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Protein

Nucleoprotein

Gene

NP

Organism
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiZaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Taxonomic identifieri128952 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Proteomesi
  • UP000007209 Componenti: Genome
  • UP000109874 Componenti: Genome
  • UP000149419 Componenti: Genome
  • UP000150973 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • helical viral capsid Source: UniProtKB-KW
  • host cell cytoplasm Source: UniProtKB-SubCell
  • viral nucleocapsid Source: CACAO

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002221711 – 739NucleoproteinAdd BLAST739

Post-translational modificationi

Phosphorylated and O-glycosylated by host.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP18272

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VP35Q051272EBI-9820219,EBI-6148294

Protein-protein interaction databases

ELMiP18272
IntActiP18272, 1 interactor

Structurei

Secondary structure

1739
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18272
SMRiP18272
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili334 – 363Sequence analysisAdd BLAST30

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.

Sequence similaritiesi

Belongs to the filoviruses nucleoprotein family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

OrthoDBiVOG09000031

Family and domain databases

InterProiView protein in InterPro
IPR008609 Ebola_NP
PfamiView protein in Pfam
PF05505 Ebola_NP, 1 hit
PIRSFiPIRSF003900 N_FiloV, 1 hit

Sequencei

Sequence statusi: Complete.

P18272-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSRPQKIWM APSLTESDMD YHKILTAGLS VQQGIVRQRV IPVYQVNNLE
60 70 80 90 100
EICQLIIQAF EAGVDFQESA DSFLLMLCLH HAYQGDYKLF LESGAVKYLE
110 120 130 140 150
GHGFRFEVKK RDGVKRLEEL LPAVSSGKNI KRTLAAMPEE ETTEANAGQF
160 170 180 190 200
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI
210 220 230 240 250
FRLMRTNFLI KFLLIHQGMH MVAGHDANDA VISNSVAQAR FSGLLIVKTV
260 270 280 290 300
LDHILQKTER GVRLHPLART AKVKNEVNSF KAALSSLAKH GEYAPFARLL
310 320 330 340 350
NLSGVNNLEH GLFPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA
360 370 380 390 400
EKQLQQYAES RELDHLGLDD QEKKILMNFH QKKNEISFQQ TNAMVTLRKE
410 420 430 440 450
RLAKLTEAIT AASLPKTSGH YDDDDDIPFP GPINDDDNPG HQDDDPTDSQ
460 470 480 490 500
DTTIPDVVVD PDDGSYGEYQ SYSENGMNAP DDLVLFDLDE DDEDTKPVPN
510 520 530 540 550
RSTKGGQQKN SQKGQHIEGR QTQSRPIQNV PGPHRTIHHA SAPLTDNDRR
560 570 580 590 600
NEPSGSTSPR MLTPINEEAD PLDDADDETS SLPPLESDDE EQDRDGTSNR
610 620 630 640 650
TPTVAPPAPV YRDHSEKKEL PQDEQQDQDH TQEARNQDSD NTQSEHSFEE
660 670 680 690 700
MYRHILRSQG PFDAVLYYHM MKDEPVVFST SDGKEYTYPD SLEEEYPPWL
710 720 730
TEKEAMNEEN RFVTLDGQQF YWPVMNHKNK FMAILQHHQ
Length:739
Mass (Da):83,287
Last modified:July 15, 1999 - v2
Checksum:i159C254EA0478886
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170E → R in AAA42977 (PubMed:2718390).Curated1
Sequence conflicti280F → L in AAA42977 (PubMed:2718390).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti72S → G in strain: Isolate mouse-adapted. 1
Natural varianti524S → F in strain: Isolate guinea pig-adapted. 1
Natural varianti648F → L in strain: Isolate guinea pig-adapted. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04337 Genomic RNA Translation: AAA42977.1
L11365 Genomic RNA Translation: AAB81001.1
AF086833 Genomic RNA Translation: AAD14590.1
AF272001 Genomic RNA Translation: AAG40164.1
AY142960 Genomic RNA Translation: AAN37504.1
AF499101 Genomic RNA Translation: AAM76031.1
PIRiA31471 VHIWEB
RefSeqiNP_066243.1, NC_002549.1

Genome annotation databases

GeneIDi911830
KEGGivg:911830

Similar proteinsi

Entry informationi

Entry nameiNCAP_EBOZM
AccessioniPrimary (citable) accession number: P18272
Secondary accession number(s): Q773N6
, Q8JS64, Q9DQD3, Q9YMG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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