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Protein

Transcription factor AP-1

Gene

Jra

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361). Plays a role in dorsal closure (PubMed:9224723).3 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • imaginal disc fusion, thorax closure Source: FlyBase
  • JNK cascade Source: FlyBase
  • MAPK cascade Source: FlyBase
  • micropyle formation Source: FlyBase
  • multicellular organism aging Source: FlyBase
  • negative regulation of antimicrobial humoral response Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: GO_Central
  • positive regulation of cell differentiation Source: GO_Central
  • positive regulation of heart contraction Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • regulation of cell cycle Source: GO_Central
  • regulation of cell death Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to cAMP Source: GO_Central
  • response to cytokine Source: GO_Central
  • response to drug Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • response to mechanical stimulus Source: GO_Central
  • response to radiation Source: GO_Central
  • synaptic growth at neuromuscular junction Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • wound healing Source: FlyBase

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-209394 Transcriptional activtion and repression of REL-68 target genes
R-DME-209409 Formation of the nuclear AP-1 transcription factor 'scaffolding complex'
R-DME-209425 Transcriptional activtion by AP-1 transcription factor
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2871796 FCERI mediated MAPK activation
R-DME-450341 Activation of the AP-1 family of transcription factors
SignaLinkiP18289

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-1
Alternative name(s):
Jun-related antigen
dJRA
dJun
Gene namesi
Name:Jra
Synonyms:jun
ORF Names:CG2275
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001291 Jra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death in mid to late embryogenesis with large anterior and dorsal holes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764371 – 289Transcription factor AP-1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP18289
PRIDEiP18289

PTM databases

iPTMnetiP18289

Expressioni

Tissue specificityi

During embryogenesis, expression is elevated in the amnioserosa, in the cells of the dorsolateral epidermis during and following germ-band retraction, in the cells at the leading dorsal edge of the epidermis and in the cells along the cephalic furrow (at protein level).1 Publication

Developmental stagei

Expressed during embryonic development.3 Publications

Gene expression databases

BgeeiFBgn0001291
ExpressionAtlasiP18289 baseline and differential
GenevisibleiP18289 DM

Interactioni

Subunit structurei

Heterodimer with kay/Fra (PubMed:1696724, PubMed:2116361). The kay-Jra complex is bound more stably to the AP-1 site than either of the two proteins alone (PubMed:2116361). Interacts with Atf3; the interaction enhances the DNA-binding activity of Atf3 (PubMed:20023169).3 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi61885, 62 interactors
DIPiDIP-18982N
IntActiP18289, 20 interactors
STRINGi7227.FBpp0303456

Structurei

3D structure databases

ProteinModelPortaliP18289
SMRiP18289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 275bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 239Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni240 – 268Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOGENOMiHOG000047089
InParanoidiP18289
KOiK04448
OMAiTFTYANM
OrthoDBiEOG091G0N0L
PhylomeDBiP18289

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P18289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPVSAAAN LSIQNAGSSG ATAIQIIPKT EPVGEEGPMS LDFQSPNLNT
60 70 80 90 100
STPNPNKRPG SLDLNSKSAK NKRIFAPLVI NSPDLSSKTV NTPDLEKILL
110 120 130 140 150
SNNLMQTPQP GKVFPTKAGP VTVEQLDFGR GFEEALHNLH TNSQAFPSAN
160 170 180 190 200
SAANSAANNT TAAAMTAVNN GISGGTFTYT NMTEGFSVIK DEPVNQASSP
210 220 230 240 250
TVNPIDMEAQ EKIKLERKRQ RNRVAASKCR KRKLERISKL EDRVKVLKGE
260 270 280
NVDLASIVKN LKDHVAQLKQ QVMEHIAAGC TVPPNSTDQ
Length:289
Mass (Da):31,021
Last modified:December 1, 2000 - v2
Checksum:iFCCA13A6D2AF32BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267 – 268QL → HV in AAA28650 (PubMed:1696724).Curated2
Sequence conflicti267 – 268QL → HV in CAA73154 (PubMed:9224723).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36181 Genomic DNA Translation: AAA28650.1
X54144 mRNA Translation: CAA38083.1
Y12573 Genomic DNA Translation: CAA73154.1
AE013599 Genomic DNA Translation: AAF58845.1
AY058562 mRNA Translation: AAL13791.1
PIRiA36011 TVFFJD
RefSeqiNP_476586.1, NM_057238.5
NP_724882.1, NM_165739.2
UniGeneiDm.3574

Genome annotation databases

EnsemblMetazoaiFBtr0088410; FBpp0087498; FBgn0001291
FBtr0088411; FBpp0087499; FBgn0001291
FBtr0330606; FBpp0303456; FBgn0001291
GeneIDi36057
KEGGidme:Dmel_CG2275

Similar proteinsi

Entry informationi

Entry nameiJRA_DROME
AccessioniPrimary (citable) accession number: P18289
Secondary accession number(s): Q0E9D8, Q9V5G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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