UniProtKB - P18334 (CSK2A_CAEEL)
Protein
Casein kinase II subunit alpha
Gene
kin-3
Organism
Caenorhabditis elegans
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2.1 Publication
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 67 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 155 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 44 – 52 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: WormBase
- protein serine/threonine kinase activity Source: CAFA
GO - Biological processi
- peptidyl-serine phosphorylation Source: CAFA
- peptidyl-threonine phosphorylation Source: GO_Central
- protein phosphorylation Source: WormBase
- regulation of cell cycle Source: GO_Central
- response to hermaphrodite contact Source: WormBase
- vulval location Source: WormBase
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Behavior, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1 1045 |
SignaLinki | P18334 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:kin-3 ORF Names:B0205.7 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | B0205.7 ; CE17321 ; WBGene00002191 ; kin-3 |
Subcellular locationi
Other locations
- axon 1 Publication
- cilium 1 Publication
- dendrite 1 Publication
- Perikaryon 1 Publication
Note: Enriched in cilia in male sensory neurons.
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: WormBase
Other locations
- axon Source: UniProtKB
- cilium Source: UniProtKB
- dendrite Source: UniProtKB
- neuronal cell body Source: UniProtKB
- non-motile cilium Source: WormBase
- perikaryon Source: UniProtKB-SubCell
- protein kinase CK2 complex Source: WormBase
Keywords - Cellular componenti
Cell projection, CiliumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085898 | 1 – 360 | Casein kinase II subunit alphaAdd BLAST | 360 |
Proteomic databases
EPDi | P18334 |
PaxDbi | P18334 |
PeptideAtlasi | P18334 |
PRIDEi | P18334 |
Expressioni
Tissue specificityi
Expressed in a subset of the adult male sensory neurons: CEM head neurons, ray RnB neurons, and hook HOB tail neurons.1 Publication
Gene expression databases
Bgeei | WBGene00002191 Expressed in 5 organ(s), highest expression level in germ line (C elegans) |
Interactioni
Subunit structurei
Tetramer of two alpha and two beta chains.
Binary interactionsi
Protein-protein interaction databases
BioGridi | 38389, 13 interactors |
IntActi | P18334, 4 interactors |
STRINGi | 6239.B0205.7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 323 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 286 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0668 Eukaryota ENOG410XNPP LUCA |
GeneTreei | ENSGT00390000004215 |
HOGENOMi | HOG000233021 |
InParanoidi | P18334 |
KOi | K03097 |
OMAi | WHSFINA |
OrthoDBi | 1098380at2759 |
PhylomeDBi | P18334 |
Family and domain databases
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P18334-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPIPSRARV YAEVNPSRPR EYWDYEAHMI EWGQIDDYQL VRKLGRGKYS
60 70 80 90 100
EVFEGFKMST DEKVVVKILK PVKKKKIKRE IKILENLRGG TNIITLLDVV
110 120 130 140 150
KDPISRTPAL IFEHVNNSDF KQLYQTLSDY DIRYYLYELL KALDFCHSQG
160 170 180 190 200
IMHRDVKPHN VMIDAEKREL RLIDWGLAEF YHPRQDYNVR VASRYFKGPE
210 220 230 240 250
LLVDYQCYDY SLDMWSLGCM LASMIFRKEP FFHGHDNYDQ LVRIAKVLGT
260 270 280 290 300
DELYEYIARY HIDLDPRFND ILGRHSRKRW ERFIHAENQH LVTPEALDFL
310 320 330 340 350
DKLLRYDHAE RLTAQEAMGH EYFRPVVEAH ARANGTEQAD GQGASNSASS
360
QSSDAKIDGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05274 Genomic DNA Translation: AAA27984.1 FO080112 Genomic DNA Translation: CCD61302.1 |
PIRi | A35562 |
RefSeqi | NP_492811.1, NM_060410.4 |
Genome annotation databases
EnsemblMetazoai | B0205.7.1; B0205.7.1; WBGene00002191 |
GeneIDi | 172978 |
KEGGi | cel:CELE_B0205.7 |
UCSCi | B0205.7 c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05274 Genomic DNA Translation: AAA27984.1 FO080112 Genomic DNA Translation: CCD61302.1 |
PIRi | A35562 |
RefSeqi | NP_492811.1, NM_060410.4 |
3D structure databases
SMRi | P18334 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 38389, 13 interactors |
IntActi | P18334, 4 interactors |
STRINGi | 6239.B0205.7 |
Proteomic databases
EPDi | P18334 |
PaxDbi | P18334 |
PeptideAtlasi | P18334 |
PRIDEi | P18334 |
Genome annotation databases
EnsemblMetazoai | B0205.7.1; B0205.7.1; WBGene00002191 |
GeneIDi | 172978 |
KEGGi | cel:CELE_B0205.7 |
UCSCi | B0205.7 c. elegans |
Organism-specific databases
CTDi | 172978 |
WormBasei | B0205.7 ; CE17321 ; WBGene00002191 ; kin-3 |
Phylogenomic databases
eggNOGi | KOG0668 Eukaryota ENOG410XNPP LUCA |
GeneTreei | ENSGT00390000004215 |
HOGENOMi | HOG000233021 |
InParanoidi | P18334 |
KOi | K03097 |
OMAi | WHSFINA |
OrthoDBi | 1098380at2759 |
PhylomeDBi | P18334 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1 1045 |
SignaLinki | P18334 |
Miscellaneous databases
PROi | PR:P18334 |
Gene expression databases
Bgeei | WBGene00002191 Expressed in 5 organ(s), highest expression level in germ line (C elegans) |
Family and domain databases
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSK2A_CAEEL | |
Accessioni | P18334Primary (citable) accession number: P18334 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | November 13, 2019 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase