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Entry version 173 (07 Apr 2021)
Sequence version 2 (01 Feb 1991)
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Protein

Proteasome subunit alpha type-1

Gene

Psma1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1169091, Activation of NF-kappaB in B cells
R-RNO-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174154, APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577, SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-202424, Downstream TCR signaling
R-RNO-2467813, Separation of Sister Chromatids
R-RNO-2871837, FCERI mediated NF-kB activation
R-RNO-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562, Regulation of ornithine decarboxylase (ODC)
R-RNO-382556, ABC-family proteins mediated transport
R-RNO-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870, Asymmetric localization of PCP proteins
R-RNO-4641257, Degradation of AXIN
R-RNO-4641258, Degradation of DVL
R-RNO-5358346, Hedgehog ligand biogenesis
R-RNO-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764, CLEC7A (Dectin-1) signaling
R-RNO-5610780, Degradation of GLI1 by the proteasome
R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684, Hedgehog 'on' state
R-RNO-5658442, Regulation of RAS by GAPs
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5676590, NIK-->noncanonical NF-kB signaling
R-RNO-5687128, MAPK6/MAPK4 signaling
R-RNO-5689603, UCH proteinases
R-RNO-5689880, Ub-specific processing proteases
R-RNO-68827, CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949, Orc1 removal from chromatin
R-RNO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69481, G2/M Checkpoints
R-RNO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-75815, Ubiquitin-dependent degradation of Cyclin D
R-RNO-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902, Regulation of RUNX2 expression and activity
R-RNO-8941858, Regulation of RUNX3 expression and activity
R-RNO-8948751, Regulation of PTEN stability and activity
R-RNO-8951664, Neddylation
R-RNO-9020702, Interleukin-1 signaling
R-RNO-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome subunit alpha type-1
Alternative name(s):
Macropain subunit C2
Multicatalytic endopeptidase complex subunit C2
Proteasome component C2
Proteasome nu chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Psma1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
61841, Psma1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001240641 – 263Proteasome subunit alpha type-1Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei110Phosphoserine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110O-linked (GlcNAc) serine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei177PhosphoserineBy similarity1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved from a C-terminal extension in the course of the conversion of the proteasome from its latent form into its active form.

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18420

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18420

PRoteomics IDEntifications database

More...
PRIDEi
P18420

2D gel databases

The World-2DPAGE database

More...
World-2DPAGEi
0004:P18420

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P18420, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18420

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P18420

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000011745, Expressed in female gonad and 22 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18420, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

Interacts with NOTCH3.

Interacts with ZFAND1 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
248289, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P18420, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000015946

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18420

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0863, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035750_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18420

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQEMVAC

Database of Orthologous Groups

More...
OrthoDBi
1222564at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18420

TreeFam database of animal gene trees

More...
TreeFami
TF106206

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03749, proteasome_alpha_type_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR023332, Proteasome_alpha-type
IPR035144, Proteasome_alpha1
IPR000426, Proteasome_asu_N
IPR001353, Proteasome_sua/b

The PANTHER Classification System

More...
PANTHERi
PTHR11599:SF12, PTHR11599:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00227, Proteasome, 1 hit
PF10584, Proteasome_A_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00948, Proteasome_A_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00388, PROTEASOME_ALPHA_1, 1 hit
PS51475, PROTEASOME_ALPHA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P18420-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK
60 70 80 90 100
RAQSELAAHQ KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD
110 120 130 140 150
RPLPVSRLVS LIGSKTQIPT QRYGRRPYGV GLLIAGYDDM GPHVFQTCPS
160 170 180 190 200
ANYFDCRAMS IGARSQSART YLERHMSEFM QCNLDELVKH GLRALRETLP
210 220 230 240 250
AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLDGLEERP QRKAQPSQAA
260
DEPAEKADEP MEH
Length:263
Mass (Da):29,518
Last modified:February 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68660696B43A4051
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M29859 mRNA Translation: AAA41943.1
D90265 mRNA Translation: BAA14312.1
BC062233 mRNA Translation: AAH62233.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A32968, SNRTC2

NCBI Reference Sequences

More...
RefSeqi
NP_058974.1, NM_017278.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000015946; ENSRNOP00000015946; ENSRNOG00000011745

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29668

UCSC genome browser

More...
UCSCi
RGD:61841, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29859 mRNA Translation: AAA41943.1
D90265 mRNA Translation: BAA14312.1
BC062233 mRNA Translation: AAH62233.1
PIRiA32968, SNRTC2
RefSeqiNP_058974.1, NM_017278.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EPCelectron microscopy12.30F1-263[»]
6EPDelectron microscopy15.40F1-263[»]
6EPEelectron microscopy12.80F1-263[»]
6EPFelectron microscopy11.80F1-263[»]
6TU3electron microscopy2.70F/T1-263[»]
SMRiP18420
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi248289, 2 interactors
IntActiP18420, 1 interactor
STRINGi10116.ENSRNOP00000015946

PTM databases

GlyGeniP18420, 1 site
iPTMnetiP18420
SwissPalmiP18420

2D gel databases

World-2DPAGEi0004:P18420

Proteomic databases

jPOSTiP18420
PaxDbiP18420
PRIDEiP18420

Genome annotation databases

EnsembliENSRNOT00000015946; ENSRNOP00000015946; ENSRNOG00000011745
GeneIDi29668
KEGGirno:29668
UCSCiRGD:61841, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5682
RGDi61841, Psma1

Phylogenomic databases

eggNOGiKOG0863, Eukaryota
GeneTreeiENSGT00550000074855
HOGENOMiCLU_035750_8_0_1
InParanoidiP18420
OMAiTQEMVAC
OrthoDBi1222564at2759
PhylomeDBiP18420
TreeFamiTF106206

Enzyme and pathway databases

ReactomeiR-RNO-1169091, Activation of NF-kappaB in B cells
R-RNO-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174154, APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577, SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-202424, Downstream TCR signaling
R-RNO-2467813, Separation of Sister Chromatids
R-RNO-2871837, FCERI mediated NF-kB activation
R-RNO-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562, Regulation of ornithine decarboxylase (ODC)
R-RNO-382556, ABC-family proteins mediated transport
R-RNO-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870, Asymmetric localization of PCP proteins
R-RNO-4641257, Degradation of AXIN
R-RNO-4641258, Degradation of DVL
R-RNO-5358346, Hedgehog ligand biogenesis
R-RNO-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764, CLEC7A (Dectin-1) signaling
R-RNO-5610780, Degradation of GLI1 by the proteasome
R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684, Hedgehog 'on' state
R-RNO-5658442, Regulation of RAS by GAPs
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5676590, NIK-->noncanonical NF-kB signaling
R-RNO-5687128, MAPK6/MAPK4 signaling
R-RNO-5689603, UCH proteinases
R-RNO-5689880, Ub-specific processing proteases
R-RNO-68827, CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949, Orc1 removal from chromatin
R-RNO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69481, G2/M Checkpoints
R-RNO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-75815, Ubiquitin-dependent degradation of Cyclin D
R-RNO-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902, Regulation of RUNX2 expression and activity
R-RNO-8941858, Regulation of RUNX3 expression and activity
R-RNO-8948751, Regulation of PTEN stability and activity
R-RNO-8951664, Neddylation
R-RNO-9020702, Interleukin-1 signaling
R-RNO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

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PROi
PR:P18420

Gene expression databases

BgeeiENSRNOG00000011745, Expressed in female gonad and 22 other tissues
GenevisibleiP18420, RN

Family and domain databases

CDDicd03749, proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR023332, Proteasome_alpha-type
IPR035144, Proteasome_alpha1
IPR000426, Proteasome_asu_N
IPR001353, Proteasome_sua/b
PANTHERiPTHR11599:SF12, PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227, Proteasome, 1 hit
PF10584, Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948, Proteasome_A_N, 1 hit
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388, PROTEASOME_ALPHA_1, 1 hit
PS51475, PROTEASOME_ALPHA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSA1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18420
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: April 7, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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