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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

PTPRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei410SubstrateBy similarity1
Active sitei442Phosphocysteine intermediateBy similarity1
Binding sitei486SubstrateBy similarity1
Active sitei732Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: ProtInc
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-5673001 RAF/MAP kinase cascade
SignaLinkiP18433
SIGNORiP18433

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Gene namesi
Name:PTPRA
Synonyms:PTPA, PTPRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132670.20
HGNCiHGNC:9664 PTPRA
MIMi176884 gene
neXtProtiNX_P18433

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 151ExtracellularSequence analysisAdd BLAST132
Transmembranei152 – 174HelicalSequence analysisAdd BLAST23
Topological domaini175 – 802CytoplasmicSequence analysisAdd BLAST628

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5786
OpenTargetsiENSG00000132670
PharmGKBiPA34009

Chemistry databases

ChEMBLiCHEMBL3918

Polymorphism and mutation databases

BioMutaiPTPRA
DMDMi126467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002543320 – 802Receptor-type tyrosine-protein phosphatase alphaAdd BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei211PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei798PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18433
PeptideAtlasiP18433
PRIDEiP18433
ProteomicsDBi53559

PTM databases

DEPODiP18433
iPTMnetiP18433
PhosphoSitePlusiP18433

Expressioni

Gene expression databases

BgeeiENSG00000132670
CleanExiHS_PTPRA
ExpressionAtlasiP18433 baseline and differential
GenevisibleiP18433 HS

Organism-specific databases

HPAiCAB034366
HPA029412
HPA069480

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111750, 56 interactors
CORUMiP18433
IntActiP18433, 15 interactors
MINTiP18433
STRINGi9606.ENSP00000369756

Chemistry databases

BindingDBiP18433

Structurei

3D structure databases

ProteinModelPortaliP18433
SMRiP18433
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 501Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST261
Domaini533 – 791Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni442 – 448Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000231464
HOVERGENiHBG053758
InParanoidiP18433
OMAiAQYWPSD
OrthoDBiEOG091G02ID
PhylomeDBiP18433
TreeFamiTF351829

Family and domain databases

Gene3Di3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR016336 Tyr_Pase_rcpt_a/e-type
IPR027262 Tyr_Pase_rcpt_alpha
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR19134:SF433 PTHR19134:SF433, 1 hit
PfamiView protein in Pfam
PF00102 Y_phosphatase, 2 hits
PIRSFiPIRSF500808 PTPR_alpha, 1 hit
PIRSF002006 PTPR_alpha_epsilon, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18433-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS
60 70 80 90 100
NPTSSLTSLS VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT
110 120 130 140 150
ISPNGTWLPD NQFTDARTEP WEGNSSTAAT TPETFPPSGN SDSKDRRDET
160 170 180 190 200
PIIAVMVALS SLLVIVFIII VLYMLRFKKY KQAGSHSNSF RLSNGRTEDV
210 220 230 240 250
EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL FREEFNALPA
260 270 280 290 300
CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF
310 320 330 340 350
INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC
360 370 380 390 400
AQYWPDQGCW TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI
410 420 430 440 450
TQFHFTSWPD FGVPFTPIGM LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG
460 470 480 490 500
TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ RCQMVQTDMQ YVFIYQALLE
510 520 530 540 550
HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL TSIKIQNDKM
560 570 580 590 600
RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK
610 620 630 640 650
DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD
660 670 680 690 700
GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV
710 720 730 740 750
GIPSDGKGMI SIIAAVQKQQ QQSGNHPITV HCSAGAGRTG TFCALSTVLE
760 770 780 790 800
RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ YEFCYKVVQE YIDAFSDYAN

FK
Length:802
Mass (Da):90,719
Last modified:March 28, 2018 - v3
Checksum:iD1E6A5E86FE4D3F0
GO
Isoform 2 (identifier: P18433-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-147: Missing.

Show »
Length:793
Mass (Da):89,703
Checksum:i487CCC1C06F6E860
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114T → M in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti122E → P in CAA37447 (PubMed:2172030).Curated1
Sequence conflicti289G → E in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti367V → A in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti493F → S in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti786K → E in CAA38662 (PubMed:2175890).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057134109P → L. Corresponds to variant dbSNP:rs1178027Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059405139 – 147Missing in isoform 2. 9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34668 mRNA Translation: AAA36528.1
X54130 mRNA Translation: CAA38065.1
X54890 mRNA Translation: CAA38662.1
X53364 mRNA Translation: CAA37447.1
AK290233 mRNA Translation: BAF82922.1
BX571753 mRNA Translation: CAE11878.1
AL121905 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10562.1
CH471133 Genomic DNA Translation: EAX10563.1
BC027308 mRNA Translation: AAH27308.1
CCDSiCCDS13038.1 [P18433-5]
CCDS13039.1 [P18433-6]
PIRiA36065
RefSeqiNP_002827.1, NM_002836.3 [P18433-5]
NP_543030.1, NM_080840.2 [P18433-6]
NP_543031.1, NM_080841.2 [P18433-6]
UniGeneiHs.269577

Genome annotation databases

EnsembliENST00000216877; ENSP00000216877; ENSG00000132670 [P18433-6]
ENST00000318266; ENSP00000314568; ENSG00000132670 [P18433-6]
ENST00000356147; ENSP00000348468; ENSG00000132670 [P18433-6]
ENST00000380393; ENSP00000369756; ENSG00000132670 [P18433-5]
ENST00000399903; ENSP00000382787; ENSG00000132670 [P18433-5]
GeneIDi5786
UCSCiuc002whj.4 human [P18433-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTPRA_HUMAN
AccessioniPrimary (citable) accession number: P18433
Secondary accession number(s): A8K2G8
, D3DVX5, Q14513, Q7Z2I2, Q96TD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 200 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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