDBi | HostDB:ENSG00000171428.13 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 | R → A, M, Q or K: Reduced enzymatic activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9 |
OpenTargetsi | ENSG00000171428 |
PharmGKBi | PA17 |
Miscellaneous databases
Pharosi | P18440, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5101 |
DrugBanki | DB11640, Amifampridine DB00244, Mesalazine DB01015, Sulfamethoxazole |
Genetic variation databases
BioMutai | NAT1 |
DMDMi | 114234 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107904 | 1 – 290 | Arylamine N-acetyltransferase 1Add BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P18440 |
jPOSTi | P18440 |
MassIVEi | P18440 |
MaxQBi | P18440 |
PaxDbi | P18440 |
PeptideAtlasi | P18440 |
PRIDEi | P18440 |
ProteomicsDBi | 53563 |
PTM databases
iPTMneti | P18440 |
PhosphoSitePlusi | P18440 |
SwissPalmi | P18440 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171428, Expressed in bronchial epithelial cell and 189 other tissues |
ExpressionAtlasi | P18440, baseline and differential |
Genevisiblei | P18440, HS |
Organism-specific databases
HPAi | ENSG00000171428, Tissue enhanced (intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 106527, 6 interactors |
IntActi | P18440, 2 interactors |
STRINGi | 9606.ENSP00000443194 |
Chemistry databases
BindingDBi | P18440 |
Miscellaneous databases
RNActi | P18440, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P18440 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P18440 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 107 | Substrate binding | 2 |
Sequence similaritiesi
Belongs to the arylamine N-acetyltransferase family.Curated
Phylogenomic databases
eggNOGi | ENOG502RD0D, Eukaryota |
GeneTreei | ENSGT00390000012054 |
HOGENOMi | CLU_049918_3_0_1 |
InParanoidi | P18440 |
PhylomeDBi | P18440 |
Family and domain databases
InterProi | View protein in InterPro IPR001447, Arylamine_N-AcTrfase IPR038765, Papain-like_cys_pep_sf |
PANTHERi | PTHR11786, PTHR11786, 1 hit |
Pfami | View protein in Pfam PF00797, Acetyltransf_2, 1 hit |
PRINTSi | PR01543, ANATRNSFRASE |
SUPFAMi | SSF54001, SSF54001, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P18440-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL
60 70 80 90 100
GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK
110 120 130 140 150
YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF
160 170 180 190 200
RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE
210 220 230 240 250
DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT
260 270 280 290
DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H5R8 | F5H5R8_HUMAN | Arylamine N-acetyltransferase | NAT1 | 352 | Annotation score: |
Polymorphismi
N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder (PubMed:7585580).1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004606 | 64 | R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs56379106EnsemblClinVar. | 1 | |
Natural variantiVAR_009510 | 117 | R → T in allele NAT1*5. 1 PublicationCorresponds to variant dbSNP:rs55641436Ensembl. | 1 | |
Natural variantiVAR_004607 | 149 | V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. 5 PublicationsCorresponds to variant dbSNP:rs4987076EnsemblClinVar. | 1 | |
Natural variantiVAR_009511 | 166 – 167 | RE → TQ in allele NAT1*5. Corresponds to variant dbSNP:rs72554608Ensembl. | 2 | |
Natural variantiVAR_009069 | 187 | R → Q in allele NAT1*14; a slow acetylator. 2 PublicationsCorresponds to variant dbSNP:rs4986782Ensembl. | 1 | |
Natural variantiVAR_009070 | 205 | M → V in allele NAT1*21. Corresponds to variant dbSNP:rs72554609Ensembl. | 1 | |
Natural variantiVAR_020384 | 207 | T → I. Corresponds to variant dbSNP:rs4987195Ensembl. | 1 | |
Natural variantiVAR_009071 | 214 | S → A in allele NAT1*11. 5 PublicationsCorresponds to variant dbSNP:rs4986783Ensembl. | 1 | |
Natural variantiVAR_009072 | 251 | D → V in allele NAT1*22. Corresponds to variant dbSNP:rs56172717Ensembl. | 1 | |
Natural variantiVAR_009073 | 261 | E → K in allele NAT1*24. Corresponds to variant dbSNP:rs72554610Ensembl. | 1 | |
Natural variantiVAR_009074 | 263 | I → V in allele NAT1*25. Corresponds to variant dbSNP:rs72554611Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17059 Genomic DNA Translation: CAA34905.1 D90041 mRNA Translation: BAA14095.1 AF032677 Genomic DNA Translation: AAB86878.1 AF032678 Genomic DNA Translation: AAB86879.1 U80835 Genomic DNA Translation: AAB62398.1 AF008204 Genomic DNA Translation: AAB84384.1 AF071552 Genomic DNA Translation: AAC24712.1 AF067408 Genomic DNA Translation: AAC24707.1 AF082903 Genomic DNA Translation: AAD13343.1 AF082904 Genomic DNA Translation: AAC32388.1 AJ278017 Genomic DNA Translation: CAC01128.1 AJ307007 Genomic DNA Translation: CAC38345.1 DQ305816 Genomic DNA Translation: ABC26192.1 DQ305817 Genomic DNA Translation: ABC26193.1 DQ305818 Genomic DNA Translation: ABC26194.1 DQ305819 Genomic DNA Translation: ABC26195.1 DQ305820 Genomic DNA Translation: ABC26196.1 DQ305821 Genomic DNA Translation: ABC26197.1 DQ305822 Genomic DNA Translation: ABC26198.1 DQ305823 Genomic DNA Translation: ABC26199.1 DQ305824 Genomic DNA Translation: ABC26200.1 DQ305825 Genomic DNA Translation: ABC26201.1 DQ305826 Genomic DNA Translation: ABC26202.1 DQ305827 Genomic DNA Translation: ABC26203.1 DQ305828 Genomic DNA Translation: ABC26204.1 DQ305829 Genomic DNA Translation: ABC26205.1 DQ305830 Genomic DNA Translation: ABC26206.1 DQ305831 Genomic DNA Translation: ABC26207.1 DQ305832 Genomic DNA Translation: ABC26208.1 DQ305833 Genomic DNA Translation: ABC26209.1 DQ305834 Genomic DNA Translation: ABC26210.1 DQ305835 Genomic DNA Translation: ABC26211.1 DQ305836 Genomic DNA Translation: ABC26212.1 DQ305837 Genomic DNA Translation: ABC26213.1 DQ305838 Genomic DNA Translation: ABC26214.1 DQ305839 Genomic DNA Translation: ABC26215.1 DQ305840 Genomic DNA Translation: ABC26216.1 DQ305841 Genomic DNA Translation: ABC26217.1 DQ305842 Genomic DNA Translation: ABC26218.1 DQ305843 Genomic DNA Translation: ABC26219.1 DQ305844 Genomic DNA Translation: ABC26220.1 DQ305845 Genomic DNA Translation: ABC26221.1 DQ305846 Genomic DNA Translation: ABC26222.1 DQ305847 Genomic DNA Translation: ABC26223.1 DQ305848 Genomic DNA Translation: ABC26224.1 DQ305849 Genomic DNA Translation: ABC26225.1 DQ305850 Genomic DNA Translation: ABC26226.1 DQ305851 Genomic DNA Translation: ABC26227.1 DQ305852 Genomic DNA Translation: ABC26228.1 DQ305853 Genomic DNA Translation: ABC26229.1 DQ305854 Genomic DNA Translation: ABC26230.1 DQ305855 Genomic DNA Translation: ABC26231.1 DQ305856 Genomic DNA Translation: ABC26232.1 DQ305857 Genomic DNA Translation: ABC26233.1 DQ305858 Genomic DNA Translation: ABC26234.1 DQ305859 Genomic DNA Translation: ABC26235.1 DQ305860 Genomic DNA Translation: ABC26236.1 DQ305861 Genomic DNA Translation: ABC26237.1 DQ305862 Genomic DNA Translation: ABC26238.1 DQ305863 Genomic DNA Translation: ABC26239.1 DQ305864 Genomic DNA Translation: ABC26240.1 DQ305865 Genomic DNA Translation: ABC26241.1 DQ305866 Genomic DNA Translation: ABC26242.1 DQ305867 Genomic DNA Translation: ABC26243.1 DQ305868 Genomic DNA Translation: ABC26244.1 DQ305869 Genomic DNA Translation: ABC26245.1 DQ305870 Genomic DNA Translation: ABC26246.1 DQ305871 Genomic DNA Translation: ABC26247.1 DQ305872 Genomic DNA Translation: ABC26248.1 DQ305873 Genomic DNA Translation: ABC26249.1 DQ305874 Genomic DNA Translation: ABC26250.1 DQ305875 Genomic DNA Translation: ABC26251.1 DQ305876 Genomic DNA Translation: ABC26252.1 DQ305877 Genomic DNA Translation: ABC26253.1 DQ305878 Genomic DNA Translation: ABC26254.1 DQ305879 Genomic DNA Translation: ABC26255.1 DQ305880 Genomic DNA Translation: ABC26256.1 DQ305881 Genomic DNA Translation: ABC26257.1 DQ305882 Genomic DNA Translation: ABC26258.1 DQ305883 Genomic DNA Translation: ABC26259.1 DQ305884 Genomic DNA Translation: ABC26260.1 DQ305885 Genomic DNA Translation: ABC26261.1 DQ305886 Genomic DNA Translation: ABC26262.1 DQ305887 Genomic DNA Translation: ABC26263.1 DQ305888 Genomic DNA Translation: ABC26264.1 DQ305889 Genomic DNA Translation: ABC26265.1 DQ305890 Genomic DNA Translation: ABC26266.1 DQ305891 Genomic DNA Translation: ABC26267.1 DQ305892 Genomic DNA Translation: ABC26268.1 DQ305893 Genomic DNA Translation: ABC26269.1 DQ305894 Genomic DNA Translation: ABC26270.1 DQ305895 Genomic DNA Translation: ABC26271.1 DQ305896 Genomic DNA Translation: ABC26272.1 DQ305897 Genomic DNA Translation: ABC26273.1 DQ305898 Genomic DNA Translation: ABC26274.1 DQ305899 Genomic DNA Translation: ABC26275.1 DQ305900 Genomic DNA Translation: ABC26276.1 DQ305901 Genomic DNA Translation: ABC26277.1 DQ305902 Genomic DNA Translation: ABC26278.1 DQ305903 Genomic DNA Translation: ABC26279.1 DQ305904 Genomic DNA Translation: ABC26280.1 DQ305905 Genomic DNA Translation: ABC26281.1 DQ305906 Genomic DNA Translation: ABC26282.1 DQ305907 Genomic DNA Translation: ABC26283.1 DQ305908 Genomic DNA Translation: ABC26284.1 DQ305909 Genomic DNA Translation: ABC26285.1 DQ305910 Genomic DNA Translation: ABC26286.1 DQ305911 Genomic DNA Translation: ABC26287.1 DQ305912 Genomic DNA Translation: ABC26288.1 DQ305913 Genomic DNA Translation: ABC26289.1 DQ305914 Genomic DNA Translation: ABC26290.1 DQ305915 Genomic DNA Translation: ABC26291.1 DQ305916 Genomic DNA Translation: ABC26292.1 DQ305917 Genomic DNA Translation: ABC26293.1 DQ305918 Genomic DNA Translation: ABC26294.1 DQ305919 Genomic DNA Translation: ABC26295.1 DQ305920 Genomic DNA Translation: ABC26296.1 DQ305921 Genomic DNA Translation: ABC26297.1 DQ305922 Genomic DNA Translation: ABC26298.1 DQ305923 Genomic DNA Translation: ABC26299.1 DQ305924 Genomic DNA Translation: ABC26300.1 DQ305925 Genomic DNA Translation: ABC26301.1 DQ305926 Genomic DNA Translation: ABC26302.1 DQ305927 Genomic DNA Translation: ABC26303.1 DQ305928 Genomic DNA Translation: ABC26304.1 DQ305929 Genomic DNA Translation: ABC26305.1 DQ305930 Genomic DNA Translation: ABC26306.1 DQ305931 Genomic DNA Translation: ABC26307.1 DQ305932 Genomic DNA Translation: ABC26308.1 DQ305933 Genomic DNA Translation: ABC26309.1 DQ305934 Genomic DNA Translation: ABC26310.1 DQ305935 Genomic DNA Translation: ABC26311.1 DQ305936 Genomic DNA Translation: ABC26312.1 DQ305937 Genomic DNA Translation: ABC26313.1 DQ305938 Genomic DNA Translation: ABC26314.1 DQ305939 Genomic DNA Translation: ABC26315.1 DQ305940 Genomic DNA Translation: ABC26316.1 DQ305941 Genomic DNA Translation: ABC26317.1 DQ305942 Genomic DNA Translation: ABC26318.1 DQ305943 Genomic DNA Translation: ABC26319.1 DQ305944 Genomic DNA Translation: ABC26320.1 DQ305945 Genomic DNA Translation: ABC26321.1 DQ305946 Genomic DNA Translation: ABC26322.1 DQ305947 Genomic DNA Translation: ABC26323.1 DQ305948 Genomic DNA Translation: ABC26324.1 DQ305949 Genomic DNA Translation: ABC26325.1 DQ305950 Genomic DNA Translation: ABC26326.1 DQ305951 Genomic DNA Translation: ABC26327.1 DQ305952 Genomic DNA Translation: ABC26328.1 DQ305953 Genomic DNA Translation: ABC26329.1 DQ305954 Genomic DNA Translation: ABC26330.1 DQ305955 Genomic DNA Translation: ABC26331.1 DQ305956 Genomic DNA Translation: ABC26332.1 DQ305957 Genomic DNA Translation: ABC26333.1 DQ305958 Genomic DNA Translation: ABC26334.1 DQ305959 Genomic DNA Translation: ABC26335.1 DQ305960 Genomic DNA Translation: ABC26336.1 DQ305961 Genomic DNA Translation: ABC26337.1 DQ305962 Genomic DNA Translation: ABC26338.1 DQ305963 Genomic DNA Translation: ABC26339.1 DQ305964 Genomic DNA Translation: ABC26340.1 DQ305965 Genomic DNA Translation: ABC26341.1 DQ305966 Genomic DNA Translation: ABC26342.1 DQ305967 Genomic DNA Translation: ABC26343.1 DQ305968 Genomic DNA Translation: ABC26344.1 DQ305969 Genomic DNA Translation: ABC26345.1 DQ305970 Genomic DNA Translation: ABC26346.1 DQ305971 Genomic DNA Translation: ABC26347.1 DQ305972 Genomic DNA Translation: ABC26348.1 DQ305973 Genomic DNA Translation: ABC26349.1 DQ305974 Genomic DNA Translation: ABC26350.1 DQ305975 Genomic DNA Translation: ABC26351.1 AK290912 mRNA Translation: BAF83601.1 AY338489 Genomic DNA Translation: AAP88036.1 AY800271 Genomic DNA Translation: AAV50002.1 BC047666 mRNA Translation: AAH47666.1 M75164 Genomic DNA Translation: AAA59905.1 |
CCDSi | CCDS6007.1 |
PIRi | A34585 |
RefSeqi | NP_000653.3, NM_000662.7 NP_001153642.1, NM_001160170.3 NP_001153643.1, NM_001160171.3 NP_001153644.1, NM_001160172.3 NP_001153645.1, NM_001160173.3 NP_001153646.1, NM_001160174.2 NP_001153651.1, NM_001160179.2 XP_006716473.1, XM_006716410.3 XP_011542991.1, XM_011544689.2 |
Genome annotation databases
Ensembli | ENST00000307719; ENSP00000307218; ENSG00000171428 ENST00000517492; ENSP00000429407; ENSG00000171428 ENST00000518029; ENSP00000428270; ENSG00000171428 ENST00000520546; ENSP00000429341; ENSG00000171428 |
GeneIDi | 9 |
KEGGi | hsa:9 |
UCSCi | uc003wyq.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NAT NAT alleles |
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17059 Genomic DNA Translation: CAA34905.1 D90041 mRNA Translation: BAA14095.1 AF032677 Genomic DNA Translation: AAB86878.1 AF032678 Genomic DNA Translation: AAB86879.1 U80835 Genomic DNA Translation: AAB62398.1 AF008204 Genomic DNA Translation: AAB84384.1 AF071552 Genomic DNA Translation: AAC24712.1 AF067408 Genomic DNA Translation: AAC24707.1 AF082903 Genomic DNA Translation: AAD13343.1 AF082904 Genomic DNA Translation: AAC32388.1 AJ278017 Genomic DNA Translation: CAC01128.1 AJ307007 Genomic DNA Translation: CAC38345.1 DQ305816 Genomic DNA Translation: ABC26192.1 DQ305817 Genomic DNA Translation: ABC26193.1 DQ305818 Genomic DNA Translation: ABC26194.1 DQ305819 Genomic DNA Translation: ABC26195.1 DQ305820 Genomic DNA Translation: ABC26196.1 DQ305821 Genomic DNA Translation: ABC26197.1 DQ305822 Genomic DNA Translation: ABC26198.1 DQ305823 Genomic DNA Translation: ABC26199.1 DQ305824 Genomic DNA Translation: ABC26200.1 DQ305825 Genomic DNA Translation: ABC26201.1 DQ305826 Genomic DNA Translation: ABC26202.1 DQ305827 Genomic DNA Translation: ABC26203.1 DQ305828 Genomic DNA Translation: ABC26204.1 DQ305829 Genomic DNA Translation: ABC26205.1 DQ305830 Genomic DNA Translation: ABC26206.1 DQ305831 Genomic DNA Translation: ABC26207.1 DQ305832 Genomic DNA Translation: ABC26208.1 DQ305833 Genomic DNA Translation: ABC26209.1 DQ305834 Genomic DNA Translation: ABC26210.1 DQ305835 Genomic DNA Translation: ABC26211.1 DQ305836 Genomic DNA Translation: ABC26212.1 DQ305837 Genomic DNA Translation: ABC26213.1 DQ305838 Genomic DNA Translation: ABC26214.1 DQ305839 Genomic DNA Translation: ABC26215.1 DQ305840 Genomic DNA Translation: ABC26216.1 DQ305841 Genomic DNA Translation: ABC26217.1 DQ305842 Genomic DNA Translation: ABC26218.1 DQ305843 Genomic DNA Translation: ABC26219.1 DQ305844 Genomic DNA Translation: ABC26220.1 DQ305845 Genomic DNA Translation: ABC26221.1 DQ305846 Genomic DNA Translation: ABC26222.1 DQ305847 Genomic DNA Translation: ABC26223.1 DQ305848 Genomic DNA Translation: ABC26224.1 DQ305849 Genomic DNA Translation: ABC26225.1 DQ305850 Genomic DNA Translation: ABC26226.1 DQ305851 Genomic DNA Translation: ABC26227.1 DQ305852 Genomic DNA Translation: ABC26228.1 DQ305853 Genomic DNA Translation: ABC26229.1 DQ305854 Genomic DNA Translation: ABC26230.1 DQ305855 Genomic DNA Translation: ABC26231.1 DQ305856 Genomic DNA Translation: ABC26232.1 DQ305857 Genomic DNA Translation: ABC26233.1 DQ305858 Genomic DNA Translation: ABC26234.1 DQ305859 Genomic DNA Translation: ABC26235.1 DQ305860 Genomic DNA Translation: ABC26236.1 DQ305861 Genomic DNA Translation: ABC26237.1 DQ305862 Genomic DNA Translation: ABC26238.1 DQ305863 Genomic DNA Translation: ABC26239.1 DQ305864 Genomic DNA Translation: ABC26240.1 DQ305865 Genomic DNA Translation: ABC26241.1 DQ305866 Genomic DNA Translation: ABC26242.1 DQ305867 Genomic DNA Translation: ABC26243.1 DQ305868 Genomic DNA Translation: ABC26244.1 DQ305869 Genomic DNA Translation: ABC26245.1 DQ305870 Genomic DNA Translation: ABC26246.1 DQ305871 Genomic DNA Translation: ABC26247.1 DQ305872 Genomic DNA Translation: ABC26248.1 DQ305873 Genomic DNA Translation: ABC26249.1 DQ305874 Genomic DNA Translation: ABC26250.1 DQ305875 Genomic DNA Translation: ABC26251.1 DQ305876 Genomic DNA Translation: ABC26252.1 DQ305877 Genomic DNA Translation: ABC26253.1 DQ305878 Genomic DNA Translation: ABC26254.1 DQ305879 Genomic DNA Translation: ABC26255.1 DQ305880 Genomic DNA Translation: ABC26256.1 DQ305881 Genomic DNA Translation: ABC26257.1 DQ305882 Genomic DNA Translation: ABC26258.1 DQ305883 Genomic DNA Translation: ABC26259.1 DQ305884 Genomic DNA Translation: ABC26260.1 DQ305885 Genomic DNA Translation: ABC26261.1 DQ305886 Genomic DNA Translation: ABC26262.1 DQ305887 Genomic DNA Translation: ABC26263.1 DQ305888 Genomic DNA Translation: ABC26264.1 DQ305889 Genomic DNA Translation: ABC26265.1 DQ305890 Genomic DNA Translation: ABC26266.1 DQ305891 Genomic DNA Translation: ABC26267.1 DQ305892 Genomic DNA Translation: ABC26268.1 DQ305893 Genomic DNA Translation: ABC26269.1 DQ305894 Genomic DNA Translation: ABC26270.1 DQ305895 Genomic DNA Translation: ABC26271.1 DQ305896 Genomic DNA Translation: ABC26272.1 DQ305897 Genomic DNA Translation: ABC26273.1 DQ305898 Genomic DNA Translation: ABC26274.1 DQ305899 Genomic DNA Translation: ABC26275.1 DQ305900 Genomic DNA Translation: ABC26276.1 DQ305901 Genomic DNA Translation: ABC26277.1 DQ305902 Genomic DNA Translation: ABC26278.1 DQ305903 Genomic DNA Translation: ABC26279.1 DQ305904 Genomic DNA Translation: ABC26280.1 DQ305905 Genomic DNA Translation: ABC26281.1 DQ305906 Genomic DNA Translation: ABC26282.1 DQ305907 Genomic DNA Translation: ABC26283.1 DQ305908 Genomic DNA Translation: ABC26284.1 DQ305909 Genomic DNA Translation: ABC26285.1 DQ305910 Genomic DNA Translation: ABC26286.1 DQ305911 Genomic DNA Translation: ABC26287.1 DQ305912 Genomic DNA Translation: ABC26288.1 DQ305913 Genomic DNA Translation: ABC26289.1 DQ305914 Genomic DNA Translation: ABC26290.1 DQ305915 Genomic DNA Translation: ABC26291.1 DQ305916 Genomic DNA Translation: ABC26292.1 DQ305917 Genomic DNA Translation: ABC26293.1 DQ305918 Genomic DNA Translation: ABC26294.1 DQ305919 Genomic DNA Translation: ABC26295.1 DQ305920 Genomic DNA Translation: ABC26296.1 DQ305921 Genomic DNA Translation: ABC26297.1 DQ305922 Genomic DNA Translation: ABC26298.1 DQ305923 Genomic DNA Translation: ABC26299.1 DQ305924 Genomic DNA Translation: ABC26300.1 DQ305925 Genomic DNA Translation: ABC26301.1 DQ305926 Genomic DNA Translation: ABC26302.1 DQ305927 Genomic DNA Translation: ABC26303.1 DQ305928 Genomic DNA Translation: ABC26304.1 DQ305929 Genomic DNA Translation: ABC26305.1 DQ305930 Genomic DNA Translation: ABC26306.1 DQ305931 Genomic DNA Translation: ABC26307.1 DQ305932 Genomic DNA Translation: ABC26308.1 DQ305933 Genomic DNA Translation: ABC26309.1 DQ305934 Genomic DNA Translation: ABC26310.1 DQ305935 Genomic DNA Translation: ABC26311.1 DQ305936 Genomic DNA Translation: ABC26312.1 DQ305937 Genomic DNA Translation: ABC26313.1 DQ305938 Genomic DNA Translation: ABC26314.1 DQ305939 Genomic DNA Translation: ABC26315.1 DQ305940 Genomic DNA Translation: ABC26316.1 DQ305941 Genomic DNA Translation: ABC26317.1 DQ305942 Genomic DNA Translation: ABC26318.1 DQ305943 Genomic DNA Translation: ABC26319.1 DQ305944 Genomic DNA Translation: ABC26320.1 DQ305945 Genomic DNA Translation: ABC26321.1 DQ305946 Genomic DNA Translation: ABC26322.1 DQ305947 Genomic DNA Translation: ABC26323.1 DQ305948 Genomic DNA Translation: ABC26324.1 DQ305949 Genomic DNA Translation: ABC26325.1 DQ305950 Genomic DNA Translation: ABC26326.1 DQ305951 Genomic DNA Translation: ABC26327.1 DQ305952 Genomic DNA Translation: ABC26328.1 DQ305953 Genomic DNA Translation: ABC26329.1 DQ305954 Genomic DNA Translation: ABC26330.1 DQ305955 Genomic DNA Translation: ABC26331.1 DQ305956 Genomic DNA Translation: ABC26332.1 DQ305957 Genomic DNA Translation: ABC26333.1 DQ305958 Genomic DNA Translation: ABC26334.1 DQ305959 Genomic DNA Translation: ABC26335.1 DQ305960 Genomic DNA Translation: ABC26336.1 DQ305961 Genomic DNA Translation: ABC26337.1 DQ305962 Genomic DNA Translation: ABC26338.1 DQ305963 Genomic DNA Translation: ABC26339.1 DQ305964 Genomic DNA Translation: ABC26340.1 DQ305965 Genomic DNA Translation: ABC26341.1 DQ305966 Genomic DNA Translation: ABC26342.1 DQ305967 Genomic DNA Translation: ABC26343.1 DQ305968 Genomic DNA Translation: ABC26344.1 DQ305969 Genomic DNA Translation: ABC26345.1 DQ305970 Genomic DNA Translation: ABC26346.1 DQ305971 Genomic DNA Translation: ABC26347.1 DQ305972 Genomic DNA Translation: ABC26348.1 DQ305973 Genomic DNA Translation: ABC26349.1 DQ305974 Genomic DNA Translation: ABC26350.1 DQ305975 Genomic DNA Translation: ABC26351.1 AK290912 mRNA Translation: BAF83601.1 AY338489 Genomic DNA Translation: AAP88036.1 AY800271 Genomic DNA Translation: AAV50002.1 BC047666 mRNA Translation: AAH47666.1 M75164 Genomic DNA Translation: AAA59905.1 |
CCDSi | CCDS6007.1 |
PIRi | A34585 |
RefSeqi | NP_000653.3, NM_000662.7 NP_001153642.1, NM_001160170.3 NP_001153643.1, NM_001160171.3 NP_001153644.1, NM_001160172.3 NP_001153645.1, NM_001160173.3 NP_001153646.1, NM_001160174.2 NP_001153651.1, NM_001160179.2 XP_006716473.1, XM_006716410.3 XP_011542991.1, XM_011544689.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DSS | model | - | @ | 1-290 | [»] | |
2GWU | model | - | A | 1-290 | [»] | |
2IJA | X-ray | 1.70 | A | 2-290 | [»] | |
2PQT | X-ray | 1.78 | A | 2-290 | [»] | |
SMRi | P18440 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106527, 6 interactors |
IntActi | P18440, 2 interactors |
STRINGi | 9606.ENSP00000443194 |
Chemistry databases
BindingDBi | P18440 |
ChEMBLi | CHEMBL5101 |
DrugBanki | DB11640, Amifampridine DB00244, Mesalazine DB01015, Sulfamethoxazole |
PTM databases
iPTMneti | P18440 |
PhosphoSitePlusi | P18440 |
SwissPalmi | P18440 |
Genetic variation databases
BioMutai | NAT1 |
DMDMi | 114234 |
Proteomic databases
EPDi | P18440 |
jPOSTi | P18440 |
MassIVEi | P18440 |
MaxQBi | P18440 |
PaxDbi | P18440 |
PeptideAtlasi | P18440 |
PRIDEi | P18440 |
ProteomicsDBi | 53563 |
Protocols and materials databases
Antibodypediai | 22350, 325 antibodies |
DNASUi | 9 |
Genome annotation databases
Ensembli | ENST00000307719; ENSP00000307218; ENSG00000171428 ENST00000517492; ENSP00000429407; ENSG00000171428 ENST00000518029; ENSP00000428270; ENSG00000171428 ENST00000520546; ENSP00000429341; ENSG00000171428 |
GeneIDi | 9 |
KEGGi | hsa:9 |
UCSCi | uc003wyq.4, human |
Organism-specific databases
CTDi | 9 |
DisGeNETi | 9 |
GeneCardsi | NAT1 |
HGNCi | HGNC:7645, NAT1 |
HPAi | ENSG00000171428, Tissue enhanced (intestine) |
MIMi | 108345, gene |
neXtProti | NX_P18440 |
OpenTargetsi | ENSG00000171428 |
PharmGKBi | PA17 |
VEuPathDBi | HostDB:ENSG00000171428.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RD0D, Eukaryota |
GeneTreei | ENSGT00390000012054 |
HOGENOMi | CLU_049918_3_0_1 |
InParanoidi | P18440 |
PhylomeDBi | P18440 |
Enzyme and pathway databases
BRENDAi | 2.3.1.5, 2681 2.3.1.88, 2681 |
PathwayCommonsi | P18440 |
Reactomei | R-HSA-156582, Acetylation |
SIGNORi | P18440 |
Miscellaneous databases
BioGRID-ORCSi | 9, 3 hits in 851 CRISPR screens |
ChiTaRSi | NAT1, human |
EvolutionaryTracei | P18440 |
GeneWikii | N-acetyltransferase_1 |
GenomeRNAii | 9 |
Pharosi | P18440, Tchem |
PROi | PR:P18440 |
RNActi | P18440, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171428, Expressed in bronchial epithelial cell and 189 other tissues |
ExpressionAtlasi | P18440, baseline and differential |
Genevisiblei | P18440, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001447, Arylamine_N-AcTrfase IPR038765, Papain-like_cys_pep_sf |
PANTHERi | PTHR11786, PTHR11786, 1 hit |
Pfami | View protein in Pfam PF00797, Acetyltransf_2, 1 hit |
PRINTSi | PR01543, ANATRNSFRASE |
SUPFAMi | SSF54001, SSF54001, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARY1_HUMAN | |
Accessioni | P18440Primary (citable) accession number: P18440 Secondary accession number(s): A8K4E7 Q96TE9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | February 1, 1991 | |
Last modified: | February 10, 2021 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families