UniProtKB - P18289 (JRA_DROME)
Protein
Transcription factor AP-1
Gene
Jra
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361). Plays a role in dorsal closure (PubMed:9224723).3 Publications
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- protein heterodimerization activity Source: FlyBase
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- chorion micropyle formation Source: FlyBase
- dorsal appendage formation Source: FlyBase
- dorsal closure Source: FlyBase
- imaginal disc fusion, thorax closure Source: FlyBase
- JNK cascade Source: FlyBase
- multicellular organism aging Source: FlyBase
- negative regulation of antimicrobial humoral response Source: FlyBase
- positive regulation of heart contraction Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- R3/R4 cell fate commitment Source: FlyBase
- regulation of cell cycle Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- synaptic growth at neuromuscular junction Source: FlyBase
- wound healing Source: FlyBase
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-209394, Transcriptional activtion and repression of REL-68 target genes R-DME-209409, Formation of the nuclear AP-1 transcription factor 'scaffolding complex' R-DME-209425, Transcriptional activtion by AP-1 transcription factor R-DME-2559580, Oxidative Stress Induced Senescence R-DME-2871796, FCERI mediated MAPK activation R-DME-450341, Activation of the AP-1 family of transcription factors R-DME-9018519, Estrogen-dependent gene expression |
SignaLinki | P18289 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-1Alternative name(s): Jun-related antigen dJRA dJun |
Gene namesi | Name:Jra Synonyms:jun ORF Names:CG2275 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0001291, Jra |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: FlyBase
Nucleus
- nuclear chromatin Source: GO_Central
- nucleoplasm Source: Reactome
- nucleus Source: FlyBase
Other locations
- transcription factor AP-1 complex Source: FlyBase
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Death in mid to late embryogenesis with large anterior and dorsal holes.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076437 | 1 – 289 | Transcription factor AP-1Add BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 82 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P18289 |
PRIDEi | P18289 |
PTM databases
iPTMneti | P18289 |
Expressioni
Tissue specificityi
During embryogenesis, expression is elevated in the amnioserosa, in the cells of the dorsolateral epidermis during and following germ-band retraction, in the cells at the leading dorsal edge of the epidermis and in the cells along the cephalic furrow (at protein level).1 Publication
Developmental stagei
Expressed during embryonic development.3 Publications
Gene expression databases
Bgeei | FBgn0001291, Expressed in saliva-secreting gland and 40 other tissues |
ExpressionAtlasi | P18289, baseline and differential |
Genevisiblei | P18289, DM |
Interactioni
Subunit structurei
Binary interactionsi
P18289
With | #Exp. | IntAct |
---|---|---|
kay [A8MPH9] | 3 | EBI-159948,EBI-22062276 |
GO - Molecular functioni
- protein heterodimerization activity Source: FlyBase
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 61885, 66 interactors |
DIPi | DIP-18982N |
IntActi | P18289, 12 interactors |
STRINGi | 7227.FBpp0087498 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 212 – 275 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 212 – 239 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 240 – 268 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0837, Eukaryota |
GeneTreei | ENSGT00940000169681 |
HOGENOMi | CLU_057007_0_0_1 |
InParanoidi | P18289 |
OMAi | ELHHQHM |
OrthoDBi | 1090460at2759 |
PhylomeDBi | P18289 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR005643, JNK IPR029823, JunD IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR11462:SF7, PTHR11462:SF7, 2 hits |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit |
PRINTSi | PR00043, LEUZIPPRJUN |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P18289-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTPVSAAAN LSIQNAGSSG ATAIQIIPKT EPVGEEGPMS LDFQSPNLNT
60 70 80 90 100
STPNPNKRPG SLDLNSKSAK NKRIFAPLVI NSPDLSSKTV NTPDLEKILL
110 120 130 140 150
SNNLMQTPQP GKVFPTKAGP VTVEQLDFGR GFEEALHNLH TNSQAFPSAN
160 170 180 190 200
SAANSAANNT TAAAMTAVNN GISGGTFTYT NMTEGFSVIK DEPVNQASSP
210 220 230 240 250
TVNPIDMEAQ EKIKLERKRQ RNRVAASKCR KRKLERISKL EDRVKVLKGE
260 270 280
NVDLASIVKN LKDHVAQLKQ QVMEHIAAGC TVPPNSTDQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KEI6 | A0A0B4KEI6_DROME | Jun-related antigen, isoform C | Jra AP-1, AP1, c-Jun, cJun, d-JRA | 372 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 267 – 268 | QL → HV in AAA28650 (PubMed:1696724).Curated | 2 | |
Sequence conflicti | 267 – 268 | QL → HV in CAA73154 (PubMed:9224723).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36181 Genomic DNA Translation: AAA28650.1 X54144 mRNA Translation: CAA38083.1 Y12573 Genomic DNA Translation: CAA73154.1 AE013599 Genomic DNA Translation: AAF58845.1 AY058562 mRNA Translation: AAL13791.1 |
PIRi | A36011, TVFFJD |
RefSeqi | NP_476586.1, NM_057238.5 NP_724882.1, NM_165739.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0088410; FBpp0087498; FBgn0001291 FBtr0088411; FBpp0087499; FBgn0001291 |
GeneIDi | 36057 |
KEGGi | dme:Dmel_CG2275 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36181 Genomic DNA Translation: AAA28650.1 X54144 mRNA Translation: CAA38083.1 Y12573 Genomic DNA Translation: CAA73154.1 AE013599 Genomic DNA Translation: AAF58845.1 AY058562 mRNA Translation: AAL13791.1 |
PIRi | A36011, TVFFJD |
RefSeqi | NP_476586.1, NM_057238.5 NP_724882.1, NM_165739.2 |
3D structure databases
SMRi | P18289 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 61885, 66 interactors |
DIPi | DIP-18982N |
IntActi | P18289, 12 interactors |
STRINGi | 7227.FBpp0087498 |
PTM databases
iPTMneti | P18289 |
Proteomic databases
PaxDbi | P18289 |
PRIDEi | P18289 |
Genome annotation databases
EnsemblMetazoai | FBtr0088410; FBpp0087498; FBgn0001291 FBtr0088411; FBpp0087499; FBgn0001291 |
GeneIDi | 36057 |
KEGGi | dme:Dmel_CG2275 |
Organism-specific databases
CTDi | 36057 |
FlyBasei | FBgn0001291, Jra |
Phylogenomic databases
eggNOGi | KOG0837, Eukaryota |
GeneTreei | ENSGT00940000169681 |
HOGENOMi | CLU_057007_0_0_1 |
InParanoidi | P18289 |
OMAi | ELHHQHM |
OrthoDBi | 1090460at2759 |
PhylomeDBi | P18289 |
Enzyme and pathway databases
Reactomei | R-DME-209394, Transcriptional activtion and repression of REL-68 target genes R-DME-209409, Formation of the nuclear AP-1 transcription factor 'scaffolding complex' R-DME-209425, Transcriptional activtion by AP-1 transcription factor R-DME-2559580, Oxidative Stress Induced Senescence R-DME-2871796, FCERI mediated MAPK activation R-DME-450341, Activation of the AP-1 family of transcription factors R-DME-9018519, Estrogen-dependent gene expression |
SignaLinki | P18289 |
Miscellaneous databases
BioGRID-ORCSi | 36057, 0 hits in 3 CRISPR screens |
GenomeRNAii | 36057 |
PROi | PR:P18289 |
Gene expression databases
Bgeei | FBgn0001291, Expressed in saliva-secreting gland and 40 other tissues |
ExpressionAtlasi | P18289, baseline and differential |
Genevisiblei | P18289, DM |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR005643, JNK IPR029823, JunD IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR11462:SF7, PTHR11462:SF7, 2 hits |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit |
PRINTSi | PR00043, LEUZIPPRJUN |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | JRA_DROME | |
Accessioni | P18289Primary (citable) accession number: P18289 Secondary accession number(s): Q0E9D8, Q9V5G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families