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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

SRD5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimally active at alkaline pHs.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
  • amide binding Source: Ensembl
  • cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
  • electron transfer activity Source: UniProtKB
  • NADPH binding Source: Ensembl
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processDifferentiation, Sexual differentiation
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07261-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.22 2681
1.3.99.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193048 Androgen biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P18405

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001636

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRD5A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145545.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11284 SRD5A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
184753 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18405

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 29HelicalSequence analysisAdd BLAST18
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6715

Open Targets

More...
OpenTargetsi
ENSG00000145545

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36112

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1787

Drug and drug target database

More...
DrugBanki
DB01126 Dutasteride
DB01216 Finasteride
DB00367 Levonorgestrel
DB09389 Norgestrel
DB06412 Oxymetholone
DB00421 Spironolactone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRD5A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002136741 – 2593-oxo-5-alpha-steroid 4-dehydrogenase 1Add BLAST259

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P18405

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18405

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P18405

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18405

PeptideAtlas

More...
PeptideAtlasi
P18405

PRoteomics IDEntifications database

More...
PRIDEi
P18405

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53557

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver and prostate (at a low level).

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Its expression is regulated by androgens such as testosterone.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145545 Expressed in 199 organ(s), highest expression level in zone of skin

CleanEx database of gene expression profiles

More...
CleanExi
HS_SRD5A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18405 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18405 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051402

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112593, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274192

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P18405

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P18405

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1638 Eukaryota
ENOG410XS6P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000046634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000050133

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003402

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18405

KEGG Orthology (KO)

More...
KOi
K12343

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEWCGFA

Database of Orthologous Groups

More...
OrthoDBi
1574389at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18405

TreeFam database of animal gene trees

More...
TreeFami
TF314668

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR

The PANTHER Classification System

More...
PANTHERi
PTHR10556 PTHR10556, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02544 Steroid_dh, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015596 5_alpha-SR2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P18405-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV
60 70 80 90 100
PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL
110 120 130 140 150
IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR
160 170 180 190 200
FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF
210 220 230 240 250
GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF

RKIIIPFLF
Length:259
Mass (Da):29,459
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEF9FD5521E43AC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RG03D6RG03_HUMAN
3-oxo-5-alpha-steroid 4-dehydrogena...
SRD5A1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDL6D6RDL6_HUMAN
3-oxo-5-alpha-steroid 4-dehydrogena...
SRD5A1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29 – 76Missing in AAF14869 (PubMed:10931946).CuratedAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M32313 mRNA Translation: AAA35490.1
M68886
, M68882, M68883, M68884, M68885 Genomic DNA Translation: AAA60995.1
AF052126 mRNA Translation: AAC28620.1
AF113128 mRNA Translation: AAF14869.1
BT006834 mRNA Translation: AAP35480.1
AY341029 Genomic DNA Translation: AAP88935.1
AK313070 mRNA Translation: BAG35898.1
CH471102 Genomic DNA Translation: EAX08104.1
BC007033 mRNA Translation: AAH07033.1
BC008673 mRNA Translation: AAH08673.1
AF073301 Genomic DNA Translation: AAC26862.1
AF073302 Genomic DNA Translation: AAC26863.1
AF073303 Genomic DNA Translation: AAC26864.1
AF073304 Genomic DNA Translation: AAC26865.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3870.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55274

NCBI Reference Sequences

More...
RefSeqi
NP_001038.1, NM_001047.3
NP_001311251.1, NM_001324322.1
NP_001311252.1, NM_001324323.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.552

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274192; ENSP00000274192; ENSG00000145545

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6715

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6715

UCSC genome browser

More...
UCSCi
uc003jdw.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

5-alpha reductase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32313 mRNA Translation: AAA35490.1
M68886
, M68882, M68883, M68884, M68885 Genomic DNA Translation: AAA60995.1
AF052126 mRNA Translation: AAC28620.1
AF113128 mRNA Translation: AAF14869.1
BT006834 mRNA Translation: AAP35480.1
AY341029 Genomic DNA Translation: AAP88935.1
AK313070 mRNA Translation: BAG35898.1
CH471102 Genomic DNA Translation: EAX08104.1
BC007033 mRNA Translation: AAH07033.1
BC008673 mRNA Translation: AAH08673.1
AF073301 Genomic DNA Translation: AAC26862.1
AF073302 Genomic DNA Translation: AAC26863.1
AF073303 Genomic DNA Translation: AAC26864.1
AF073304 Genomic DNA Translation: AAC26865.1
CCDSiCCDS3870.1
PIRiA55274
RefSeqiNP_001038.1, NM_001047.3
NP_001311251.1, NM_001324322.1
NP_001311252.1, NM_001324323.1
UniGeneiHs.552

3D structure databases

ProteinModelPortaliP18405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112593, 3 interactors
STRINGi9606.ENSP00000274192

Chemistry databases

BindingDBiP18405
ChEMBLiCHEMBL1787
DrugBankiDB01126 Dutasteride
DB01216 Finasteride
DB00367 Levonorgestrel
DB09389 Norgestrel
DB06412 Oxymetholone
DB00421 Spironolactone
SwissLipidsiSLP:000001636

PTM databases

PhosphoSitePlusiP18405

Polymorphism and mutation databases

BioMutaiSRD5A1
DMDMi134151

Proteomic databases

EPDiP18405
jPOSTiP18405
MaxQBiP18405
PaxDbiP18405
PeptideAtlasiP18405
PRIDEiP18405
ProteomicsDBi53557

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6715
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274192; ENSP00000274192; ENSG00000145545
GeneIDi6715
KEGGihsa:6715
UCSCiuc003jdw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6715
DisGeNETi6715
EuPathDBiHostDB:ENSG00000145545.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRD5A1
HGNCiHGNC:11284 SRD5A1
HPAiHPA051402
MIMi184753 gene
neXtProtiNX_P18405
OpenTargetsiENSG00000145545
PharmGKBiPA36112

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1638 Eukaryota
ENOG410XS6P LUCA
GeneTreeiENSGT00510000046634
HOGENOMiHOG000050133
HOVERGENiHBG003402
InParanoidiP18405
KOiK12343
OMAiVEWCGFA
OrthoDBi1574389at2759
PhylomeDBiP18405
TreeFamiTF314668

Enzyme and pathway databases

BioCyciMetaCyc:HS07261-MONOMER
BRENDAi1.3.1.22 2681
1.3.99.5 2681
ReactomeiR-HSA-193048 Androgen biosynthesis
SIGNORiP18405

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SRD5A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6715

Protein Ontology

More...
PROi
PR:P18405

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145545 Expressed in 199 organ(s), highest expression level in zone of skin
CleanExiHS_SRD5A1
ExpressionAtlasiP18405 baseline and differential
GenevisibleiP18405 HS

Family and domain databases

InterProiView protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039357 SRD5A/TECR
PANTHERiPTHR10556 PTHR10556, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PIRSFiPIRSF015596 5_alpha-SR2, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS5A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18405
Secondary accession number(s): B2R7Q1
, Q9UHY4, Q9UP36, Q9UP37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: January 16, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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