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UniProtKB - P18433 (PTPRA_HUMAN)

Entry version 223 (02 Jun 2021)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

PTPRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity).

Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei410SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei442Phosphocysteine intermediateBy similarity1
Binding sitei486SubstrateBy similarity1
Active sitei732Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.48, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18433

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375165, NCAM signaling for neurite out-growth
R-HSA-5673001, RAF/MAP kinase cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P18433

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18433

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRA
Synonyms:PTPA, PTPRL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9664, PTPRA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176884, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18433

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132670.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 151ExtracellularSequence analysisAdd BLAST132
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei152 – 174HelicalSequence analysisAdd BLAST23
Topological domaini175 – 802CytoplasmicSequence analysisAdd BLAST628

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi798Y → F: Abolishes integrin-mediated interaction with BCAR1 and BCAR3 and reduces interaction between BCAR1 and CRK and, BCAR1 and SRC. Abolishes integrin-induced SRC-mediated tyrosine phosphorylation of BCAR1. Abolishes integrin-mediated recruitment of BCAR1, BCAR3, CRK and PTPRA to focal adhesions. Reduces integrin-mediated activation and membrane recruitment of RAC1 and CDC42. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5786

Open Targets

More...OpenTargetsi		ENSG00000132670

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34009

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18433, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3918

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTPRA

Domain mapping of disease mutations (DMDM)

More...DMDMi		126467

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002543320 – 802Receptor-type tyrosine-protein phosphatase alphaAdd BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei211PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei798PhosphotyrosineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18433

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18433

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18433

PeptideAtlas

More...PeptideAtlasi		P18433

PRoteomics IDEntifications database

More...PRIDEi		P18433

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		PTPRA

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P18433, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18433

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18433

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132670, Expressed in calcaneal tendon and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18433, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18433, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132670, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain), and SRC (PubMed:22801373). Within the complex, interacts (when phosphorylated on Tyr-798) with BCAR3 (via SH2 domain) (PubMed:22801373).

Interacts with GRB2 (PubMed:22801373).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111750, 121 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P18433

Protein interaction database and analysis system

More...IntActi		P18433, 56 interactors

Molecular INTeraction database

More...MINTi		P18433

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000369756

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18433, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1802
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18433

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini241 – 501Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST261
Domaini533 – 791Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 59DisorderedSequence analysisAdd BLAST21
Regioni79 – 146DisorderedSequence analysisAdd BLAST68
Regioni442 – 448Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 139Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4228, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159585

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001645_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18433

Identification of Orthologs from Complete Genome Data

More...OMAi		QGRMGVC

Database of Orthologous Groups

More...OrthoDBi		411281at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18433

TreeFam database of animal gene trees

More...TreeFami		TF351829

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR016336, Tyr_Pase_rcpt_a/e-type
IPR027262, Tyr_Pase_rcpt_alpha
IPR000387, TYR_PHOSPHATASE_dom

The PANTHER Classification System

More...PANTHERi		PTHR19134:SF433, PTHR19134:SF433, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00102, Y_phosphatase, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF500808, PTPR_alpha, 1 hit
PIRSF002006, PTPR_alpha_epsilon, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 2 hits
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P18433-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS 
        60         70         80         90        100
NPTSSLTSLS VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT 
       110        120        130        140        150
ISPNGTWLPD NQFTDARTEP WEGNSSTAAT TPETFPPSGN SDSKDRRDET 
       160        170        180        190        200
PIIAVMVALS SLLVIVFIII VLYMLRFKKY KQAGSHSNSF RLSNGRTEDV 
       210        220        230        240        250
EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL FREEFNALPA 
       260        270        280        290        300
CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF 
       310        320        330        340        350
INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC 
       360        370        380        390        400
AQYWPDQGCW TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI 
       410        420        430        440        450
TQFHFTSWPD FGVPFTPIGM LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG 
       460        470        480        490        500
TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ RCQMVQTDMQ YVFIYQALLE 
       510        520        530        540        550
HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL TSIKIQNDKM 
       560        570        580        590        600
RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK 
       610        620        630        640        650
DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD 
       660        670        680        690        700
GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV 
       710        720        730        740        750
GIPSDGKGMI SIIAAVQKQQ QQSGNHPITV HCSAGAGRTG TFCALSTVLE 
       760        770        780        790        800
RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ YEFCYKVVQE YIDAFSDYAN 

FK
Length:802
Mass (Da):90,719
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1E6A5E86FE4D3F0
GO
Isoform 2 (identifier: P18433-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-147: Missing.

Show »
Length:793
Mass (Da):89,703
Checksum:i487CCC1C06F6E860
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JWG0Q5JWG0_HUMAN
Protein-tyrosine-phosphatase
PTPRA
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JWG2Q5JWG2_HUMAN
Protein-tyrosine-phosphatase
PTPRA
175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JWG3Q5JWG3_HUMAN
Protein-tyrosine-phosphatase
PTPRA
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114T → M in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti122E → P in CAA37447 (PubMed:2172030).Curated1
Sequence conflicti289G → E in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti367V → A in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti493F → S in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti786K → E in CAA38662 (PubMed:2175890).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057134109P → L. Corresponds to variant dbSNP:rs1178027Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059405139 – 147Missing in isoform 2. 9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M34668 mRNA Translation: AAA36528.1
X54130 mRNA Translation: CAA38065.1
X54890 mRNA Translation: CAA38662.1
X53364 mRNA Translation: CAA37447.1
AK290233 mRNA Translation: BAF82922.1
BX571753 mRNA Translation: CAE11878.1
AL121905 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10562.1
CH471133 Genomic DNA Translation: EAX10563.1
BC027308 mRNA Translation: AAH27308.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13038.1 [P18433-5]
CCDS13039.1 [P18433-6]

Protein sequence database of the Protein Information Resource

More...PIRi		A36065

NCBI Reference Sequences

More...RefSeqi		NP_002827.1, NM_002836.3 [P18433-5]
NP_543030.1, NM_080840.2 [P18433-6]
NP_543031.1, NM_080841.2 [P18433-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216877; ENSP00000216877; ENSG00000132670 [P18433-6]
ENST00000318266; ENSP00000314568; ENSG00000132670 [P18433-6]
ENST00000356147; ENSP00000348468; ENSG00000132670 [P18433-6]
ENST00000380393; ENSP00000369756; ENSG00000132670 [P18433-5]
ENST00000399903; ENSP00000382787; ENSG00000132670 [P18433-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5786

UCSC genome browser

More...UCSCi		uc002whj.4, human [P18433-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34668 mRNA Translation: AAA36528.1
X54130 mRNA Translation: CAA38065.1
X54890 mRNA Translation: CAA38662.1
X53364 mRNA Translation: CAA37447.1
AK290233 mRNA Translation: BAF82922.1
BX571753 mRNA Translation: CAE11878.1
AL121905 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10562.1
CH471133 Genomic DNA Translation: EAX10563.1
BC027308 mRNA Translation: AAH27308.1
CCDSiCCDS13038.1 [P18433-5]
CCDS13039.1 [P18433-6]
PIRiA36065
RefSeqiNP_002827.1, NM_002836.3 [P18433-5]
NP_543030.1, NM_080840.2 [P18433-6]
NP_543031.1, NM_080841.2 [P18433-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6UZTX-ray1.80A/B211-802[»]
SMRiP18433
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111750, 121 interactors
CORUMiP18433
IntActiP18433, 56 interactors
MINTiP18433
STRINGi9606.ENSP00000369756

Chemistry databases

ChEMBLiCHEMBL3918

PTM databases

DEPODiPTPRA
GlyGeniP18433, 7 sites
iPTMnetiP18433
PhosphoSitePlusiP18433

Genetic variation databases

BioMutaiPTPRA
DMDMi126467

Proteomic databases

jPOSTiP18433
MassIVEiP18433
PaxDbiP18433
PeptideAtlasiP18433
PRIDEiP18433

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7130, 507 antibodies

The DNASU plasmid repository

More...DNASUi		5786

Genome annotation databases

EnsembliENST00000216877; ENSP00000216877; ENSG00000132670 [P18433-6]
ENST00000318266; ENSP00000314568; ENSG00000132670 [P18433-6]
ENST00000356147; ENSP00000348468; ENSG00000132670 [P18433-6]
ENST00000380393; ENSP00000369756; ENSG00000132670 [P18433-5]
ENST00000399903; ENSP00000382787; ENSG00000132670 [P18433-5]
GeneIDi5786
KEGGihsa:5786
UCSCiuc002whj.4, human [P18433-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5786
DisGeNETi5786

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTPRA
HGNCiHGNC:9664, PTPRA
HPAiENSG00000132670, Low tissue specificity
MIMi176884, gene
neXtProtiNX_P18433
OpenTargetsiENSG00000132670
PharmGKBiPA34009
VEuPathDBiHostDB:ENSG00000132670.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4228, Eukaryota
GeneTreeiENSGT00940000159585
HOGENOMiCLU_001645_8_0_1
InParanoidiP18433
OMAiQGRMGVC
OrthoDBi411281at2759
PhylomeDBiP18433
TreeFamiTF351829

Enzyme and pathway databases

BRENDAi3.1.3.48, 2681
PathwayCommonsiP18433
ReactomeiR-HSA-375165, NCAM signaling for neurite out-growth
R-HSA-5673001, RAF/MAP kinase cascade
SignaLinkiP18433
SIGNORiP18433

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5786, 7 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PTPRA, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PTPRA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5786
PharosiP18433, Tchem

Protein Ontology

More...PROi		PR:P18433
RNActiP18433, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132670, Expressed in calcaneal tendon and 245 other tissues
ExpressionAtlasiP18433, baseline and differential
GenevisibleiP18433, HS

Family and domain databases

Gene3Di3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR016336, Tyr_Pase_rcpt_a/e-type
IPR027262, Tyr_Pase_rcpt_alpha
IPR000387, TYR_PHOSPHATASE_dom
PANTHERiPTHR19134:SF433, PTHR19134:SF433, 1 hit
PfamiView protein in Pfam
PF00102, Y_phosphatase, 2 hits
PIRSFiPIRSF500808, PTPR_alpha, 1 hit
PIRSF002006, PTPR_alpha_epsilon, 1 hit
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits
SUPFAMiSSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 2 hits
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18433
Secondary accession number(s): A8K2G8
, D3DVX5, Q14513, Q7Z2I2, Q96TD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 223 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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