UniProtKB - P18433 (PTPRA_HUMAN)
Protein
Receptor-type tyrosine-protein phosphatase alpha
Gene
PTPRA
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 410 | SubstrateBy similarity | 1 | |
Active sitei | 442 | Phosphocysteine intermediateBy similarity | 1 | |
Binding sitei | 486 | SubstrateBy similarity | 1 | |
Active sitei | 732 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: ProtInc
- Ras guanyl-nucleotide exchange factor activity Source: Reactome
- transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc
GO - Biological processi
- axon guidance Source: Reactome
- insulin receptor signaling pathway Source: Ensembl
- MAPK cascade Source: Reactome
- modulation of chemical synaptic transmission Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.1.3.48 2681 |
Reactomei | R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-5673001 RAF/MAP kinase cascade |
SignaLinki | P18433 |
SIGNORi | P18433 |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)Short name: Protein-tyrosine phosphatase alpha Short name: R-PTP-alpha |
Gene namesi | Name:PTPRA Synonyms:PTPA, PTPRL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132670.20 |
HGNCi | HGNC:9664 PTPRA |
MIMi | 176884 gene |
neXtProti | NX_P18433 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- integral component of synaptic membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- receptor complex Source: MGI
- Schaffer collateral - CA1 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 151 | ExtracellularSequence analysisAdd BLAST | 132 | |
Transmembranei | 152 – 174 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 175 – 802 | CytoplasmicSequence analysisAdd BLAST | 628 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5786 |
OpenTargetsi | ENSG00000132670 |
PharmGKBi | PA34009 |
Chemistry databases
ChEMBLi | CHEMBL3918 |
Polymorphism and mutation databases
BioMutai | PTPRA |
DMDMi | 126467 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000025433 | 20 – 802 | Receptor-type tyrosine-protein phosphatase alphaAdd BLAST | 783 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 124 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 | |
Modified residuei | 213 | PhosphoserineBy similarity | 1 | |
Modified residuei | 798 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P18433 |
jPOSTi | P18433 |
PaxDbi | P18433 |
PeptideAtlasi | P18433 |
PRIDEi | P18433 |
ProteomicsDBi | 53559 |
PTM databases
DEPODi | P18433 |
iPTMneti | P18433 |
PhosphoSitePlusi | P18433 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132670 Expressed in 231 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | P18433 baseline and differential |
Genevisiblei | P18433 HS |
Organism-specific databases
HPAi | CAB034366 HPA029412 HPA069480 |
Interactioni
Binary interactionsi
GO - Molecular functioni
- Ras guanyl-nucleotide exchange factor activity Source: Reactome
Protein-protein interaction databases
BioGridi | 111750, 57 interactors |
CORUMi | P18433 |
IntActi | P18433, 17 interactors |
MINTi | P18433 |
STRINGi | 9606.ENSP00000369756 |
Chemistry databases
BindingDBi | P18433 |
Structurei
3D structure databases
ProteinModelPortali | P18433 |
SMRi | P18433 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 241 – 501 | Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST | 261 | |
Domaini | 533 – 791 | Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 442 – 448 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4228 Eukaryota COG5599 LUCA |
GeneTreei | ENSGT00940000159585 |
HOGENOMi | HOG000231464 |
HOVERGENi | HBG053758 |
InParanoidi | P18433 |
KOi | K18032 |
OMAi | LTLGPTY |
OrthoDBi | 411281at2759 |
PhylomeDBi | P18433 |
TreeFami | TF351829 |
Family and domain databases
Gene3Di | 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR016336 Tyr_Pase_rcpt_a/e-type IPR027262 Tyr_Pase_rcpt_alpha IPR000387 TYR_PHOSPHATASE_dom |
PANTHERi | PTHR19134:SF433 PTHR19134:SF433, 1 hit |
Pfami | View protein in Pfam PF00102 Y_phosphatase, 2 hits |
PIRSFi | PIRSF500808 PTPR_alpha, 1 hit PIRSF002006 PTPR_alpha_epsilon, 1 hit |
PRINTSi | PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits |
SUPFAMi | SSF52799 SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P18433-5) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS
60 70 80 90 100
NPTSSLTSLS VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT
110 120 130 140 150
ISPNGTWLPD NQFTDARTEP WEGNSSTAAT TPETFPPSGN SDSKDRRDET
160 170 180 190 200
PIIAVMVALS SLLVIVFIII VLYMLRFKKY KQAGSHSNSF RLSNGRTEDV
210 220 230 240 250
EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL FREEFNALPA
260 270 280 290 300
CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF
310 320 330 340 350
INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC
360 370 380 390 400
AQYWPDQGCW TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI
410 420 430 440 450
TQFHFTSWPD FGVPFTPIGM LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG
460 470 480 490 500
TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ RCQMVQTDMQ YVFIYQALLE
510 520 530 540 550
HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL TSIKIQNDKM
560 570 580 590 600
RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK
610 620 630 640 650
DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD
660 670 680 690 700
GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV
710 720 730 740 750
GIPSDGKGMI SIIAAVQKQQ QQSGNHPITV HCSAGAGRTG TFCALSTVLE
760 770 780 790 800
RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ YEFCYKVVQE YIDAFSDYAN
FK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JWG2 | Q5JWG2_HUMAN | Receptor-type tyrosine-protein phos... | PTPRA | 175 | Annotation score: | ||
Q5JWG3 | Q5JWG3_HUMAN | Receptor-type tyrosine-protein phos... | PTPRA | 138 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | T → M in CAA38662 (PubMed:2175890).Curated | 1 | |
Sequence conflicti | 122 | E → P in CAA37447 (PubMed:2172030).Curated | 1 | |
Sequence conflicti | 289 | G → E in CAA38662 (PubMed:2175890).Curated | 1 | |
Sequence conflicti | 367 | V → A in CAA38662 (PubMed:2175890).Curated | 1 | |
Sequence conflicti | 493 | F → S in CAA38662 (PubMed:2175890).Curated | 1 | |
Sequence conflicti | 786 | K → E in CAA38662 (PubMed:2175890).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057134 | 109 | P → L. Corresponds to variant dbSNP:rs1178027Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059405 | 139 – 147 | Missing in isoform 2. | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34668 mRNA Translation: AAA36528.1 X54130 mRNA Translation: CAA38065.1 X54890 mRNA Translation: CAA38662.1 X53364 mRNA Translation: CAA37447.1 AK290233 mRNA Translation: BAF82922.1 BX571753 mRNA Translation: CAE11878.1 AL121905 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10562.1 CH471133 Genomic DNA Translation: EAX10563.1 BC027308 mRNA Translation: AAH27308.1 |
CCDSi | CCDS13038.1 [P18433-5] CCDS13039.1 [P18433-6] |
PIRi | A36065 |
RefSeqi | NP_002827.1, NM_002836.3 [P18433-5] NP_543030.1, NM_080840.2 [P18433-6] NP_543031.1, NM_080841.2 [P18433-6] |
UniGenei | Hs.269577 |
Genome annotation databases
Ensembli | ENST00000216877; ENSP00000216877; ENSG00000132670 [P18433-6] ENST00000318266; ENSP00000314568; ENSG00000132670 [P18433-6] ENST00000356147; ENSP00000348468; ENSG00000132670 [P18433-6] ENST00000380393; ENSP00000369756; ENSG00000132670 [P18433-5] ENST00000399903; ENSP00000382787; ENSG00000132670 [P18433-5] |
GeneIDi | 5786 |
KEGGi | hsa:5786 |
UCSCi | uc002whj.4 human [P18433-5] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34668 mRNA Translation: AAA36528.1 X54130 mRNA Translation: CAA38065.1 X54890 mRNA Translation: CAA38662.1 X53364 mRNA Translation: CAA37447.1 AK290233 mRNA Translation: BAF82922.1 BX571753 mRNA Translation: CAE11878.1 AL121905 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10562.1 CH471133 Genomic DNA Translation: EAX10563.1 BC027308 mRNA Translation: AAH27308.1 |
CCDSi | CCDS13038.1 [P18433-5] CCDS13039.1 [P18433-6] |
PIRi | A36065 |
RefSeqi | NP_002827.1, NM_002836.3 [P18433-5] NP_543030.1, NM_080840.2 [P18433-6] NP_543031.1, NM_080841.2 [P18433-6] |
UniGenei | Hs.269577 |
3D structure databases
ProteinModelPortali | P18433 |
SMRi | P18433 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 111750, 57 interactors |
CORUMi | P18433 |
IntActi | P18433, 17 interactors |
MINTi | P18433 |
STRINGi | 9606.ENSP00000369756 |
Chemistry databases
BindingDBi | P18433 |
ChEMBLi | CHEMBL3918 |
PTM databases
DEPODi | P18433 |
iPTMneti | P18433 |
PhosphoSitePlusi | P18433 |
Polymorphism and mutation databases
BioMutai | PTPRA |
DMDMi | 126467 |
Proteomic databases
EPDi | P18433 |
jPOSTi | P18433 |
PaxDbi | P18433 |
PeptideAtlasi | P18433 |
PRIDEi | P18433 |
ProteomicsDBi | 53559 |
Protocols and materials databases
DNASUi | 5786 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000216877; ENSP00000216877; ENSG00000132670 [P18433-6] ENST00000318266; ENSP00000314568; ENSG00000132670 [P18433-6] ENST00000356147; ENSP00000348468; ENSG00000132670 [P18433-6] ENST00000380393; ENSP00000369756; ENSG00000132670 [P18433-5] ENST00000399903; ENSP00000382787; ENSG00000132670 [P18433-5] |
GeneIDi | 5786 |
KEGGi | hsa:5786 |
UCSCi | uc002whj.4 human [P18433-5] |
Organism-specific databases
CTDi | 5786 |
DisGeNETi | 5786 |
EuPathDBi | HostDB:ENSG00000132670.20 |
GeneCardsi | PTPRA |
HGNCi | HGNC:9664 PTPRA |
HPAi | CAB034366 HPA029412 HPA069480 |
MIMi | 176884 gene |
neXtProti | NX_P18433 |
OpenTargetsi | ENSG00000132670 |
PharmGKBi | PA34009 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4228 Eukaryota COG5599 LUCA |
GeneTreei | ENSGT00940000159585 |
HOGENOMi | HOG000231464 |
HOVERGENi | HBG053758 |
InParanoidi | P18433 |
KOi | K18032 |
OMAi | LTLGPTY |
OrthoDBi | 411281at2759 |
PhylomeDBi | P18433 |
TreeFami | TF351829 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48 2681 |
Reactomei | R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-5673001 RAF/MAP kinase cascade |
SignaLinki | P18433 |
SIGNORi | P18433 |
Miscellaneous databases
ChiTaRSi | PTPRA human |
GeneWikii | PTPRA |
GenomeRNAii | 5786 |
PROi | PR:P18433 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132670 Expressed in 231 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | P18433 baseline and differential |
Genevisiblei | P18433 HS |
Family and domain databases
Gene3Di | 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR016336 Tyr_Pase_rcpt_a/e-type IPR027262 Tyr_Pase_rcpt_alpha IPR000387 TYR_PHOSPHATASE_dom |
PANTHERi | PTHR19134:SF433 PTHR19134:SF433, 1 hit |
Pfami | View protein in Pfam PF00102 Y_phosphatase, 2 hits |
PIRSFi | PIRSF500808 PTPR_alpha, 1 hit PIRSF002006 PTPR_alpha_epsilon, 1 hit |
PRINTSi | PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits |
SUPFAMi | SSF52799 SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | PTPRA_HUMAN | |
Accessioni | P18433Primary (citable) accession number: P18433 Secondary accession number(s): A8K2G8 Q96TD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 13, 2019 | |
This is version 207 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations