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UniProtKB - P18440 (ARY1_HUMAN)

Entry version 190 (10 Feb 2021)
Sequence version 2 (01 Feb 1991)
Previous versions | rss
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Protein

Arylamine N-acetyltransferase 1

Gene

NAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Miscellaneous

NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.

Caution

The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei68Acyl-thioester intermediate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei103Coenzyme ABy similarity1
Binding sitei104Coenzyme A; via amide nitrogenBy similarity1
Active sitei1071
Active sitei1221
Binding sitei208Coenzyme ABy similarity1
Binding sitei214Coenzyme ABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.5, 2681
2.3.1.88, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18440

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156582, Acetylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18440

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 1
Monomorphic arylamine N-acetyltransferase
Short name:
MNAT
N-acetyltransferase type 1
Short name:
NAT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAT1
Synonyms:AAC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7645, NAT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		108345, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18440

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000171428.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64R → A, M, Q or K: Reduced enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9

Open Targets

More...OpenTargetsi		ENSG00000171428

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA17

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18440, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5101

Drug and drug target database

More...DrugBanki		DB11640, Amifampridine
DB00244, Mesalazine
DB01015, Sulfamethoxazole

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NAT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		114234

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001079041 – 290Arylamine N-acetyltransferase 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P18440

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18440

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18440

MaxQB - The MaxQuant DataBase

More...MaxQBi		P18440

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18440

PeptideAtlas

More...PeptideAtlasi		P18440

PRoteomics IDEntifications database

More...PRIDEi		P18440

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53563

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18440

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18440

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P18440

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171428, Expressed in bronchial epithelial cell and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18440, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18440, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171428, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106527, 6 interactors

Protein interaction database and analysis system

More...IntActi		P18440, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000443194

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P18440

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18440, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18440

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P18440

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 107Substrate binding2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the arylamine N-acetyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RD0D, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049918_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18440

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18440

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001447, Arylamine_N-AcTrfase
IPR038765, Papain-like_cys_pep_sf

The PANTHER Classification System

More...PANTHERi		PTHR11786, PTHR11786, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00797, Acetyltransf_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01543, ANATRNSFRASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P18440-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL 
        60         70         80         90        100
GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK 
       110        120        130        140        150
YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF 
       160        170        180        190        200
RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE 
       210        220        230        240        250
DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT 
       260        270        280        290
DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI
Length:290
Mass (Da):33,899
Last modified:February 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC015F7F3D4830107
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H5R8F5H5R8_HUMAN
Arylamine N-acetyltransferase
NAT1
352Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder (PubMed:7585580).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00460664R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs56379106EnsemblClinVar.1
Natural variantiVAR_009510117R → T in allele NAT1*5. 1 PublicationCorresponds to variant dbSNP:rs55641436Ensembl.1
Natural variantiVAR_004607149V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. 5 PublicationsCorresponds to variant dbSNP:rs4987076EnsemblClinVar.1
Natural variantiVAR_009511166 – 167RE → TQ in allele NAT1*5. Corresponds to variant dbSNP:rs72554608Ensembl.2
Natural variantiVAR_009069187R → Q in allele NAT1*14; a slow acetylator. 2 PublicationsCorresponds to variant dbSNP:rs4986782Ensembl.1
Natural variantiVAR_009070205M → V in allele NAT1*21. Corresponds to variant dbSNP:rs72554609Ensembl.1
Natural variantiVAR_020384207T → I. Corresponds to variant dbSNP:rs4987195Ensembl.1
Natural variantiVAR_009071214S → A in allele NAT1*11. 5 PublicationsCorresponds to variant dbSNP:rs4986783Ensembl.1
Natural variantiVAR_009072251D → V in allele NAT1*22. Corresponds to variant dbSNP:rs56172717Ensembl.1
Natural variantiVAR_009073261E → K in allele NAT1*24. Corresponds to variant dbSNP:rs72554610Ensembl.1
Natural variantiVAR_009074263I → V in allele NAT1*25. Corresponds to variant dbSNP:rs72554611Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X17059 Genomic DNA Translation: CAA34905.1
D90041 mRNA Translation: BAA14095.1
AF032677 Genomic DNA Translation: AAB86878.1
AF032678 Genomic DNA Translation: AAB86879.1
U80835 Genomic DNA Translation: AAB62398.1
AF008204 Genomic DNA Translation: AAB84384.1
AF071552 Genomic DNA Translation: AAC24712.1
AF067408 Genomic DNA Translation: AAC24707.1
AF082903 Genomic DNA Translation: AAD13343.1
AF082904 Genomic DNA Translation: AAC32388.1
AJ278017 Genomic DNA Translation: CAC01128.1
AJ307007 Genomic DNA Translation: CAC38345.1
DQ305816 Genomic DNA Translation: ABC26192.1
DQ305817 Genomic DNA Translation: ABC26193.1
DQ305818 Genomic DNA Translation: ABC26194.1
DQ305819 Genomic DNA Translation: ABC26195.1
DQ305820 Genomic DNA Translation: ABC26196.1
DQ305821 Genomic DNA Translation: ABC26197.1
DQ305822 Genomic DNA Translation: ABC26198.1
DQ305823 Genomic DNA Translation: ABC26199.1
DQ305824 Genomic DNA Translation: ABC26200.1
DQ305825 Genomic DNA Translation: ABC26201.1
DQ305826 Genomic DNA Translation: ABC26202.1
DQ305827 Genomic DNA Translation: ABC26203.1
DQ305828 Genomic DNA Translation: ABC26204.1
DQ305829 Genomic DNA Translation: ABC26205.1
DQ305830 Genomic DNA Translation: ABC26206.1
DQ305831 Genomic DNA Translation: ABC26207.1
DQ305832 Genomic DNA Translation: ABC26208.1
DQ305833 Genomic DNA Translation: ABC26209.1
DQ305834 Genomic DNA Translation: ABC26210.1
DQ305835 Genomic DNA Translation: ABC26211.1
DQ305836 Genomic DNA Translation: ABC26212.1
DQ305837 Genomic DNA Translation: ABC26213.1
DQ305838 Genomic DNA Translation: ABC26214.1
DQ305839 Genomic DNA Translation: ABC26215.1
DQ305840 Genomic DNA Translation: ABC26216.1
DQ305841 Genomic DNA Translation: ABC26217.1
DQ305842 Genomic DNA Translation: ABC26218.1
DQ305843 Genomic DNA Translation: ABC26219.1
DQ305844 Genomic DNA Translation: ABC26220.1
DQ305845 Genomic DNA Translation: ABC26221.1
DQ305846 Genomic DNA Translation: ABC26222.1
DQ305847 Genomic DNA Translation: ABC26223.1
DQ305848 Genomic DNA Translation: ABC26224.1
DQ305849 Genomic DNA Translation: ABC26225.1
DQ305850 Genomic DNA Translation: ABC26226.1
DQ305851 Genomic DNA Translation: ABC26227.1
DQ305852 Genomic DNA Translation: ABC26228.1
DQ305853 Genomic DNA Translation: ABC26229.1
DQ305854 Genomic DNA Translation: ABC26230.1
DQ305855 Genomic DNA Translation: ABC26231.1
DQ305856 Genomic DNA Translation: ABC26232.1
DQ305857 Genomic DNA Translation: ABC26233.1
DQ305858 Genomic DNA Translation: ABC26234.1
DQ305859 Genomic DNA Translation: ABC26235.1
DQ305860 Genomic DNA Translation: ABC26236.1
DQ305861 Genomic DNA Translation: ABC26237.1
DQ305862 Genomic DNA Translation: ABC26238.1
DQ305863 Genomic DNA Translation: ABC26239.1
DQ305864 Genomic DNA Translation: ABC26240.1
DQ305865 Genomic DNA Translation: ABC26241.1
DQ305866 Genomic DNA Translation: ABC26242.1
DQ305867 Genomic DNA Translation: ABC26243.1
DQ305868 Genomic DNA Translation: ABC26244.1
DQ305869 Genomic DNA Translation: ABC26245.1
DQ305870 Genomic DNA Translation: ABC26246.1
DQ305871 Genomic DNA Translation: ABC26247.1
DQ305872 Genomic DNA Translation: ABC26248.1
DQ305873 Genomic DNA Translation: ABC26249.1
DQ305874 Genomic DNA Translation: ABC26250.1
DQ305875 Genomic DNA Translation: ABC26251.1
DQ305876 Genomic DNA Translation: ABC26252.1
DQ305877 Genomic DNA Translation: ABC26253.1
DQ305878 Genomic DNA Translation: ABC26254.1
DQ305879 Genomic DNA Translation: ABC26255.1
DQ305880 Genomic DNA Translation: ABC26256.1
DQ305881 Genomic DNA Translation: ABC26257.1
DQ305882 Genomic DNA Translation: ABC26258.1
DQ305883 Genomic DNA Translation: ABC26259.1
DQ305884 Genomic DNA Translation: ABC26260.1
DQ305885 Genomic DNA Translation: ABC26261.1
DQ305886 Genomic DNA Translation: ABC26262.1
DQ305887 Genomic DNA Translation: ABC26263.1
DQ305888 Genomic DNA Translation: ABC26264.1
DQ305889 Genomic DNA Translation: ABC26265.1
DQ305890 Genomic DNA Translation: ABC26266.1
DQ305891 Genomic DNA Translation: ABC26267.1
DQ305892 Genomic DNA Translation: ABC26268.1
DQ305893 Genomic DNA Translation: ABC26269.1
DQ305894 Genomic DNA Translation: ABC26270.1
DQ305895 Genomic DNA Translation: ABC26271.1
DQ305896 Genomic DNA Translation: ABC26272.1
DQ305897 Genomic DNA Translation: ABC26273.1
DQ305898 Genomic DNA Translation: ABC26274.1
DQ305899 Genomic DNA Translation: ABC26275.1
DQ305900 Genomic DNA Translation: ABC26276.1
DQ305901 Genomic DNA Translation: ABC26277.1
DQ305902 Genomic DNA Translation: ABC26278.1
DQ305903 Genomic DNA Translation: ABC26279.1
DQ305904 Genomic DNA Translation: ABC26280.1
DQ305905 Genomic DNA Translation: ABC26281.1
DQ305906 Genomic DNA Translation: ABC26282.1
DQ305907 Genomic DNA Translation: ABC26283.1
DQ305908 Genomic DNA Translation: ABC26284.1
DQ305909 Genomic DNA Translation: ABC26285.1
DQ305910 Genomic DNA Translation: ABC26286.1
DQ305911 Genomic DNA Translation: ABC26287.1
DQ305912 Genomic DNA Translation: ABC26288.1
DQ305913 Genomic DNA Translation: ABC26289.1
DQ305914 Genomic DNA Translation: ABC26290.1
DQ305915 Genomic DNA Translation: ABC26291.1
DQ305916 Genomic DNA Translation: ABC26292.1
DQ305917 Genomic DNA Translation: ABC26293.1
DQ305918 Genomic DNA Translation: ABC26294.1
DQ305919 Genomic DNA Translation: ABC26295.1
DQ305920 Genomic DNA Translation: ABC26296.1
DQ305921 Genomic DNA Translation: ABC26297.1
DQ305922 Genomic DNA Translation: ABC26298.1
DQ305923 Genomic DNA Translation: ABC26299.1
DQ305924 Genomic DNA Translation: ABC26300.1
DQ305925 Genomic DNA Translation: ABC26301.1
DQ305926 Genomic DNA Translation: ABC26302.1
DQ305927 Genomic DNA Translation: ABC26303.1
DQ305928 Genomic DNA Translation: ABC26304.1
DQ305929 Genomic DNA Translation: ABC26305.1
DQ305930 Genomic DNA Translation: ABC26306.1
DQ305931 Genomic DNA Translation: ABC26307.1
DQ305932 Genomic DNA Translation: ABC26308.1
DQ305933 Genomic DNA Translation: ABC26309.1
DQ305934 Genomic DNA Translation: ABC26310.1
DQ305935 Genomic DNA Translation: ABC26311.1
DQ305936 Genomic DNA Translation: ABC26312.1
DQ305937 Genomic DNA Translation: ABC26313.1
DQ305938 Genomic DNA Translation: ABC26314.1
DQ305939 Genomic DNA Translation: ABC26315.1
DQ305940 Genomic DNA Translation: ABC26316.1
DQ305941 Genomic DNA Translation: ABC26317.1
DQ305942 Genomic DNA Translation: ABC26318.1
DQ305943 Genomic DNA Translation: ABC26319.1
DQ305944 Genomic DNA Translation: ABC26320.1
DQ305945 Genomic DNA Translation: ABC26321.1
DQ305946 Genomic DNA Translation: ABC26322.1
DQ305947 Genomic DNA Translation: ABC26323.1
DQ305948 Genomic DNA Translation: ABC26324.1
DQ305949 Genomic DNA Translation: ABC26325.1
DQ305950 Genomic DNA Translation: ABC26326.1
DQ305951 Genomic DNA Translation: ABC26327.1
DQ305952 Genomic DNA Translation: ABC26328.1
DQ305953 Genomic DNA Translation: ABC26329.1
DQ305954 Genomic DNA Translation: ABC26330.1
DQ305955 Genomic DNA Translation: ABC26331.1
DQ305956 Genomic DNA Translation: ABC26332.1
DQ305957 Genomic DNA Translation: ABC26333.1
DQ305958 Genomic DNA Translation: ABC26334.1
DQ305959 Genomic DNA Translation: ABC26335.1
DQ305960 Genomic DNA Translation: ABC26336.1
DQ305961 Genomic DNA Translation: ABC26337.1
DQ305962 Genomic DNA Translation: ABC26338.1
DQ305963 Genomic DNA Translation: ABC26339.1
DQ305964 Genomic DNA Translation: ABC26340.1
DQ305965 Genomic DNA Translation: ABC26341.1
DQ305966 Genomic DNA Translation: ABC26342.1
DQ305967 Genomic DNA Translation: ABC26343.1
DQ305968 Genomic DNA Translation: ABC26344.1
DQ305969 Genomic DNA Translation: ABC26345.1
DQ305970 Genomic DNA Translation: ABC26346.1
DQ305971 Genomic DNA Translation: ABC26347.1
DQ305972 Genomic DNA Translation: ABC26348.1
DQ305973 Genomic DNA Translation: ABC26349.1
DQ305974 Genomic DNA Translation: ABC26350.1
DQ305975 Genomic DNA Translation: ABC26351.1
AK290912 mRNA Translation: BAF83601.1
AY338489 Genomic DNA Translation: AAP88036.1
AY800271 Genomic DNA Translation: AAV50002.1
BC047666 mRNA Translation: AAH47666.1
M75164 Genomic DNA Translation: AAA59905.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6007.1

Protein sequence database of the Protein Information Resource

More...PIRi		A34585

NCBI Reference Sequences

More...RefSeqi		NP_000653.3, NM_000662.7
NP_001153642.1, NM_001160170.3
NP_001153643.1, NM_001160171.3
NP_001153644.1, NM_001160172.3
NP_001153645.1, NM_001160173.3
NP_001153646.1, NM_001160174.2
NP_001153651.1, NM_001160179.2
XP_006716473.1, XM_006716410.3
XP_011542991.1, XM_011544689.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000307719; ENSP00000307218; ENSG00000171428
ENST00000517492; ENSP00000429407; ENSG00000171428
ENST00000518029; ENSP00000428270; ENSG00000171428
ENST00000520546; ENSP00000429341; ENSG00000171428

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9

UCSC genome browser

More...UCSCi		uc003wyq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NAT

NAT alleles

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17059 Genomic DNA Translation: CAA34905.1
D90041 mRNA Translation: BAA14095.1
AF032677 Genomic DNA Translation: AAB86878.1
AF032678 Genomic DNA Translation: AAB86879.1
U80835 Genomic DNA Translation: AAB62398.1
AF008204 Genomic DNA Translation: AAB84384.1
AF071552 Genomic DNA Translation: AAC24712.1
AF067408 Genomic DNA Translation: AAC24707.1
AF082903 Genomic DNA Translation: AAD13343.1
AF082904 Genomic DNA Translation: AAC32388.1
AJ278017 Genomic DNA Translation: CAC01128.1
AJ307007 Genomic DNA Translation: CAC38345.1
DQ305816 Genomic DNA Translation: ABC26192.1
DQ305817 Genomic DNA Translation: ABC26193.1
DQ305818 Genomic DNA Translation: ABC26194.1
DQ305819 Genomic DNA Translation: ABC26195.1
DQ305820 Genomic DNA Translation: ABC26196.1
DQ305821 Genomic DNA Translation: ABC26197.1
DQ305822 Genomic DNA Translation: ABC26198.1
DQ305823 Genomic DNA Translation: ABC26199.1
DQ305824 Genomic DNA Translation: ABC26200.1
DQ305825 Genomic DNA Translation: ABC26201.1
DQ305826 Genomic DNA Translation: ABC26202.1
DQ305827 Genomic DNA Translation: ABC26203.1
DQ305828 Genomic DNA Translation: ABC26204.1
DQ305829 Genomic DNA Translation: ABC26205.1
DQ305830 Genomic DNA Translation: ABC26206.1
DQ305831 Genomic DNA Translation: ABC26207.1
DQ305832 Genomic DNA Translation: ABC26208.1
DQ305833 Genomic DNA Translation: ABC26209.1
DQ305834 Genomic DNA Translation: ABC26210.1
DQ305835 Genomic DNA Translation: ABC26211.1
DQ305836 Genomic DNA Translation: ABC26212.1
DQ305837 Genomic DNA Translation: ABC26213.1
DQ305838 Genomic DNA Translation: ABC26214.1
DQ305839 Genomic DNA Translation: ABC26215.1
DQ305840 Genomic DNA Translation: ABC26216.1
DQ305841 Genomic DNA Translation: ABC26217.1
DQ305842 Genomic DNA Translation: ABC26218.1
DQ305843 Genomic DNA Translation: ABC26219.1
DQ305844 Genomic DNA Translation: ABC26220.1
DQ305845 Genomic DNA Translation: ABC26221.1
DQ305846 Genomic DNA Translation: ABC26222.1
DQ305847 Genomic DNA Translation: ABC26223.1
DQ305848 Genomic DNA Translation: ABC26224.1
DQ305849 Genomic DNA Translation: ABC26225.1
DQ305850 Genomic DNA Translation: ABC26226.1
DQ305851 Genomic DNA Translation: ABC26227.1
DQ305852 Genomic DNA Translation: ABC26228.1
DQ305853 Genomic DNA Translation: ABC26229.1
DQ305854 Genomic DNA Translation: ABC26230.1
DQ305855 Genomic DNA Translation: ABC26231.1
DQ305856 Genomic DNA Translation: ABC26232.1
DQ305857 Genomic DNA Translation: ABC26233.1
DQ305858 Genomic DNA Translation: ABC26234.1
DQ305859 Genomic DNA Translation: ABC26235.1
DQ305860 Genomic DNA Translation: ABC26236.1
DQ305861 Genomic DNA Translation: ABC26237.1
DQ305862 Genomic DNA Translation: ABC26238.1
DQ305863 Genomic DNA Translation: ABC26239.1
DQ305864 Genomic DNA Translation: ABC26240.1
DQ305865 Genomic DNA Translation: ABC26241.1
DQ305866 Genomic DNA Translation: ABC26242.1
DQ305867 Genomic DNA Translation: ABC26243.1
DQ305868 Genomic DNA Translation: ABC26244.1
DQ305869 Genomic DNA Translation: ABC26245.1
DQ305870 Genomic DNA Translation: ABC26246.1
DQ305871 Genomic DNA Translation: ABC26247.1
DQ305872 Genomic DNA Translation: ABC26248.1
DQ305873 Genomic DNA Translation: ABC26249.1
DQ305874 Genomic DNA Translation: ABC26250.1
DQ305875 Genomic DNA Translation: ABC26251.1
DQ305876 Genomic DNA Translation: ABC26252.1
DQ305877 Genomic DNA Translation: ABC26253.1
DQ305878 Genomic DNA Translation: ABC26254.1
DQ305879 Genomic DNA Translation: ABC26255.1
DQ305880 Genomic DNA Translation: ABC26256.1
DQ305881 Genomic DNA Translation: ABC26257.1
DQ305882 Genomic DNA Translation: ABC26258.1
DQ305883 Genomic DNA Translation: ABC26259.1
DQ305884 Genomic DNA Translation: ABC26260.1
DQ305885 Genomic DNA Translation: ABC26261.1
DQ305886 Genomic DNA Translation: ABC26262.1
DQ305887 Genomic DNA Translation: ABC26263.1
DQ305888 Genomic DNA Translation: ABC26264.1
DQ305889 Genomic DNA Translation: ABC26265.1
DQ305890 Genomic DNA Translation: ABC26266.1
DQ305891 Genomic DNA Translation: ABC26267.1
DQ305892 Genomic DNA Translation: ABC26268.1
DQ305893 Genomic DNA Translation: ABC26269.1
DQ305894 Genomic DNA Translation: ABC26270.1
DQ305895 Genomic DNA Translation: ABC26271.1
DQ305896 Genomic DNA Translation: ABC26272.1
DQ305897 Genomic DNA Translation: ABC26273.1
DQ305898 Genomic DNA Translation: ABC26274.1
DQ305899 Genomic DNA Translation: ABC26275.1
DQ305900 Genomic DNA Translation: ABC26276.1
DQ305901 Genomic DNA Translation: ABC26277.1
DQ305902 Genomic DNA Translation: ABC26278.1
DQ305903 Genomic DNA Translation: ABC26279.1
DQ305904 Genomic DNA Translation: ABC26280.1
DQ305905 Genomic DNA Translation: ABC26281.1
DQ305906 Genomic DNA Translation: ABC26282.1
DQ305907 Genomic DNA Translation: ABC26283.1
DQ305908 Genomic DNA Translation: ABC26284.1
DQ305909 Genomic DNA Translation: ABC26285.1
DQ305910 Genomic DNA Translation: ABC26286.1
DQ305911 Genomic DNA Translation: ABC26287.1
DQ305912 Genomic DNA Translation: ABC26288.1
DQ305913 Genomic DNA Translation: ABC26289.1
DQ305914 Genomic DNA Translation: ABC26290.1
DQ305915 Genomic DNA Translation: ABC26291.1
DQ305916 Genomic DNA Translation: ABC26292.1
DQ305917 Genomic DNA Translation: ABC26293.1
DQ305918 Genomic DNA Translation: ABC26294.1
DQ305919 Genomic DNA Translation: ABC26295.1
DQ305920 Genomic DNA Translation: ABC26296.1
DQ305921 Genomic DNA Translation: ABC26297.1
DQ305922 Genomic DNA Translation: ABC26298.1
DQ305923 Genomic DNA Translation: ABC26299.1
DQ305924 Genomic DNA Translation: ABC26300.1
DQ305925 Genomic DNA Translation: ABC26301.1
DQ305926 Genomic DNA Translation: ABC26302.1
DQ305927 Genomic DNA Translation: ABC26303.1
DQ305928 Genomic DNA Translation: ABC26304.1
DQ305929 Genomic DNA Translation: ABC26305.1
DQ305930 Genomic DNA Translation: ABC26306.1
DQ305931 Genomic DNA Translation: ABC26307.1
DQ305932 Genomic DNA Translation: ABC26308.1
DQ305933 Genomic DNA Translation: ABC26309.1
DQ305934 Genomic DNA Translation: ABC26310.1
DQ305935 Genomic DNA Translation: ABC26311.1
DQ305936 Genomic DNA Translation: ABC26312.1
DQ305937 Genomic DNA Translation: ABC26313.1
DQ305938 Genomic DNA Translation: ABC26314.1
DQ305939 Genomic DNA Translation: ABC26315.1
DQ305940 Genomic DNA Translation: ABC26316.1
DQ305941 Genomic DNA Translation: ABC26317.1
DQ305942 Genomic DNA Translation: ABC26318.1
DQ305943 Genomic DNA Translation: ABC26319.1
DQ305944 Genomic DNA Translation: ABC26320.1
DQ305945 Genomic DNA Translation: ABC26321.1
DQ305946 Genomic DNA Translation: ABC26322.1
DQ305947 Genomic DNA Translation: ABC26323.1
DQ305948 Genomic DNA Translation: ABC26324.1
DQ305949 Genomic DNA Translation: ABC26325.1
DQ305950 Genomic DNA Translation: ABC26326.1
DQ305951 Genomic DNA Translation: ABC26327.1
DQ305952 Genomic DNA Translation: ABC26328.1
DQ305953 Genomic DNA Translation: ABC26329.1
DQ305954 Genomic DNA Translation: ABC26330.1
DQ305955 Genomic DNA Translation: ABC26331.1
DQ305956 Genomic DNA Translation: ABC26332.1
DQ305957 Genomic DNA Translation: ABC26333.1
DQ305958 Genomic DNA Translation: ABC26334.1
DQ305959 Genomic DNA Translation: ABC26335.1
DQ305960 Genomic DNA Translation: ABC26336.1
DQ305961 Genomic DNA Translation: ABC26337.1
DQ305962 Genomic DNA Translation: ABC26338.1
DQ305963 Genomic DNA Translation: ABC26339.1
DQ305964 Genomic DNA Translation: ABC26340.1
DQ305965 Genomic DNA Translation: ABC26341.1
DQ305966 Genomic DNA Translation: ABC26342.1
DQ305967 Genomic DNA Translation: ABC26343.1
DQ305968 Genomic DNA Translation: ABC26344.1
DQ305969 Genomic DNA Translation: ABC26345.1
DQ305970 Genomic DNA Translation: ABC26346.1
DQ305971 Genomic DNA Translation: ABC26347.1
DQ305972 Genomic DNA Translation: ABC26348.1
DQ305973 Genomic DNA Translation: ABC26349.1
DQ305974 Genomic DNA Translation: ABC26350.1
DQ305975 Genomic DNA Translation: ABC26351.1
AK290912 mRNA Translation: BAF83601.1
AY338489 Genomic DNA Translation: AAP88036.1
AY800271 Genomic DNA Translation: AAV50002.1
BC047666 mRNA Translation: AAH47666.1
M75164 Genomic DNA Translation: AAA59905.1
CCDSiCCDS6007.1
PIRiA34585
RefSeqiNP_000653.3, NM_000662.7
NP_001153642.1, NM_001160170.3
NP_001153643.1, NM_001160171.3
NP_001153644.1, NM_001160172.3
NP_001153645.1, NM_001160173.3
NP_001153646.1, NM_001160174.2
NP_001153651.1, NM_001160179.2
XP_006716473.1, XM_006716410.3
XP_011542991.1, XM_011544689.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DSSmodel-@1-290[»]
2GWUmodel-A1-290[»]
2IJAX-ray1.70A2-290[»]
2PQTX-ray1.78A2-290[»]
SMRiP18440
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106527, 6 interactors
IntActiP18440, 2 interactors
STRINGi9606.ENSP00000443194

Chemistry databases

BindingDBiP18440
ChEMBLiCHEMBL5101
DrugBankiDB11640, Amifampridine
DB00244, Mesalazine
DB01015, Sulfamethoxazole

PTM databases

iPTMnetiP18440
PhosphoSitePlusiP18440
SwissPalmiP18440

Genetic variation databases

BioMutaiNAT1
DMDMi114234

Proteomic databases

EPDiP18440
jPOSTiP18440
MassIVEiP18440
MaxQBiP18440
PaxDbiP18440
PeptideAtlasiP18440
PRIDEiP18440
ProteomicsDBi53563

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22350, 325 antibodies

The DNASU plasmid repository

More...DNASUi		9

Genome annotation databases

EnsembliENST00000307719; ENSP00000307218; ENSG00000171428
ENST00000517492; ENSP00000429407; ENSG00000171428
ENST00000518029; ENSP00000428270; ENSG00000171428
ENST00000520546; ENSP00000429341; ENSG00000171428
GeneIDi9
KEGGihsa:9
UCSCiuc003wyq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9
DisGeNETi9

GeneCards: human genes, protein and diseases

More...GeneCardsi		NAT1
HGNCiHGNC:7645, NAT1
HPAiENSG00000171428, Tissue enhanced (intestine)
MIMi108345, gene
neXtProtiNX_P18440
OpenTargetsiENSG00000171428
PharmGKBiPA17
VEuPathDBiHostDB:ENSG00000171428.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RD0D, Eukaryota
GeneTreeiENSGT00390000012054
HOGENOMiCLU_049918_3_0_1
InParanoidiP18440
PhylomeDBiP18440

Enzyme and pathway databases

BRENDAi2.3.1.5, 2681
2.3.1.88, 2681
PathwayCommonsiP18440
ReactomeiR-HSA-156582, Acetylation
SIGNORiP18440

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9, 3 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NAT1, human
EvolutionaryTraceiP18440

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		N-acetyltransferase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9
PharosiP18440, Tchem

Protein Ontology

More...PROi		PR:P18440
RNActiP18440, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171428, Expressed in bronchial epithelial cell and 189 other tissues
ExpressionAtlasiP18440, baseline and differential
GenevisibleiP18440, HS

Family and domain databases

InterProiView protein in InterPro
IPR001447, Arylamine_N-AcTrfase
IPR038765, Papain-like_cys_pep_sf
PANTHERiPTHR11786, PTHR11786, 1 hit
PfamiView protein in Pfam
PF00797, Acetyltransf_2, 1 hit
PRINTSiPR01543, ANATRNSFRASE
SUPFAMiSSF54001, SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARY1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18440
Secondary accession number(s): A8K4E7
, O15159, O15300, Q546N1, Q96TE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: February 10, 2021
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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