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Entry version 167 (13 Feb 2019)
Sequence version 3 (17 Oct 2006)
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Protein

Lipopolysaccharide-binding protein

Gene

LBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).1 Publication4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipopeptide binding Source: AgBase
  • lipopolysaccharide binding Source: MGI
  • lipoteichoic acid binding Source: MGI
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity, Lipid transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166020 Transfer of LPS from LBP carrier to CD14
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P18428

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.40.1.2 the bactericidal permeability increasing protein (bpip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipopolysaccharide-binding protein
Short name:
LBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000129988.5

Human Gene Nomenclature Database

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HGNCi
HGNC:6517 LBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151990 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18428

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3929

Open Targets

More...
OpenTargetsi
ENSG00000129988

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30303

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001715826 – 481Lipopolysaccharide-binding proteinAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi159 ↔ 198By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P18428

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P18428

MaxQB - The MaxQuant DataBase

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MaxQBi
P18428

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18428

PeptideAtlas

More...
PeptideAtlasi
P18428

PRoteomics IDEntifications database

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PRIDEi
P18428

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53558

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P18428

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18428

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18428

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in blood serum (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129988 Expressed in 94 organ(s), highest expression level in right lobe of liver

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P18428 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025905
HPA001508

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131624EBI-3927059,EBI-2211957

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110121, 16 interactors

Database of interacting proteins

More...
DIPi
DIP-90N

Protein interaction database and analysis system

More...
IntActi
P18428, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000217407

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P18428

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P18428

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4160 Eukaryota
ENOG410Z88E LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000110583

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231250

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002797

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P18428

KEGG Orthology (KO)

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KOi
K05399

Identification of Orthologs from Complete Genome Data

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OMAi
HYEFHSL

Database of Orthologous Groups

More...
OrthoDBi
1242894at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18428

TreeFam database of animal gene trees

More...
TreeFami
TF315617

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR030180 LBP
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N

The PANTHER Classification System

More...
PANTHERi
PTHR10504 PTHR10504, 1 hit
PTHR10504:SF66 PTHR10504:SF66, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002417 Lipid_binding_protein, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55394 SSF55394, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P18428-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL
60 70 80 90 100
QSELLRITLP DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG
110 120 130 140 150
LSLSISDSSI RVQGRWKVRK SFFKLQGSFD VSVKGISISV NLLLGSESSG
160 170 180 190 200
RPTVTASSCS SDIADVEVDM SGDLGWLLNL FHNQIESKFQ KVLESRICEM
210 220 230 240 250
IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA QMLEVMFKGE
260 270 280 290 300
IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN
310 320 330 340 350
FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN
360 370 380 390 400
FSPGNLSVDP YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG
410 420 430 440 450
FLKPGKVKVE LKESKVGLFN AELLEALLNY YILNTFYPKF NDKLAEGFPL
460 470 480
PLLKRVQLYD LGLQIHKDFL FLGANVQYMR V
Length:481
Mass (Da):53,384
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A0E4B9E5E604C72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6R → H (PubMed:7517398).Curated1
Sequence conflicti22E → C (PubMed:7517398).Curated1
Sequence conflicti82N → K in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti128S → F in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti154 – 157VTAS → GYCL in AAA59493 (PubMed:2402637).Curated4
Sequence conflicti174L → S in AAA59493 (PubMed:2402637).Curated1
Sequence conflicti257R → S in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti266 – 270VMSLP → A in AAA59493 (PubMed:2402637).Curated5
Sequence conflicti369L → H in AAC39547 (PubMed:9441745).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0282439P → L. Corresponds to variant dbSNP:rs2232580Ensembl.1
Natural variantiVAR_049737111R → Q. Corresponds to variant dbSNP:rs2232583Ensembl.1
Natural variantiVAR_028244125L → I. Corresponds to variant dbSNP:rs2232585Ensembl.1
Natural variantiVAR_049738147E → K. Corresponds to variant dbSNP:rs36015492Ensembl.1
Natural variantiVAR_061293157S → C. Corresponds to variant dbSNP:rs2232586Ensembl.1
Natural variantiVAR_028245166V → M. Corresponds to variant dbSNP:rs5744204Ensembl.1
Natural variantiVAR_028246242M → I. Corresponds to variant dbSNP:rs2232601Ensembl.1
Natural variantiVAR_028247283D → G. Corresponds to variant dbSNP:rs2232607Ensembl.1
Natural variantiVAR_028248294H → R. Corresponds to variant dbSNP:rs2232608Ensembl.1
Natural variantiVAR_028249333P → L Abolishes lipopolysaccharide binding and causes increased proteolytic degradation of the protein. 1 PublicationCorresponds to variant dbSNP:rs2232613EnsemblClinVar.1
Natural variantiVAR_028250339L → F. Corresponds to variant dbSNP:rs5744212Ensembl.1
Natural variantiVAR_049739364I → T. Corresponds to variant dbSNP:rs2232615Ensembl.1
Natural variantiVAR_028251436F → L3 PublicationsCorresponds to variant dbSNP:rs2232618Ensembl.1
Natural variantiVAR_028252445A → T. Corresponds to variant dbSNP:rs2232619Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M35533 mRNA Translation: AAA59493.1
X98657
, X98658, X98659, X98660, X98661, X98662, X98663, X98664, X98665, X98666, X98667, X98668 Genomic DNA Translation: CAA67226.1
AF013512
, AF013500, AF013501, AF013502, AF013503, AF013504, AF013505, AF013506, AF013507, AF013508, AF013509, AF013510, AF013511 Genomic DNA Translation: AAC39547.1
AF105067 mRNA Translation: AAD21962.1
AK313625 mRNA Translation: BAG36385.1
AL080249 Genomic DNA Translation: CAC10462.1
CH471077 Genomic DNA Translation: EAW76034.1
L42172 Genomic DNA Translation: AAA66446.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13304.1

Protein sequence database of the Protein Information Resource

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PIRi
A35843
A54136

NCBI Reference Sequences

More...
RefSeqi
NP_004130.2, NM_004139.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.154078

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000217407; ENSP00000217407; ENSG00000129988

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3929

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3929

UCSC genome browser

More...
UCSCi
uc002xic.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35533 mRNA Translation: AAA59493.1
X98657
, X98658, X98659, X98660, X98661, X98662, X98663, X98664, X98665, X98666, X98667, X98668 Genomic DNA Translation: CAA67226.1
AF013512
, AF013500, AF013501, AF013502, AF013503, AF013504, AF013505, AF013506, AF013507, AF013508, AF013509, AF013510, AF013511 Genomic DNA Translation: AAC39547.1
AF105067 mRNA Translation: AAD21962.1
AK313625 mRNA Translation: BAG36385.1
AL080249 Genomic DNA Translation: CAC10462.1
CH471077 Genomic DNA Translation: EAW76034.1
L42172 Genomic DNA Translation: AAA66446.1
CCDSiCCDS13304.1
PIRiA35843
A54136
RefSeqiNP_004130.2, NM_004139.4
UniGeneiHs.154078

3D structure databases

ProteinModelPortaliP18428
SMRiP18428
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110121, 16 interactors
DIPiDIP-90N
IntActiP18428, 14 interactors
STRINGi9606.ENSP00000217407

Protein family/group databases

TCDBi1.C.40.1.2 the bactericidal permeability increasing protein (bpip) family

PTM databases

iPTMnetiP18428
PhosphoSitePlusiP18428

Polymorphism and mutation databases

BioMutaiLBP
DMDMi116242615

Proteomic databases

EPDiP18428
jPOSTiP18428
MaxQBiP18428
PaxDbiP18428
PeptideAtlasiP18428
PRIDEiP18428
ProteomicsDBi53558
TopDownProteomicsiP18428

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217407; ENSP00000217407; ENSG00000129988
GeneIDi3929
KEGGihsa:3929
UCSCiuc002xic.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3929
DisGeNETi3929
EuPathDBiHostDB:ENSG00000129988.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LBP
HGNCiHGNC:6517 LBP
HPAiCAB025905
HPA001508
MIMi151990 gene
neXtProtiNX_P18428
OpenTargetsiENSG00000129988
PharmGKBiPA30303

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110583
HOGENOMiHOG000231250
HOVERGENiHBG002797
InParanoidiP18428
KOiK05399
OMAiHYEFHSL
OrthoDBi1242894at2759
PhylomeDBiP18428
TreeFamiTF315617

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166020 Transfer of LPS from LBP carrier to CD14
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkiP18428

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Lipopolysaccharide-binding_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3929

Protein Ontology

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PROi
PR:P18428

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000129988 Expressed in 94 organ(s), highest expression level in right lobe of liver
GenevisibleiP18428 HS

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR030180 LBP
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF66 PTHR10504:SF66, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF002417 Lipid_binding_protein, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
PROSITEiView protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18428
Secondary accession number(s): B2R938
, O43438, Q92672, Q9H403, Q9UD66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: February 13, 2019
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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