UniProtKB - P18435 (HBE_TARSY)
Protein
Hemoglobin subunit epsilon
Gene
HBE1
Organism
Tarsius syrichta (Philippine tarsier)
Status
Functioni
The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Iron (heme distal ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 93 | Iron (heme proximal ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit epsilonAlternative name(s): Epsilon-globin Hemoglobin epsilon chain |
Gene namesi | Name:HBE1 |
Organismi | Tarsius syrichta (Philippine tarsier) |
Taxonomic identifieri | 1868482 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Tarsiiformes › Tarsiidae › Carlito |
Proteomesi |
|
Subcellular locationi
Cytosol
- hemoglobin complex Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053231 | 1 – 147 | Hemoglobin subunit epsilonAdd BLAST | 147 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | P18435 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378 Eukaryota COG1018 LUCA |
HOGENOMi | HOG000036868 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P18435-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVHLTAEEKS SVTSLWGKMN VDEAGGEALG RLLVVYPWTQ RFFDNFGNLS
60 70 80 90 100
SSSAIMGNPK VKAHGKKVLT SFGDAIKNMD NLKGAFAKLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVIILVTHFG KDFTPEVQVA WQKLVSGVAT ALAHKYH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81411 Unassigned DNA Translation: AAA16712.1 M33970 Genomic DNA Translation: AAA36958.1 |
PIRi | I57442 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81411 Unassigned DNA Translation: AAA16712.1 M33970 Genomic DNA Translation: AAA36958.1 |
PIRi | I57442 |
3D structure databases
SMRi | P18435 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P18435 |
Phylogenomic databases
eggNOGi | KOG3378 Eukaryota COG1018 LUCA |
HOGENOMi | HOG000036868 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HBE_TARSY | |
Accessioni | P18435Primary (citable) accession number: P18435 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 18, 2019 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families